Development of Pseudomonas aeruginosa Lectin LecA Inhibitor by using Bivalent Galactosides Supported on Polyproline Peptide Scaffolds

Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties

(2017) Marion Donnier-Maréchal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Toward the Rational Design of Galactosylated Glycoclusters That Target Pseudomonas aeruginosa Lectin A (LecA): Influence of Linker Arms That Lead to Low-Nanomolar Multivalent Ligands

(2016) Shuai Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa

(2016) Ines Joachim et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA

(2016) Myriam Bergmann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers

(2016) Gaëlle Michaud et al.   Chemical Science

Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA

(2015) Ricardo Visini et al.   ACS Chemical Biology

Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

(2015) Susan E. Northfield et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Thiourea-based spacers in potent divalent inhibitors of Pseudomonas aeruginosa virulence lectin LecA

(2015) Aliaksei V. Pukin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Mannose-centered aromatic galactoclusters inhibit the biofilm formation of Pseudomonas aeruginosa

(2015) Caroline Ligeour et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Functionalization of a Rigid Divalent Ligand for LecA, a Bacterial Adhesion Lectin

(2015) Ou Fu et al.   ChemistryOpen

A LecA Ligand Identified from a Galactoside-Conjugate Array Inhibits Host Cell Invasion byPseudomonas aeruginosa

(2014) Alexandre Novoa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure Binding Relationship of Galactosylated Glycoclusters toward Pseudomonas aeruginosa Lectin LecA Using a DNA-Based Carbohydrate Microarray

(2014) Béatrice Gerland et al.   BIOCONJUGATE CHEMISTRY

A highly versatile convergent/divergent “onion peel” synthetic strategy toward potent multivalent glycodendrimers

(2014) Rishi Sharma et al.   CHEMICAL COMMUNICATIONS

Glycomimetics versus Multivalent Glycoconjugates for the Design of High Affinity Lectin Ligands

(2014) Samy Cecioni et al.   CHEMICAL REVIEWS

Synthesis of Galactoclusters by Metal-Free Thiol “Click Chemistry” and Their Binding Affinities forPseudomonas aeruginosaLectin LecA

(2014) Caroline Ligeour et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Antiadhesive Properties of Glycoclusters against Pseudomonas aeruginosa Lung Infection

(2014) Amine M. Boukerb et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Crystal Structure of an Oligoproline PPII-Helix, at Last

(2014) Patrick Wilhelm et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The influence of the aromatic aglycon of galactoclusters on the binding of LecA: a case study with O-phenyl, S-phenyl, O-benzyl, S-benzyl, O-biphenyl and O-naphthyl aglycons

(2014) Francesca Casoni et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

CH−π “T-Shape” Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa Lectin LecA

(2013) Rameshwar U. Kadam et al.   ACS Chemical Biology

Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors

(2013) Francesca Pertici et al.   Beilstein Journal of Organic Chemistry

Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions

(2013) Naresh Kottari et al.   CHEMICAL COMMUNICATIONS

Bridging lectin binding sites by multivalent carbohydrates

(2013) Valentin Wittmann et al.   CHEMICAL SOCIETY REVIEWS

Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors

(2013) Jean-Louis Reymond et al.   CHEMICAL SOCIETY REVIEWS

Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors ofPseudomonas aeruginosaBiofilms Targeting LecA

(2013) Rameshwar U. Kadam et al.   CHEMISTRY-A EUROPEAN JOURNAL

Optimizing Divalent Inhibitors ofPseudomonas aeruginosaLectin LecA by Using A Rigid Spacer

(2013) Francesca Pertici et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Multivalent Carbohydrate-Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA fromPseudomonas aeruginosa

(2013) Marina L. Gening et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of guanidino sugar conjugates as GlcβArg analogs

(2013) Amrita Srivastava et al.   GLYCOCONJUGATE JOURNAL

Prospects for new antibiotics: a molecule-centered perspective

(2013) Christopher T Walsh et al.   JOURNAL OF ANTIBIOTICS

Hybrid Bombesin Analogues: Combining an Agonist and an Antagonist in Defined Distances for Optimized Tumor Targeting

(2013) Carsten Kroll et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins

(2013) Virgil Percec et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Aromatic thioglycoside inhibitors against the virulence factor LecA from Pseudomonas aeruginosa

(2013) Jacques Rodrigue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA

(2012) Francesca Pertici et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Ullmann-Type Reductive Homocoupling of Iodoaryl Glycosides

(2012) Milan Bergeron-Brlek et al.   JOURNAL OF ORGANIC CHEMISTRY

A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms

(2011) Rameshwar U. Kadam et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Dodecavalent Fullerene-Based Glycoclusters and Evaluation of Their Binding Properties towards a Bacterial Lectin

(2011) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photo-Click Immobilization on Quartz Crystal Microbalance Sensors for Selective Carbohydrate−Protein Interaction Analyses

(2010) Oscar Norberg et al.   ANALYTICAL CHEMISTRY

Application of Halide Molten Salts as Novel Reaction Media for O-Glycosidic Bond Formation

(2010) Vineet Kumar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

NDM-1 — A Cause for Worldwide Concern

(2010) Robert C. Moellering   NEW ENGLAND JOURNAL OF MEDICINE

Achieving High Affinity towards a Bacterial Lectin through Multivalent Topological Isomers of Calix[4]arene Glycoconjugates

(2009) Samy Cecioni et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role of LecA and LecB Lectins in Pseudomonas aeruginosa-Induced Lung Injury and Effect of Carbohydrate Ligands

(2009) C. Chemani et al.   INFECTION AND IMMUNITY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES