Article
Biochemistry & Molecular Biology
Marko Hojnik, Masa Sinreih, Maja Anko, Neli Hevir-Kene, Tamara Knific, Bostjan Pirs, Snjezana Frkovic Grazio, Tea Lanisnik Rizner
Summary: Estrogens play an important role in endometrial cancer through ERα, ERβ, and GPER. This study found decreased levels of ERα and lower protein levels of ERβ and GPER in EC tissue. Significant correlations were observed between ESR1 and ESR2, as well as GPER variant 3,4 and ESR1 and ESR2 at the mRNA level. Further studies are needed to examine the potential of ERβ and GPER as prognostic markers, provided that specific and validated antibodies are available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Keith A. Hall, Edward J. Filardo
Summary: Estrogens play a crucial role in the pathogenesis of various cancers, especially in relation to environmental estrogens and GPER receptors. However, the current antiestrogen therapy for breast cancer does not consider these factors, indicating the need for a more holistic approach, such as targeting GPER receptors.
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Chemistry, Medicinal
Ning Dong, Yongli Du, Yong Zheng, Haibin Zhang, Huiting Lv, Zhijia Yan
Summary: This paper summarizes the research progress and structure-activity relationships of tamoxifen analogs modulating these three nuclear receptors reported in the literature and introduces the relationship between these three nuclear receptor-mediated diseases and tamoxifen analogs to guide the research of novel tamoxifen analogs.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Qianfeng Liu, Yongzhe Liu, Xiaoyu Li, Dan Wang, Ai Zhang, Jing Pang, Jiayu He, Xi Chen, Nai-jun Tang
Summary: This study used the comparative toxicogenomics database to investigate the molecular pathways associated with PFASs-induced breast cancer. It confirmed the correlation between PFASs contamination and breast cancer development, and identified the role of estrogen receptors in mediating the effects of PFOA on breast cancer cell migration and invasion.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Ting Xu, Ding Ma, Sheng Chen, Rui Tang, Jianling Yang, Chunhui Meng, Yang Feng, Li Liu, Jiangfen Wang, Haojun Luo, Keda Yu
Summary: GPER has been found to mediate estrogenic actions in TNBC and is correlated with clinical variables, survival, and metastasis. High GPER expression is associated with high-risk TNBC subtype and poor prognosis, providing new insights and potential strategies for endocrine therapy in TNBC.
Article
Endocrinology & Metabolism
Anne-Louise Gannon, Laura O'Hara, Ian J. Mason, Anne Jorgensen, Hanne Frederiksen, Michael Curley, Laura Milne, Sarah Smith, Rod T. Mitchell, Lee B. Smith
Summary: Adrenal androgens are not essential for adrenal development and X-zone regression in females, but play crucial roles in suppressing post-partum corticosterone levels and spindle cell development. These results suggest sexually dimorphic regulation of the adrenal X-zone by androgen receptor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Cuifen Li, Manli Xie, Weiwei Wang, Yanyan Liu, Dan Liao, Jingwen Yin, Hao Huang
Summary: This study is the first and most comprehensive investigation of the association between ERs and depression in women, and the findings support the concept that ERs participate in the etiology of sex heterogeneity in depression.
FRONTIERS IN GENETICS
(2022)
Article
Anatomy & Morphology
Natalia Lagunas, Jose Manuel Fernandez-Garcia, Noemi Blanco, Antonio Ballesta, Beatriz Carrillo, Maria-Angeles Arevalo, Paloma Collado, Helena Pinos, Daniela Grassi
Summary: Sex steroid hormones exert organizational and activational effects on the brain and peripheral tissues. Estradiol, testosterone, and their metabolites exert their biological action through genomic and non-genomic mechanisms. The expression of estrogen receptors (ERs) and androgen receptors (AR) differs between males and females, suggesting a sex-dependent regulation. This study investigates the effects of estrogens and androgens on the pituitary and adrenal glands, and suggests that neonatal modification of these pathways can lead to permanent changes in neuroendocrine functions.
FRONTIERS IN NEUROANATOMY
(2022)
Review
Endocrinology & Metabolism
Deborah Simao Souza, Carla Macheroni, Gustavo Jose Silva Pereira, Carolina Meloni Vicente, Catarina Segreti Porto
Summary: Prostate cancer is the most common cancer among men worldwide, and hormone-related factors, such as androgens, estrogens, and their receptors, play a crucial role in its development and progression. Galectin-3, a family of proteins, is involved in various stages of tumor development and progression, but its expression regulation is still poorly understood. This review focuses on the interplay between Galectin-3 and estrogen receptor signaling pathways in prostate cancer cells and proposes a molecular mechanism involving ER, Galectin-3, and beta-catenin in the modulation of nuclear transcriptional events. Further understanding of the role of Galectin-3 and ER in prostate cancer could lead to the discovery of new drug targets to treat castration-resistant prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Oncology
Zhongqin Gong, Shucai Yang, Minghui Wei, Alexander C. Vlantis, Jason Y. K. Chan, C. Andrew van Hasselt, Dongcai Li, Xianhai Zeng, Lingbin Xue, Michael C. F. Tong, George G. Chen
Summary: Thyroid cancer is more common in women, suggesting a potential role of sex hormones in its development. Estrogen receptors alpha and beta have been found to play an important role in the pathogenesis of thyroid cancer. However, the expression and function of different isoforms of these receptors in thyroid cancer are still not well understood. This review aims to summarize the expression and roles of estrogen receptor alpha and beta isoforms in thyroid cancer, providing new insights into modulating their alternative RNA splicing against thyroid cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Rhonda Voskuhl, Jens Kuhle, Prabha Siddarth, Noriko Itoh, Kevin Patel, Allan MacKenzie-Graham
Summary: Estrogens, depending on type, dose, and timing, have shown neuroprotective effects in both preclinical models and women during health and disease. In this study, oral administration of estriol, a unique estrogen during pregnancy, at a dose of 8 mg, reduced serum neurofilament light chain in nonpregnant women with multiple sclerosis, suggesting a potential protective role in neuro-axonal injury. This study supports the use of serum neurofilament light chain as a biomarker in multiple sclerosis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Review
Neurosciences
Felipe A. Bustamante-Barrientos, Maxs Mendez-Ruette, Alexander Ortloff, Patricia Luz-Crawford, Francisco J. Rivera, Carlos D. Figueroa, Luis Molina, Luis Federico Batiz
Summary: Estrogens and estrogen-like molecules have a significant impact on the biology of various cell types, with estrogen receptors playing a crucial role in modulating cell proliferation, differentiation, and survival, particularly in the central nervous system. Estrogens can exert neuroprotective roles, regulate the balance between proliferation and differentiation of neural stem/progenitor cells, and influence neurogenesis through multiple mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Camila Calfio, Francisca Donoso, J. Pablo Huidobro-Toro
Summary: The study showed that the vasorelaxation induced by anthocyanins or their corresponding glycosides is achieved through increased NO production rather than antioxidant potential, highlighting the nutraceutical role of natural products in cardiovascular diseases.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Dominikay Kazmierczak, Karol Jopek, Karolina Sterzynska, Michal Nowicki, Marcin Rucinski, Radoslaw Januchowski
Summary: This study aimed to detect changes in miRNA expression levels in two cisplatin and two paclitaxel-resistant variants of the A2780 ovarian cancer cell line, and to identify miRNAs responsible for the regulation of drug-resistance genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Afsaneh Golkar-Narenji, Pawel Antosik, Shelly Nolin, Marcin Rucinski, Karol Jopek, Agnieszka Zok, Jaroslaw Sobolewski, Maurycy Jankowski, Maciej Zdun, Dorota Bukowska, Katarzyna Stefanska, Jedrzej M. Jaskowski, Hanna Piotrowska-Kempisty, Paul Mozdziak, Bartosz Kempisty
Summary: Modern science is committed to finding environmentally friendly solutions, and cellular agriculture is an important field in sustainable agriculture. This study compared different culture methods for myosatellite cells and found that suspension culture may cause the loss of physiological characteristics and gain of plasticity. Further investigation is needed to ensure the viability of suspension culture for industrial application.
Article
Biochemistry & Molecular Biology
Piotr Stasiak, Dominika Kazmierczak, Karol Jopek, Michal Nowicki, Marcin Rucinski, Radoslaw Januchowski
Summary: Epithelial ovarian cancer has the highest mortality due to late diagnosis and resistance to chemotherapy. MiRNA can regulate the expression of drug-resistance genes, possibly affecting the sensitivity of cancer cells to chemotherapy drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Marianna Tyczewska, Marta Szyszka, Karol Jopek, Marcin Rucinski
Summary: The expression changes of peptides and their receptors, as well as steroidogenesis enzymes, were investigated in the hypothalamus, pituitary, and adrenal glands of rats after intraperitoneal administration of peptides. The results showed significant expression changes in the hypothalamus and pituitary after 1-hour exposure to peptides, including a decrease in corticotropin-releasing hormone expression and a decrease in the expression of galanin receptors. The expression of steroidogenesis enzymes also changed, with an increase in cholesterol desmolase expression after peptide administration.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Stefanska, Lucie Nemcova, Malgorzata Blatkiewicz, Wojciech Pienkowski, Marcin Rucinski, Maciej Zabel, Paul Mozdziak, Marzenna Podhorska-Okolow, Piotr Dziegiel, Bartosz Kempisty
Summary: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) possess multilineage differentiation potential and specific surface markers. In this study, RNA sequencing analysis revealed differentially expressed genes associated with apoptosis and identified upregulation of ZBTB16 and FOXO1, as well as downregulation of TGFA, in all differentiated groups. Additionally, several novel marker genes related to WJ-MSCs differentiation were identified. This study sheds light on the molecular mechanisms involved in long-term culture and differentiation of WJ-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marianna Tyczewska, Patrycja Sujka-Kordowska, Marta Szyszka, Karol Jopek, Malgorzata Blatkiewicz, Ludwik K. Malendowicz, Marcin Rucinski
Summary: The homeostasis of the adrenal gland is crucial for its proper functioning in both non-stressful and stressful conditions, involving interactions between different types of cells. However, there is insufficient information regarding marker gene expression in the rat adrenal gland under non-stressful conditions. This study aimed to determine the expression of marker genes in different zones of the rat adrenal gland and revealed distinct expression patterns of interstitial cell markers in specific zones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Rut Bryl, Mariusz J. Nawrocki, Karol Jopek, Mariusz Kaczmarek, Dorota Bukowska, Pawel Antosik, Paul Mozdziak, Maciej Zabel, Piotr Dziegiel, Bartosz Kempisty
Summary: Heart failure is a leading cause of death globally, and current treatment options are often not sufficient. Autologous stem cell transplant shows promise as an alternative approach in clinical management. Studies have revealed differentially expressed genes in cell cultures from the heart, suggesting the involvement of stem cell maintenance and proliferation in myocardial regeneration.
Article
Biochemistry & Molecular Biology
Malgorzata Blatkiewicz, Kacper Kaminski, Marta Szyszka, Zaid Al-Shakarchi, Anna Olechnowicz, Ewelina Stelcer, Hanna Komarowska, Marianna Tyczewska, Anna Klimont, Marek Karczewski, Tomasz Wierzbicki, Joanna Mikolajczyk-Stecyna, Marek Ruchala, Ludwik K. Malendowicz, Marcin Rucinski
Summary: The study examines the association of ZWILCH gene with adrenocortical carcinoma (ACC). The higher expression of ZWILCH gene was found in ACC tissue compared to normal adrenal glands. Upregulation of ZWILCH is correlated with tumor mitotic rate and patient survival. The enhanced ZWILCH level is also associated with activation of genes involved in cell proliferation and inhibition of genes related to the immune system.
Article
Biochemistry & Molecular Biology
Remigiusz Domin, Michal Pytka, Mikolaj Zolynski, Jan Nizinski, Marcin Rucinski, Przemyslaw Guzik, Jacek Zielinski, Marek Ruchala
Summary: This study aimed to investigate the relationship between serum MOTS-c concentration and muscle strength parameters, as well as oxygen consumption, in physically active individuals. The results showed that higher serum MOTS-c concentration was associated with greater muscle mass, force, and power, but not with exercise capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Izycka, Marcin Rucinski, Malgorzata Andrzejewska, Sebastian Szubert, Ewa Nowak-Markwitz, Karolina Sterzynska
Summary: Recurrent disease and treatment-associated chemoresistance are major contributors to poor clinical outcomes in ovarian cancer patients. This study investigated the expression of CSC-associated markers ALDH1A, CD44, and CD133 to predict patient prognosis. ALDH1A1-positive patients had significantly shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that ALDH1A1 expression, FIGO stage III-IV, and residual disease were associated with shorter OS. Targeting ALDH1A1-positive cancer cells may be a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Anna Rawluszko-Wieczorek, Julia Lipowicz, Marta Nowacka, Kamila Ostrowska, Paulina Pietras, Malgorzata Blatkiewicz, Marcin Rucinski, Pawel Piotr Jagodzinski, Michal Nowicki
Summary: The presence of estrogen receptor beta (ER beta) is inversely correlated with the occurrence of colorectal cancer (CRC), and low expression of ER beta is associated with poorer overall survival of CRC patients. ER beta can inhibit tumorigenesis through various molecular pathways and also has an impact on the hypoxic response in CRC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)