N-Terminal Cu-Binding Motifs (Xxx-Zzz-His, Xxx-His) and Their Derivatives: Chemistry, Biology and Medicinal Applications

The N-terminus of hepcidin is a strong and potentially biologically relevant Cu(II) chelator

(2018) Dawid Płonka et al.   INORGANICA CHIMICA ACTA

Cu(II) Binding to the Peptide Ala-His-His, a Chimera of the Canonical Cu(II)-Binding Motifs Xxx-His and Xxx-Zzz-His

(2017) Paulina Gonzalez et al.   INORGANIC CHEMISTRY

Copper(II) Complexes with ATCUN Peptide Analogues: Studies on Redox Activity in Different Solutions

(2017) Magdalena Z. Wiloch et al.   JOURNAL OF THE ELECTROCHEMICAL SOCIETY

The Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's Disease

(2017) Simon C. Drew   Frontiers in Neuroscience

Resistance of Cu(Aβ4- 16) to Copper Capture by Metallothionein-3 Supports a Function for the Aβ4- 42 Peptide as a Synaptic CuII Scavenger

(2016) Nina E. Wezynfeld et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Coordinating properties of peptides containing histidyl residues

(2016) Imre Sóvágó et al.   COORDINATION CHEMISTRY REVIEWS

Enhanced stability of Cu2+–ATCUN complexes under physiologically relevant conditions by insertion of structurally bulky and hydrophobic amino acid residues into the ATCUN motif

(2016) Takaaki Miyamoto et al.   DALTON TRANSACTIONS

Interactions of α-Factor-1, a Yeast Pheromone, and Its Analogue with Copper(II) Ions and Low-Molecular-Weight Ligands Yield Very Stable Complexes

(2016) Karolina Bossak et al.   INORGANIC CHEMISTRY

Copper Exchange and Redox Activity of a Prototypical 8-Hydroxyquinoline: Implications for Therapeutic Chelation

(2016) Mariusz Mital et al.   INORGANIC CHEMISTRY

Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt ATCUN Metallopeptide

(2016) Banu Kandemir et al.   INORGANIC CHEMISTRY

Copper(II) binding properties of hepcidin

(2016) Kanokwan Kulprachakarn et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Sequence proximity between Cu(II) and Cu(I) binding sites of human copper transporter 1 model peptides defines reactivity with ascorbate and O 2

(2016) Stefanie Schwab et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Tuning the Redox Properties of Copper(II) Complexes with Amyloid-β Peptides

(2016) Magdalena Z. Wiloch et al.   JOURNAL OF THE ELECTROCHEMICAL SOCIETY

Designing metallodrugs with nuclease and protease activity

(2016) Caleb Mawuli Agbale et al.   Metallomics

A Functional Role for Aβ in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding

(2015) Mariusz Mital et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hybrid peptide ATCUN-sh-Buforin: Influence of the ATCUN charge and stereochemistry on antimicrobial activity

(2015) M. Daben J. Libardo et al.   BIOCHIMIE

Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

(2015) C. Wende et al.   CHEMICAL COMMUNICATIONS

Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA

(2015) Martin James Ross et al.   DALTON TRANSACTIONS

A novel copper-chelating strategy for fluorescent proteins to image dynamic copper fluctuations on live cell surfaces

(2015) Yoon-Aa Choi et al.   Chemical Science

Central Role of the Copper-Binding Motif in the Complex Mechanism of Action of Ixosin: Enhancing Oxidative Damage and Promoting Synergy with Ixosin B

(2015) M. Daben J. Libardo et al.   ACS Infectious Diseases

Introduction of a Fluorescent Probe to Amyloid-β to Reveal Kinetic Insights into Its Interactions with Copper(II)

(2014) Thomas Branch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G-Quadruplex Telomeric DNA by an Anticancer Copper-Acridine-ATCUN Complex

(2014) Zhen Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Antimicrobial activity of trout hepcidin

(2014) Claudio A. Álvarez et al.   FISH & SHELLFISH IMMUNOLOGY

Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs

(2014) Kosh P. Neupane et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Tachykinin Peptide Neurokinin B Binds Copper Forming an Unusual [CuII(NKB)2] Complex and Inhibits Copper Uptake into 1321N1 Astrocytoma Cells

(2013) Debora Russino et al.   ACS Chemical Neuroscience

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

(2013) Jeff C. Joyner et al.   CHEMICAL COMMUNICATIONS

Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs

(2013) Sonia Melino et al.   FEBS Journal

Macrocyclization of the ATCUN Motif Controls Metal Binding and Catalysis

(2013) Kosh P. Neupane et al.   INORGANIC CHEMISTRY

Fenton-like copper redox chemistry revisited: Hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production

(2013) A. Ninh Pham et al.   JOURNAL OF CATALYSIS

Kinetics and mechanisms of oxidative cleavage of HIV RRE RNA by Rev-coupled transition metal–chelates

(2013) Jeff C. Joyner et al.   Chemical Science

Catalytic metallodrugs targeting HCV IRES RNA

(2012) Seth Bradford et al.   CHEMICAL COMMUNICATIONS

Inhibition of Cu-Amyloid-β by using Bifunctional Peptides with β-Sheet Breaker and Chelator Moieties

(2012) Madeleine Jensen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Affinity of copper and zinc ions to proteins and peptides related to neurodegenerative conditions (Aβ, APP, α-synuclein, PrP)

(2012) Izabela Zawisza et al.   COORDINATION CHEMISTRY REVIEWS

Coordination of redox active metal ions to the amyloid precursor protein and to amyloid-β peptides involved in Alzheimer disease. Part 1: An overview

(2012) Christelle Hureau   COORDINATION CHEMISTRY REVIEWS

Peptides as complexing agents: Factors influencing the structure and thermodynamic stability of peptide complexes

(2012) Imre Sóvágó et al.   COORDINATION CHEMISTRY REVIEWS

Chelation therapy in Wilson's disease: from d-penicillamine to the design of selective bioinspired intracellular Cu(i) chelators

(2012) Pascale Delangle et al.   DALTON TRANSACTIONS

Selective control of Cu(II) complex stability in histidine peptides by β-alanine

(2012) Justyna Nagaj et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

X-ray and Solution Structures of CuIIGHK and CuIIDAHK Complexes: Influence on Their Redox Properties

(2011) Christelle Hureau et al.   CHEMISTRY-A EUROPEAN JOURNAL

Thermodynamic study of Cu2+ binding to the DAHK and GHK peptides by isothermal titration calorimetry (ITC) with the weaker competitor glycine

(2011) Ana Trapaidze et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Targeted Cleavage of HIV RRE RNA by Rev-Coupled Transition Metal Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Model Peptides Provide New Insights into the Role of Histidine Residues as Potential Ligands in Human Cellular Copper Acquisition via Ctr1

(2011) Kathryn L. Haas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Functions, One Molecule: A Metal-Binding and a Targeting Moiety to Combat Alzheimer's Disease

(2010) Christelle Hureau  et al.   CHEMBIOCHEM

Copper Transfer from Cu-Aβ to Human Serum Albumin Inhibits Aggregation, Radical Production and Reduces Aβ Toxicity

(2009) Lorena Perrone et al.   CHEMBIOCHEM

Copper·Lys-Gly-His-Lys mediated cleavage of tRNAPhe: Studies of reaction mechanism and cleavage specificity

(2009) Seth Bradford et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

N-terminal fragment of the anti-angiogenic human endostatin binds copper(II) with very high affinity

(2009) András Kolozsi et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology