Designing metallodrugs with nuclease and protease activity

64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133+ cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite

(2016) Yukie Yoshii et al.   CANCER LETTERS

Recent advances in the chemistry of selenium-containing heterocycles: Five-membered ring systems

(2016) Mohamed Elsherbini et al.   COORDINATION CHEMISTRY REVIEWS

Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

(2016) Waseem A. Wani et al.   COORDINATION CHEMISTRY REVIEWS

Enhanced stability of Cu2+–ATCUN complexes under physiologically relevant conditions by insertion of structurally bulky and hydrophobic amino acid residues into the ATCUN motif

(2016) Takaaki Miyamoto et al.   DALTON TRANSACTIONS

Investigation of the Inertness to Hydrolysis of Platinum(IV) Prodrugs

(2016) Ida Ritacco et al.   INORGANIC CHEMISTRY

Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt ATCUN Metallopeptide

(2016) Banu Kandemir et al.   INORGANIC CHEMISTRY

Bovine serum albumin binding, antioxidant and anticancer properties of an oxidovanadium(IV) complex with luteolin

(2016) Luciana G. Naso et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Adsorption of the cis-[Pt(NH3)2(P2O7)]2− (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues

(2016) Michele Benedetti et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole

(2016) Rodrigo S. Corrêa et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Novel multicharged silver(I)–NHC complexes derived from zwitterionic 1,3-symmetrically and 1,3-unsymmetrically substituted imidazoles and benzimidazoles: Synthesis and cytotoxic properties

(2016) Marika Marinelli et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Acidic tumor microenvironment in human melanoma

(2016) Ines Böhme et al.   Pigment Cell & Melanoma Research

A signal-on electrochemical strategy for protease detection based on the formation of ATCUN-Cu(II)

(2016) Ning Xia et al.   SENSORS AND ACTUATORS B-CHEMICAL

Anti-biofilm Activity as a Health Issue

(2016) Sylvie Miquel et al.   Frontiers in Microbiology

Editorial: Cancer Nanotheranostics: What Have We Learned So Far?

(2016) João Conde et al.   Frontiers in Chemistry

Copper-binding tripeptide motif increases potency of the antimicrobial peptide Anoplin via Reactive Oxygen Species generation

(2015) M. Daben J. Libardo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hybrid peptide ATCUN-sh-Buforin: Influence of the ATCUN charge and stereochemistry on antimicrobial activity

(2015) M. Daben J. Libardo et al.   BIOCHIMIE

Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway

(2015) Valéry L. Payen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage

(2015) C. Wende et al.   CHEMICAL COMMUNICATIONS

Noble metals in medicine: Latest advances

(2015) Serenella Medici et al.   COORDINATION CHEMISTRY REVIEWS

Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA

(2015) Martin James Ross et al.   DALTON TRANSACTIONS

Biologically active [Pd2L4]4+ quadruply-stranded helicates: stability and cytotoxicity

(2015) Samantha M. McNeill et al.   DALTON TRANSACTIONS

Biofilm formation mechanisms and targets for developing antibiofilm agents

(2015) Nira Rabin et al.   Future Medicinal Chemistry

Design, Preparation, and Characterization of Zn and Cu Metallopeptides Based On Tetradentate Aminopyridine Ligands Showing Enhanced DNA Cleavage Activity

(2015) Marta Soler et al.   INORGANIC CHEMISTRY

Coordination compounds in cancer: Past, present and perspectives

(2015) Federica Trudu et al.   Journal of Applied Biomedicine

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

(2015) Gregory W. Severin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Light-Activated Protein Inhibition through Photoinduced Electron Transfer of a Ruthenium(II)–Cobalt(III) Bimetallic Complex

(2015) Robert J. Holbrook et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis, characterization and fungicidal activity of binary and ternary metal(II) complexes derived from 4,4′-((4-nitro-1,2-phenylene) bis(azanylylidene))bis(3-(hydroxyimino)pentan-2-one)

(2015) Abdou S. El-Tabl et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

A novel copper-chelating strategy for fluorescent proteins to image dynamic copper fluctuations on live cell surfaces

(2015) Yoon-Aa Choi et al.   Chemical Science

Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design

(2015) Joan J. Soldevila-Barreda et al.   Nature Communications

Toward the Design of a Catalytic Metallodrug: Selective Cleavage of G-Quadruplex Telomeric DNA by an Anticancer Copper-Acridine-ATCUN Complex

(2014) Zhen Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugation of a New Series of Dithiocarbazate Schiff Base Copper(II) Complexes with Vectors Selected to Enhance Antibacterial Activity

(2014) May Lee Low et al.   BIOCONJUGATE CHEMISTRY

Rational Design of Alpha-Helical Antimicrobial Peptides: Do's and Don'ts

(2014) Lars Erik Uggerhøj et al.   CHEMBIOCHEM

Antibiotic Adjuvants: Diverse Strategies for Controlling Drug-Resistant Pathogens

(2014) Erin E. Gill et al.   Chemical Biology & Drug Design

Deactivation in Homogeneous Transition Metal Catalysis: Causes, Avoidance, and Cure

(2014) Robert H. Crabtree   CHEMICAL REVIEWS

Metallodrugs in Medicinal Inorganic Chemistry

(2014) Katja Dralle Mjos et al.   CHEMICAL REVIEWS

Bioinorganic Chemistry of Antimicrobial and Host-Defense Peptides

(2014) M. Daben J. Libardo et al.   COMMENTS ON INORGANIC CHEMISTRY

Metal-based anticancer chemotherapeutic agents

(2014) Nafees Muhammad et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Formulations for Antimicrobial Peptides

(2014) Ana Carmona-Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inactivation of sortase A mediated by metal ATCUN complexes

(2014) Insiya Fidai et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metal-binding and redox properties of substituted linear and cyclic ATCUN motifs

(2014) Kosh P. Neupane et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Sortase A: An ideal target for anti-virulence drug development

(2014) Stella Cascioferro et al.   MICROBIAL PATHOGENESIS

Cellular Transport Mechanisms of Cytotoxic Metallodrugs: An Overview beyond Cisplatin

(2014) Sarah Spreckelmeyer et al.   MOLECULES

Development of New Peptide-based Chelating Agents for Site-specific Radiolabeling with 64Cu

(2014) Takaaki Miyamoto et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN

Peptidomimetics as a new generation of antimicrobial agents: current progress

(2014) Patricia Mendez-Samperio   Infection and Drug Resistance

Challenges for Metals in Medicine: How Nanotechnology May Help To Shape the Future

(2013) Nicolas P. E. Barry et al.   ACS Nano

Curb challenges of the “Trojan Horse” approach: Smart strategies in achieving effective yet safe cell-penetrating peptide-based drug delivery

(2013) Yongzhuo Huang et al.   ADVANCED DRUG DELIVERY REVIEWS

Rational Design of Engineered Cationic Antimicrobial Peptides Consisting Exclusively of Arginine and Tryptophan, and Their Activity against Multidrug-Resistant Pathogens

(2013) Berthony Deslouches et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Structure-Activity Relationship Study of Organometallic Bioconjugates of the Cyclic Octapeptide Octreotate

(2013) Annika Gross et al.   CHEMBIOCHEM

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity

(2013) Jeff C. Joyner et al.   CHEMICAL COMMUNICATIONS

Lability and Liability of Endogenous Copper Pools

(2013) F. W. Outten et al.   JOURNAL OF BACTERIOLOGY

Fenton-like copper redox chemistry revisited: Hydrogen peroxide and superoxide mediation of copper-catalyzed oxidant production

(2013) A. Ninh Pham et al.   JOURNAL OF CATALYSIS

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity

(2013) Chinavenmeni S. Velu et al.   JOURNAL OF CLINICAL INVESTIGATION

Kinetics and mechanisms of oxidative cleavage of HIV RRE RNA by Rev-coupled transition metal–chelates

(2013) Jeff C. Joyner et al.   Chemical Science

Peptide array based discovery of synthetic antimicrobial peptides

(2013) Chris W. Diehnelt   Frontiers in Microbiology

Proteomic and Metallomic Strategies for Understanding the Mode of Action of Anticancer Metallodrugs

(2012) Chiara Gabbiani et al.   Anti-Cancer Agents in Medicinal Chemistry

Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups

(2012) H Bauke Albada et al.   Beilstein Journal of Organic Chemistry

Factors Influencing the DNA Nuclease Activity of Iron, Cobalt, Nickel, and Copper Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeted Catalytic Inactivation of Angiotensin Converting Enzyme by Lisinopril-Coupled Transition-Metal Chelates

(2011) Jeff C. Joyner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Solution Study of the Interaction of the Cu(II) Ions with HisGlyGlyTrp Tetrapeptide and Its Evaluation as Superoxide Dismutase Mimetic Complex

(2011) Raj Kumar Singh et al.   PROTEIN AND PEPTIDE LETTERS

Cleavage Agents for α-Synuclein

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

New chelating ligands for Co(III)-based peptide-cleaving catalysts selective for pathogenic proteins of amyloidoses

(2010) Woo Suk Chei et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Enhanced Cellular Uptake and Cytotoxicity Studies of Organometallic Bioconjugates of the NLS Peptide in Hep G2 Cells

(2009) Fozia Noor et al.   CHEMBIOCHEM

Application of Metal Coordination Chemistry To Explore and Manipulate Cell Biology

(2009) Kathryn L. Haas et al.   CHEMICAL REVIEWS

Metallotherapeutics: Novel Strategies in Drug Design

(2009) Lalintip Hocharoen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper·Lys-Gly-His-Lys mediated cleavage of tRNAPhe: Studies of reaction mechanism and cleavage specificity

(2009) Seth Bradford et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Metal complexes as artificial proteases: toward catalytic drugs

(2008) Junghun Suh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Catalytic metallodrugs

(2008) James A. Cowan   PURE AND APPLIED CHEMISTRY