Article
Ecology
Jacobo Aguirre
Summary: Fitness landscapes are now shown to be more navigable than previously thought, where fitness maxima can be reached from almost any other phenotype while avoiding rare fitness valleys.
NATURE ECOLOGY & EVOLUTION
(2022)
Article
Psychiatry
Katharine A. Smith, Louise M. Howard, Simone N. Vigod, Armando D'Agostino, Andrea Cipriani
Summary: The COVID-19 pandemic has exacerbated inequalities and risk factors for mental disorders, especially in perinatal mental health. Access to services has been reduced and perinatal anxiety and depressive symptoms have increased. Telepsychiatry offers advantages, but further examination is needed. Clinicians will need expertise in navigating a hybrid model and there is a need for urgent and coordinated guidance and planning across organizations involved in perinatal mental health care.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Engineering, Civil
Joanes Jawan, Tajul Ariffin Musa, Wan Anom Wan Aris, Rozlan Putit, Ramzi Abdillah, Mohamad Iskandar Mohamad Usop
Summary: This paper reviews the geodetic survey work carried out from 1918 to 1968 in East Malaysia and Brunei, covering approximately 204,119 square kilometers. The survey work involved establishing survey control networks using measurements of angles and distances, resulting in a series of reference points known as 'trigs'. However, this classical geodetic datum is not compatible with the current surveying trends based on Global Navigation Satellite System technologies. The paper also covers the concepts and history of triangulation systems, datums, and the status of the transformation plan to modernize the geodetic datum for Sarawak.
Review
Pharmacology & Pharmacy
Bruno P. Imbimbo, Stefania Ippati, Mark Watling, Claudia Balducci
Summary: The failure of single-target therapies in Alzheimer's disease highlights the need for more multimodal approaches to address neurodegeneration in order to make progress. Researchers suggest reevaluating assumptions and considering alternative strategies to effectively modify disease progression in the future.
EXPERT OPINION ON DRUG DISCOVERY
(2021)
Article
Energy & Fuels
Divya Monga, Nagaraj P. Shetti, Soumen Basu, Kakarla Raghava Reddy, Michael Badawi, Adrian Bonilla-Petriciolet, Tejraj M. Aminabhavi
Summary: The accelerated urbanization and industrialization worldwide has increased pollution and posed environmental risks to public health and ecosystems. Biochar has emerged as a viable and cost-effective solution for detoxification, and this review emphasizes its crucial role in removing toxic emerging pollutants. The review covers the synthesis and applications of engineered biochars, discussing their properties and interaction mechanisms with pollutants. The versatility of biochar and its composites in adsorption, photocatalysis, and oxidation processes in aquatic environments is also highlighted. Prospective research directions and opportunities in biochar research are discussed.
Article
Education, Scientific Disciplines
Jessica Sherman, Laura Beth Kalvas, Emma C. Schlegel
Summary: This study aims to explore the characteristics, benefits, and challenges of peer mentorship in Doctor of Philosophy in Nursing (PhD-N) programs. The results showed that 55.2% of PhD-N students have received some form of peer mentorship, while barriers to peer mentorship include lack of time and institutional support, fear of burdening others, and poorly matched mentors. Therefore, academic institutions should establish a culture that promotes and supports peer mentorship.
NURSE EDUCATION TODAY
(2023)
Review
Microbiology
Ghassan Matar, Melhem Bilen
Summary: This review summarizes the efforts made to describe the human microbiota through culturomics and the advancements in culturing the organisms residing at different body sites.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Review
Obstetrics & Gynecology
Leslie Myatt
Summary: Despite intensive investigation, predicting, treating, or preventing preeclampsia remains challenging due to its heterogeneity and long-term effects on both the fetus and the mother. Efforts to predict early and treat with therapies such as low-dose aspirin or antioxidants have been hindered by the diverse presentation of preeclampsia. Identifying phenotypes and establishing international standards are crucial in order to develop effective prediction and treatment strategies.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Alex Vorsters, F. Xavier Bosch, Mario Poljak, Dur-E-Nayab Waheed, Margaret Stanley, Suzanne M. Garland
Summary: The COVID-19 pandemic has created opportunities for HPV prevention and control, but also poses potential public health threats. Existing resources and experiences should be utilized to continue promoting HPV vaccination and testing to prevent HPV-related cancers.
PREVENTIVE MEDICINE
(2022)
Editorial Material
Cell & Tissue Engineering
Massimo Mastrangeli, Janny van den Eijnden-van Raaji
Summary: Organ-on-chip (OoC) technology is thriving due to the availability of stem cells and international OoC programs. Coordinated standardization, qualification, and independent testing of devices are needed to further develop OoC technology and maximize its potential in drug development, disease modeling, and personalized medicine. The OoC roadmap can guide the way forward.
Editorial Material
Hematology
Saar Gill
Summary: The study reported the results of a multicenter phase 1/2 trial using a CD3 epsilon x 3 CD123 bispecific drug, flotetuzumab, in AML patients. The drug belongs to a class of dual affinity retargeting proteins (DARTs) that bring together T cells with CD123-expressing AML blasts. CD123, although not unique to AML blasts and also expressed on some normal hematopoietic cell populations, remains a leading potential cell surface target for immunotherapy in AML.
Review
Microbiology
James P. R. Connolly, Andrew J. Roe, Nicky O'Boyle
Summary: Studying the adaptive evolutionary trajectories in bacteria has contributed to a better understanding of stress responses, revealed important insights into microbial physiology, facilitated the production of highly optimized strains for biotechnology, and enhanced our understanding of genomic plasticity in chronic infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Energy & Fuels
Srijoni Banerjee, Dipankar Ghosh, Chetan Pandit, Sagnik Saha, Anwesha Mohapatra, Soumya Pandit, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj, Ram Prasad
Summary: Microalgae have shown great potential as a prominent source for biomass production in the production of biofuels and bioenergy. They are capable of producing high yields of biomass and fuel while occupying smaller land footprints. Additionally, microalgae can be utilized in wastewater treatment and the generation of bioelectricity.
Review
Clinical Neurology
Giovanni Bellomo, Chiara Maria Giulia De Luca, Federico Paolini Paoletti, Lorenzo Gaetani, Fabio Moda, Lucilla Parnetti
Summary: Parkinson's disease is the second most common neurodegenerative disease, and its diagnosis is currently based on motor symptoms. Seed amplification assays have the potential to identify Parkinson's disease at an earlier stage.
Review
Engineering, Environmental
Vikas Kumar, Ekta Singh, Shivani Singh, Ashok Pandey, Preeti Chaturvedi Bhargava
Summary: Plastics are essential in our daily lives due to their convenience, affordability, strength, versatility, and durability. However, their excessive usage in packaging, pharmaceuticals, agriculture, and other industries has resulted in severe environmental damages and raised serious concerns.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
James J. Goedert, Xing Hua, Agata Bielecka, Isao Okayasu, Ginger L. Milne, Gieira S. Jones, Mutsunori Fujiwara, Rashmi Sinha, Yunhu Wan, Xia Xu, Jacques Ravel, Jianxin Shi, Noah W. Palm, Heather Spencer Feigelson
BRITISH JOURNAL OF CANCER
(2018)
Article
Multidisciplinary Sciences
Joep Grootjans, Niklas Krupka, Shuhei Hosomi, Juan D. Matute, Thomas Hanley, Svetlana Saveljeva, Thomas Gensollen, Jarom Heijmans, Hai Li, Julien P. Limenitakis, Stephanie C. Ganal-Vonarburg, Shengbao Suo, Adrienne M. Luoma, Yosuke Shimodaira, Jinzhi Duan, David Q. Shih, Margaret E. Conner, Jonathan N. Glickman, Gwenny M. Fuhler, Noah W. Palm, Marcel R. de Zoete, C. Janneke van der Woude, Guo-Cheng Yuan, Kai W. Wucherpfennig, Stephan R. Targan, Philip Rosenstiel, Richard A. Flavell, Kathy D. McCoy, Andrew J. Macpherson, Arthur Kaser, Richard S. Blumberg
Article
Biochemistry & Molecular Biology
Haiwei Chen, Phu-Khat Nwe, Yi Yang, Connor E. Rosen, Agata A. Bielecka, Manik Kuchroo, Gary W. Cline, Andrew C. Kruse, Aaron M. Ring, Jason M. Crawford, Noah W. Palm
Article
Multidisciplinary Sciences
Angel G. Solis, Piotr Bielecki, Holly R. Steach, Lokesh Sharma, Christian C. D. Harman, Sanguk Yun, Marcel R. de Zoete, James N. Warnock, S. D. Filip To, Autumn G. York, Matthias Mack, Martin A. Schwartz, Charles. S. Dela Cruz, Noah W. Palm, Ruaidhri Jackson, Richard A. Flavell
Article
Chemistry, Multidisciplinary
Joonseok Oh, Nam Y. Kim, Haiwei Chen, Noah W. Palm, Jason M. Crawford
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Correction
Multidisciplinary Sciences
Angel G. Solis, Piotr Bielecki, Holly R. Steach, Lokesh Sharma, Christian C. D. Harman, Sanguk Yun, Marcel R. de Zoete, James N. Warnock, S. D. Filip To, Autumn G. York, Matthias Mack, Martin A. Schwartz, Charles. S. Dela Cruz, Noah W. Palm, Ruaidhri Jackson, Richard A. Flavell
Article
Multidisciplinary Sciences
Jason R. Catanzaro, Juliet D. Strauss, Agata Bielecka, Anthony F. Porto, Francis M. Lobos, Andrea Urban, Whitman B. Schofield, Noah W. Palm
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Yi Yang, Mytien Nguyen, Varnica Khetrapal, Nicole D. Sonnert, Anjelica L. Martin, Haiwei Chen, Martin A. Kriegel, Noah W. Palm
Summary: This study reveals that within-host evolution of gut commensal bacteria plays a critical role in bacterial translocation and initiation of inflammation. Gut microbiota strains can adapt and evolve, affecting their propensity to elicit inflammatory diseases. The changes in bacterial behavior are associated with genetic mutations, altered microbial gene expression programs, and remodelled cell wall structures.
Review
Immunology
Mytien Nguyen, Noah W. Palm
Summary: Research on the microbiota-gut-brain axis has shown the crucial interactions between gut microbiota, the immune system, and the brain in various diseases and disorders. Modern studies focus on neuro-immune-microbiota interactions and understanding the mechanisms underlying the diverse impacts of the microbiome on human health. This research may lead to new approaches for treating diseases influenced by the complex connections between microbiota and the brain in the future.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Microbiology
Guus H. van Muijlwijk, Tyler A. Rice, Richard A. Flavell, Noah W. Palm, Marcel R. de Zoete
Summary: Through the culturomics study on bacterial species associated with inflammatory bowel disease, two isolates tentatively identified as members of the family Erysipelotrichaceae were found to be closely related to Allobaculum stercoricanis. These isolates, strain 128T and 539T, showed strict anaerobic growth in long chains at temperatures between 37 and 42 degrees Celsius.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haiwei Chen, Connor E. Rosen, Jaime A. Gonzalez-Hernandez, Deguang Song, Jan Potempa, Aaron M. Ring, Noah W. Palm
Summary: The study developed a highly multiplexed screening technology called PRESTO-Salsa that can evaluate nearly all conventional GPCRs in a single well of a 96-well plate. Using this technology, researchers screened 1,041 human-associated metabolites and discovered previously unreported GPCR agonists. They also generated an atlas of microbiome-GPCR interactions across multiple body sites, revealing conserved patterns of GPCR engagement and activation. These findings contribute to a better understanding of metabolite-GPCR interactions.
Article
Gastroenterology & Hepatology
Guus H. van Muijlwijk, Guido van Mierlo, Pascal W. T. C. Jansen, Michiel Vermeulen, Nancy M. C. Bleumink-Pluym, Noah W. Palm, Jos P. M. van Putten, Marcel R. de Zoete
Summary: The human gut microbiota plays a key role in intestinal health and disease, with some bacteria linked to human diseases exploiting the inner mucus layer as an important niche. A newly identified IBD-associated species, Allobaculum mucolyticum, was found to carry up to 60 genes encoding putative Carbohydrate Active Enzymes (CAZymes) that may contribute to mucosal colonization. Mass spectrometry revealed the presence of 49 CAZymes, with 26 significantly enriched in its secretome, suggesting that A. mucolyticum's CAZyme secretion may facilitate bacterial colonization and degradation of the mucus layer.
Article
Multidisciplinary Sciences
Jeff W. Chen, Tyler A. Rice, Jason M. Bannock, Agata A. Bielecka, Juliet D. Strauss, Jason R. Catanzaro, Haowei Wang, Laurence C. Menard, Jennifer H. Anolik, Noah W. Palm, Eric Meffre
Review
Immunology
June L. Round, Noah W. Palm
SCIENCE IMMUNOLOGY
(2018)
