Review
Pharmacology & Pharmacy
Masomeh Maleki, Asal Golchin, Forough Alemi, Simin Younesi, Zatollah Asemi, Samira Javadi, Payam Ali Khiavi, Jafar Soleinmapour, Bahman Yousefi
Summary: This study systematically reviewed the cytotoxic effects and apoptosis of nanoparticles (NPs) on cellular viability in vitro. It found that 43.47% of synthesized NPs showed no toxicity to osteosarcoma cells, while 39.13% showed time and/or concentration-related cytotoxicity. There was a significant difference in the half-maximal inhibitory concentration (IC50) between drug and drug/NP in all studies, indicating the potential for using NPs as drug delivery systems.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Materials Science, Characterization & Testing
Ruiling Xu, Junhui Sui, Mingda Zhao, Yuedi Yang, Lei Tong, Yongmei Liu, Yong Sun, Yujiang Fan, Jie Liang, Xingdong Zhang
Summary: This study developed trastuzumab functionalized nanoparticles for the treatment of HER-2 positive breast cancer cells. The results showed significant cell uptake and cytotoxic effect in HER-2 positive cells, while no differences were observed in HER-2 negative cells.
Article
Pharmacology & Pharmacy
Surendra Agrawal, Divya Budhwani, Pravina Gurjar, Darshan Telange, Vijay Lambole
Summary: Pullulan, a biodegradable polymer, has various qualities but its insolubility in organic solvents, mechanical characteristics, and lack of macromolecule-carrying ability groups limit its application in the pharmaceutical industry. Modification methods like periodate oxidation and PEG incorporation can enhance its solubility, mechanical properties, pH sensitivity, and drug delivery, while also offering anticoagulant and antimicrobial properties.
Article
Nanoscience & Nanotechnology
Yi Zhang, Qing Jiang, Xinyi Liu, Liping Peng, Xinyi Tang, Ling Li, Xiao Ling, Xiaoping Yang, Chunlian He, Xiaojun Tao, Defu Hou
Summary: The study investigated the impact of hydrophobic groups on the structural properties and function of polymer nanoparticles. The results demonstrated that polymer NPs with higher hydrophobicity exhibited smaller size, higher drug capacity, and greater cell efficiency.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Joanna Sobska, Magdalena Waszkielewicz, Anna Podlesny-Drabiniok, Joanna Olesiak-Banska, Wojciech Krezel, Katarzyna Matczyszyn
Summary: Gold nanoparticles hold great promise for clinical and preclinical applications, but toxicity and accumulation issues are major barriers. Research on Au18 gold nanoclusters with low toxicity and good biodistribution profile may contribute to future biomedical studies.
Article
Biochemistry & Molecular Biology
Edyta Maron, Pawel Krysinski, Michal Chudy
Summary: The article introduces magnetoliposomes as potential carriers of doxorubicin. The magnetic properties of nanoparticles embedded in liposomes enable targeted drug delivery to cancer cells and subsequent release using an external magnetic field. The cytotoxicity of empty and doxorubicin-loaded magnetoliposomes was evaluated in cancerous and normal breast cells. The study shows that magnetoliposomes with doxorubicin exhibit high cytotoxicity on tumor cells and low cytotoxicity on normal cells, indicating their potential application in drug release in cancer cells under the influence of a magnetic field.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Biotechnology & Applied Microbiology
Ioana A. Duceac, Sergiu Coseri
Summary: This article discusses the importance of finding novel materials in the biomedical field, focusing on the advantages of polysaccharides produced from natural resources. It also examines the chemical and biological characteristics of several primary polysaccharides and their derivatives.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Jin-Hu Dong, Yao Ma, Rong Li, Wen-Tao Zhang, Meng-Qian Zhang, Fan-Ning Meng, Kai Ding, Hai-Tao Jiang, Yong-Kuan Gong
Summary: The research team developed a smart drug delivery system based on mesoporous silica nanoparticles, allowing for controlled release and targeted delivery to tumor cells with high selectivity and killing efficacy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Yingying Zhong, Tiantian Wang, Zhiting Lao, Minglei Lu, Shan Liang, Xiping Cui, Qing-lan Li, Suqing Zhao
Summary: The innovative synthesis of Au-Au/IrO2 nanocomposite with tandem enzyme-mimicking activity leads to the preparation of a highly stable and reusable Au-Au/IrO2@Cu(PABA) reactor. This reactor exhibits excellent catalytic efficiency, organic solvent stability, acid resistance, and antibacterial activity, making it suitable for organic dye degradation and antibacterial applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Usama A. Fahmy, Waleed S. Alharbi, Alshaimaa M. Almehmady, Abdulmohsin J. Alamoudi, Singkome Tima, Rasha A. Mansouri, Ulfat M. Omar, Osama A. A. Ahmed, Shadi A. Zakai, Ahmed A. Aldarmahi, Alaa Bagalagel, Reem Diri, Nabil A. Alhakamy
Summary: The study demonstrated that the phytosome formulation of THQ had significant antiproliferative and apoptosis-inducing effects on A549 lung cancer cells, as well as causing cell cycle arrest and increasing apoptosis rate, while also significantly affecting the expression of related genes.
Article
Chemistry, Analytical
Titilope John Jayeoye, Uraiwan Sirimahachai, Panwadee Wattanasin, Thitima Rujiralai
Summary: The stable and dispersed aqueous nanocomposite of poly(aniline boronic acid)/gum tragacanth stabilized silver nanoparticles (PABA/GT@AgNPs) was synthesized and used as a colorimetric nanoprobe for Hg2+. It showed good sensitivity, wide linear range, and was not affected by other interfering ions.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Lucas S. Ribeiro, Renata L. Sala, Thaiane A. Robeldo, Ricardo C. Borra, Emerson R. Camargo
Summary: Conventional systemic drug delivery methods are less effective compared to localized delivery systems. This study developed thermoresponsive nanocomposites based on poly(N-vinylcaprolactam) and silica particles for efficient and controlled release of hydrophobic and hydrophilic drugs. The nanocomposites exhibited improved rheological properties and prevented diffusion away from the injection site. The synthesized materials achieved controlled drug release for 7 days and showed promising inhibitory effects on carcinoma cells while being non-toxic to healthy cells.
Article
Chemistry, Multidisciplinary
Alina Aktanova, Tatjana Abramova, Ekaterina Pashkina, Olga Boeva, Lyubov Grishina, Ekaterina Kovalenko, Vladimir Kozlov
Summary: Research on cucurbiturils is focused on improving solubility, selectivity, stability, binding and release properties. The study found that cucurbiturils have high biocompatibility, with no cytotoxicity at concentrations below 0.3 mM. However, they may increase lymphocyte apoptosis levels and enhance hemolysis in relevant media.
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC.
Article
Chemistry, Multidisciplinary
Qingtao Song, Yilin Liu, Xiaoyong Ding, Miao Feng, Jing Li, Wenjuan Liu, Bohan Wang, Zhongwei Gu
Summary: An active drug delivery platform of Mg micromotors is proposed to overcome MDR and enhance drug permeability for treating HCC. The platform, made of biocompatible materials, allows autonomous motion and increases the diffusion of chemotherapy drugs, leading to improved drug distribution within cells. Moreover, the hydrogen produced during the motion helps eliminate reactive oxygen species in cells. Compared to inert groups, the absorption of drugs from the active micromotors is significantly higher. At a concentration of 1 mg/mL, the micromotors also exhibit enhanced anti-tumor activity, reducing cell proliferation by almost 30%.
Article
Polymer Science
Pattra Lertsarawut, Thitirat Rattanawongwiboon, Theeranan Tangthong, Sakchai Laksee, Tanagorn Kwamman, Butri Phuttharak, Phayao Romruensukharom, Phiriyatorn Suwanmala, Kasinee Hemvichian
Summary: This research successfully scaled up the production of starch-based super water absorbent (SWA) through radiation-induced graft polymerization and validated its practical benefits in agricultural applications, demonstrating its strong water absorption capacity and ability to enhance the growth of young rubber trees.
Article
Polymer Science
Sakchai Laksee, Chamaiporn Supachettapun, Nongnuj Muangsin, Pattra Lertsarawut, Thitirat Rattanawongwiboon, Phitchan Sricharoen, Nunticha Limchoowong, Threeraphat Chutimasakul, Tanagorn Kwamman, Kasinee Hemvichian
Summary: This study introduces a new method for delivering hydrophobic camptothecin using targeted gold nanohybrids, which enhances the efficacy and selectivity of the system while reducing toxicity to normal cells.
Article
Chemistry, Multidisciplinary
Montri Aiempanakit, Jariyaporn Sangkaworn, Nattawan Worawannotai, Kritapas Laohhasurayotin, Weerachai Sangchay, Sakchai Laksee, Cheewita Suwanchawalit
Summary: In this study, a laccaic acid-modified TiO2 photocatalyst was prepared and its physical properties were examined. The results showed that the laccaic acid modification improved the photocatalytic performance of TiO2, making it effective under visible light irradiation.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Thitirat Rattanawongwiboon, Siriwat Soontaranon, Kasinee Hemvichian, Pattra Lertsarawut, Sakchai Laksee, Roppon Picha
Summary: Particle size and size distribution are critical parameters for nanomaterials, as demonstrated in this study of gold nanoparticles synthesized using a green method. The TEM and SAXS results revealed spherical AuNPs with sizes ranging from 10-30 nm, providing essential information for future metallic nanoparticles synthesis and applications.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Montri Aiempanakit, Penpicha Sudjai, Kittiyaporn Singsumphan, Sakchai Laksee, Cheewita Suwanchawalit
Summary: The photocatalytic efficiency of ZnO nanorods modified by brazilein was investigated. The visible light-responsive photocatalytic efficiency of ZnO nanorods was improved with the increase of brazilein concentration. ZnO nanorods modified with 5.0%w/v of brazilein achieved the highest photocatalytic efficiency under visible light irradiation.
JOURNAL OF METALS MATERIALS AND MINERALS
(2022)
Article
Chemistry, Physical
Worachote Photaram, Monrudee Liangruksa, Montri Aiempanakit, Cheewita Suwanchawalit, Anurat Wisitsoraat, Jirasak Sukunta, Sakchai Laksee, Chawarat Siriwong
Summary: Gas sensing devices are crucial in various applications and there is a pressing need for improved sensing materials and advanced sensor devices. This study combines theoretical and experimental approaches to design and fabricate a hybrid zinc oxide/graphene material for enhanced performance. The research demonstrates that the Zn12O12/graphene nanohybrid shows excellent gas sensing properties, particularly for ethanol gas detection.
APPLIED SURFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
C. Suwanchawalit, C. Deeleepojananan, N. Triamnak, P. Opanasopit, S. Laksee, S. Suvokhiaw
Summary: In this study, incorporation of anions of indigo carmine dye and dodecyl sulphate to CaAl-layered double hydroxides (LDHs) was carried out by the coprecipitation method. The effect of Ca2+/Al3+ ions ratio on the color and photostability of the composites, as well as cytotoxicity on cells, was investigated. The results showed that the composites exhibited good photostability and biocompatibility.
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES
(2022)
Article
Crystallography
Suwadee Jiajaroen, Raul Diaz-Torres, Sakchai Laksee, Kittipong Chainok
Summary: A europium(III) coordination compound based on thiopheneacrylic acid (Htpa) was synthesized and characterized. The crystal structure of the compound revealed hydrogen bonding interactions between the Eu ion and Htpa molecule, which were further analyzed using Hirshfeld surface analysis.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Crystallography
Nareekarn Meebua, Wanatchaporn Pentes, Kittipong Chainok, Sakchai Laksee, Nanthawat Wannarit
Summary: This is a crystal structure composed of a one-dimensional copper(II) coordination polymer, in which monodentate ligands and bridging sulfate anions form chains. The crystal structure is consolidated by weak hydrogen bonding, C-H center dot center dot center dot pi, and pi-pi interactions, forming a three-dimensional supramolecular network.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yonrapach Areerob, Chaowalit Hamontree, Phitchan Sricharoen, Nunticha Limchoowong, Sakchai Laksee, Won-Chun Oh, Kongsak Pattarith
Summary: A novel gamma-irradiated chitosan-doped reduced graphene-CuInS2 composite was used as the counter electrode to address the issues associated with traditional counter electrodes. It exhibited higher photovoltaic efficiency compared to a Pt-based device.
Article
Crystallography
Chatphorn Theppitak, Sakchai Laksee, Kittipong Chainok
Summary: This article describes the crystal structure of a lanthanide(III) compound, which consists of Tb3+ ions, acetohydrazide ligands, and nitrate anions. The crystal forms a three-dimensional supramolecular architecture.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sakchai Laksee, Kanokwan Sansanaphongpricha, Songchan Puthong, Naunpun Sangphech, Tanapat Palaga, Nongnuj Muangsin
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Applied
Sakchai Laksee, Songchan Puthong, Thapong Teerawatananond, Tanapat Palaga, Nongnuj Muangsina
CARBOHYDRATE POLYMERS
(2017)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
