Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1

(2017) Jan Bednar et al.   MOLECULAR CELL

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

(2017) Kayo Nozawa et al.   NATURE

Nucleosome–Chd1 structure and implications for chromatin remodelling

(2017) Lucas Farnung et al.   NATURE

Models of global gene expression define major domains of cell type and tissue identity

(2017) Andrew P. Hutchins et al.   NUCLEIC ACIDS RESEARCH

Impact of cytosine methylation on DNA binding specificities of human transcription factors

(2017) Yimeng Yin et al.   SCIENCE

Molecular basis for the genome engagement by Sox proteins

(2017) Linlin Hou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pioneer factors and ATP-dependent chromatin remodeling factors interact dynamically: A new perspective

(2016) Erin E. Swinstead et al.   BIOESSAYS

The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells

(2016) Hitoshi Niwa et al.   BMC EVOLUTIONARY BIOLOGY

Pioneer transcription factors, chromatin dynamics, and cell fate control

(2016) Kenneth S Zaret et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Changing POU dimerization preferences converts Oct6 into a pluripotency inducer

(2016) Stepan Jerabek et al.   EMBO REPORTS

Chromatin Scanning by Dynamic Binding of Pioneer Factors

(2016) Kenneth S. Zaret et al.   MOLECULAR CELL

Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction

(2016) Miriam Klaus et al.   NUCLEIC ACIDS RESEARCH

Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq

(2016) Yiming K. Chang et al.   NUCLEIC ACIDS RESEARCH

Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming

(2016) Jun Chen et al.   Cell Reports

Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming

(2016) Wensong Jin et al.   Scientific Reports

Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming

(2015) Abdenour Soufi et al.   CELL

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells

(2015) T. K. Mistri et al.   EMBO REPORTS

DNA-dependent formation of transcription factor pairs alters their binding specificity

(2015) Arttu Jolma et al.   NATURE

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

(2015) Itay Maza et al.   NATURE BIOTECHNOLOGY

Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage

(2015) Ori Bar-Nur et al.   NATURE BIOTECHNOLOGY

DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

(2015) Kamesh Narasimhan et al.   NUCLEIC ACIDS RESEARCH

Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition

(2015) Xiangqian Kong et al.   NUCLEIC ACIDS RESEARCH

Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency

(2015) Natalia Tapia et al.   Scientific Reports

Cooperative DNA Recognition Modulated by an Interplay between Protein-Protein Interactions and DNA-Mediated Allostery

(2015) Felipe Merino et al.   PLoS Computational Biology

Reprogramming cells with synthetic proteins

(2014) Xiao-Xiao Yang et al.   ASIAN JOURNAL OF ANDROLOGY

Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells

(2014) Jiji Chen et al.   CELL

Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity

(2014) Matthew T. Weirauch et al.   CELL

Small Molecules Facilitate the Reprogramming of Mouse Fibroblasts into Pancreatic Lineages

(2014) Ke Li et al.   Cell Stem Cell

Chemical approaches to cell reprogramming

(2014) Chen Yu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The POU-er of gene nomenclature

(2014) S. R. Frankenberg et al.   DEVELOPMENT

The Early Expansion and Evolutionary Dynamics of POU Class Genes

(2014) David A. Gold et al.   MOLECULAR BIOLOGY AND EVOLUTION

Required enhancer–matrin-3 network interactions for a homeodomain transcription program

(2014) Dorota Skowronska-Krawczyk et al.   NATURE

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units

(2014) F. Song et al.   SCIENCE

Structural Basis for the SOX-Dependent Genomic Redistribution of OCT4 in Stem Cell Differentiation

(2014) Felipe Merino et al.   STRUCTURE

Small Molecules Enable Cardiac Reprogramming of Mouse Fibroblasts with a Single Factor, Oct4

(2014) Haixia Wang et al.   Cell Reports

Conversion of Human Fibroblasts to Functional Endothelial Cells by Defined Factors

(2013) Jun Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

OCT4: Dynamic DNA binding pioneers stem cell pluripotency

(2013) Stepan Jerabek et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

(2013) Orly L. Wapinski et al.   CELL

DNA-Binding Specificities of Human Transcription Factors

(2013) Arttu Jolma et al.   CELL

Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells

(2013) Saiyong Zhu et al.   CELL RESEARCH

Toward directed reprogramming through exogenous factors

(2013) Changsheng Lin et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Oct transcription factors in development and stem cells: insights and mechanisms

(2013) D. Tantin   DEVELOPMENT

Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

(2013) Irene Aksoy et al.   EMBO JOURNAL

Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation

(2013) Jinsuk Kang et al.   FASEB JOURNAL

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes

(2013) J. M. Caravaca et al.   GENES & DEVELOPMENT

A unique Oct4 interface is crucial for reprogramming to pluripotency

(2013) Daniel Esch et al.   NATURE CELL BIOLOGY

Probing Allostery Through DNA

(2013) S. Kim et al.   SCIENCE

Genome-Wide Quantitative Enhancer Activity Maps Identified by STARR-seq

(2013) C. D. Arnold et al.   SCIENCE

Sox Transcription Factors Require Selective Interactions with Oct4 and Specific Transactivation Functions to Mediate Reprogramming

(2013) Irene Aksoy et al.   STEM CELLS

SOX2 Co-Occupies Distal Enhancer Elements with Distinct POU Factors in ESCs and NPCs to Specify Cell State

(2013) Michael A. Lodato et al.   PLoS Genetics

Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome

(2012) Abdenour Soufi et al.   CELL

O-GlcNAc Regulates Pluripotency and Reprogramming by Directly Acting on Core Components of the Pluripotency Network

(2012) Hyonchol Jang et al.   Cell Stem Cell

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

(2012) Dong Wook Han et al.   Cell Stem Cell

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

(2012) Marc Thier et al.   Cell Stem Cell

The many roads to Rome: induction of neural precursor cells from fibroblasts

(2012) Ernesto Lujan et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Reciprocal Regulation of Akt and Oct4 Promotes the Self-Renewal and Survival of Embryonal Carcinoma Cells

(2012) Yuanji Lin et al.   MOLECULAR CELL

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming

(2012) Abed AlFatah Mansour et al.   NATURE

Generation of human induced pluripotent stem cells from urine samples

(2012) Ting Zhou et al.   Nature Protocols

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements

(2012) Calista K. L. Ng et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation regulates human OCT4

(2012) J. Brumbaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

(2012) E. Lujan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of the Sox4 HMG domain–DNA complex suggests a mechanism for positional interdependence in DNA recognition

(2011) Ralf Jauch et al.   BIOCHEMICAL JOURNAL

RETRACTED: Directed Conversion of Alzheimer's Disease Patient Skin Fibroblasts into Functional Neurons

(2011) Liang Qiang et al.   CELL

Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network

(2011) Yen-Sin Ang et al.   CELL

Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1

(2011) Jai-Hee Moon et al.   CELL RESEARCH

Oct4 links multiple epigenetic pathways to the pluripotency network

(2011) Junjun Ding et al.   CELL RESEARCH

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Reprogramming Factor Expression Initiates Widespread Targeted Chromatin Remodeling

(2011) Richard P. Koche et al.   Cell Stem Cell

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Combinatorial binding of transcription factors in the pluripotency control regions of the genome

(2011) L. Ferraris et al.   GENOME RESEARCH

Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

(2011) Momoko Maekawa et al.   NATURE

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy

(2011) Jem A. Efe et al.   NATURE CELL BIOLOGY

Skn-1a (Pou2f3) specifies taste receptor cell lineage

(2011) Ichiro Matsumoto et al.   NATURE NEUROSCIENCE

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers

(2011) Nithya Baburajendran et al.   NUCLEIC ACIDS RESEARCH

Dynamic Regulation of Oct1 during Mitosis by Phosphorylation and Ubiquitination

(2011) Jinsuk Kang et al.   PLoS One

Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells

(2011) Kah Yong Tan et al.   PLoS One

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intra- and intermolecular translocation of the bi-domain transcription factor Oct1 characterized by liquid crystal and paramagnetic NMR

(2011) Y. Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Transcription Factor Reprogramming of Hair Follicle Dermal Papilla Cells to Induced Pluripotent Stem Cells

(2011) Su-Yi Tsai et al.   STEM CELLS

Reprogramming of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4

(2011) Tong Wu et al.   STEM CELLS

Conversion of Sox17 into a Pluripotency Reprogramming Factor by Reengineering Its Association with Oct4 on DNA

(2011) Ralf Jauch et al.   STEM CELLS

BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone

(2010) Jiekai Chen et al.   CELL RESEARCH

Generation of iPSCs from mouse fibroblasts with a single gene, Oct4 and small molecules

(2010) Yanqin Li et al.   CELL RESEARCH

An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells

(2010) Debbie L.C. van den Berg et al.   Cell Stem Cell

An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease

(2010) Mercedes Pardo et al.   Cell Stem Cell

Rapid and efficient reprogramming of human amnion-derived cells into pluripotency by three factors OCT4/SOX2/NANOG

(2010) Hong-xi Zhao et al.   DIFFERENTIATION

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes

(2010) Hua Liu et al.   HEPATOLOGY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Direct conversion of human fibroblasts to multilineage blood progenitors

(2010) Eva Szabo et al.   NATURE

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors

(2010) Nithya BabuRajendran et al.   NUCLEIC ACIDS RESEARCH

Human and mouse adipose-derived cells support feeder-independent induction of pluripotent stem cells

(2010) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Oct-3 POU-homeodomain in solution, as determined by triple resonance heteronuclear multidimensional NMR spectroscopy

(2010) Eugene H. Morita et al.   PROTEIN SCIENCE

Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA

(2010) Ralf Jauch et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Generation of Induced Pluripotent Stem Cells from Human Adipose-Derived Stem Cells Without c-MYC

(2010) Tetsuhiro Aoki et al.   TISSUE ENGINEERING PART A

O-GlcNAc modifications regulate cell survival and epiboly during zebrafish development

(2009) Danielle M Webster et al.   BMC DEVELOPMENTAL BIOLOGY

Oct4-Induced Pluripotency in Adult Neural Stem Cells

(2009) Jeong Beom Kim et al.   CELL

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Generation of Induced Pluripotent Stem Cells from Human Cord Blood

(2009) Alexandra Haase et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cells from Human Cord Blood Using OCT4 and SOX2

(2009) Alessandra Giorgetti et al.   Cell Stem Cell

Tgfβ Signal Inhibition Cooperates in the Induction of iPSCs and Replaces Sox2 and cMyc

(2009) Nimet Maherali et al.   CURRENT BIOLOGY

Exhaustive Search for Over-represented DNA Sequence Motifs with CisFinder

(2009) A. A. Sharov et al.   DNA RESEARCH

A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress

(2009) J. Kang et al.   GENES & DEVELOPMENT

Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts

(2009) Noriko Tsubooka et al.   GENES TO CELLS

Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells

(2009) J. Utikal et al.   JOURNAL OF CELL SCIENCE

The Structure of Sox17 Bound to DNA Reveals a Conserved Bending Topology but Selective Protein Interaction Platforms

(2009) Paaventhan Palasingam et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of human Brn-5 transcription factor in complex with CRH gene promoter

(2009) Jose Henrique Pereira et al.   JOURNAL OF STRUCTURAL BIOLOGY

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

(2009) Gabsang Lee et al.   NATURE

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Direct reprogramming of human neural stem cells by OCT4

(2009) Jeong Beom Kim et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb

(2009) Bo Feng et al.   NATURE CELL BIOLOGY

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

(2009) Sarah Eminli et al.   NATURE GENETICS

Post-Translational Regulation of Oct4 Transcriptional Activity

(2009) Jonathan P. Saxe et al.   PLoS One

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

(2009) C. A. Lyssiotis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and Complexity in DNA Recognition by Transcription Factors

(2009) G. Badis et al.   SCIENCE

Oct4 and Klf4 Reprogram Dermal Papilla Cells into Induced Pluripotent Stem Cells

(2009) Su-Yi Tsai et al.   STEM CELLS

iPS Cells Reprogrammed From Human Mesenchymal-Like Stem/Progenitor Cells of Dental Tissue Origin

(2009) Xing Yan et al.   STEM CELLS AND DEVELOPMENT

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

(2008) Jacob Hanna et al.   CELL

Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

(2008) Xi Chen et al.   CELL

A Combined Chemical and Genetic Approach for the Generation of Induced Pluripotent Stem Cells

(2008) Yan Shi et al.   Cell Stem Cell

Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

(2008) Yang Zhao et al.   Cell Stem Cell

c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts

(2008) Marius Wernig et al.   Cell Stem Cell

A High-Efficiency System for the Generation and Study of Human Induced Pluripotent Stem Cells

(2008) Nimet Maherali et al.   Cell Stem Cell

Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

(2008) Yan Shi et al.   Cell Stem Cell

Novel Variants ofOct-3/4Gene Expressed in Mouse Somatic Cells

(2008) Nobuhiko Mizuno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

(2008) Jeong Beom Kim et al.   NATURE

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

(2008) Trond Aasen et al.   NATURE BIOTECHNOLOGY

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Generation of human induced pluripotent stem cells from dermal fibroblasts

(2008) W. E. Lowry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

(2008) T. Aoi et al.   SCIENCE

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE

OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells

(2008) Yaser Atlasi et al.   STEM CELLS

Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition

(2008) Jose Silva et al.   PLOS BIOLOGY