TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

B-cell lymphoma 2 inhibitor ABT-737 induces Beclin1- and reactive oxygen species-dependent autophagy in Adriamycin-resistant human hepatocellular carcinoma cells

(2017) Xiaoxiao Yao et al.   TUMOR BIOLOGY

Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis

(2016) Hongjie Pan et al.   BMC BIOCHEMISTRY

Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome

(2016) Gabrielle C Geddes et al.   GENETICS IN MEDICINE

Silibinin negatively contributes to primary cilia length via autophagy regulated by histone deacetylase 6 in confluent mouse embryo fibroblast 3T3-L1 cells

(2016) Qian Xu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling

(2016) Søren T. Christensen et al.   Cold Spring Harbor Perspectives in Biology

Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function

(2016) Claudio R. Cortés et al.   Scientific Reports

TGFβ1 – induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner

(2016) Marie-Noëlle Labour et al.   Scientific Reports

Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways

(2015) Shixuan Wang et al.   Autophagy

Sonic hedgehog patterning during cerebellar development

(2015) Annarita De Luca et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition

(2015) Antje Thien et al.   DEVELOPMENTAL CELL

Ins and outs of GPCR signaling in primary cilia

(2015) K. B. Schou et al.   EMBO REPORTS

Hedgehog Signaling during Appendage Development and Regeneration

(2015) Bhairab Singh et al.   Genes

A quick signal of starvation induced autophagy: Transcription versus post-translational modification of LC3

(2014) Md. Razaul Karim et al.   ANALYTICAL BIOCHEMISTRY

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity

(2014) N. Santos et al.   JOURNAL OF CELL SCIENCE

TGF-β-Activated Kinase 1 (TAK1) Signaling Regulates TGF-β-Induced WNT-5A Expression in Airway Smooth Muscle Cells via Sp1 and β-Catenin

(2014) Kuldeep Kumawat et al.   PLoS One

G-protein-coupled receptors, Hedgehog signaling and primary cilia

(2014) Saikat Mukhopadhyay et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model

(2013) Samer Z. Kaylani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

(2013) Hilaire C. Lam et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional interaction between autophagy and ciliogenesis

(2013) Olatz Pampliega et al.   NATURE

Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites

(2013) Zaiming Tang et al.   NATURE

Inversin/Nephrocystin-2 Is Required for Fibroblast Polarity and Directional Cell Migration

(2013) Iben R. Veland et al.   PLoS One

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling Long-Term Signaling: Receptor Dynamics Determine Attenuation and Refractory Behavior of the TGF-  Pathway

(2013) P. Vizan et al.   Science Signaling

TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium

(2013) Christian Alexandro Clement et al.   Cell Reports

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Identification of a novel Wnt5a-CK1ε-Dvl2-Plk1-mediated primary cilia disassembly pathway

(2012) Kyung Ho Lee et al.   EMBO JOURNAL

PDGFR  signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways

(2012) D. L. Clement et al.   JOURNAL OF CELL SCIENCE

TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

(2012) Christian C. Dibble et al.   MOLECULAR CELL

Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation

(2012) S. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development

(2011) Ellen J. Ezratty et al.   CELL

NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

(2011) Sandra Habbig et al.   JOURNAL OF CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Ciliopathies

(2011) Friedhelm Hildebrandt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction

(2010) Marianne Hoogeveen-Westerveld et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Double trouble: When Sonic hedgehog signaling meets TSC inactivation

(2010) Bobby Bhatia et al.   CELL CYCLE

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts

(2010) Linda Schneider et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of In Situ to Invasive Breast Carcinoma Transition

(2008) Min Hu et al.   CANCER CELL

Distinct Roles for Mammalian Target of Rapamycin Complexes in the Fibroblast Response to Transforming Growth Factor- 

(2008) R. A. Rahimi et al.   CANCER RESEARCH

Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway

(2008) Linda M. DiBella et al.   HUMAN MOLECULAR GENETICS

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

Tuberous sclerosis

(2008) Paolo Curatolo et al.   LANCET

The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

(2008) J. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

The tuberous sclerosis gene products hamartin and tuberin are multifunctional proteins with a wide spectrum of interacting partners

(2008) Margit Rosner et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia

(2008) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA