Article
Chemistry, Multidisciplinary
Adrian I. Doig, Tyler A. Tuck, Brandon LeBlanc, Thomas G. Back
Summary: In this study, several 2,7-dialkoxy-substituted naphthalene-1,8-peri-diselenides were synthesized and tested for their catalytic antioxidant activity. Acidic conditions increased the catalytic activity, while basic conditions suppressed it. The highest activity was observed with a 2,7-bis(triethyleneglycol) derivative. Further investigation revealed that a thiol-dependent single electron transfer reaction occurred under the conditions of the assay, which could be reversed by the addition of triethylamine.
Article
Chemistry, Analytical
Linlin Zhang, Jie Wang, Chenglong Zhao, Feijin Zhou, Cheng Yao, Chan Song
Summary: The nanozymes-based sensing platforms have attracted attention in recent years due to their outstanding performances in practical applications. In this study, magnetic Fe nanoparticles with peroxidase-like activity were developed for fast detection of glutathione (GSH). The Fe nanoparticles were easily prepared through a simple method and exhibited high catalytic activity. The developed sensing system based on Fe nanoparticles can be used for colorimetric biosensors with naked-eye detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Rama Alhasan, Guilherme M. Martins, Pedro P. de Castro, Rahman Shah Zaib Saleem, Ali Zaiter, Isabelle Fries-Raeth, Alexandra Kleinclauss, Caroline Perrin-Sarrado, Patrick Chaimbault, Eufranio N. da Silva Junior, Caroline Gaucher, Claus Jacob
Summary: Decreased selenium levels and increased oxidative stress have been linked to chronic diseases. This study synthesized and evaluated a series of organic selenium compounds for their antioxidant activities. The seleno-hydantoin derivatives exhibited glutathione peroxidase-like activity and show potential for treating chronic diseases.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Xia Kong, Rufeng Yang, Yongguang Li, Ying Wei, Yilan Sun, Haoyuan Lyu, Dexin Yin, Xixi Zhu, Guang Lu, Qingyun Liu
Summary: A novel peroxidase-like enzyme based on Co3O4 and binuclear phthalocyanine was synthesized, showing enhanced catalytic activity and potential application for colorimetric detection of glutathione.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Laura Perez-Garrido, Mariano Ortega-Munoz, Fernando Hernandez-Mateo, F. Javier Lopez-Jaramillo, Francisco Santoyo-Gonzalez
Summary: Selenium (Se) has both antioxidant and pro-oxidant activity, and its biological effect depends on dose and speciation. Acid anhydride-coated carbon dots (AA-CD) can be used as a platform for preparing nanoparticles containing chemically defined Se. These nanoparticles show tunable hydrosolubility and exhibit glutathione peroxidase-like activity and cytotoxicity. The toxicity of the nanoparticles depends on dose, time, and intracellular glutathione (GSH) content, and is neutralized over time.
Article
Chemistry, Physical
Laura Perez-Garrido, Mariano Ortega-Munoz, Fernando Hernandez-Mateo, F. Javier Lopez-Jaramillo, Francisco Santoyo-Gonzalez
Summary: Selenium (Se) is a dual-faced element with both antioxidant and pro-oxidant activities. Selenium nanoparticles are of great interest but their preparation for biomedical applications is not easy. Acid anhydride-coated carbon dots (AACD) are proposed as a platform for chemically defined Se nanoparticles. The resulting CD-SeCN nanoparticles exhibit tunable hydrosolubility and show potential as anticancer agents with differential cytotoxicity based on cellular glutathione content.
Article
Chemistry, Inorganic & Nuclear
Xiaoyan Cao, Hui Yang, Qiulian Wei, Yanting Yang, Mei Liu, Qingyun Liu, Xianxi Zhang
Summary: Pt/NiCo layered double hydroxides nanocomposites were successfully prepared using a one-pot hydrothermal method, demonstrating excellent peroxidase-like activity and catalytic performance. The material shows rapid response for real-time detection and sensitivity towards H2O2 and glutathione.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Organic
Kai N. Sands, Benjamin S. Gelfand, Thomas G. Back
Summary: Aryl selenonic acids were synthesized from aryl bromides via a one-pot method, with yields ranging from 77-90%. The synthesis involved metalation, selenation, oxidation with hydrogen peroxide, and ion exchange. One derivative readily dehydrated to form a cyclic selenonic ester, while two minor byproducts were identified as mixed salts of aryl selenonic acids with either aryl seleninic or selenious acid through X-ray crystallography.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Analytical
Liyuan Fan, Xianbing Ji, Guoqing Lin, Kai Liu, Shengfu Chen, Guanglong Ma, Weili Xue, Xiaoyu Zhang, Longgang Wang
Summary: The platinum nanoclusters stabilized by LP exhibited high catalytic oxidation activity, enabling sensitive detection of glucose and glutathione concentrations.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Patricia P. Adriani, Fernanda C. R. de Paiva, Gabriel S. de Oliveira, Amanda C. Leite, Adriana S. Sanches, Adriana Rios Lopes, Marcio V. B. Dias, Felipe S. Chambergo
Summary: The study characterized the functional and structural features of a glutathione peroxidase (GPx) identified in Trichoderma reesei, demonstrating that TrGPx is a thioredoxin peroxidase with better hydrolysis activity towards H2O2 than t-BOOH. Additionally, TrGPx showed optimal pH range and half-life at 80 degrees Celsius.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Roberto Maria-Hormigos, Agueda Molinero-Fernandez, Miguel Angel Lopez, Beatriz Jurado-Sanchez, Alberto Escarpa
Summary: Prussian Blue/chitosan enzyme mimetic tubular micromotors are used for on-the-fly (bio)-sensing assays. These micromotors exhibit enzyme mimetic capabilities and can autonomously propel using oxygen bubbles. They can also detect analytes and simplify sensing steps. By combining with chitosan, these micromotors can be functionalized with acetylthiocholinesterase enzyme for fast inhibition assays. This research holds great potential for various (bio)-sensing applications, including forensics.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sun-Chol Yu, In-Chol Kim, Kum-Ju Ri, Jin Ri, Hartmut Kuehn
Summary: Molecular docking studies revealed that the distance between selenenylsulfides and the active site plays a crucial role in inhibiting the glutathione peroxidase (GPx)-like activity by preventing reduction by glutathione reductase (GR). Additionally, strong binding of selenenylsulfides to the active site results in inhibition of GPx-like activity.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Analytical
Ning Jiang, Chuang Zhang, Meng Li, Shuai Li, Zhili Hao, Zhengqiang Li, Zhuofu Wu, Chen Li
Summary: The assessment of glutathione (GSH) levels with the colorimetric assay relying on the oxidation of TMB catalyzed by nanomaterials shows promising results for early diagnostics. The D-amino acid incorporated nanoflowers with larger diameter size exhibited high sensitivity and stability in detecting GSH, indicating its potential application in clinical diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Quan V. Vo, Do Thi Ngoc Hang, Nguyen Thi Hoa, Pham Cam Nam, Tuan Quang Duong, Adam Mechler
Summary: 4-Mercaptoimidazole (4MC) is a potent radical scavenger with good antioxidant activity, especially against the hydroxyl radical. It demonstrates excellent antiradical activity against various free radicals, such as CH3O, CCl3O, HOO, CH3OO, CCl3OO, NO2, O-2(-), SO4-, DPPH, and ABTS(+). In addition, 4MC has the potential to enhance bioactivity through a regeneration cycle involving the scavenging of O-2(-) and HOO radicals.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Clinical Neurology
Qing-Zhang Tuo, Shashank Masaldan, Adam Southon, Celeste Mawal, Scott Ayton, Ashley Bush, Peng Lei, Abdel Ali Belaidi
Summary: The emergence of ferroptosis as a cell death pathway associated with brain disorders highlights the importance of developing therapeutics targeting the brain and protecting neurons. Selenium compounds have shown to be effective in inhibiting ferroptosis, with organic selenium compounds like methylselenocysteine providing protection against neuronal damage in ischemia-reperfusion injury in vivo. This suggests the potential use of ferroptosis inhibitors and specific selenium compounds in preventing neuronal damage in ischemic stroke and other related brain diseases.
