Review
Biochemistry & Molecular Biology
Gabriel Berdugo-Vega, Shonali Dhingra, Federico Calegari
Summary: This article reviews a wealth of research in cellular, anatomical, behavioral, and computational studies on the mammalian hippocampus, aiming to understand the fundamental mechanisms underlying cognition. Despite accumulating knowledge on how the hippocampus processes and stores information for learning and memory, our understanding of hippocampal cognitive function remains incomplete. The article discusses the structural separability of the two blades of the dentate gyrus in the hippocampus and proposes a model that suggests differences in connectivity and adult neurogenesis in the two blades may contribute to subtly different cognitive functions.
Review
Neurosciences
Jessica E. Malberg, Rene Hen, Torsten M. Madsen
Summary: Duman's research has shown that long-term treatment with antidepressant drugs increases neurogenesis in the subgranular zone of the adult hippocampus, providing critical insights into the neurotrophic hypothesis of depression and synaptic plasticity. It has been demonstrated that neurogenesis may be necessary for the clinical effects of antidepressant drugs, and his lab continues to investigate neurotrophic factors and synaptic plasticity. Preclinical studies have also shown that newer antidepressant compounds impact neurogenesis and synaptic plasticity.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Heather Bondi, Valeria Bortolotto, Pier Luigi Canonico, Mariagrazia Grilli
Summary: This study found that astrocytes in the hippocampus and entorhinal cortex of middle-aged mice have different responses to aging. Astrocytes in the dorsal DG showed a significant increase in morphological complexity, while astrocytes in the ventral DG and entorhinal cortex underwent remarkable changes. These findings suggest a new level of complexity in structural changes associated with brain aging.
NEUROBIOLOGY OF AGING
(2021)
Review
Neurosciences
Jesse D. Cushman, Michael R. Drew, Franklin B. Krasne
Summary: The primary function of juvenile and adult hippocampal neurogenesis appears to be allowing behavioral experience to shape connectivity in the dentate gyrus and optimize hippocampal circuits for future learning. This environmental sculpting reduces overlap among memory representations, provides more information, and allows for more memories to be stored accurately. The decline of neurogenesis prior to adulthood may be explained by this prospective function of sculpting hippocampal circuits.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Neurosciences
Lyles R. Clark, Sanghee Yun, Nana K. Acquah, Priya L. Kumar, Hannah E. Metheny, Rikley C. C. Paixao, Akivas S. Cohen, Amelia J. Eisch
Summary: This study discusses the impact of mild traumatic brain injuries (mTBIs) on the process of adult hippocampal DG neurogenesis. The results show that mTBI induces transient increases in neurogenesis in the ipsilateral hippocampal region, but not in the contralateral hemisphere. These findings are important for understanding the functional implications of TBI-induced neurogenesis and potential neuron replacement or repair after TBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Wei Wang, Mengdi Wang, Meng Yang, Bo Zeng, Wenying Qiu, Qiang Ma, Xiaoxi Jing, Qianqian Zhang, Bosong Wang, Chonghai Yin, Jiyao Zhang, Yuxin Ge, Yufeng Lu, Weizhi Ji, Qian Wu, Chao Ma, Xiaoqun Wang
Summary: This study investigates the cellular heterogeneity and molecular characteristics of the hippocampi in macaques and aged humans using droplet-based single-nucleus RNA sequencing (snRNA-seq). The findings reveal the dynamics of the neurogenic lineage and the diversity of astrocytes and microglia in the hippocampus. Primate-specific markers are identified and their functions are validated. Additionally, active astrocytes and microglia with proinflammatory responses are observed in aged samples, suggesting their contribution to the decrease and variability of adult hippocampal neurogenesis.
Review
Neurosciences
Gaifen Li, Jia Liu, Yuying Guan, Xunming Ji
Summary: Hypoxia plays a crucial role in regulating various cell functions, including stem cells and neural stem cells. Hypoxia stimulation in specific brain regions can promote proliferation, migration, and maturation of neural stem cells, potentially offering a promising strategy for treating central nervous system diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Cell Biology
Laura Micheli, Giorgio D'Andrea, Teresa Maria Creanza, Daniel Volpe, Nicola Ancona, Raffaella Scardigli, Felice Tirone
Summary: Neural stem cells in neurogenic niches divide throughout adulthood, but their number decreases with age. The cyclin-dependent kinase inhibitor p16Ink4a plays a role in maintaining the pool of stem cells in aged mice. It regulates stem cell self-renewal and prevents their activation after a neurogenic stimulus. Transcriptome analysis of the dentate gyrus in p16Ink4a knockout mice revealed genes involved in apoptotic, neuroinflammation, synaptic activity, and stem cell activation processes. These findings contribute to understanding the regulation of stem cell reactivity and provide insights into potential therapeutic targets for age-related neurodegenerative diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Psychiatry
Hu Meng, Qiongwei Li, Jinxin Wang, Weihua Yue, Dai Zhang, Xiaoxuan Sun, Lifang Wang, Jun Li
Summary: Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social interaction and communication. This study aimed to improve the social deficit in a mouse model by increasing neurogenesis in the hippocampus. Three approaches were used: repeated oxytocin administration, enriched environment, and overexpression of Cdk4-CyclinD1 complex in neural stem cells. Results showed increased proliferation of neural stem cells and newborn neurons, as well as significant improvement in social recognition deficit. These findings provide new insight into the treatment of autism.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Michel Baudry, Wenyue Su, Jeffrey Seinfeld, Jiandong Sun, Xiaoning Bi
Summary: The study found that the absence of calpain-1 in mutant mice reduced the rate of cell proliferation and long-term survival of newly-generated neurons in the adult hippocampus. Differential gene expression related to cell division, cell migration, cell proliferation, and cell survival was identified in the brains of calpain-1 knockout mice, suggesting a significant impact on neurogenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Myriam Bunting, Jason Shing-Cheong Kwan, Guang-Jie Zhou, Krishnamoorthi Senthilkumar, Ashok Iyaswamy, Ping-Kei Chan, Min Li, Kenneth Mei-Yee Leung, Siva-Sundara Kumar Durairajan, Karen Siu-Ling Lam, Leung-Wing Chu, Richard Festenstein, Sookja Kim Chung, Koon-Ho Chan
Summary: The decrease in circulating adiponectin levels is associated with neurodegeneration, neuroinflammation, and Alzheimer's disease pathologies. Increasing adiponectin through treatments like adipoRon can improve neuronal insulin signaling, memory functions, and reduce amyloid levels in Alzheimer's disease models.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Sara Bottes, Baptiste N. Jaeger, Gregor-Alexander Pilz, David J. Jorg, John Darby Cole, Merit Kruse, Lachlan Harris, Vladislav Korobeynyk, Izaskun Mallona, Fritjof Helmchen, Francois Guillemot, Benjamin D. Simons, Sebastian Jessberger
Summary: Researchers identified long-term self-renewing neural stem cells (NSCs) in the adult mouse hippocampus using intravital imaging and single-cell RNA sequencing. They found that Gli1-targeted NSCs exhibit long-term self-renewal, while Ascl1-targeted NSCs have limited proliferative activity before exhaustion. The study revealed the existence of heterogeneous NSC populations with diverse behavioral properties in contributing to neurogenesis in the adult hippocampus.
NATURE NEUROSCIENCE
(2021)
Review
Clinical Neurology
Carlos A. Lafourcade, Fraser T. Sparks, Angelique Bordey, Ursula Wyneken, Michael H. Mohammadi
Summary: The hippocampal formation is crucial in the development of temporal lobe epilepsy (TLE), a disease characterized by recurrent, unprovoked epileptic discharges. The hippocampal dentate gyrus (DG) acts as a filter to prevent excessive excitation and is considered critical in the progression of epileptogenesis. Endogenous cannabinoids (endocannabinoids) play a central role in regulating neuronal activity in the DG circuit. This review summarizes recent findings on the role of the DG in controlling hyperexcitability and discusses the potential therapeutic interventions using cannabinoids.
Article
Cell Biology
Kelsey D. McDermott, M. Agustina Frechou, Jake T. Jordan, Sunaina S. Martin, J. Tiago Goncalves
Summary: Aging is associated with cognitive deficits, especially in spatial memory. The hippocampal dentate gyrus (DG) is important for processing spatial information but is vulnerable to aging. Using two-photon calcium imaging, researchers found that neuronal activity and spatial representations in the DG were impaired in aged mice. However, with repeated exposure to the same environment, spatial tuning and information levels in aged mice improved, while activity remained elevated.
Article
Nutrition & Dietetics
Woosuk Kim, Hyo Young Jung, Dae Young Yoo, Hyun Jung Kwon, Kyu Ri Hahn, Dae Won Kim, Yeo Sung Yoon, Soo Young Choi, In Koo Hwang
Summary: The study demonstrates that GPE-R has neuroprotective effects against ischemic damage and inflammation in the hippocampus, reducing locomotor hyperactivity and increasing neuronal survival. It also shows a decrease in pro-inflammatory cytokines and activated microglia after ischemia/reperfusion, indicating GPE-R as a potential agent for protecting neurons from ischemic damage.
Article
Cell Biology
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, In Koo Hwang, Goang-Min Choi, In Bok Chang, Dae Won Kim, Seung Myung Moon
Summary: Tat-SH3GL2 protects neurons from oxidative and ischemic damage by reducing lipid peroxidation and inflammation, and improving synaptic plasticity after ischemia.
Article
Biochemistry & Molecular Biology
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: The study found that Tat-p27 can inhibit neuronal damage by reducing oxidative stress, alpha-synuclein expression, and inflammatory responses.
NEUROCHEMICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Seung J. Baek, Bruce D. Hammock, In-Koo Hwang, Qingxiao Li, Naima Moustaid-Moussa, Yeonhwa Park, Stephen Safe, Nanjoo Suh, Sun-Shin Yi, Darryl C. Zeldin, Qixin Zhong, Jennifer Alyce Bradbury, Matthew L. Edin, Joan P. Graves, Hyo-Young Jung, Young-Hyun Jung, Mi-Bo Kim, Woosuk Kim, Jaehak Lee, Hong Li, Jong-Seok Moon, Ik-Dong Yoo, Yiren Yue, Ji-Young Lee, Ho-Jae Han
Summary: In the 21st century, the incidence of metabolic and chronic diseases, such as cancer, obesity, and inflammation-related diseases, has sharply increased, with inflammation and oxidative stress being major underlying causes. Natural products and their bioactive components are increasingly recognized as promising therapeutic agents for these diseases due to their antioxidant and anti-inflammatory properties. Research in this area has expanded significantly to include chemical identification, mechanism of action determination, food fortification, supplement development, and enhancing bioavailability and bioactivity through nanotechnology.
Article
Plant Sciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Soon-Sung Lim, Beom-Goo Kang, Yong-Bok Jo, Dong-Sool Yu, Soo Young Choi, In Koo Hwang, Dae Won Kim
Summary: The study showed that Cissus verticillata leaf extract has significant benefits in alleviating obesity and memory deficits induced by a high-fat diet in mice, with the improvement associated with increased levels of BDNF in the hippocampus.
Article
Neurosciences
Woosuk Kim, Hyun Jung Kwon, Hyo Young Jung, Kyu Ri Hahn, Yeo Sung Yoon, In Koo Hwang, Soo Young Choi, Dae Won Kim
Summary: Purpurin has significant therapeutic effects on oxidative stress in HT22 cells and ischemic damage in gerbil hippocampus by improving cell survival, reducing DNA fragmentation and reactive oxygen species, inhibiting apoptosis-related protein levels, and decreasing inflammatory responses.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Woosuk Kim, Hyo Young Jung, Hyun Jung Kwon, Dae Won Kim, In Koo Hwang, Yeo Sung Yoon
Summary: Feeding mice a diet enriched with cuprizone can induce demyelination in the corpus callosum and increase neural progenitor cells in the dentate gyrus. This damage is more pronounced in young adult mice and may be associated with changes in BDNF and pCREB levels.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hyo Young Jung, Hyun Jung Kwon, Woosuk Kim, Kyu Ri Hahn, Seung Myung Moon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: Phosphoglycerate mutase 5 (PGAM5), a glycolytic enzyme, has been found to play a significant role in oxidative stress and ischemic damage. In this study, the authors investigated the effects of PGAM5 on HT22 hippocampal cells and gerbil hippocampus, demonstrating its neuroprotective effects and its ability to alleviate oxidative stress and ischemia-induced neuronal death.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, the researchers synthesized the Tat-CHIP fusion protein and successfully delivered it into brain cells. The results showed that Tat-CHIP has antioxidant and neuroprotective effects, making it a potential therapeutic agent against ischemic damage.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kyu Ri Hahn, Hyun Jung Kwon, Woosuk Kim, Hyo Young Jung, In Koo Hwang, Dae Won Kim, Yeo Sung Yoon
Summary: This study investigated the neuroprotective effects of SOD1 against cuprizone-induced demyelination and adult hippocampal neurogenesis in C57BL/6 mice. It was found that the fusion protein PEP-1-SOD1 could alleviate the damage caused by cuprizone in terms of demyelination and neurogenesis in the hippocampus.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hyun Jung Kwon, Kyu Ri Hahn, Sung Min Nam, Yeo Sung Yoon, Seung Myung Moon, In Koo Hwang, Dae Won Kim
Summary: Purpurin has potent anti-oxidant and anti-inflammatory effects in brain damage. This study shows that purpurin can ameliorate the aging phenotypes induced by D-galactose and improve memory impairment in mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Veterinary Sciences
Dae Young Yoo, Woosuk Kim, Hyo Young Jung, In Koo Hwang
Summary: The expression of somatostatin (SST) in the hippocampus of rats increases during postnatal development but decreases after P21. This study suggests that SST is closely associated with the differentiation of neuroblasts in the hippocampus during postnatal development.
VETERINARY SCIENCES
(2023)
Article
Cell Biology
Kyu Ri Hahn, Hyun Jung Kwon, Yeo Sung Yoon, Dae Won Kim, In Koo Hwang
Summary: In this study, a fusion protein PEP-1-PGK1 was synthesized that can cross the blood-brain barrier, and it was found that low concentrations of PEP-1-PGK1 can prevent neuronal stress and ischemia-related damage.
Article
Medicine, Research & Experimental
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Min Soo Kang, Hyun Jung Kwon, Jung Hoon Choi, Yeo Sung Yoon, Dae Won Kim, Dae Young Yoo, Moo-Ho Won, In Koo Hwang
Summary: The study investigated the time-dependent changes in the expression of vacuolar H+-ATPase V1B2 in the hippocampus after transient forebrain ischemia, revealing a transient increase in ATP6V1B2 expression following ischemia. This increase may be a compensatory mechanism for ischemia-related dysfunction of ATP6V1B2 in the hippocampus.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Hyo Young Jung, Woosuk Kim, Kyu Ri Hahn, Sung Min Nam, Sun Shin Yi, Hyun Jung Kwon, Min Soo Kang, Jung Hoon Choi, Dae Won Kim, Yeo Sung Yoon, In Koo Hwang
Summary: The study revealed that EP2 levels decrease with age in the hippocampus and are closely linked to the differentiation of neuroblasts in the dentate gyrus.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)