4.7 Article

Synthesis and characterization of biofunctional quaternized xylan-Fe2O3 core/shell nanocomposites and modification with polylysine and folic acid

Journal

CARBOHYDRATE POLYMERS
Volume 199, Issue -, Pages 382-389

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2018.07.003

Keywords

Quaternized xylan; QX-Fe(2)O(3)nanocomposites; Core/shell; Structure; FA modification; PLL modification

Funding

  1. National Natural Science Foundation of China [21336002, 31430092, 21506068, 81771879]
  2. Guangdong Natural Science Funds for Distinguished Young Scholar [2016A030306027, 2017A030306029]
  3. Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program [2015TQ01C488]
  4. State Key Laboratory of Pulp and Paper Engineering
  5. Fundamental Research Funds for the Central Universities
  6. Guangdong Natural Science Funds [2017A030313130]

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The aims of this study are to prepare quaternized xylan-Fe2O3 (QX-Fe2O3) core/shell nanocomposites and explore their potential application in the biomedical fields. gamma-Fe2O3 nanoparticles synthesized by a facile solvothermal process are coated with QX via reverse microemulsion method and further modified by polylysine (PLL) and folic acid (FA) to prepare PLL-QX-Fe2O3 and FA-QX-Fe2O3 nanoparticles. An obvious strong absorption of gamma-Fe2O3 at 580 cm(-1) in the spectra of QX-Fe2O3 is observed, the Fe element content of QX-Fe2O3 is 30-75 mu g/mL and the saturation magnetization of QX-Fe2O3 nanoparticles is 1.49 emu/g. The gamma-Fe2O3 and QX-Fe2O3 nanoparticles are of regular sphericity with diameter of 50-100 nm and 60-150 nm, respectively. The highest zeta potential of QX-Fe2O3 nanoparticles is -41 mV, and the PLL-QX-Fe2O3 nanoparticles have a positive potential with a maximum value of 45.2 mV. In addition, FA-QX-Fe2O3 showed excellent performance in T-2-weighted Magnetic Resonance (MR) imaging with an r(2) value of 190 mM(-1)S(-1). Each nanocomposite has its own inherent properties, which contributes to its versatile utilization and application potential.

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