Mutations in the signal transducer and activator of transcription family of genes in cancer

The role of STAT3 in leading the crosstalk between human cancers and the immune system

(2018) Yu Wang et al.   CANCER LETTERS

Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses

(2017) Biman Saikia et al.   INDIAN JOURNAL OF PEDIATRICS

The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment

(2017) Nakho Chang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

(2017) Jing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large granular lymphocytic leukemia. Current diagnostic and therapeutic approaches and novel treatment options

(2017) Estella Matutes   Expert Review of Hematology

STATs in NK-Cells: The Good, the Bad, and the Ugly

(2017) Dagmar Gotthardt et al.   Frontiers in Immunology

High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia

(2016) E. I. Andersson et al.   BLOOD

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia

(2016) Cristina López et al.   BRITISH JOURNAL OF HAEMATOLOGY

Pure Red Cell Aplasia and Autoimmune Hemolytic Anemia Sequentially Occurring in a Patient with Large Granular T-lymphocytic Leukemia

(2016) Xuemei Qin et al.   INTERNAL MEDICINE

JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma

(2016) M-L Nairismägi et al.   LEUKEMIA

Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies

(2015) A. L. Wong et al.   ANNALS OF ONCOLOGY

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours

(2015) S J Thomas et al.   BRITISH JOURNAL OF CANCER

Convergent Mutations and Kinase Fusions Lead to Oncogenic STAT3 Activation in Anaplastic Large Cell Lymphoma

(2015) Ramona Crescenzo et al.   CANCER CELL

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies

(2015) Michinori Ogura et al.   CANCER SCIENCE

Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia

(2015) E Andersson et al.   LEUKEMIA

Uncovering the pathogenesis of large granular lymphocytic leukemia—novelSTAT3andSTAT5bmutations

(2014) Hanna L. M. Rajala et al.   ANNALS OF MEDICINE

Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia

(2014) M. J. Kiel et al.   BLOOD

Genomic Profiling of Hepatocellular Adenomas Reveals Recurrent FRK-Activating Mutations and the Mechanisms of Malignant Transformation

(2014) Camilla Pilati et al.   CANCER CELL

Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors

(2014) Johanna C. Bendell et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Clinical Implications of Phosphorylated STAT3 Expression in De Novo Diffuse Large B-cell Lymphoma

(2014) C. Y. Ok et al.   CLINICAL CANCER RESEARCH

The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia

(2014) H. L. M. Rajala et al.   HAEMATOLOGICA

STAT3 mutations are present in aggressive B-cell lymphomas including a subset of diffuse large B-cell lymphomas with CD30 expression

(2014) R. S. Ohgami et al.   HAEMATOLOGICA

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

(2014) Sarah E Flanagan et al.   NATURE GENETICS

STAT3 Inhibitors: Finding a Home in Lymphoma and Leukemia

(2014) J. Munoz et al.   ONCOLOGIST

Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia

(2013) A. Teramo et al.   BLOOD

Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia

(2013) H. L. M. Rajala et al.   BLOOD

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

(2013) Mi-Jung Kim et al.   CANCER LETTERS

STAT3gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia

(2013) Fumihiro Ishida et al.   CANCER SCIENCE

STAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia

(2013) Zhi-Yuan Qiu et al.   Journal of Hematology & Oncology

STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia

(2013) R S Ohgami et al.   LEUKEMIA

A Novel Missense (M206K) STAT3 Mutation in Diffuse Large B Cell Lymphoma Deregulates STAT3 Signaling

(2013) Guangzhen Hu et al.   PLoS One

Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation

(2013) E I Andersson et al.   Blood Cancer Journal

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases

(2013) F Hayakawa et al.   Blood Cancer Journal

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

(2012) A. Jerez et al.   BLOOD

STAT3 mutations are highly specific for large granular lymphocytic leukemia

(2012) A Fasan et al.   LEUKEMIA

SomaticSTAT3Mutations in Large Granular Lymphocytic Leukemia

(2012) Hanna L.M. Koskela et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

Paucity of genotype–phenotype correlations in STAT3 mutation positive Hyper IgE Syndrome (HIES)

(2011) Jennifer Heimall et al.   CLINICAL IMMUNOLOGY

High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma

(2011) Wu ZL et al.   Journal of Hematology & Oncology

Refining the diagnosis of T-cell large granular lymphocytic leukemia by combining distinct patterns of antigen expression with T-cell clonality studies

(2011) R S Ohgami et al.   LEUKEMIA