Article
Biochemistry & Molecular Biology
Simon Faba, Marina P. Arrieta, Julio Romero, Angel Aguero, Alejandra Torres, Sara Martinez, Emilio Rayon, Maria Jose Galotto
Summary: This study aimed to develop PLA bionanocomposite foams loaded with carvacrol cocrystal by supercritical CO2 for controlled release in food packaging. The results showed that the addition of nanoclay improved the mechanical properties of the composite, and a higher content of C30B increased the incorporation of carvacrol. The prepared nanocomposite foam exhibited lower diffusion coefficient and antioxidant activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Pharmacology & Pharmacy
Karina C. Scheiner, Roel F. Maas-Bakker, Mies J. van Steenbergen, Steven P. Schwendeman, Wim E. Hennink, Robbert J. Kok
Summary: The study investigated active self-encapsulation (ASE) for simultaneous loading and controlled release of multiple growth factors, showing that ASE is a suitable method for co-loading growth factors which can provide sustained release profiles of bioactive growth factors, which is attractive for vascularization of biomaterial implants.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Polymer Science
Diego Valor, Antonio Montes, Marilia Monteiro, Ignacio Garcia-Casas, Clara Pereyra, Enrique Martinez de la Ossa
Summary: Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were produced by supercritical foaming processes. The study showed that increasing pressure facilitated greater impregnation of rutin into the polymer foam pores, and modifying certain variables resulted in considerable differences in the drug release profiles.
Review
Biochemistry & Molecular Biology
Dario Rodrigues do Nascimento Junior, Antonio Tabernero, Elaine Christine de Magalhaes Cabral Albuquerque, Silvio Alexandre Beisl Vieira de Melo
Summary: This review examines the encapsulation processes for biopesticides and highlights the use of supercritical fluid technology (SFT) for encapsulating biopesticides. It also discusses the potential and prospects of using SFT in the field, as well as the challenges to be overcome in the future.
Article
Chemistry, Physical
Yuhan Dong, Pengcheng Gu, Qiying Yi, Hui Hu, Xiting Cheng, Ziyang Zhang, Lijuan Zhang, Yan Bai
Summary: Poly(L-lactic acid) microparticles loaded with growth factors were prepared using modified SEDS method, which effectively controlled the release rate while maintaining bioactivity. This study demonstrated the potential of using these carriers for controlled release of bioactive drugs.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Article
Chemistry, Physical
Paola Franco, Iolanda De Marco
Summary: The study used Supercritical Antisolvent coprecipitation to prepare controlled-release systems of antihistamines, showing significantly prolonged release of the active ingredients and achieving last generation formulations with bimodal releases.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Green & Sustainable Science & Technology
Yanwei Hu, Xingqing Yan, Lei Chen, Shuai Yu, Changyuan Liu, Jianliang Yu
Summary: This paper describes experimental studies and computational fluid dynamics simulation on the diffusion of atmospheric CO2 after leakage from high-pressure CO2 pipelines. It proposes a prediction model for the leakage hazard area and quantitatively analyzes the relationship between the caliber of supercritical CO2 leakage and the dangerous distance, providing a feasible method for determining the leakage hazard of supercritical CO2 transportation.
INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL
(2022)
Article
Multidisciplinary Sciences
Yi Zhou, Lunan Yang, Zhen Liu, Yang Sun, Junfei Huang, Bingcheng Liu, Quan Wang, Leyu Wang, Yong Miao, Malcolm Xing, Zhiqi Hu
Summary: We developed a switchable hydrogel film adhesive with pattern-tunable wrinkles to control adhesion, addressing the challenges of on-demand adherence and detachment from tissue surfaces. The generated compressive stress from the bilayer system leads to self-similar wrinkling patterns at different wavelengths, regulating interfacial adhesion. We demonstrated the application of our adhesive in a random skin flap model, showing its potential for tissue sealing, neovascularization promotion, and gradual detachment through dynamic wrinkling pattern transition.
Article
Engineering, Chemical
Mariangela Guastaferro, Lucia Baldino, Stefano Cardea, Ernesto Reverchon
Summary: Supercritical CO2-assisted electrospray was used to achieve sustained release of ceftriaxone sodium from polylactic acid nanoparticles. By adjusting the process conditions, the release time was increased by 240 times.
Article
Pharmacology & Pharmacy
Johannes Schmid, Martin A. Wahl, Rolf Daniels
Summary: The loading of 3D printed drug carriers with APIs using supercritical CO2 shows potential for personalized medicine. By adjusting the pore sizes of the carriers, the drug release rate of the dosage forms can be easily tailored to individual needs.
Article
Energy & Fuels
Qixin Yuan, Yongsheng Zhang, Tao Wang, Jiawei Wang, Carlos E. Romero
Summary: The accelerated mineralization of fly ash is a potential way to reduce CO2 emissions. Supercritical CO2 can improve mineralization efficiency and the presence of water promotes mineralization.
Article
Pharmacology & Pharmacy
Truc T. Ngo, Jae D. Kim
Summary: The study focuses on the design and implementation of effective drug delivery systems by engineering and predicting drug release behavior. A drug delivery system composed of a methacrylate-based polymer and flurbiprofen was studied, and its sustained release profile in a controlled phosphate-buffered saline solution was characterized. Through the application of a computer algorithm, the drug release time duration and maximum release at steady state were determined. Empirical models and Fick's law were used to analyze the drug release mechanism and estimate diffusion coefficients. The study provides insights into the influence of supercritical carbon dioxide processing conditions on diffusion behavior and offers opportunities for the tunable design of drug delivery systems for targeted treatment specifications.
Article
Pharmacology & Pharmacy
Isabela Trindade Coutinho, Ligia Passos Maia-Obi, Mathilde Champeau
Summary: The study compared drug loading efficiency and release duration of implants loaded with aspirin using soaking and supercritical CO2 (scCO(2)) impregnation methods. The results showed that scCO(2) impregnation achieved higher drug loadings and prolonged drug release compared to soaking method, indicating its adequacy for higher aspirin loadings.
Review
Biochemistry & Molecular Biology
Shengzhou Shan, Qingfeng Li, Tracy Criswell, Anthony Atala, Yuanyuan Zhang
Summary: Sphincter dysfunction is a common consequence of neuromuscular impairment in tubule organs, resulting from trauma, inflammation, and aging. Conventional pharmacological treatments have limited success, prompting the exploration of cell- or growth factor-based therapies. However, challenges such as poor cell retention and viability, and the short half-life of growth factors have hindered clinical translation. Natural biomaterials offer a promising solution for controlled growth factor delivery, which has shown improved outcomes in sphincter function recovery. This review provides insights into the potential therapeutic role of stem cells combined with controlled release of growth factors, highlighting their use in preclinical studies as a new strategy to treat incontinence or sphincter dysfunction.
CELL AND BIOSCIENCE
(2023)
Article
Thermodynamics
Juwei Lou, Jiangfeng Wang, Jiaxi Xia, Yang Du, Pan Zhao, Shunsen Wang
Summary: This paper proposes a novel energy storage-based supercritical CO2 power system with an ejector to achieve rapid energy storage and release, ensuring high conversion efficiency of nuclear energy. The performance of the proposed system is examined using thermodynamic mathematical models, and parametric analysis and optimization are conducted to obtain optimal system performance. The evaluation of performance under energy storage and release conditions demonstrates the power regulation capacity of the system. Results show that the proposed system has an optimum thermal efficiency of 44.58% and corresponding exergy efficiency of 66.94% under given conditions. Furthermore, the study reveals the impact of mass flow rate storage and release on power load, as well as the maximum regulation capacity for power load.
ENERGY CONVERSION AND MANAGEMENT
(2022)
Article
Engineering, Biomedical
Qiang Yang, Huali Chen, Yan Bai, Yang Cao, Wenjing Hu, Liangke Zhang
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Engineering, Biomedical
Yue He, Jingyuan Wan, Yang Yang, Pei Yuan, Cheng Yang, Zhigang Wang, Liangke Zhang
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Engineering, Biomedical
Qiang Yang, Pan Li, Haitao Ran, Jingyuan Wan, Huan Chen, Huali Chen, Zhigang Wang, Liangke Zhang
ACTA BIOMATERIALIA
(2019)
Article
Chemistry, Applied
Ting Zhao, Shiwei Qin, Linna Peng, Pan Li, Tao Feng, Jingyuan Wan, Pei Yuan, Liangke Zhang
CARBOHYDRATE POLYMERS
(2019)
Article
Engineering, Biomedical
Tao Feng, Jingyuan Wan, Pan Li, Haitao Ran, Huali Chen, Zhigang Wang, Liangke Zhang
Article
Biochemistry & Molecular Biology
Qi Xiong, Yiwu Wang, Jingyuan Wan, Pei Yuan, Huali Chen, Liangke Zhang
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Immunology
Jin Liu, Yinglin Yuan, Xia Gong, Liangke Zhang, Qin Zhou, Shengwang Wu, Xue Zhang, Jun Hu, Ge Kuang, Xinru Yin, Jingyuan Wan, Yonghua Yuan
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Immunology
Sen Yang, Ge Kuang, Liangke Zhang, Shengwang Wu, Zizuo Zhao, Bin Wang, Xinru Yin, Xia Gong, Jingyuan Wan
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biophysics
Huan Chen, Huali Chen, Yiwu Wang, Yan Bai, Pei Yuan, Zhanghong Che, Liangke Zhang
Summary: The study introduced a novel self-coated nanoparticle for targeted drug delivery and the synergistic effect of photothermal therapy and chemotherapy, showing promising prospects in tumor therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Tianbao Wang, Jiahui Yang, Hongmei Kang, Liangke Zhang, Huan Chen
Summary: This study successfully prepared a novel type of nanoparticle by embedding hyaluronic acid, which exhibited good biosafety and efficient conversion of near-infrared laser energy to thermal energy. The active targeting capability mediated by hyaluronic acid significantly increased the uptake of nanoparticles by tumor cells, resulting in strong growth inhibitory effect on tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Jiahui Yang, Liu Yang, Qin Li, Liangke Zhang
Summary: In this study, ferrocene-based nanoparticles were constructed using copper ions and ferrocene derivatives for the first time. The nanoparticles demonstrated good photothermal conversion properties and efficient Fenton effect, indicating their potential in tumor treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Hongmei Kang, Lamei Chen, Qin Li, Huan Chen, Liangke Zhang
Summary: In this study, a hyaluronic acid-modified ruthenium nanoaggregate and glucose oxidase-loaded manganese dioxide nanoflowers have been prepared. These nanomaterials can generate oxygen in the tumor microenvironment, alleviate tumor tissue hypoxia, and achieve high-temperature ablation of solid tumors. Additionally, they can consume glucose in the presence of oxygen, reduce tumor nutrient supply, and produce cytotoxic hydroxyl radicals, thereby enhancing the antitumor effect. The nanomaterials can also actively target tumor cells, improving the overall therapeutic effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Pharmacology & Pharmacy
Xueyan Liu, Liangke Zhang, Wengao Jiang, Zhangyou Yang, Zongjie Gan, Chao Yu, Ran Tao, Huali Chen
Article
Materials Science, Biomaterials
Chongyan Mou, Yang Yang, Yan Bai, Pei Yuan, Yiwu Wang, Liangke Zhang
JOURNAL OF MATERIALS CHEMISTRY B
(2019)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)