Cyclic Seleninate Esters, Spirodioxyselenuranes and Related Compounds: New Classes of Biological Antioxidants That Emulate Glutathione Peroxidase

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Jonathan Kil et al.   LANCET

Organoselenium compounds as mimics of selenoproteins and thiol modifier agents

(2017) Nilda V. Barbosa et al.   Metallomics

Multifunctional Antioxidants: Regenerable Radical-Trapping and Hydroperoxide-Decomposing Ebselenols

(2016) Shailesh Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The role of methoxy substituents in regulating the activity of selenides that serve as spirodioxyselenurane precursors and glutathione peroxidase mimetics

(2016) David J. Press et al.   CANADIAN JOURNAL OF CHEMISTRY

Enhanced Glutathione Peroxidase Activity of Water-Soluble and Polyethylene Glycol-Supported Selenides, Related Spirodioxyselenuranes, and Pincer Selenuranes

(2016) Nicole M. R. McNeil et al.   JOURNAL OF ORGANIC CHEMISTRY

Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla

(2016) Charles Masaki et al.   PSYCHOPHARMACOLOGY

Small Organoselenium Compounds: More than just Glutathione Peroxidase Mimics

(2015) Thomas Wirth   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of Ring Size and Polar Functional Groups on the Glutathione Peroxidase-Like Antioxidant Activity of Water-Soluble Cyclic Selenides

(2015) Kenta Arai et al.   JOURNAL OF ORGANIC CHEMISTRY

Effect of Methoxy Substituents on the Activation Barriers of the Glutathione Peroxidase-Like Mechanism of an Aromatic Cyclic Seleninate

(2015) Craig Bayse et al.   MOLECULES

Substituent Effects on the Stability and Antioxidant Activity of Spirodiazaselenuranes

(2015) Devappa Lamani et al.   MOLECULES

Synthesis, Structure and Antioxidant Activity of Cyclohexene-Fused Selenuranes and Related Derivatives

(2015) Poonam Prasad et al.   MOLECULES

Oxidation of Disulfides to Thiolsulfinates with Hydrogen Peroxide and a Cyclic Seleninate Ester Catalyst

(2015) Nicole McNeil et al.   MOLECULES

Insights into the catalytic mechanism of synthetic glutathione peroxidase mimetics

(2015) Debasish Bhowmick et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pyridoxine-Derived Organoselenium Compounds with Glutathione Peroxidase-Like and Chain-Breaking Antioxidant Activity

(2014) Vijay P. Singh et al.   CHEMISTRY-A EUROPEAN JOURNAL

Regenerable Antioxidants-Introduction of Chalcogen Substituents into Tocopherols

(2014) Jia-fei Poon et al.   CHEMISTRY-A EUROPEAN JOURNAL

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum

(2014) Thomas Ramming et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthesis, Structure, and Thermolysis of Tetracoordinated 1λ4,2-Selenazetidines Bearing Two Chiral Centers at the 3- and 4-Positions

(2014) Yuya Daicho et al.   HETEROATOM CHEMISTRY

Effects of Methoxy Substituents on the Glutathione Peroxidase-like Activity of Cyclic Seleninate Esters

(2014) David J. Press et al.   JOURNAL OF ORGANIC CHEMISTRY

Are Reactive Oxygen Species Always Detrimental to Pathogens?

(2013) Claudia N. Paiva et al.   ANTIOXIDANTS & REDOX SIGNALING

The early research and development of ebselen

(2013) Michael J. Parnham et al.   BIOCHEMICAL PHARMACOLOGY

Modeling the Glutathione Peroxidase-Like Activity of a Cyclic Seleninate by DFT and Solvent-Assisted Proton Exchange

(2013) Craig A. Bayse et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Fluxional Cyclic Seleninate Ester: NMR and Computational Studies, Glutathione Peroxidase-like Behavior, and Unexpected Rearrangement

(2013) Nicole M. R. McNeil et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Water-Soluble Vinyl Selenides and Their High Glutathione Peroxidase (GPx)-Like Antioxidant Activity

(2013) Samuel Braverman et al.   SYNTHESIS-STUTTGART

A safe lithium mimetic for bipolar disorder

(2013) Nisha Singh et al.   Nature Communications

Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis

(2012) Regina Brigelius-Flohé et al.   Annals of the New York Academy of Sciences

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Cyclic Seleninate Esters as Catalysts for the Oxidation of Sulfides to Sulfoxides, Epoxidation of Alkenes, and Conversion of Enamines to α-Hydroxyketones

(2012) Eric A. Mercier et al.   JOURNAL OF ORGANIC CHEMISTRY

NMR and Computational Studies of the Configurational Properties of Spirodioxyselenuranes. Are Dynamic Exchange Processes or Temperature-Dependent Chemical Shifts Involved?

(2012) David J. Press et al.   JOURNAL OF ORGANIC CHEMISTRY

Sound medicine

(2012) Elie Dolgin   NATURE MEDICINE

Spirodiazaselenuranes: synthesis, structure and antioxidant activity

(2012) Devappa S. Lamani et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Composition and Evolution of the Vertebrate and Mammalian Selenoproteomes

(2012) Marco Mariotti et al.   PLoS One

Synthesis, Structure, and Glutathione Peroxidase-Like Activity of Amino Acid Containing Ebselen Analogues and Diaryl Diselenides

(2011) Karuthapandi Selvakumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Anionic Hypervalent Cyclic Selenenate Esters: Relevance to the Hypervalent Intermediates in Nucleophilic Substitution Reactions at the Selenium(II) Center

(2011) Karuthapandi Selvakumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Cyclic Selenenate/Seleninate Esters Stabilized by ortho-Nitro Coordination: Their Glutathione Peroxidase-Like Activities

(2011) Vijay P. Singh et al.   Chemistry-An Asian Journal

Synthesis and structural characterization of pincer type bicyclic diacyloxy- and diazaselenuranes

(2011) K. Selvakumar et al.   DALTON TRANSACTIONS

Genesis and development of DPPH method of antioxidant assay

(2011) Sagar B. Kedare et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Immunomodulating tellurium compounds as anti-cancer agents

(2011) Benjamin Sredni   SEMINARS IN CANCER BIOLOGY

Intramolecular homolytic substitution of seleninates – a computational study

(2011) Anne C. Neves et al.   TETRAHEDRON

Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants

(2010) Krishna P. Bhabak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives

(2010) Katrin Knop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organoselenium Chemistry: Role of Intramolecular Interactions†

(2010) Anna J. Mukherjee et al.   CHEMICAL REVIEWS

Aromatic Ring Strain in Arylselenenyl Bromides: Role in Facile Synthesis of Selenenate Esters via Intramolecular Cyclization

(2010) K. Selvakumar et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selenium- and Tellurium-Containing Multifunctional Redox Agents as Biochemical Redox Modulators with Selective Cytotoxicity

(2010) Vincent Jamier et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Chain-Breaking Pyridinol Antioxidants

(2010) Sangit Kumar et al.   JOURNAL OF ORGANIC CHEMISTRY

Long-Lasting Antioxidant Protection: A Regenerable BHA Analogue

(2010) Henrik Johansson et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Structure, Spirocyclization Mechanism, and Glutathione Peroxidase-like Antioxidant Activity of Stable Spirodiazaselenurane and Spirodiazatellurane

(2010) Bani Kanta Sarma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tellurium: an element with great biological potency and potential

(2010) Lalla Aicha Ba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-Phenoxyethanol derived diselenide and related compounds; synthesis of a seven-membered seleninate ester

(2010) Santosh K. Tripathi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms

(2009) Chee Chew Lim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protection against reactive oxygen species by selenoproteins

(2009) Holger Steinbrenner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Water-Soluble Cyclic Selenide with Enhanced Glutathione Peroxidase-Like Catalytic Activities

(2009) Fumio Kumakura et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Emerging PEGylated drugs

(2009) Jung Seok Kang et al.   EXPERT OPINION ON EMERGING DRUGS

Catalase and glutathione peroxidase mimics

(2008) Brian J. Day   BIOCHEMICAL PHARMACOLOGY

Antioxidant Activity of the Anti-Inflammatory Compound Ebselen: A Reversible Cyclization Pathway via Selenenic and Seleninic Acid Intermediates

(2008) Bani Kanta Sarma et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent advances in spirochalcogenurane stereochemistry—A mini review

(2008) Stig Allenmark   CHIRALITY

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

(2008) Connie H. Y. Wong et al.   JOURNAL OF NEUROCHEMISTRY

Substituent Effects upon the Catalytic Activity of Aromatic Cyclic Seleninate Esters and Spirodioxyselenuranes That Act as Glutathione Peroxidase Mimetics

(2008) David J. Press et al.   JOURNAL OF ORGANIC CHEMISTRY

Biomimetic Seleninates and Selenonates

(2008) Mohannad Abdo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Applications of Water-Soluble Selenides and Selenoxides to Protein Chemistry

(2008) Michio Iwaoka et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS