Article
Immunology
Banndith Cheat, Coralie Torrens, Asmaa Foda, Brigitte Baroukh, Jeremy Sadoine, Lotfi Slimani, Veronique Witko-Sarsat, Olivier Huck, Marjolaine Gosset, Jerome Bouchet
Summary: Our study investigates the role of NLRP3 in periodontitis, demonstrating its ambiguous role in neutrophils and its interaction with Porphyromonas gingivalis. The study reveals that NLRP3 is involved in regulatory pathways that limit periodontitis in mouse models, but its protective effect is diminished in the presence of P. gingivalis. Overexpression of NLRP3 in connective tissue leads to increased production of mature IL-1 beta and mobilization of neutrophils, while NLRP3 deficiency results in lower IL-1 beta expression and almost no neutrophil mobilization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ting Gong, Qi Chen, Hongchen Mao, Yao Zhang, Huan Ren, Mengmeng Xu, Hong Chen, Deqin Yang
Summary: This study found that the outer membrane vesicles of Porphyromonas gingivalis (Pg OMVs) can cause memory and learning impairments in elderly mice, damage the blood-brain barrier, activate neuroinflammatory responses, promote phosphorylation of Tau protein, and trigger NLRP3 inflammasome. These findings suggest that Pg OMVs play an important role in the development of Alzheimer's disease-like pathology induced by Porphyromonas gingivalis, and the activation of NLRP3 inflammasome may be one possible mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Yufei Yao, Xin Shen, Maolin Zhou, Boyu Tang
Summary: Periodontitis is closely related to oral cancer, with periodontal pathogens potentially promoting tumor growth and proliferation. In vivo and in vitro studies showed that periodontitis-associated bacteria can significantly increase cell proliferation and S phase cells, as well as induce alveolar bone resorption in mice models with oral squamous cell carcinoma (OSCC). Furthermore, the expression of inflammatory cytokines and downstream signaling molecules were upregulated in tumor tissues of the P+ group, suggesting a potential new molecular mechanism between periodontitis-related bacteria and OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Cell Biology
Zeyuan Gao, Xiuhong Weng, Donghu Yu, Zhiyong Pan, Mingjuan Zhao, Bo Cheng, Zhiqiang Li
Summary: Periodontitis is significantly associated with the risk of lung and digestive system cancers, as well as potentially various brain diseases. A study found that P. gingivalis LPS can promote glioma cell proliferation and migration, and increase levels of TNF-alpha, TGF-beta, MMP2, MMP9, and phosphorylation of Akt. Poor periodontal status was significantly higher in glioma patients compared to those with benign tumors, suggesting a possible association between periodontal infection and glioma progression.
Article
Biochemistry & Molecular Biology
Mengyuan Li, Yueyang Liu, Xueyi Nie, Boli Ma, Yabo Ma, Yuxin Hou, Yi Yang, Jinrui Xu, Yujiong Wang
Summary: The study found that S100A4 and GSDMD were significantly up-regulated in the peripheral blood of patients with pulmonary tuberculosis, and S100A4 promotes macrophage pyroptosis induced by Mycobacterium tuberculosis infection through activation of the NF-κB/NLRP3 inflammasome signaling pathway. These findings provide new insights into the role of S100A4 in Mycobacterium tuberculosis-induced macrophage pyroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Di Liu, Yizhi Xiao, Bin Zhou, Siming Gao, Liya Li, Lijuan Zhao, Weilin Chen, Bingying Dai, Qiuxiang Li, Huiqian Duan, Xiaoxia Zuo, Hui Luo, Honglin Zhu
Summary: The study revealed upregulated glycolysis in lesioned muscle tissues of DM/PM, which activated the NLRP3 inflammasome and led to pyroptosis in muscle cells. PKM2 and the NLRP3 inflammasome were upregulated and positively correlated in DM/PM muscle fibers. Levels of PKM2 and IL-1 beta were high in patients with anti-signal recognition particle autoantibody expression, suggesting potential new biomarkers for muscle damage.
Article
Biochemistry & Molecular Biology
Jacopo Pizzicannella, Luigia Fonticoli, Simone Guarnieri, Guya D. Marconi, Thangavelu Soundara Rajan, Oriana Trubiani, Francesca Diomede
Summary: This study found that ascorbic acid can alleviate the inflammation and reactive oxygen species generation induced by lipopolysaccharide in human gingival mesenchymal stem cells and endothelial committed hGMSCs. Through suppression of specific pathways, it shows anti-inflammatory effects in vitro.
Article
Microbiology
Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li
Summary: This study found that MARK4 promotes the activation of NLRP3 inflammasome and pyroptosis in P. gingivalis-infected macrophages by affecting microtubule dynamics. Inhibition of MARK4 may be a potential therapeutic target for regulating NLRP3 inflammasome during the progress of periodontitis.
JOURNAL OF ORAL MICROBIOLOGY
(2022)
Article
Oncology
Zhi-chen Guo, Si-li Jing, Sakendeke Jumatai, Zhong-cheng Gong
Summary: The significance of Porphyromonas gingivalis in promoting tumour progression in the tumour microenvironment of oral squamous cell carcinoma (OSCC) was determined.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shiho Sugawara, Taichi Ishikawa, Shu Sato, Hidemichi Kihara, Masayuki Taira, Minoru Sasaki, Hisatomo Kondo
Summary: The use of nanotitania derived from titanium in the oral cavity may exacerbate the onset of peri-implantitis, and the presence of periodontal pathogens could further worsen the condition. These findings suggest that titanium materials may play a crucial role in the pathogenesis of peri-implantitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yuri Song, Jin Chung, Grzegorz Wegrzyn
Summary: This study found that the relative abundance of Porphyromonas gingivalis (P. gingivalis) was significantly higher in periodontitis patients, especially in the elderly. The inflammatory response to P. gingivalis infection was greater in older individuals, and they also experienced more severe bone loss. These findings enhance understanding of the relationship between periodontal immunosenescence and inflammatory response in the elderly.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Environmental Sciences
Xiaoying Zhu, Wudi Hao, Ziyue Liu, Yushuai Song, Chenyu Hao, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure activates microglia and induces neuroinflammation through P2X7-NLRP3 pathway. P2X7 and HIF-1 alpha have a mutual regulatory relationship in the progression of neuroinflammation. BBG and YC-1 intervention can relieve the injuries caused by aluminum-induced neuroinflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Wudi Hao, Chenyu Hao, Chengrong Wu, Yuqing Xu, Shengwen Wu, Xiaobo Lu, Jinghua Yang, Cuihong Jin
Summary: Aluminum exposure can induce neuronal cell pyroptosis and neuroinflammation through the DDX3X-NLRP3 inflammasome signaling pathway, which can be alleviated by Rsv through activating SIRT1.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou, Cha-Xiang Guan
Summary: This study found that the activation of Fn14 worsens acute lung injury (ALI) by amplifying the activation of the NLRP3 inflammasome. Blocking Fn14 may be a potential way to treat ALI.
MOLECULAR MEDICINE
(2022)
Article
Dermatology
Yao Yuan, Natalia Salinas Parra, Qianming Chen, Ramiro Iglesias-Bartolome
Summary: In this study, the transcriptional targeting of YAP1 and TAZ in basal cell carcinoma was investigated using a TEAD inhibitor, showing reduced proliferation and increased differentiation of cancer cells. The findings also revealed YAP1/TAZ.TEAD-independent effects impacting STAT3 and NF-kappa B pathways in cancer cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yue Du, Die Lv, Bomiao Cui, Xiaoying Li, Hongli Chen, Yingzhu Kang, Qianming Chen, Yun Feng, Ping Zhang, Jiao Chen, Xuedong Zhou
Summary: In this study, it was found that PKD1 is correlated with metastasis and poor prognosis in SACC patients. Inhibition of PKD1 attenuated proliferation, migration, invasion, and EMT of SACC cells, while kinase active PKD1 promoted cell migration. The mechanism involves PKD1 regulating Snail protein stability to impact SACC metastasis.
Article
Dentistry, Oral Surgery & Medicine
Sidi Zhang, Qianming Chen, Chao Yang, Jiayu Shi, Yansong Lin, Shijun Duan, Bing Shi, Zhonglin Jia
Summary: This study identified new potential SNPs around IRF6 associated with non-syndromic orofacial cleft (NSOC) in Western Han Chinese, and found that these SNPs have different transmission patterns and parent-of-origin effects in different subtypes, indicating their potential importance in the development of the disease.
Letter
Dentistry, Oral Surgery & Medicine
Yilong Hao, Yao Yuan, Yining Li, Qianming Chen
Article
Chemistry, Multidisciplinary
Jing Liu, Moyuan Qu, Canran Wang, Yumeng Xue, Hui Huang, Qianming Chen, Wujin Sun, Xingwu Zhou, Guihua Xu, Xing Jiang
Summary: This study designed a hemostatic and anti-inflammatory hydrogel patch for promoting diabetic wound healing. The hydrogel was able to regulate macrophage phenotype, promote fibroblast proliferation and migration, and accelerate angiogenesis. The hydrogel can effectively promote wound closure and tissue regeneration, making it a simple, economical, effective, and safe treatment for diabetic wounds.
Review
Dentistry, Oral Surgery & Medicine
Xin Zeng, Xin Jin, Liang Zhong, Gang Zhou, Ming Zhong, Wenmei Wang, Yuan Fan, Qing Liu, Xiangmin Qi, Xiaobing Guan, Zhimin Yan, Xuemin Shen, Yingfang Wu, Lijie Fan, Zhi Wang, Yuan He, Hongxia Dan, Jiantang Yang, Hui Wang, Dongjuan Liu, Hui Feng, Kai Jiao, Qianming Chen
Summary: This study summarizes the diagnostic work-up for difficult and complicated oral ulcers, providing a standardized procedure to improve diagnostic efficiency.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Zhiwei Jiang, Na Li, Qin Shao, Danji Zhu, Yuting Feng, Yang Wang, Mengjia Yu, Lingfei Ren, Qianming Chen, Guoli Yang
Summary: This study successfully isolated a new population of mesenchymal stem cells (PMSCs) from rat hard palates and fabricated scaffold-free 3D cell aggregates using light-controlled cell sheet technology. Transplantation of the PMSC aggregates significantly enhanced bone formation and implant osseointegration in vivo, demonstrating their potential as a powerful tool for tissue engineering.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Ziang Xu, Qi Han, Dan Yang, Yijun Li, Qianhui Shang, Jiaxin Liu, Weiqi Li, Hao Xu, Qianming Chen
Summary: This study developed a workflow for predicting the response to immunosuppressive therapy in oral lichen planus (OLP) by acquiring image-based features and constructing prediction models. The study found that microscopic structure can reveal the biological implications of these features and predict the response to immunosuppressive therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maofeng Qing, Yu Zhou, Jiakuan Peng, Qianhui Shang, Jiaxin Deng, Xin Zeng, Hao Xu, Qianming Chen
Summary: This study aimed to investigate the expression of interleukin-6 (IL-6) family in local tissues of oral lichen planus (OLP) patients and its correlation with presentations and outcomes. The results showed that the expression of IL-6 family significantly increased in erosive type OLP patients. Additionally, IL-6 family factors were significantly increased in the recurrent erosion group compared to the persistent nonerosion group. Multiple regression analysis revealed that the increased expression of IL-6 family was closely related to clinical types and outcomes of OLP.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Letter
Cell Biology
Rui Liu, Qianming Chen
Article
Materials Science, Multidisciplinary
Tiannan Liu, Yuqi Du, Yujie Yan, Shaojuan Song, Jiajia Qi, Xin Xia, Xiaopei Hu, Qianming Chen, Jiang Liu, Xin Zeng, Hang Zhao
Summary: In this study, a pH-responsive dual-functional isoG-based supramolecular hydrogel with excellent stability and sustained release capability was successfully developed. Both in vitro and in vivo experiments demonstrated its biocompatibility, biodegradability, and significant inhibition of tumor growth. This is the first example of a pH-responsive dual-functional isoG-based supramolecular hydrogel integrating localized delivery and anti-cancer activity in one molecule.
Article
Dentistry, Oral Surgery & Medicine
Yansong Song, Ling Ren, Jiaxin Liu, Xin Zeng, Qianming Chen, Hongxia Dan
Summary: The core outcome set (COS) is a minimum set of outcomes that should be reported by all clinical trials in a specific health field. The use of COS in clinical studies can reduce heterogeneity, facilitate systematic review, and increase the utility of studies. The importance of COS in oral health has recently been recognized.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Review
Immunology
Xiaoting Deng, Ying Wang, Lu Jiang, Jing Li, Qianming Chen
Summary: Oral lichen planus (OLP) is a chronic immune inflammatory disease that affects the oral mucosa and has the potential to develop into oral squamous cell carcinoma (OSCC). The etiology of OLP is still unknown, but immune dysregulation may play a vital role in its pathogenesis. This review focuses on the relationship between OLP and its immune microenvironment, summarizing the current developments in immunology, functional cell types, crucial cytokines, and signaling pathways involved. The potential application of targeted immune microenvironment therapy for OLP is highlighted.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Surgery
You Zhang, Yuqi Wu, Dan Pan, Zhenyu Zhang, Lu Jiang, Xiaodong Feng, Yuchen Jiang, Xiaobo Luo, Qianming Chen
Summary: This study aimed to evaluate the diagnostic accuracy of narrow band imaging (NBI) for malignant transformations of potentially malignant disorders (OPMD) in the oral cavity. The results showed that defining IPCL II and above as a positive result demonstrated the highest diagnostic accuracy for OPMD malignant transformations.
FRONTIERS IN SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yahui Wang, Fan Tang, Zhiyong Li, Qianming Chen
Summary: This retrospective study investigated and compared the features of SBCs and ABCs of the jaw. The study found that SBCs and ABCs mostly occur in adolescents and young adults, are generally asymptomatic and found incidentally, and the final diagnosis depends on pathological examination. Curettage combined with bone grafting is the main treatment method.