Article
Biochemistry & Molecular Biology
Guangzhao Huang, Su Chen, Jumpei Washio, Grace Paka Lubamba, Nobuhiro Takahashi, Chunjie Li
Summary: Increasing evidence indicates the involvement of aerobic glycolysis in the progression of oral squamous cell carcinoma (OSCC). In this study, we focused on glycolysis-related gene sets to identify potential therapeutic targets for OSCC. Differential expression analysis revealed 66 differentially expressed core genes (DECGs) and identified six genes that may serve as prognostic factors. A risk model based on DECGs was established, and DEPDC1 was found to be related to advanced stage cancer and lymph node metastasis. Functional experiments demonstrated that DEPDC1 promotes aerobic glycolysis, migration, and invasion of OSCC via the WNT/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Zehang Zhuang, Jing Huang, Weiwang Wang, Cheng Wang, Pei Yu, Jing Hu, Haichao Liu, Hanqi Yin, Jinsong Hou, Xiqiang Liu
Summary: This study identified a differentiation-related lncRNA, TINCR, in oral squamous cell carcinoma (OSCC). TINCR was found to be downregulated in tumor tissues and correlated with pathological differentiation and lymph node metastasis. Function experiments showed that TINCR played a crucial role in cell differentiation and suppressed cell migration and invasion in OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiao Yang, Haifeng Ma, Min Zhang, Renzhong Wang, Xiaoyu Li
Summary: The aberrant expression of TRIM32 is elevated in oral squamous cell carcinoma, and it promotes tumor growth and glycolysis by inhibiting FBP2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ying Ye, Menghan Wang, Guoyu Wang, Zhongchao Mai, Borong Zhou, Yang Han, Juhua Zhuang, Wei Xia
Summary: This study discovered that miR4458HG plays a significant role in glucose metabolism in patients with hepatocellular carcinoma. It affects HCC cell proliferation, activates the glycolysis pathway, and promotes polarization of tumor-associated macrophages. miR4458HG binds to IGF2BP2, increasing the stability of target mRNAs, thus altering HCC glycolysis and tumor cell physiology. Additionally, HCC-derived miR4458HG can be wrapped in exosomes and promote the polarization of tumor-associated macrophages. Therefore, miR4458HG is oncogenic in nature among HCC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Oncology
Jianfei Tang, Xiaodan Fang, Juan Chen, Haixia Zhang, Zhangui Tang
Summary: Oral squamous cell carcinoma (OSCC) is a highly lethal malignancy worldwide, with long non-coding RNAs (lncRNAs) playing crucial regulatory roles in OSCC by influencing tumor initiation and progression. This review discusses the functions, molecular mechanisms, and interactions with the tumor microenvironment of lncRNAs in OSCC, highlighting their potential as diagnostic, prognostic, and therapeutic targets. Furthermore, it explores lncRNA-targeted therapeutic techniques such as CRISPR-Cas9 and immune checkpoint therapies to target lncRNAs and the PD-1/PD-L1 axis, presenting future perspectives in OSCC therapy that require further research for clinical applications.
Review
Immunology
Suchitra Singh, Ajay Kumar Singh
Summary: Oral cancer is a significant contributor to the global cancer burden, and oral bacteria, particularly Porphyromonas gingivalis, are believed to play a crucial role in its spread. Understanding the pathogenesis of P. gingivalis in oral squamous cell carcinoma is of great importance.
MICROBES AND INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Yongzhen Mo, Yumin Wang, Shuai Zhang, Fang Xiong, Qijia Yan, Xianjie Jiang, Xiangying Deng, Yian Wang, Chunmei Fan, Le Tang, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Qianjin Liao, Can Guo, Yong Li, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Wei Xiong
Summary: Our study revealed that a novel circRNA, circRNF13, plays a crucial role in NPC development through the circRNF13-SUMO2-GLUT1 axis. CircRNF13 inhibits NPC proliferation and metastasis by activating SUMO2 and regulating the AMPK-mTOR pathway to inhibit glycolysis. This research provides a theoretical basis for further understanding NPC pathogenesis and developing targeted therapies.
Article
Biochemistry & Molecular Biology
Anthony Nguyen, Anna H. Kim, Mo K. Kang, No-Hee Park, Reuben H. Kim, Yong Kim, Ki-Hyuk Shin
Summary: Chronic alcohol exposure promotes cancer stemness and aerobic glycolysis through activation of NFAT signaling. This study provides new insights into the roles of cancer stemness and metabolic reprogramming in the mechanism of alcohol-mediated carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Xiongming Zhou, Danfeng Xue, Jiaxuan Qiu
Summary: The study utilized ssGSEA and WGCNA algorithms to investigate glycolysis in OSCC, finding that glycolytic scores were significantly correlated with prognosis and identifying 5 HUB genes associated with glycolysis that could potentially serve as therapeutic targets for future OSCC treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemistry & Molecular Biology
Chukkris Heawchaiyaphum, Hironori Yoshiyama, Hisashi Iizasa, Ati Burassakarn, Zolzaya Tumurgan, Tipaya Ekalaksananan, Chamsai Pientong
Summary: This study revealed the oncogenic role of EBV in the progression of oral squamous cell carcinoma (OSCC) by inducing the Warburg effect and altering cancer stemness.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jinlin Wen, Panpan Yin, Ying Su, Feng Gao, Yanlin Wu, Wenbin Zhang, Peng Chi, Jiahui Chen, Xinyan Zhang
Summary: This study found that high mobility group box 1 (HMGB1) plays an important role in modulating the crosstalk between tumor-associated macrophages (TAMs) and oral squamous cell carcinoma (OSCC) cells. HMGB1 is involved in regulating TAM polarization, cell recruitment, and tumor progression in OSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Minmin Ji, Yuesheng Lv, Chaoqun Chen, Dingya Xing, Chao Zhou, Jinyao Zhao, Yangfan Qi, Jinrui Zhang, Yang Wang, Xiang Ma, Wei Xu, Wenjing Zhang, Xiaojie Li
Summary: This study found that metformin can inhibit the proliferation and migration of oral squamous cell carcinoma by regulating RNA alternative splicing, especially the splicing of the NUBP2 gene, which inhibits cancer cell proliferation.
Article
Dentistry, Oral Surgery & Medicine
Yi Liu, Tong Wang, Ronghua Li
Summary: The study found that glycolysis-immune-related genes could be used to predict the prognosis of oral squamous cell carcinoma patients. By constructing a risk score model, patients with different prognoses can be effectively stratified.
Review
Physiology
Yiwen Xue, Xiao Song, Siyu Fan, Runzhi Deng
Summary: This article reviews the role of tumor-associated macrophages (TAMs) in the invasion, metastasis, angiogenesis, and immunosuppression of oral squamous cell carcinoma (OSCC), as well as discusses the therapeutic strategies targeting TAMs for the treatment of OSCC.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Oncology
Alexandra Ruth Glathar, Akinsola Oyelakin, Kasturi Bala Nayak, Jennifer Sosa, Rose-Anne Romano, Satrajit Sinha
Summary: Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity, with a high mortality rate due to late diagnosis and lack of effective targeted treatments. Identification of potential prognostic biomarkers and understanding the role of p63 in OSCC could lead to improved therapies and patient outcomes. In this study, a mouse model was used to investigate the oncogenic role of p63 and generate a p63-driven gene expression signature that may have implications for human OSCC.
Article
Dentistry, Oral Surgery & Medicine
L. Wen, W. Mu, H. Lu, X. Wang, J. Fang, Y. Jia, Q. Li, D. Wang, S. Wen, J. Guo, W. Dai, X. Ren, J. Cui, G. Zeng, J. Gao, Z. Wang, B. Cheng
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Dentistry, Oral Surgery & Medicine
Xiangqi Liu, Qunxing Li, Ying Zhou, Xinlin He, Juan Fang, Huanzi Lu, Xi Wang, Dikan Wang, Da Ma, Bin Cheng, Guiqing Liao, Zhi Wang
Summary: The study revealed that T-cell expression of TIGIT is elevated in patients with oral squamous cell carcinoma (OSCC) and is associated with T stage and nodal invasion. Additionally, TIGIT-expressing T cells display a dysfunctional and inhibitory phenotype, while TIGIT blockade enhances proliferation ability and cytokine production in CD4(+) and CD8(+) T cells.
Article
Oncology
Xi Wang, Yiqun Jia, Liling Wen, Wenxin Mu, Xianrui Wu, Tao Liu, Xiangqi Liu, Juan Fang, Yizhao Luan, Ping Chen, Jinlong Gao, Ky-Anh Nguyen, Jun Cui, Gucheng Zeng, Ping Lan, Qianming Chen, Bin Cheng, Zhi Wang
Summary: The study reveals that the periodontal pathogen P. gingivalis can promote colorectal tumorigenesis by recruiting myeloid cells and creating a proinflammatory tumor microenvironment.
Review
Cell Biology
Shuqiong Wen, Huanzi Lu, Dikan Wang, Junyi Guo, Wenxiao Dai, Zhi Wang
Summary: TCF-1 plays a crucial role in T cell development and memory formation, while exhausted CD8(+) T cells expressing this factor may have a stimulating effect on enhancing immune response and improving response to immunotherapy. Intratumoral exhausted CD8(+) T cells expressing TCF-1 represent a subset with stem cell-like properties associated with improved antitumor immunity and response to immune checkpoint blockade.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Review
Immunology
Dongjia Lin, Lisa Yang, Liling Wen, Huanzi Lu, Qianming Chen, Zhi Wang
Summary: Oral mucosal disease (OMD), also known as soft tissue oral disease, is a range of disorders affecting the mucosa and soft tissue in the oral cavity. The unclear etiology may involve dysbiosis of oral mucosa and saliva-resident microbiota, impacting immune response and epithelial barrier function, leading to OMD. Research suggests diverse oral microbial dysbiosis in different diseases, implying potential causal pathogens across various oral pathologies. This literature review explores how microbial dysbiosis interacts with mucosal adaptive immune cells and the epithelial barrier in OMD, focusing on representative OMDs including oral candidiasis, oral lichen planus, recurrent aphthous ulcer, oral leukoplakia, and oral squamous cell carcinoma.
MUCOSAL IMMUNOLOGY
(2021)
Article
Oncology
Si-yuan Zhang, Xian-yue Ren, Chun-yang Wang, Xi-juan Chen, Ruo-yan Cao, Qin Liu, Xue Pan, Jia-ying Zhou, Wei-lin Zhang, Xin-Ran Tang, Bin Cheng, Tong Wu
Summary: The study classified OSCC patients into epithelial and mesenchymal phenotypes based on EMT signature genes, revealing that mesenchymal subtype tumors have higher immune cell infiltration and immunosuppressive characteristics. A novel prognostic classifier incorporating EMT score, immune checkpoint expressions, and TNM stages was developed and validated to improve prediction efficiency in OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: This study identifies subtypes of head and neck squamous cell carcinoma based on immune-related lncRNAs and characterizes their biological behaviors. The researchers found that certain subtypes are associated with good prognosis and sensitivity to immunotherapy, and identified a critical lncRNA TRG-AS1 involved in the tumor microenvironment. This provides new potential targets for the treatment of this subtype.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Zihang Ling, Wei Li, Jiaqi Hu, Yuanyuan Li, Miao Deng, Siyuan Zhang, Xianyue Ren, Tong Wu, Juan Xia, Bin Cheng, Xiaoan Tao
Summary: The CCL2-CCR4-Vav2-Rac1-p-MLC signaling pathway plays a critical role in the migration and metastasis of HNSCC, suggesting CCR4 as a potential molecular target for HNSCC therapy.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Jianmin Peng, Qinchao Hu, Xijuan Chen, Chunyang Wang, Jiayu Zhang, Xianyue Ren, Yun Wang, Xiaoan Tao, Huan Li, Ming Song, Bin Cheng, Tong Wu, Juan Xia
Summary: Obesity promotes the incidence of oral squamous cell carcinoma by altering the immune microenvironment and increasing the number of myeloid-derived suppressor cells (MDSCs). Targeting MDSCs in cancer immunotherapy may have greater efficacy in obese patients with OSCC.
CELL DEATH & DISEASE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yanting Wang, Xianyue Ren, Weiyu Li, Ruoyan Cao, Suyang Liu, Laibo Jiang, Bin Cheng, Juan Xia
Summary: SPDEF acts as a tumor suppressor in HNSCC by transcriptionally activating NR4A1, leading to inhibition of AKT, MAPK, and NF-kappa B signaling pathways. Low expression of SPDEF is associated with poor clinical outcomes in HNSCC patients, and restoration of SPDEF inhibits cell proliferation in HNSCC.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yang Chen, Yin Zhao, Xiaojing Yang, Xianyue Ren, Shengyan Huang, Sha Gong, Xirong Tan, Junyan Li, Shiwei He, Yingqin Li, Xiaohong Hong, Qian Li, Cong Ding, Xueliang Fang, Jun Ma, Na Liu
Summary: This study demonstrates that the deubiquitinase USP44 enhances the radiosensitivity of nasopharyngeal carcinoma cells by promoting the degradation of Ku80. Low expression of USP44 is associated with poor prognosis and tumor relapse in clinical settings.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Ruoyan Cao, Weilin Zhang, Hongjian Zhang, Lixuan Wang, Xijuan Chen, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS in head and neck squamous cell carcinoma (HNSCC). The expression of PRDX1, PRDX4, and PRDX5 in HNSCC is increased, while the expression of PRDX2 is decreased. Higher expression of PRDX4/5/6 indicates poor prognosis, while lower expression of PRDX1/5 is associated with more immune cell infiltration, higher expression of immune-related molecules, and a likely response to anti-PD-1 treatment. Knockdown of PRDX5 inhibits HNSCC cell proliferation, invasion, and metastasis, and promotes apoptosis through its antioxidant property. This study highlights the potential role of PRDXs, particularly PRDX5, in HNSCC and suggests it as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Xijuan Chen, Qin Liu, Yingyao Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang, Xue Pan, Siyuan Zhang, Chuwen Chen, Tong Wu, Juan Xia, Bin Cheng, Xiaobing Chen, Xianyue Ren
Summary: CES2 downregulation in OSCC plays a crucial role in maintaining lipid homeostasis and reducing lipotoxicity during tumor progression. Restoring CES2 expression can inhibit OSCC cell viability, migration, invasion, and tumor growth by reprogramming lipid metabolism and inducing mitochondrial dysfunction. Targeting CES2 may provide a potential therapeutic strategy for OSCC.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Wei Chen, Xijuan Chen, Lixuan Wang, Rongchun Yang, Weilin Zhang, Siyuan Zhang, Juan Xia, Bin Cheng, Tong Wu, Xianyue Ren
Summary: Mitochondria are key in maintaining oxidative balance and cell death regulation during cancer cell growth. TIPE3 downregulation through promoter hypermethylation is the main alteration in TIPEs during HNSCC development.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Yanting Wang, Yuanyuan Li, Laibo Jiang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: The higher expression levels of glycolysis markers, including GLUT1, MCT4, HK2, and PKM2, are associated with poorer overall survival and disease-free survival in head and neck squamous cell carcinoma patients. These markers could serve as potential prognostic predictors and therapeutic targets in the management of HNSCC.
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
