Smooth muscle cell and arterial aging: basic and clinical aspects

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

(2018) Preety Panwar et al.   MATRIX BIOLOGY

Aortic–Brachial Arterial Stiffness Gradient and Cardiovascular Risk in the CommunityNovelty and Significance

(2017) Teemu J. Niiranen et al.   HYPERTENSION

Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA

(2017) Yaming Jiu et al.   JOURNAL OF CELL SCIENCE

Roles of platelet-derived growth factor in vascular calcification

(2017) Liu Ouyang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Elastin microfibril interface–located protein 1, transforming growth factor beta, and implications on cardiovascular complications

(2017) Amy Randell et al.   Journal of the American Society of Hypertension

Role of the Immune System in Hypertension

(2017) Bernardo Rodriguez-Iturbe et al.   PHYSIOLOGICAL REVIEWS

Vascular Smooth Muscle Cells and Arterial Stiffening: Relevance in Development, Aging, and Disease

(2017) Patrick Lacolley et al.   PHYSIOLOGICAL REVIEWS

Vinculin forms a directionally asymmetric catch bond with F-actin

(2017) Derek L. Huang et al.   SCIENCE

Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway

(2017) Daisuke Kinoshita et al.   Oncotarget

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions

(2017) Jochen Steppan et al.   Journal of the American Heart Association

Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment

(2017) D. Verzola et al.   Scientific Reports

Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration

(2017) Xuechong Hong et al.   Scientific Reports

Vimentin knockout results in increased expression of sub-endothelial basement membrane components and carotid stiffness in mice

(2017) Benoit Langlois et al.   Scientific Reports

Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence

(2016) Tengfei Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Medial Arterial CalcificationHighlights

(2016) Chin Yee Ho et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and DissectionsHighlights

(2016) Dianna M. Milewicz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Extracellular Matrix Disarray as a Mechanism for Greater Abdominal Versus Thoracic Aortic Stiffness With Aging in PrimatesSignificance

(2016) Jie Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation

(2016) Pauline Afonso et al.   ATHEROSCLEROSIS

Inhibition of SRF/myocardin reduces aortic stiffness by targeting vascular smooth muscle cell stiffening in hypertension

(2016) Ning Zhou et al.   CARDIOVASCULAR RESEARCH

Matrix ageing and vascular impacts: focus on elastin fragmentation

(2016) Laurent Duca et al.   CARDIOVASCULAR RESEARCH

A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation

(2016) Daniel M. DiRenzo et al.   CELLULAR SIGNALLING

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4Novelty and Significance

(2016) Mark W. Majesky et al.   CIRCULATION RESEARCH

Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in FemalesNovelty and Significance

(2016) Guanghong Jia et al.   CIRCULATION RESEARCH

Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis ModelsNovelty and Significance

(2016) Joel Chappell et al.   CIRCULATION RESEARCH

Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic StiffnessNovelty and Significance

(2016) Jessica L. Fry et al.   HYPERTENSION

Aortic–Brachial Pulse Wave Velocity RatioNovelty and Significance

(2016) Catherine Fortier et al.   HYPERTENSION

Linear and Nonlinear Viscoelastic Arterial Wall Models: Application on Animals

(2016) Arthur R. Ghigo et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

The anti-ageing hormone klotho induces Nrf2-mediated antioxidant defences in human aortic smooth muscle cells

(2016) Giuseppe Maltese et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis

(2016) Jeremie Joffre et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

An iPSC-derived vascular model of Marfan syndrome identifies key mediators of smooth muscle cell death

(2016) Alessandra Granata et al.   NATURE GENETICS

Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage

(2016) Kevin Retailleau et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension: Toward contractile versus synthetic phenotypes

(2016) Alexis Régent et al.   PROTEOMICS

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation

(2016) Henrick Horita et al.   Nature Communications

Macrophage Foam Cell–Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion

(2016) Chenguang Niu et al.   Journal of the American Heart Association

Prelamin A Accumulation Attenuates Rac1 Activity and Increases the Intrinsic Migrational Persistence of Aged Vascular Smooth Muscle Cells

(2016) Lauren Porter et al.   Cells

Proteome Analysis of Human Arterial Tissue Discloses Associations Between the Vascular Content of Small Leucine-Rich Repeat Proteoglycans and Pulse Wave VelocitySignificance

(2015) Maria Lyck Hansen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia

(2015) Li Wang et al.   CARDIOVASCULAR RESEARCH

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction

(2015) A. Boufenzer et al.   CIRCULATION RESEARCH

Between Rho(k) and a Hard Place: The Relation Between Vessel Wall Stiffness, Endothelial Contractility, and Cardiovascular Disease

(2015) S. Huveneers et al.   CIRCULATION RESEARCH

Myh11R247C/R247C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity

(2015) Chiara Bellini et al.   JOURNAL OF BIOMECHANICS

Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission

(2015) V. Auernheimer et al.   JOURNAL OF CELL SCIENCE

PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration

(2015) Jagadeesh Janjanam et al.   MOLECULAR BIOLOGY OF THE CELL

“Smooth Muscle Cell Stiffness Syndrome”—Revisiting the Structural Basis of Arterial Stiffness

(2015) Nancy L. Sehgel et al.   Frontiers in Physiology

Autophagic regulation of smooth muscle cell biology

(2015) Joshua K. Salabei et al.   Redox Biology

Vascular Smooth Muscle Cell Stiffness and Adhesion to Collagen I Modified by Vasoactive Agonists

(2015) Zhongkui Hong et al.   PLoS One

And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat

(2014) Kelly M. Grimes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Age-related loss of SirT1 expression results in dysregulated human vascular smooth muscle cell function

(2014) Anne Marie Thompson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

(2014) Magnus Bäck et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E −/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet

(2014) Subroto Chatterjee et al.   CIRCULATION

Angiotensin II and Vascular Injury

(2014) Augusto C. Montezano et al.   CURRENT HYPERTENSION REPORTS

The Effect of Ageing on Vascular Smooth Muscle Cell Behaviour - A Mini-Review

(2014) Bethan Alice Monk et al.   GERONTOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Dysfunctional Mechanosensing in Aneurysms

(2014) J. D. Humphrey et al.   SCIENCE

Native extracellular matrix: a new scaffolding platform for repair of damaged muscle

(2014) Laura Teodori et al.   Frontiers in Physiology

Lysophosphatidic acid induces integrin activation in vascular smooth muscle and alters arteriolar myogenic vasoconstriction

(2014) Marius C. Staiculescu et al.   Frontiers in Physiology

Increased vascular smooth muscle cell stiffness: a novel mechanism for aortic stiffness in hypertension

(2013) Nancy L. Sehgel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Variation of mechanical properties and quantitative proteomics of VSMC along the arterial tree

(2013) Carla Luana Dinardo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Integrating actin dynamics, mechanotransduction and integrin activation: The multiple functions of actin binding proteins in focal adhesions

(2013) Corina Ciobanasu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Aortic Pulse Wave Velocity Improves Cardiovascular Event Prediction

(2013) Yoav Ben-Shlomo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Vascular biomechanical properties in mice with smooth muscle specific deletion of Ndst1

(2013) Neeta Adhikari et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease

(2013) Amy McCurley et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Focal Adhesion: A Regulated Component of Aortic Stiffness

(2013) Robert J. Saphirstein et al.   PLoS One

Proinflammation: the key to arterial aging

(2013) Mingyi Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Protein composition and biomechanical properties of in vivo-derived basement membranes

(2013) Willi Halfter et al.   Cell Adhesion & Migration

Palmitate induces interleukin-8 expression in human aortic vascular smooth muscle cells via Toll-like receptor 4/nuclear factor-κB pathway (TLR4/NF-κB通路介导了软脂酸诱导人主动脉血管平滑肌细胞白细胞介素-8的基因表达)

(2013) Jinxing Quan et al.   Journal of Diabetes

The Role of Tissue Renin-Angiotensin-Aldosterone System in the Development of Endothelial Dysfunction and Arterial Stiffness

(2013) Annayya R. Aroor et al.   Frontiers in Endocrinology

MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling

(2012) Mingyi Wang et al.   AGING CELL

The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles

(2012) P. Lacolley et al.   CARDIOVASCULAR RESEARCH

Calpain-1 Regulation of Matrix Metalloproteinase 2 Activity in Vascular Smooth Muscle Cells Facilitates Age-Associated Aortic Wall Calcification and Fibrosis

(2012) Liqun Jiang et al.   HYPERTENSION

Absence of Cardiotrophin 1 Is Associated With Decreased Age-Dependent Arterial Stiffness and Increased Longevity in Mice

(2012) Natalia López-Andrés et al.   HYPERTENSION

Procontractile G protein–mediated signaling pathways antagonistically regulate smooth muscle differentiation in vascular remodeling

(2012) Till F. Althoff et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sex Difference in Cardiovascular Risk

(2012) Véronique Regnault et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms

(2012) Matthew R. Alexander et al.   PHYSIOLOGICAL GENOMICS

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling

(2011) Mohanasundari Pajaniappan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Epigenetic Control of Smooth Muscle Cell Differentiation and Phenotypic Switching in Vascular Development and Disease

(2011) Matthew R. Alexander et al.   Annual Review of Physiology

Smooth Muscle Cell Apoptosis Promotes Vessel Remodeling and Repair via Activation of Cell Migration, Proliferation, and Collagen Synthesis

(2011) Haixiang Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Micromanaging Vascular Smooth Muscle Cell Differentiation and Phenotypic Modulation

(2011) Brandi N. Davis-Dusenbery et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix Metalloproteinase-2 Proteolysis of Calponin-1 Contributes to Vascular Hypocontractility in Endotoxemic Rats

(2011) Michele M. Castro et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

(2011) L. Scheppke et al.   BLOOD

Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik Study

(2011) Gary F. Mitchell et al.   BRAIN

Lysozyme M–Positive Monocytes Mediate Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction

(2011) Philip Wenzel et al.   CIRCULATION

Mechanisms of TGF-β-Induced Differentiation in Human Vascular Smooth Muscle Cells

(2011) Yuefeng Tang et al.   JOURNAL OF VASCULAR RESEARCH

A Local Proinflammatory Signalling Loop Facilitates Adverse Age-Associated Arterial Remodeling

(2011) Mingyi Wang et al.   PLoS One

Short Communication: Vascular Smooth Muscle Cell Stiffness As a Mechanism for Increased Aortic Stiffness With Aging

(2010) Hongyu Qiu et al.   CIRCULATION RESEARCH

Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness

(2010) Lakshmi Santhanam et al.   CIRCULATION RESEARCH

Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’

(2010)   EUROPEAN HEART JOURNAL

Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

(2010) Alexander W. Krug et al.   HYPERTENSION

TGFβ-induced GRK2 expression attenuates AngII-regulated vascular smooth muscle cell proliferation and migration

(2009) Jimin Guo et al.   CELLULAR SIGNALLING

Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide

(2009) Dilek Telci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular matrix-specific focal adhesions in vascular smooth muscle produce mechanically active adhesion sites

(2008) Zhe Sun et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of sphingosine kinase by muscarinic receptors enhances NO-mediated and attenuates EDHF-mediated vasorelaxation

(2008) Arthur C. M. Mulders et al.   BASIC RESEARCH IN CARDIOLOGY

Arterial remodeling in vascular disease: a key role for hyaluronan and versican

(2008) Thomas et al.   Frontiers in Bioscience-Landmark

Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells

(2008) Muyao Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Transglutaminases in Vascular Biology: Relevance for Vascular Remodeling and Atherosclerosis

(2008) Erik N.T.P. Bakker et al.   JOURNAL OF VASCULAR RESEARCH

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Thrombin regulates vascular smooth muscle cell proteoglycan synthesis via PAR-1 and multiple downstream signalling pathways

(2008) Melanie E. Ivey et al.   THROMBOSIS RESEARCH