Recent advances in spirocyclization of indole derivatives

Catalytic Asymmetric Dearomatization of Indolyl Dihydropyridines through an Enamine Isomerization/Spirocyclization/Transfer Hydrogenation Sequence

(2018) Zi-Lei Xia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents

(2017) Lidan Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unified Approach to Fused and Spirocyclic Oxindoles through Lewis-Acid-Promoted Opening of Spiroepoxyoxindoles with Allylsilanes: Application to the Formal Synthesis of (±)-Physovenine

(2017) Brijesh M. Sharma et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized 3-Spiro[cyclopropa[a]pyrrolizine]- and 3-Spiro[3-azabicyclo[3.1.0]hexane]oxindoles from Cyclopropenes and Azomethine Ylides via [3 + 2]-Cycloaddition

(2017) Alexander S. Filatov et al.   JOURNAL OF ORGANIC CHEMISTRY

Assembly of Indolenines, 3-Amino Oxindoles, and Aldehydes into Indolenine-Substituted Spiro[pyrrolidin-2,3′-oxindoles] via 1,3-Dipolar Cycloaddition with Divergent Diastereoselectivities

(2017) Guodong Zhu et al.   JOURNAL OF ORGANIC CHEMISTRY

Lanthanide amide-catalyzed one-pot functionalization of isatins: synthesis of spiro[cyclopropan-1,3′-oxindoles] and 2-oxoindolin-3-yl phosphates

(2017) Cheng Peng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Reversal of Selectivity in C3-Allylation and Formal [3 + 2]-Cycloaddition of Spiro-epoxyoxindole: Unified Synthesis of Spiro-furanooxindole, (±)-N-Methylcoerulescine, (±)-Physovenine, and 3a-Allylhexahydropyrrolo[2,3-b]indole

(2017) Saumen Hajra et al.   ORGANIC LETTERS

Asymmetric [3 + 2] Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and α,β-Enones with Divergent Diastereocontrol on the Spiro[pyrrolidine-oxindoles]

(2017) Guodong Zhu et al.   ORGANIC LETTERS

Chiral Diphosphine–Palladium-Catalyzed Sequential Asymmetric Double-Friedel–Crafts Alkylation and N-Hemiketalization for Spiro-polycyclic Indole Derivatives

(2017) Nai-Kai Li et al.   ORGANIC LETTERS

A novel three-component method for the synthesis of spiro[chromeno [4′,3′:4,5] pyrimido[1,2- b ] indazole-7,3′-indoline]-2′,6(9 H )-dione

(2017) Amol Maruti Jadhav et al.   TETRAHEDRON

Total synthesis of natural spiro-trisindole enantiomers similisines A, B and their stereoisomers

(2017) Lunyong Shi et al.   TETRAHEDRON LETTERS

Synthesis of spiropyrazoline oxindoles by a formal [4 + 1] annulation reaction between 3-bromooxindoles and in situ-derived 1,2-diaza-1,3-dienes

(2017) Dong-Zhen Chen et al.   Organic Chemistry Frontiers

Asymmetric Synthesis of 2′-Trifluoromethylated Spiro-pyrrolidine-3,3′-oxindolesviaSquaramide-Catalyzed Umpolung and 1,3-Dipolar Cycloaddition

(2016) Jinhuan Su et al.   ADVANCED SYNTHESIS & CATALYSIS

Diastereoselective Intramolecular Aldol-Type Trapping of Zwitterionic Intermediates by Ketones for the Synthesis of Spiro[chroman-4,3′-oxindole] Derivatives

(2016) Shikun Jia et al.   ADVANCED SYNTHESIS & CATALYSIS

Regioselective Friedel-Crafts Reaction of Electron-Rich Benzenoid Arenes and Spiroepoxyoxindole at the Spiro-Centre: Efficient Synthesis of Benzofuroindolines and 2H- Spiro[benzofuran]-3,3′-oxindoles

(2016) Saumen Hajra et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Spiro[piperidine-3,3′-oxindoles]viaGold(I)-Catalyzed Dearomatization ofN-Propargyl- andN-Homoallenyl-2-bromotryptamines

(2016) Valentin Magné et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis of Spirobenzazepinones with Atroposelectivity and Spiro-1,2-Diazepinones by NHC-Catalyzed [3+4] Annulation Reactions

(2016) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron(III)-Catalyzed Arylation of Spiro-Epoxyoxindoles with Phenols/Naphthols towards the Synthesis of Spirocyclic Oxindoles

(2016) Mupeng Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

The First Enantioselective Organocatalytic Synthesis of 3-Spiro-α-Alkylidene-γ-Butyrolactone Oxindoles

(2016) Lucia Cerisoli et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hydrogen-Bonding Network Promoted [3+2] Cycloaddition: Asymmetric Catalytic Construction of Spiro-pseudoindoxyl Derivatives

(2016) Liang-Jie Zhang et al.   Chemistry-An Asian Journal

Enantioselective Cascade Reaction of α-Cyano Ketones and Isatylidene Malononitriles: Asymmetric Construction of Spiro[4H-pyran-oxindoles]

(2016) Jin Xie et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Ring-Contraction Disproportionation/Spirocyclization Cascade Reaction of Isochromeno[4,3-b]indol-5(11H)-ones: Synthesis of N-Unsubstituted Spirocycles

(2016) Xiang Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd-catalyzed cascade allylic alkylation and dearomatization reactions of indoles with vinyloxirane

(2016) Run-Duo Gao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The organocatalytic asymmetric Neber reaction for the enantioselective synthesis of spirooxindole 2H-azirines

(2016) Jian-Qiang Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Catalyzed Oxidative Dearomatization/Spirocyclization of Indole-2-Carboxamides: Synthesis of 2-Spiro-pseudoindoxyls

(2016) Lingkai Kong et al.   ORGANIC LETTERS

Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction

(2016) Luyi Zhu et al.   ORGANIC LETTERS

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

(2016) Jia-Xing Zhang et al.   ORGANIC LETTERS

Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water

(2016) Amreeta Preetam et al.   TETRAHEDRON LETTERS

Silver-Nanoparticle-Catalyzed Dearomatization of Indoles toward 3-Spiroindolenines via a 5-exo-dig Spirocyclization

(2016) Felix Schröder et al.   ACS Catalysis

Leaching-Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions

(2015) Felix Schröder et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Spirocyclic Indolenines

(2015) Michael J. James et al.   CHEMISTRY-A EUROPEAN JOURNAL

Supported gold nanoparticles as efficient and reusable heterogeneous catalyst for cycloisomerization reactions

(2015) Felix Schröder et al.   GREEN CHEMISTRY

Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database

(2012) Jean-Louis Reymond et al.   ACS Chemical Neuroscience

A Diversity-Oriented Approach to Spiroindolines: Post-Ugi Gold-Catalyzed Diastereoselective Domino Cyclization

(2012) Sachin G. Modha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Enantioselective Construction of Spiroindolenines by Ir-Catalyzed Allylic Alkylation Reactions

(2010) Qing-Feng Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY