Article
Computer Science, Artificial Intelligence
Raphael Rissler, Mario Nadj, Maximilian X. X. Li, Nico Loewe, Michael T. T. Knierim, Alexander Maedche
Summary: This article presents the research results of using heart rate variability (HRV) and a Random Forest classifier to distinguish high and low flow, contributing to the investigation of flow from a physiological perspective. The findings demonstrate that flow-classifiers based on HRV features alone can achieve accuracies of 68.5% (lab) and 70.6% (field). These findings lay the foundation for future development of physio-adaptive systems to enhance employee performance.
IEEE TRANSACTIONS ON AFFECTIVE COMPUTING
(2023)
Article
Pediatrics
Alicija Vileito, Christian V. Hulzebos, Mona C. Toet, Dyvonne H. Baptist, Eduard A. A. Verhagen, Marion J. Siebelink
Summary: Neonatal organ and tissue donation is not common in the Netherlands, partly due to low awareness of this option. A study on two NICUs in the country found that a small proportion of term-born neonates were suitable for organ donation, while a higher proportion could donate tissue. Increasing awareness about neonatal donation could help identify more potential donors.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Pharmacology & Pharmacy
Sunil Sharma, Robert Stansbury, Benjamin Hackett, Henrik Fox
Summary: Obstructive sleep apnea (OSA) and pulmonary hypertension (PH) are known to be associated, with limited understanding of the relationship which appears to be bidirectional. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. Further research on the mechanisms of this relationship is important.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Physiology
Fernando Sousa Honorato, Lysleine Alves de Deus, Andrea Lucena Reis, Rodrigo Vanerson Passos Neves, Hugo de Luca Correa, Ana Paola Brasil Medeiros, Debora Fernanda Haberland, Radames Maciel Vitor Medeiros, Jonato Prestes, Carlos Ernesto Santos Ferreira, Thiago Santos Rosa
Summary: This study analyzed the influence of hypobaric hypoxia on cardiac autonomic function and its association with physical fitness. The results showed a decrease in heart rate variability indices during hypoxia and no association between the time of onset of hypoxia symptoms and physical fitness. The study suggests that cardiac autonomic modulation is more sensitive to hypobaric hypoxia than self-reported symptoms.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Nic Fleming
Summary: Female and Black researchers discuss the effects of sexism and racism during meetings.
Article
Cardiac & Cardiovascular Systems
Jason W. Greenberg, Stephen H. Fatuzzo, Aadhyasri Ramineni, Clifford Chin, Samuel G. Wittekind, Angela Lorts, David G. Lehenbauer, Louis B. Louis, Farhan Zafar, David L. S. Morales
Summary: This study aimed to determine whether the odds of heart transplantation offer acceptance differed for adult and pediatric candidates depending on the day on which the offer occurred. The study found that both adult and pediatric candidates had lower odds of accepting transplantation offers on weekends, holidays, and during academic conferences. This phenomenon is important for ensuring optimal organ allocation throughout the year.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Geriatrics & Gerontology
Giana Carli Lorenzini, Alison Bell, Annika Olsson
Summary: This study explores how older people manage multiple medications and associated packaging in their self-care process. By collecting and analyzing data through photographs, diaries, and interviews, the study identifies challenges in medication packaging design for older people and the need for improvement.
Article
Psychology, Multidisciplinary
Yuli Astutik, Slamet Setiawan, Syafi'ul Anam
Summary: This study longitudinally analyzed university students' cognition in learning an English for young learners (EYL) course. The findings indicate a significant change in pre-service teachers' cognition, such as their motivation, perception, and belief. It was observed that students' interest in teaching English to young learners and the duration of studying EYL teaching knowledge do not necessarily guarantee their conviction to pursue a teaching profession.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Cell Biology
Fangze Huang, Ronghua Yang, Zezhou Xiao, Yu Xie, Xuefeng Lin, Peng Zhu, Pengyu Zhou, Jun Lu, Shaoyi Zheng
Summary: Ferroptosis, a novel form of non-apoptotic regulated cell death driven by iron and lethal lipid hydroperoxides, plays a critical role in the development of cardiovascular diseases. Recent studies have shown that ferroptosis inhibitors and other substances can alleviate myocardial injury by targeting the ferroptosis pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Mark Dust
Summary: A significant number of U.S. adults experience traumatic events, leading to millions of individuals developing PTSD and costing billions of dollars in healthcare. The Community Resilience Model (CRM) and Mental and Emotional Self-Management (MESM) were studied as potential solutions for PTSD resulting from traumatic events. This pilot study found that MESM had a short-term effect on cardiac vagal tone, but more research is needed to validate the results and explore the potential of physiological resilience to traumatic stress.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marie Tindborg, Anders Koch, Mikael Andersson, Klaus Juul, Uka Wilhjelm Geisler, Bolette Soborg, Sascha Wilk Michelsen
Summary: The incidence rates of heart disease (HD) and congenital heart disease (CHD) were compared between young Inuit populations in Greenland and Denmark. It was found that the incidence rate of HD was lower in Greenland compared to Denmark, while the incidence rates of CHD were similar in both countries. Individuals of Inuit/mixed ethnicity had a higher risk of both HD and CHD compared to non-Inuit individuals in both countries.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Computer Science, Cybernetics
Xinyuan Wang, Qian Xing, Qiao Jin, Danli Wang
Summary: To cultivate children's computational thinking, researchers have developed various programming systems. Among them, tangible programming systems combined with graphic output have gained popularity due to their intuitive input and diverse visual feedback. However, few of these systems support collaborative learning or programming. In response to this gap, we present a novel tangible and collaborative enabled programming system called Lighters, designed for children aged 7-10, with two types of collaboration modes (block-based and role-based). Through a user experiment with 24 children, we collected physiological (EDA), questionnaire, video recording, and interview data for analysis. Based on the results, Lighters are effective in facilitating collaborative programming learning for children. Moreover, Lighters can evoke positive emotions and enthusiasm for programming. Role-based collaboration is found to be more likely to stimulate children's emotional states and have a better effect on learning programming compared to block-based collaboration.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2023)
Article
Geosciences, Multidisciplinary
R. Damian Nance, David A. D. Evans, J. Brendan Murphy
Summary: The existence of the putative Ediacaran supercontinent Pannotia has been questioned and the interpretation of related data is controversial, but it plays a crucial role in the evolution of supercontinent cycles.
EARTH-SCIENCE REVIEWS
(2022)
Article
Peripheral Vascular Disease
Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Zhongyun Wang, Ursa Bezan Petric, Ming Chang Hu, Scott A. Smith, Masaki Mizuno, Wanpen Vongpatanasin
Summary: This study found that SGLT2i can reduce blood pressure in hypertensive patients and attenuate renal sympathetic nerve activity and skeletal muscle reflex activity. Additionally, the study found that SGLT2i has no impact on glycemic control. These findings have important clinical implications for preventing hypertension and hypertensive heart disease in young prehypertensive individuals.
Review
Pharmacology & Pharmacy
Jialun Zhang, Peining Zhu, Siyu Li, Yufei Gao, Yue Xing
Summary: Trimethylamine oxide (TMAO), a metabolite of gut microbiota, has been found to play a role in the pathophysiological progression of heart and renal diseases and significantly affect outcomes in chronic heart failure and chronic kidney disease. However, its association with cardiorenal syndrome is still uncertain.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ruben A. Alexanian, Kaushiki Mahapatra, Di Lang, Ravi Vaidyanathan, Yogananda S. Markandeya, Ramandeep K. Gill, Andrew J. Zhai, Anisa Dhillon, Martin R. Lea, Sara Abozeid, Eric G. Schmuck, Amish N. Raval, Lee L. Eckhardt, Alexey V. Glukhov, Pratik A. Lalit, Timothy J. Kamp
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Genetics & Heredity
Corey L. Anderson, Tim C. Routes, Lee L. Eckhardt, Brian P. Delisle, Craig T. January, Timothy J. Kamp
GENETICS IN MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Forum Kamdar, Satyabrata Das, Wuming Gong, Andre Klaassen Kamdar, Tatyana A. Meyers, Pruthvi Shah, James M. Ervasti, DeWayne Townsend, Timothy J. Kamp, Joseph C. Wu, Mary G. Garry, Jianyi Zhang, Daniel J. Garry
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
B. N. Napiwocki, D. Lang, A. Stempien, J. Zhang, R. Vaidyanathan, J. C. Makielski, L. L. Eckhardt, A. V. Glukhov, T. J. Kamp, W. C. Crone
Summary: The study introduces a novel in vitro platform with patterned extracellular matrix that promotes the alignment of hPSC-CMs, enabling the formation of a functional cardiac syncytium. This biomimetic platform with electrical and mechanical readout capabilities can be used for cardiac disease research, drug impact analysis, and cardiomyocyte function assessment, promising high throughput evaluation of drug safety and efficacy.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Chaw Yee Beh, Ray Putra Prajnamitra, Li-Lun Chen, Patrick Ching-Ho Hsieh
Summary: The development of biomimetic nanoparticles as a novel drug delivery platform to enhance drug biocompatibility and specificity, particularly in the tumour microenvironment, has been discussed. By integrating different types of biomaterials onto the surface of nanoparticles to mimic the natural biological features and functions of cells, these nanoparticles can evade clearance by the immune system and reduce potential toxic side effects. Despite rapid progress in this field, there is still a need to advance biomimetic-based nanomedicine for clinical use, especially in the context of malignant tumors.
Editorial Material
Cardiac & Cardiovascular Systems
Valentina Lo Sardo, Timothy J. Kamp
Article
Genetics & Heredity
Corey L. Anderson, Emma R. Langer, Timothy C. Routes, Seamus F. McWilliams, Igor Bereslavskyy, Timothy J. Kamp, Lee L. Eckhardt
Summary: This study found that lamin A aggregation is a major contributor to skeletal and cardiac laminopathies, with aggregation-prone variants destabilizing the domain. Additionally, the research demonstrated an experimental platform for characterizing laminopathic variants in human cardiomyocytes and provided support for a functional assay in assessing the pathogenicity of myopathic variants.
NPJ GENOMIC MEDICINE
(2021)
Article
Biology
Jianhua Zhang, Zachery R. Gregorich, Ran Tao, Gina C. Kim, Pratik A. Lalit, Juliana L. Carvalho, Yogananda Markandeya, Deane F. Mosher, Sean P. Palecek, Timothy J. Kamp, Gordana Vunjak-Novakovic
Summary: This study reveals the importance of extracellular matrix (ECM) proteins, specifically fibronectin (FN), in promoting cardiac differentiation of human pluripotent stem cells (hPSCs). The presence of FN in the ECM is essential for effective cardiac differentiation, while other ECM proteins like laminin-111 and laminin-521 inhibit this process. Inhibition of certain integrin receptors and integrin-linked kinase can also impair cardiac differentiation.
Review
Cell Biology
Martin W. Nicholson, Chien-Yu Ting, Darien Z. H. Chan, Yu-Che Cheng, Yi-Chan Lee, Ching-Chuan Hsu, Ching-Ying Huang, Patrick C. H. Hsieh
Summary: The advent of induced pluripotent stem cells has greatly advanced our understanding of human disease molecular mechanisms and shown significant potential in drug development and validation. However, limitations such as variability between iPSC lines and their maturity still exist.
Article
Chemistry, Medicinal
Martin W. Nicholson, Ching-Ying Huang, Jyun-Yuan Wang, Chien-Yu Ting, Yu-Che Cheng, Darien Z. H. Chan, Yi-Chan Lee, Ching-Chuan Hsu, Yu-Hung Hsu, Cindy M. C. Chang, Marvin L. Hsieh, Yuan-Yuan Cheng, Yi-Ling Lin, Chien-Hsiun Chen, Ying-Ta Wu, Timothy A. Hacker, Joseph C. Wu, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: This study utilized a drug screening platform based on human induced pluripotent stem cells to evaluate the cardiotoxicity and neurotoxicity of anti-COVID-19 drugs. The researchers found that certain drugs displayed cardiotoxic or neurotoxic effects, providing valuable information for clinicians when choosing treatment options.
Review
Biochemistry & Molecular Biology
Jia-Jung Lee, Chuang-Yu Lin, Hung-Chun Chen, Patrick C. H. Hsieh, Yi-Wen Chiu, Jer-Ming Chang
Summary: Human induced pluripotent stem cells (iPSCs) have opened up a wide range of opportunities for research and potential therapeutic uses since their discovery in 2007. This review examines the development of iPSC reprogramming and characterization technologies, provides an updated list of stem cell biobanks, and highlights important iPSC-based research on diseases such as autosomal dominant kidney disease and SARS-CoV-2 kidney involvement. The review also discusses challenges and future perspectives.
Article
Neurosciences
Daniel G. P. Turner, Willem J. De Lange, Yanlong Zhu, Christopher L. Coe, Judith Simcox, Ying Ge, Timothy J. Kamp, J. Carter Ralphe, Alexey V. Glukhov
Summary: Cardiovascular disease, the leading cause of death in the USA, is aggravated by elevated mechanical stress from hypertension. This study investigates the loss of caveolae, plasma membrane structures that buffer mechanical stress, in pathological conditions associated with chronically stretched myocardium. The findings identify neutral sphingomyelinases (nSMase) as mechanoregulated mediators of caveolae loss, ceramide production, and blunted beta-adrenergic response in a human cardiac model.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Engineering, Multidisciplinary
Te-An Chen, Dhavan Sharma, Wenkai Jia, Donggi Ha, Kun Man, Jianhua Zhang, Yong Yang, Yuxiao Zhou, Timothy J. Kamp, Feng Zhao
Summary: Cell-derived extracellular matrix (ECM) is increasingly used in tissue engineering due to its ability to provide tailored signals for cellular responses. This study compared two detergent-based decellularization methods and found that EDTA + SDS treatment was more efficient in preserving the structure and bioactive substances of the ECM scaffold.
Article
Cell Biology
Ching-Ying Huang, Ling-Hui Li, Wan-Tseng Hsu, Yu-Che Cheng, Martin W. Nicholson, Chun-Lin Liu, Chien-Yu Ting, Hui-Wen Ko, Shih-Han Syu, Cheng-Hao Wen, Zhuge Yan, Hsiang-Po Huang, Hong-Lin Su, Po-Min Chiang, Chia-Ning Shen, Hsin-Fu Chen, B. Lin Ju Yen, Huai-En Lu, Shiaw-Min Hwang, Shih-Hwa Chiou, Hong-Nerng Ho, Jer-Yuarn Wu, Timothy J. Kamp, Joseph C. Wu, Patrick C. H. Hsieh
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
