Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis

Systematic analysis of ATG13 domain requirements for autophagy induction

(2018) Nora Wallot-Hieke et al.   Autophagy

PKM2 knockdown influences SREBP activation and lipid synthesis in bovine mammary-gland epithelial MAC-T cells

(2018) Bing-Qian Su et al.   BIOTECHNOLOGY LETTERS

Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage

(2018) Önder Aybastıer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

NADPH oxidase NOX2 mediates TLR2/6-dependent release of GM-CSF from endothelial cells

(2017) Jutta Schuett et al.   FASEB JOURNAL

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

(2017) Go J. Yoshida   Journal of Hematology & Oncology

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

(2017) Kuang Shen et al.   MOLECULAR CELL

AMPK β1 reduces tumor progression and improves survival in p53 null mice

(2017) Vanessa P. Houde et al.   Molecular Oncology

Out of Warburg effect: An effective cancer treatment targeting the tumor specific metabolism and dysregulated pH

(2017) Laurent Schwartz et al.   SEMINARS IN CANCER BIOLOGY

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells

(2017) Joachim Bischof et al.   TUMOR BIOLOGY

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

(2017) Thomas Bohnacker et al.   Nature Communications

Antimicrobial Peptides Secreted From Human Cryopreserved Viable Amniotic Membrane Contribute to its Antibacterial Activity

(2017) Yong Mao et al.   Scientific Reports

Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm

(2016) Majing Luo et al.   Autophagy

Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

(2016) I. A. Netland et al.   BMC CANCER

Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer

(2016) Le Zhang et al.   CELL CYCLE

Targeted Inhibition of Rictor/mTORC2 in Cancer Treatment: A New Era after Rapamycin

(2016) Zhipeng Zou et al.   CURRENT CANCER DRUG TARGETS

Mitochondrial ROS regulation of proliferating cells

(2016) Lauren Diebold et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

(2016) M.D. Mantzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

Reactive oxygen species in redox cancer therapy

(2015) Lingying Tong et al.   CANCER LETTERS

Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes

(2015) M. Robertson-Tessi et al.   CANCER RESEARCH

Therapeutic strategies targeting cancer stem cells

(2015) Go J. Yoshida et al.   CANCER SCIENCE

Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease

(2015) Dongmei Zhang et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging system in reactive oxygen species

(2015) T. Mizuno et al.   GYNECOLOGIC ONCOLOGY

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ca2+ movement and apoptosis induced by deltamethrin in Madin–Darby canine kidney canine renal tubular cells

(2015) Fang-Jin Liu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Mitochondrial mass, a new metabolic biomarker for stem-like cancer cells: Understanding WNT/FGF-driven anabolic signaling

(2015) Rebecca Lamb et al.   Oncotarget

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

(2015) Laura Poillet-Perez et al.   Redox Biology

Targeting autophagy in cancer management – strategies and developments

(2015) Bulent Ozpolat et al.   Cancer Management and Research

Identification of Atg3 as an intrinsically disordered polypeptide yields insights into the molecular dynamics of autophagy-related proteins in yeast

(2014) Hana Popelka et al.   Autophagy

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

(2014) Nelma Pértega-Gomes et al.   BMC CANCER

Metabolic differences in breast cancer stem cells and differentiated progeny

(2014) Erina Vlashi et al.   BREAST CANCER RESEARCH AND TREATMENT

The requirement for freshly isolated human colorectal cancer (CRC) cells in isolating CRC stem cells

(2014) F Fan et al.   BRITISH JOURNAL OF CANCER

Osteopontin-CD44 Signaling in the Glioma Perivascular Niche Enhances Cancer Stem Cell Phenotypes and Promotes Aggressive Tumor Growth

(2014) Alexander Pietras et al.   Cell Stem Cell

Combination of Oxidative Stress and FOXM1 Inhibitors Induces Apoptosis in Cancer Cells and Inhibits Xenograft Tumor Growth

(2013) Marianna Halasi et al.   AMERICAN JOURNAL OF PATHOLOGY

Three-dimensional culture of sebaceous gland cells revealing the role of prostaglandin E2-induced activation of canonical Wnt signaling

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EpCAM expression in the prostate cancer makes the difference in the response to growth factors

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation

(2013) Go J. Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

(2013) V. Estrella et al.   CANCER RESEARCH

Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets

(2013) Maria Grazia Cipolleschi et al.   CELL CYCLE

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research

(2013) Valentina Bravatà et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacologic Activation of PKM2 Slows Lung Tumor Xenograft Growth

(2013) K. M. Parnell et al.   MOLECULAR CANCER THERAPEUTICS

Elucidation of How Cancer Cells Avoid Acidosis through Comparative Transcriptomic Data Analysis

(2013) Kun Xu et al.   PLoS One

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

(2012) Nicola Ivan Orlotti et al.   Autophagy

Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

(2012) Clare Davies et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

(2012) Go J Yoshida et al.   BMC CANCER

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

(2012) Charles Kung et al.   CHEMISTRY & BIOLOGY

A crucial role for Nox 1 in redox-dependent regulation of Wnt-β-catenin signaling

(2012) Seheli Kajla et al.   FASEB JOURNAL

p85α SH2 Domain Phosphorylation by IKK Promotes Feedback Inhibition of PI3K and Akt in Response to Cellular Starvation

(2012) William C. Comb et al.   MOLECULAR CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

(2012) Marianna Scrima et al.   PLoS One

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

Increased CD13 Expression Reduces Reactive Oxygen Species, Promoting Survival of Liver Cancer Stem Cells via an Epithelial–Mesenchymal Transition-like Phenomenon

(2011) Ho Min Kim et al.   ANNALS OF SURGICAL ONCOLOGY

The PI3K, Metabolic, and Autophagy Networks: Interactive Partners in Cellular Health and Disease

(2011) Naval P. Shanware et al.   Annual Review of Pharmacology and Toxicology

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

(2011) Shinji Saiki et al.   Autophagy

CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

(2011) Takatsugu Ishimoto et al.   CANCER CELL

Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells

(2011) Hiroto Izumi et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

(2011) Aaron C-H. Chen et al.   PLoS One

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting glutamine metabolism sensitizes melanoma cells to TRAIL-induced death

(2010) J.-Z. Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD133 expression in chemo-resistant Ewing sarcoma cells

(2010) Xiaohua Jiang et al.   BMC CANCER

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Tumor Necrosis Factor-α and Apoptosis Signal-Regulating Kinase 1 Control Reactive Oxygen Species Release, Mitochondrial Autophagy and C-Jun N-Terminal Kinase/P38 Phosphorylation During Necrotizing Enterocolitis

(2010) Naira Baregamian et al.   Oxidative Medicine and Cellular Longevity

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

GLUT1 gene is a potential hypoxic marker in colorectal cancer patients

(2009) Fu-Yen Chung et al.   BMC CANCER

HIF-1: upstream and downstream of cancer metabolism

(2009) Gregg L Semenza   CURRENT OPINION IN GENETICS & DEVELOPMENT

Therapeutic targeting of microenvironmental interactions in leukemia: Mechanisms and approaches

(2009) Marina Konopleva et al.   DRUG RESISTANCE UPDATES

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

(2009) K. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is required during cycling hypoxia to lower production of reactive oxygen species

(2009) Kasper M.A. Rouschop et al.   RADIOTHERAPY AND ONCOLOGY

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE