Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond

Ca 2+ signaling, apoptosis and autophagy in the developing cochlea: Milestones to hearing acquisition

(2018) Fabio Mammano et al.   CELL CALCIUM

Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells

(2018) Min Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Extracellular Vesicles Arising from Apoptotic Cells in Tumors: Roles in Cancer Pathogenesis and Potential Clinical Applications

(2017) Catherine Lynch et al.   Frontiers in Immunology

Venetoclax: First Global Approval

(2016) Emma D. Deeks   DRUGS

Low levels of Caspase-3 predict favourable response to 5FU-based chemotherapy in advanced colorectal cancer: Caspase-3 inhibition as a therapeutic approach

(2016) L Flanagan et al.   Cell Death & Disease

CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

(2016) Austin Xun Ding et al.   eLife

What cell death does in development

(2015) Zahra Zakeri et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death

(2015) Gabriel Ichim et al.   MOLECULAR CELL

Caspase-3 Promotes Genetic Instability and Carcinogenesis

(2015) Xinjian Liu et al.   MOLECULAR CELL

ATM kinase sustains HER2 tumorigenicity in breast cancer

(2015) Venturina Stagni et al.   Nature Communications

The molecular mechanisms underlying the therapeutic resistance of cancer stem cells

(2014) Jun-Kyum Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Stemness in Human Thyroid Cancers and Derived Cell Lines: The Role of Asymmetrically Dividing Cancer Stem Cells Resistant to Chemotherapy

(2014) Risheng Ma et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

An agent-based model of cancer stem cell initiated avascular tumour growth and metastasis: the effect of seeding frequency and location

(2014) K.-A. Norton et al.   Journal of the Royal Society Interface

Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

(2014) Antonina V. Kurtova et al.   NATURE

The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm−/− mice

(2013) S Biswas et al.   CELL DEATH AND DIFFERENTIATION

Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion

(2013) Vivek A Rudrapatna et al.   EMBO REPORTS

Prediction of response to radiotherapy in the treatment of esophageal cancer using stem cell markers

(2013) Justin K. Smit et al.   RADIOTHERAPY AND ONCOLOGY

Developmental signaling pathways in cancer stem cells of solid tumors

(2012) Christina Karamboulas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia

(2012) M. S. Davids et al.   BLOOD

Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response

(2012) Ho Lam Tang et al.   MOLECULAR BIOLOGY OF THE CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Methylome analysis reveals Jak-STAT pathway deregulation in putative breast cancer stem cells

(2011) Héctor Hernández-Vargas et al.   Epigenetics

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

(2011) James D. Orth et al.   MOLECULAR BIOLOGY OF THE CELL

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

Role of p53 in Cell Death and Human Cancers

(2011) Toshinori Ozaki et al.   Cancers

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts

(2010) Fang Li et al.   Cell Stem Cell

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

(2010) V. Labi et al.   GENES & DEVELOPMENT

Apoptosis-promoted tumorigenesis:  -irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

(2010) E. M. Michalak et al.   GENES & DEVELOPMENT

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TRAIL treatment provokes mutations in surviving cells

(2010) M M Lovric et al.   ONCOGENE

Targeting the Mechanisms of Resistance to Chemotherapy and Radiotherapy with the Cancer Stem Cell Hypothesis

(2010) Ryan Morrison et al.   Journal of Oncology

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

(2009) S. Barbero et al.   CANCER RESEARCH

Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration

(2009) Simona Chera et al.   DEVELOPMENTAL CELL

Rab5 Mediates Caspase-8–promoted Cell Motility and Metastasis

(2009) Vicente A. Torres et al.   MOLECULAR BIOLOGY OF THE CELL

Ronin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells

(2008) Marion Dejosez et al.   CELL

Roles of TGF-β family signaling in stem cell renewal and differentiation

(2008) Tetsuro Watabe et al.   CELL RESEARCH

Caspase Activity Mediates the Differentiation of Embryonic Stem Cells

(2008) Jun Fujita et al.   Cell Stem Cell

Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL ONCOLOGY

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY