Article
Immunology
Sonia Kiran, Mousumi Mandal, Ahmed Rakib, Amandeep Bajwa, Udai P. Singh
Summary: This study investigates the role and mechanism of miR-10a-3p in adipose inflammation and adipogenesis using ex vivo and in vitro approaches. The findings suggest that miR-10a-3p mimic reduces the expression of inflammatory cells and cytokines, and induces the expression of FoxP3 in adipose tissue. In vitro experiments also show that miR-10a-3p mimic reduces the expression of inflammatory genes and lipid accumulation. This study provides a new opportunity for the development of miR-10a-3p as a novel therapeutic for adipose inflammation and its associated metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tao Su, Suchao Huang, Yanmin Zhang, Yajuan Guo, Shuwei Zhang, Jiaji Guan, Mingjing Meng, Linxin Liu, Caiyan Wang, Dihua Yu, Hiu-Yee Kwan, Zhiying Huang, Qiuju Huang, Elaine Lai-Han Leung, Ming Hu, Ying Wang, Zhongqiu Liu, Linlin Lu
Summary: Acidosis is a harsh tumor microenvironment that promotes lung cancer metastasis by inhibiting miR-7-5p expression and increasing TGF-beta 2 expression. The study identifies miR-7-5p as a novel biomarker and therapeutic target for lung cancer treatment.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Yu-Ting Huang, An-Chieh Cheng, Hui-Chi Tang, Guo-Cheng Huang, Ling Cai, Ta-Hsien Lin, Kou-Juey Wu, Ping-Hui Tseng, Greg G. Wang, Wei-Yi Chen
Summary: The study reveals that USP7 regulates the autoregulation of SMAD3 in p53-deficient lung cancer, inhibiting cell progression. USP7 mediates SMAD3 de-monoubiquitination, enhancing SMAD3 autoregulation to suppress cancer progression in p53-deficient lung cancer.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Pharmacology & Pharmacy
Shuang Wang, Juan Li, Yingjuan He, Yonghong Ran, Binghui Lu, Jining Gao, Chang Shu, Jie Li, Yazhen Zhao, Xin Zhang, Yuhui Hao
Summary: The study found that MET/PLGANPS had a better therapeutic effect on RILI than MET, alleviating RILI by inhibiting the miR-21/TGF-beta 1/Smad3 pathway.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Yang-Zhi Hu, Zhi-Li Hu, Tian-You Liao, Yuan Li, Yun-Long Pan
Summary: This study aimed to investigate the effects of lncRNA SND1-IT1, miR-124, and COL4A1 gene on TGF-beta 1-induced EMT in gastric cancer (GC). Through the analysis of tissue samples and experiments on HGC-27 cells, the results demonstrated that TGF-beta 1 can regulate cancer cell migration, invasion, and stimulate EMT through the SND1-IT1/miR-124/COL4A1 axis in GC.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Biochemistry & Molecular Biology
Mehri Naghdalipour, Nariman Moradi, Reza Fadaei, Shekufe Rezghi Barez, Shirin Sayyahfar, Marjan Mokhtare, Toktam Kazemi Fard, Soudabeh Fallah, Aboulreza Esteghamati
Summary: This study evaluated the expression of TGF-beta signaling pathway genes and their regulatory microRNAs in patients with ulcerative colitis (UC). The results showed increased expression of TGF-beta 1 and SMAD3 in UC patients compared to controls. In addition, miR-21 and miR-433 were found to be higher in UC patients, while miR-590 was lower. Furthermore, miR-433 was positively correlated with SMAD3 and TGF-beta, while miR-21 was positively correlated with TGF-beta 1. MiR-590 was negatively correlated with SMAD2 and SMAD3. These findings suggest the importance of TGF-beta signaling pathway-related microRNAs in the pathogenesis of UC.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Oncology
Lian-Jing Cao, Yi-Jun Zhang, Si-Qi Dong, Xi-Zhao Li, Xia-Ting Tong, Dong Chen, Zi-Yi Wu, Xiao-Hui Zheng, Wen-Qiong Xue, Wei-Hua Jia, Jiang-Bo Zhang
Summary: The study found that elevated ATAD2 expression was significantly associated with lymph node metastasis, advanced clinical stage, and poor survival of ESCC patients. ATAD2 promotes ESCC metastasis through regulating the C/EBP beta /TGF-beta 1/Smad3/Snail signaling pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Ruihong Yuan, Xiaoming Dai, Yisong Li, Chunshan Li, Liu Liu
Summary: The study showed that miR-29a-modified hADSC exosomes can decrease scar formation by inhibiting the TGF-beta 2/Smad3 signaling pathway, as well as inhibiting the proliferation and migration of HSFBs.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Neha S. Dole, Jihee Yoon, David A. Monteiro, Jason Yang, Courtney M. Mazur, Serra Kaya, Cassandra D. Belair, Tamara Alliston
Summary: This study investigated a microRNA-dependent mechanism mediating the crosstalk between TGF-β and Wnt signaling in osteocytes exposed to fluid shear stress, revealing that miR-100 integrates the functions of these two essential pathways by antagonizing Wnt signaling.
Article
Medicine, Research & Experimental
Haitao Wang, Sen Guo, Seung-Jin Kim, Fangyuan Shao, Joshua Wing Kei Ho, Kuan Un Wong, Zhengqiang Miao, Dapeng Hao, Ming Zhao, Jun Xu, Jianming Zeng, Koon Ho Wong, Lijun Di, Ada Hang-Heng Wong, Xiaoling Xu, Chu-Xia Deng
Summary: Cisplatin at different doses has varying effects on breast cancer growth and metastasis, with higher doses inhibiting both growth and metastasis but causing severe side effects, and lower doses only blocking metastasis. Cisplatin prevents breast cancer metastasis by blocking early EMT steps.
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose Antonio Serrato, Blanca Ortiz-Quintero
Summary: The high mortality from lung cancer is mainly due to metastasis at the time of diagnosis. Recent research suggests that tumor cell exosomes play a significant role in tumor progression and metastasis. They release biologically active components to distant organs, directing tumor metastasis.
Article
Oncology
Yu-Bo Wei, Dong-Min Liang, Mei-Ling Zhang, You-Jie Li, Hong-Fang Sun, Qin Wang, Yan Liang, Yan-Mei Li, Ran-Ran Wang, Zhen-Lin Yang, Pingyu Wang, Shu-Yang Xie
Summary: This study showed that the lncRNA-WFDC21P is significantly increased in triple-negative breast cancer (TNBC) and is associated with poor patient survival. Overexpression of WFDC21P promotes TNBC cell proliferation and metastasis. It interacts with miR-628-5p to negatively regulate Smad3-related gene expression, suppressing cell proliferation and metastasis. N6-methyladenosine (m6A) modification upregulates WFDC21P expression, and METTL3 plays a role in this process by promoting TNBC cell proliferation and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kathleen Watt, Kathrin Tyryshkin, Neil Renwick, Andrew W. B. Craig
TRANSLATIONAL ONCOLOGY
(2020)
Article
Oncology
Justin J. M. Wong, Paula S. Ginter, Kathrin Tyryshkin, Xiaojing Yang, Jina Nanayakkara, Zier Zhou, Thomas Tuschl, Yao-Tseng Chen, Neil Renwick
Article
Multidisciplinary Sciences
Xiaojing Yang, Jina Nanayakkara, Duncan Claypool, Sadegh Saghafinia, Justin J. M. Wong, Minqi Xu, Xiantao Wang, Christopher J. B. Nicol, Iacovos P. Michael, Markus Hafner, Xiaolong Yang, Neil Renwick
Summary: The miR-375/YAP axis plays a critical role in neuroendocrine differentiation and tumorigenesis in lung carcinoid cells, affecting functions such as neural differentiation, exocytosis, and secretion. This axis involves distinct transcriptomic changes, leading to significant reductions in cell proliferation, transformation, and tumor growth.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Emily Kaczmarek, Blake Pyman, Jina Nanayakkara, Thomas Tuschl, Kathrin Tyryshkin, Neil Renwick, Parvin Mousavi
Summary: A deep cancer classifier was developed using miRNA expression profiles and deep learning, which showed high performance in distinguishing neoplastic and nonneoplastic tissue samples and identified candidate biomarkers.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Biochemical Research Methods
Emily Kaczmarek, Jina Nanayakkara, Alireza Sedghi, Mehran Pesteie, Thomas Tuschl, Neil Renwick, Parvin Mousavi
Summary: An unsupervised deep learning framework was developed to study miRNA dysregulation in cancer, achieving high accuracy in classifying neoplasticity status and tissue-of-origin. This approach provides a new method for cancer classification and treatment selection based on molecular properties.
BMC BIOINFORMATICS
(2022)
Review
Cell Biology
Sabrina Yu, Alex L. C. Tam, Robert Campbell, Neil Renwick
Summary: This narrative review summarizes the research articles on the potential anti- and pro-fibrotic mechanisms of noncoding RNAs following glaucoma filtration surgery. The results suggest that certain miRNAs and lncRNAs have anti-fibrotic effects, while others may play a pro-fibrotic role in filtration surgery fibrosis.
Article
Biochemistry & Molecular Biology
Christos Karampelias, Kathleen Watt, Charlotte L. Mattsson, Angel Fernandez Ruiz, Habib Rezanejad, Jiarui Mi, Xiaojing Liu, Lianhe Chu, Jason W. Locasale, Gregory S. Korbutt, Meritxell Rovira, Ola Larsson, Olov Andersson
Summary: This study identifies CID661578 as a small molecule that can induce pancreatic beta-cell regeneration by targeting MNK2 and enhancing protein synthesis. This finding reveals a novel targetable role of MNK2-controlled translation in beta-cell regeneration.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Justin Gerolami, Justin Jong Mun Wong, Ricky Zhang, Tong Chen, Tashifa Imtiaz, Miranda Smith, Tamara Jamaspishvili, Madhuri Koti, Janice Irene Glasgow, Parvin Mousavi, Neil Renwick, Kathrin Tyryshkin
Summary: This study introduces a novel molecular feature selection tool for identifying potential biomarkers in '-omics' data. Genes identified with this tool showed superior performance in identifying prostate adenocarcinoma subtypes with a significantly smaller set of genes. Additionally, a user-friendly graphical interface for the tool is available for free download, providing a valuable asset for biomarker discovery studies.
Article
Biology
Akihiro Yamashita, Olesia Ignatenko, Mai Nguyen, Raphaelle Lambert, Kathleen Watt, Caroline Daneault, Isabelle Robillard-Frayne, Ivan Topisirovic, Christine Des Rosiers, Heidi M. McBride
Summary: Peroxisomes play a central role in regulating metabolic and signaling pathways, but the mechanisms by which peroxisome status is communicated and integrated into cellular signaling pathways are not well understood. In this study, the cellular responses to peroxisomal proteotoxic stress were investigated. It was found that depletion of the peroxisomal protease/chaperone LONP2 led to cell-specific stress responses, including the activation of the integrated stress response (ISR) and upregulation of ribosomal biogenesis gene expression levels in COS-7 cells. Common changes between COS-7 and U2OS cell lines included repression of the retinoic acid signaling pathway and upregulation of sphingolipids. Accumulation of cholesterol in endomembrane compartments was observed in both cell lines. These unexpected consequences of peroxisomal stress provide important insights into tissue-specific responses in peroxisomal disorders.
Article
Hematology
Robert Kloosterman, Matteo Zago-Schmitt, Julie Grabell, Lisa Thibeault, Patricia A. De Lima, Mackenzie Bowman, Kathrin Tyryshkin, Charles C. T. Hindmarch, Neil Renwick, Paula James
Summary: In this study, a multiomic approach was used to evaluate transcriptome-wide differences between type 1 VWD and control ECFCs during basal and stimulated VWF release. Differences in mRNA and miRNA expression were found between type 1 VWD and control ECFCs during both basal and stimulated VWF release. These differences may contribute to bleeding in type 1 VWD and could potentially lead to the discovery of new biomarkers and therapeutic targets.
Article
Medicine, Research & Experimental
L. G. Gol'dfarb, V. A. Vladimirtsev, F. A. Platonov, D. M. Asher, N. M. Renvik, T. Y. Nikolayeva
Summary: The occurrence of secondary cases of VEM in previously unaffected populations confirms its transmissible nature, with measures such as prolonged hospitalization and improved living conditions leading to a decline in incidence and eventual disappearance of VEM. No new cases have been reported since 2012.
YAKUT MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Jina Nanayakkara, Kathrin Tyryshkin, Xiaojing Yang, Justin J. M. Wong, Kaitlin Vanderbeck, Paula S. Ginter, Theresa Scognamiglio, Yao-Tseng Chen, Nicole Panarelli, Nai-Kong Cheung, Frederike Dijk, Iddo Z. Ben-Dov, Michelle Kang Kim, Simron Singh, Pavel Morozov, Klaas E. A. Max, Thomas Tuschl, Neil Renwick
Meeting Abstract
Gastroenterology & Hepatology
Jina Nanayakkara, Kathrin Tyryshkin, Xiaojing Yang, Justin Wong, Thomas Tuschl, Neil Renwick
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)