Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis

Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation

(2016) Angélique Pabois et al.   BIOCHEMICAL PHARMACOLOGY

An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages

(2016) Kyung Ho Han et al.   FASEB JOURNAL

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion DevelopmentSignificance

(2015) Jun-ichiro Koga et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors

(2015) E. G. Chiorean et al.   CLINICAL CANCER RESEARCH

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch1–Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration

(2015) Reza Riahi et al.   Nature Communications

A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression

(2015) Sisi Ma et al.   Oncotarget

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Tumor-Associated Macrophages as a Paradigm of Macrophage Plasticity, Diversity, and Polarization

(2013) Alberto Mantovani et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

(2013) E. Zajac et al.   BLOOD

Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results

(2012) David Hasan et al.   Journal of Neuroinflammation

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

(2012) D. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch controls the magnitude of T helper cell responses by promoting cellular longevity

(2012) C. Helbig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

(2011) S. K.- J. Landor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Inhibition of Delta-Like-4–Mediated Signaling Impairs Reparative Angiogenesis After Ischemia

(2010) Ayman Al Haj Zen et al.   CIRCULATION RESEARCH

Direct Comparison of Dll1- and Dll4-Mediated Notch Activation Levels Shows Differential Lymphomyeloid Lineage Commitment Outcomes

(2010) M. Mohtashami et al.   JOURNAL OF IMMUNOLOGY

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Dll1 and Dll4: similar, but not the same

(2009) M. Gessler   BLOOD

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch1 upregulates LPS-induced macrophage activation by increasing NF-κB activity

(2009) Eva Monsalve et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of T Cell Activation by Notch Ligand, DLL4, Promotes IL-17 Production and Rorc Activation

(2009) S. Mukherjee et al.   JOURNAL OF IMMUNOLOGY

Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

(2009) Thibaut Quillard et al.   PLoS One

Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis

(2008) T. Quillard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY