Practical synthesis of pharmaceutically relevant molecules enriched in sp3 character

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool

(2016) Ignacio Colomer et al.   CHEMICAL COMMUNICATIONS

Single-Electron Transmetalation: An Enabling Technology for Secondary Alkylboron Cross-Coupling

(2015) David N. Primer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dosage delivery of sensitive reagents enables glove-box-free synthesis

(2015) Aaron C. Sather et al.   NATURE

Nonracemic Allylic Boronates through Enantiotopic-Group-Selective Cross-Coupling of Geminal Bis(boronates) and Vinyl Halides

(2014) Bowman Potter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Catalytic Enantiotopic-Group-Selective Suzuki Reaction for the Construction of Chiral Organoboronates

(2014) Chunrui Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlorides

(2014) Ling Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient Synthesis of α-Heteroaryl Piperidines Using a Pd-Catalyzed Suzuki Cross-Coupling–Reduction Sequence

(2014) Kevin D. Hesp et al.   ORGANIC LETTERS

Diastereoconvergent Negishi Cross-Coupling Using Functionalized Cyclohexylzinc Reagents

(2014) Kohei Moriya et al.   ORGANIC LETTERS

Highly Selective Palladium-Catalyzed Cross-Coupling of Secondary Alkylzinc Reagents with Heteroaryl Halides

(2014) Yang Yang et al.   ORGANIC LETTERS

Stereoretentive Pd-catalysed Stille cross-coupling reactions of secondary alkyl azastannatranes and aryl halides

(2013) Ling Li et al.   Nature Chemistry

Stereospecific Cross-Coupling of Secondary Organotrifluoroborates: Potassium 1-(Benzyloxy)alkyltrifluoroborates

(2012) Gary A. Molander et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Negishi cross-coupling of secondary alkylzinc halides with aryl/heteroaryl halides using Pd–PEPPSI–IPent

(2011) Selçuk Çalimsiz et al.   CHEMICAL COMMUNICATIONS

Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners

(2011) Ranjan Jana et al.   CHEMICAL REVIEWS

Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates

(2011) Amruta Joshi-Pangu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides

(2011) Amruta Joshi-Pangu et al.   ORGANIC LETTERS

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

(2010) Anh P. Truong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D2Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16)

(2010) Fredrik Pettersson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pd-catalyzed Cross-Coupling of α-(Acyloxy)-tri-n-butylstannanes with Alkenyl, Aryl, and Heteroaryl Electrophiles

(2010) Mohan Goli et al.   ORGANIC LETTERS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Suzuki−Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides

(2009) Spencer D. Dreher et al.   JOURNAL OF ORGANIC CHEMISTRY

Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

(2009) Chong Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY