Article
Chemistry, Inorganic & Nuclear
Lei Sun, Yue Zhang, Xiao-sen Lv, Hong-da Li
Summary: Lanthanide metal-organic framework materials (Ln-MOFs) have various structures and unique luminescence properties, making them a promising fluorescence sensing material for rapid detection of explosives and fingerprint development. They exhibit high selectivity and sensitive fluorescence quenching response to nitro explosives and can be reused after being washed with ethanol.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Patrik Osusky, Maros Smolicek, Jela Nociarova, Erik Rakovsky, Peter Hrobarik
Summary: This study developed a low-cost but efficient reducing and methylating agent, which can achieve N,N-dimethylation of nitro- and amino-substituted arenes. This method is applicable for large-scale synthesis and can provide high yields when common methylating agents fail.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Wenbo Liu, Nana Li, Xia Zhang, Yu Zhao, Ziao Zong, Ruixue Wu, Jiaping Tong, Caifeng Bi, Feng Shao, Yuhua Fan
Summary: The study explores the potential applications of zinc-based MOFs in the chemical sensing field, revealing that 1-4 can sensitively and selectively detect four pollutants with good performance in the presence of multiple interfering substances.
CRYSTAL GROWTH & DESIGN
(2021)
Article
Chemistry, Analytical
Minghui Zhu, Yaqin Chai, Ruo Yuan, Bo Zu, Yali Yuan
Summary: The dual-mode biosensor constructed in this study utilized dual CHA and enzyme cascade catalysis amplification to achieve sensitive and accurate detection of miRNA-21. It effectively addressed the low sensitivity and accuracy issues in traditional biosensors, providing a wide detection range and potential as an efficient and universal biosensing avenue.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Leena Majumder, Nayim Sepay, Biswadip Banerji
Summary: Self-assembled structures derived from short peptides, like the dityrosine-based short peptide (TP) studied in this research, have great potential in various domains. Through spectroscopic studies and single crystal X-ray analysis, it was confirmed that TP adopted a B-sheet pattern and further self-assembled into B-sheet-promoted helical architectures. This is the first crystallographic report of this kind of short peptide adopting B-sheet-promoted helical structures. CD spectroscopy, NMR study, and other analyses also supported the self-assembly phenomenon of TP. These small peptide units mimicking protein secondary structures could be of pivotal significance.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Physical
Jinglin Shen, Yue Bi, Hao Zhang, Liandi Xu, Jin Feng, Wei Qi
Summary: Gold nanoclusters (AuNCs) are inorganic-organic hybrid nanomaterials with exceptional photoluminescent properties, understanding their photoluminescent mechanism is crucial for developing functional materials. The emission intensity of thiobarbituric acid-modified AuNCs (TBA-AuNCs) can be significantly enhanced through co-assembly with Ba2+, and ligand to metal charge transfer (LMCT) plays a key role in regulating the emission property. Furthermore, the TBA-AuNCs/Ba2+ complex can be used as a chemical sensor for detecting nitro-containing compounds based on this special photoluminescent mechanism.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Ragini Agrawal, Virender Kumar Pal, Amit Singh, Thimmaiah Govindaraju
Summary: Identifying and characterizing a highly conserved antiparallel G-quadruplex (GQ)-forming DNA sequence within the SARS-CoV-2 genome, researchers developed a novel benzobisthiazole-based fluorogenic probe for specific target recognition. This probe, used in a cost-effective assay involving PCR amplification and endpoint fluorescence detection, demonstrates a potential diagnostic tool for SARS-CoV-2 clinical samples. The study suggests a general strategy that can be adapted for developing specific diagnostic assays targeting different noncanonical nucleic acid sequences.
Review
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Sumon Pratihar, Shuo Shi, Thimmaiah Govindaraju
Summary: Nucleic acid-based architectures have provided numerous opportunities for basic and applied research in DNA nanotechnology. By utilizing conventional and unconventional base pairing interactions, functional nucleic acid systems and devices that respond to changes in pH have been designed, offering biocompatibility and structural programmability. This Mini-Review highlights recent advancements in nucleic acid architectonics, particularly pH-driven molecular systems including nanoscale architectures, nanomachines, hydrogels, targeted bioimaging, and drug delivery architectures. The review concludes by emphasizing the challenges and opportunities for future developments.
Article
Biochemistry & Molecular Biology
Mouli Konar, Debasis Ghosh, Sourav Samanta, Thimmaiah Govindaraju
Summary: This study highlights the importance of investigating and addressing the adverse effects of A beta aggregation on neuronal cells, with a focus on the design and evaluation of peptidomimetics containing cyclic dipeptide units. The results suggest that the Akd(NMC) peptide with CDP units at specific positions shows promise in understanding and alleviating A beta aggregation-induced cellular toxicity and stiffness.
RSC CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Dikshaa Padhi, Thimmaiah Govindaraju
Summary: This article discusses the potential and possibilities of drug repurposing and hybrid drug design in the treatment of AD, presenting several potential drug candidates and discussing their plausible mechanisms of action.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pandeeswar Makam, Sharma S. R. K. C. Yamijala, Venkata S. Bhadram, Linda J. W. Shimon, Bryan M. Wong, Ehud Gazit
Summary: The study presents a simple and efficient single amino acid bionanozyme that can catalyze the rapid oxidation of phenolic contaminants and detect neurotransmitters. Compared to natural enzymes, this copper-coordinated bionanozyme is more cost-effective, efficient, and versatile.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Madhu Ramesh, Chenikkayala Balachandra, Prayasee Baruah, Thimmaiah Govindaraju
Summary: Liquid-liquid phase separation (LLPS) is a complex physicochemical phenomenon mediated by multivalent transient weak interactions among macromolecules like polymers, proteins, and nucleic acids. It has implications in cellular physiology and disease conditions like cancer and neurodegenerative disorders. Limited chemical tools exist to modulate protein LLPS, and the development of small-molecule modulators (SMMs) could provide therapeutic potential for neurodegenerative disorders. Rationally designed cyclic dipeptide (CDP)-based SMMs have been shown to effectively inhibit and dissolve Zn-mediated tau LLPS condensates, as well as inhibit tau condensate-to-fibril transition, establishing a novel platform for the development of therapeutics for neurodegenerative disorders.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: Efficient delivery of bioactive ingredients into cells remains a challenge, and cell-penetrating peptides (CPPs) have emerged as promising delivery vehicles. In this study, novel CPPs derived from the flexible and disordered tail extensions of DNA-binding Ku proteins were developed. The lead CPP, Ku-P4, demonstrated high internalization efficacy and biocompatibility. The presence of proline residue was crucial for maintaining the intrinsically disordered state and biocompatibility. Biophysical and DNA binding studies revealed that Ku-P4 efficiently condensed DNA into positively charged polyplexes, which were then able to penetrate the cell membrane and deliver the plasmid DNA inside the cell. These findings suggest that these novel CPPs have the potential to enhance the cellular uptake and therapeutic efficacy of peptide-drug or gene conjugates.
ACS BIO & MED CHEM AU
(2023)
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Mohamed Nabeel Mattath, Thimmaiah Govindaraju
Summary: Pathogenic genomes with noncanonical G-quadruplex (GQ) forming sequences are potential targets for diagnosis. The GQ-forming cDNA sequences of SARS-CoV-2 have been identified and validated as reliable diagnostic targets. High fidelity fluorescence detection of specific cDNA GQs derived from the SARS-CoV-2 RNA genome is demonstrated using small molecular probes.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Sumon Pratihar, Krithi K. Bhagavath, Thimmaiah Govindaraju
Summary: Theranostics, the integration of therapy and diagnostics, is crucial for monitoring disease progression and treatment response. Advancements in medicinal chemistry and technology have led to the development of targeted therapeutic drugs that also provide real-time updates on disease progression and treatment. The inclusion of imaging in therapy has significantly improved the prognosis of devastating diseases. Theranostic agents play important roles in early-stage drug development and clinical-stage therapeutic-containing drug candidates.
RSC CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Haibin Zhang, Debasis Ghosh, Thimmaiah Govindaraju, Shuo Shi
Summary: Biocomputing, using DNAs as its primary building blocks, is the most promising alternative for next-generation molecular computers. DNA nanoclusters (NCs) have unique self-assembly properties and programmability, making them promising candidates for biosensing applications. Thymine overhang-modified DNA-templated NCs are chemosensing ensembles capable of driving elementary and complex logic operations. These NCs can also be used for advanced DNA logic devices and error detection.
Article
Chemistry, Multidisciplinary
Madhu Ramesh, Thimmaiah Govindaraju
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that contributes significantly to global dementia cases. The pathology of AD is characterized by the accumulation of amyloid beta plaques and tau neurofibrillary tangles. Despite a lack of complete understanding and approved treatments, research has revealed the multifactorial nature of AD. Therefore, developing multipronged approaches targeting multiple biomarkers and targets is crucial for effective diagnosis and therapeutics.
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Chunyan Dong, Thimmaiah Govindaraju, Shuo Shi
Summary: Boolean operations based on DNA have promising applications in biocomputing. By introducing parity generator and parity checker, bit errors can be effectively evaluated. In this study, a DNA hybrid architecture platform was constructed using a chemosensing ensemble and a binary to gray code encoder was used to convert the transmitted and received data into secure information.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Dikshaa Padhi, Chenikkayala Balachandra, Madhu Ramesh, Thimmaiah Govindaraju
Summary: A series of 2,2'-bipyridine derivatives with structurally unique biomolecular auxiliaries were synthesized and found to effectively ameliorate amyloid toxicity and oxidative stress observed in Alzheimer's disease (AD).
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Debasis Ghosh, Mouli Konar, Tanmay Mondal, Thimmaiah Govindaraju
Summary: The differential structures of designer peptidomimetics derived from amyloid beta (Aβ14-23) peptide were manipulated to stabilize distinct Cu oxidation states, which catalyzed different chemical reactions effectively. By incorporating cyclic dipeptide (CDP) and pyrene (Py) units, the Cu-chelation and self-assembly properties of Aβ14-23 peptide were tuned to form nanosheets and micelle-like core-shell structures. These structures demonstrated the ability to stabilize Cu-II and Cu-I states separately and catalyze tandem oxidative-hydrolysis and alkyne-azide cycloaddition reactions.
NANOSCALE ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
