Facilitation of Ca2+ -induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment

Redox imbalance due to the loss of mitochondrial NAD(P)-transhydrogenase markedly aggravates high fat diet-induced fatty liver disease in mice

(2017) Claudia D.C. Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pravastatin Chronic Treatment Sensitizes Hypercholesterolemic Mice Muscle to Mitochondrial Permeability Transition: Protection by Creatine or Coenzyme Q10

(2017) Estela N. B. Busanello et al.   Frontiers in Pharmacology

A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J and C57BL/6NJ Mice

(2016) Kelsey H. Fisher-Wellman et al.   DIABETES

The Contribution of Nicotinamide Nucleotide Transhydrogenase to Peroxide Detoxification Is Dependent on the Respiratory State and Counterbalanced by Other Sources of NADPH in Liver Mitochondria

(2016) Juliana Aparecida Ronchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Protective effects of l-carnitine and piracetam against mitochondrial permeability transition and PC3 cell necrosis induced by simvastatin

(2013) Rute A.P. Costa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities

(2013) Juliana A. Ronchi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protection of rat skeletal muscle fibers by either L-carnitine or coenzyme Q10 against statins toxicity mediated by mitochondrial reactive oxygen generation

(2013) P. G. La Guardia et al.   Frontiers in Physiology

Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

(2012) Tiago R. Figueira et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency

(2012) Eirini Meimaridou et al.   NATURE GENETICS

Simvastatin inducing PC3 prostate cancer cell necrosis mediated by calcineurin and mitochondrial dysfunction

(2008) Kívia A. P. Oliveira et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Oxidative stress in hypercholesterolemic LDL (low-density lipoprotein) receptor knockout mice is associated with low content of mitochondrial NADP-linked substrates and is partially reversed by citrate replacement

(2007) Bruno A. Paim et al.   FREE RADICAL BIOLOGY AND MEDICINE