Article
Chemistry, Multidisciplinary
Yaoru Huang, Po-Yung Chen, Tzu-Yen Cheng, Jeng-Fong Chiou
Summary: This study investigated the outcomes of reirradiation for recurrent HCC and found that better local control could prolong survival. The results suggest that reirradiation may be a viable treatment option for recurrent HCC.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Run-Da Huang, Zhuang Sun, Xiao-Hui Wang, Yun-Ming Tian, Ying-Lin Peng, Jing-Yun Wang, Wei-Wei Xiao, Chun-Yan Chen, Xiao-Wu Deng, Fei Han
Summary: Comorbidity is an important prognostic factor for locally recurrent nasopharyngeal carcinoma patients undergoing reirradiation. A nomogram developed in this study can help predict the probability of death after reirradiation and guide individualized management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhouying Peng, Yumin Wang, Yaxuan Wang, Ruohao Fan, Kelei Gao, Hua Zhang, Weihong Jiang
Summary: This meta-analysis compared the efficacy of IMRT and ES for high T-stage recurrent NPC. Results suggest that ES may improve survival in recurrent NPC with rT3-4, with potentially fewer complications. More studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Otorhinolaryngology
Wanpeng Li, Qianqian Zhang, Fu Chen, Haoyuan Xu, Qiang Liu, Huan Wang, Huankang Zhang, Quan Liu, Yurong Gu, Houyong Li, Xicai Sun, Hongmeng Yu, Dehui Wang
Summary: This study compared the efficacy of endoscopic surgery and intensity-modulated radiotherapy (IMRT) in patients with advanced recurrent nasopharyngeal carcinoma (rNPC). The results showed that endoscopic surgery had a higher survival rate and fewer complications, suggesting that it may be a more promising salvage treatment for advanced rNPC.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Oncology
Yijun Hua, Rui You, Zhiqiang Wang, Peiyu Huang, Mei Lin, Yanfeng Ouyang, Yulong Xie, Xiong Zou, Youping Liu, Chongyang Duan, Yonglong Liu, Chenmei Gu, Rongzeng Liu, Qi Yang, Rou Jiang, Mengxia Zhang, Xi Ding, Siyuan Chen, Chao Lin, Rui Sun, Mingyuan Chen
Summary: The combination of toripalimab and IMRT was well-tolerated and showed promising antitumor activity in patients with recurrent nasopharyngeal carcinoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Wai Tong Ng, Yoke Lim Soong, Yong Chan Ahn, Hussain AlHussain, Horace C. W. Choi, June Corry, Vincent Gregoire, Kevin J. Harrington, Chao Su Hu, Kenneth Jensen, Dora L. Kwong, Johannes A. Langendijk, Quynh Thu Le, Nancy Y. Lee, Jin Ching Lin, Tai Xiang Lu, William M. Mendenhall, Brian O'Sullivan, Enis Ozyar, Jian Ji Pan, Lester J. Peters, Sharon S. Poh, David I. Rosenthal, Giuseppe Sanguineti, Yungan Tao, Joseph T. Wee, Sue S. Yom, Melvin L. K. Chua, Anne W. M. Lee
Summary: The reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging due to the delicate balance needed between achieving local salvage and minimizing treatment toxicities. High-level evidence is lacking, but pragmatic consensus guidelines based on expert opinions provide useful references for decision-making. Through iterative revisions, recommendations with high-to-moderate agreement were formulated regarding general treatment strategies and details of reirradiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Health Care Sciences & Services
Ronald Wihal Oei, Yingchen Lyu, Lulu Ye, Fangfang Kong, Chengrun Du, Ruiping Zhai, Tingting Xu, Chunying Shen, Xiayun He, Lin Kong, Chaosu Hu, Hongmei Ying
Summary: This study compared the performance of the Cox proportional hazards model (CPH) with the conditional survival forest (CSF) and DeepSurv, two state-of-the-art machine learning algorithms, for disease progression prediction in nasopharyngeal carcinoma (NPC), with DeepSurv achieving the best performance.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Yibin Liu, Nan Huang, Junxiao Gao, Bin He, Hongming Huang, Liangcai Wan, Qinming Cai, Zhenchao Zhu, Suizi Zhou, Jing Wang, Xiaohui Wang, Qianhui Qiu, Fei Han
Summary: This study compared the clinical outcomes and complications of salvage endoscopic nasopharyngectomy (ENPG) with intensity-modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (rNPC). The results showed that ENPG had comparable efficacy to IMRT but lower incidence of treatment-related complications.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Oncology
Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan, Shao-Jun Lin
Summary: This study compared the efficacy and toxicity of radiotherapy combined with nimotuzumab versus chemoradiotherapy in patients with locally recurrent nasopharyngeal carcinoma. The results showed no significant difference in survival rates between the two groups, but the CRT group had a higher incidence of severe late radiation injuries. Further studies are needed to confirm these findings.
Review
Oncology
Lin Su, Lei She, Liangfang Shen
Summary: Nasopharyngeal carcinoma is a common malignant tumor of the head and neck, originating from the mucous epithelium of the nasopharynx. Symptoms are often missed, with majority of patients presenting with locally advanced disease. Concurrent radiation therapy with chemotherapy can improve regional control, but distant metastasis remains a challenge. Adjuvant chemotherapy's role in treating locally advanced NPC is still unclear and associated with increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Wanzun Lin, Yun Sun, Xianxin Qiu, Qingting Huang, Lin Kong, Jiade J. Lu
Summary: The study found that high expression of VMP1 in glioma patients is associated with faster disease progression and poorer prognosis. Depletion of VMP1 by CRISPR-Cas9 gene editing significantly inhibits cell proliferation, increases cell death, and induces cell cycle arrest. Knockout of VMP1 blocks autophagic flux and sensitizes glioma cells to radiotherapy and chemotherapy.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Jiyi Hu, Qingting Huang, Jing Gao, Weixu Hu, Jing Yang, Xiyin Guan, Xianxin Qiu, Wenna Zhang, Lin Kong, Jiade J. Lu
Summary: The study demonstrated that the combination of IMRT with CIRT boost therapy provides excellent disease control and favorable toxicity profile for patients with non-metastatic nasopharyngeal carcinoma. The results suggest that this mixed treatment strategy is safe and well-tolerated, with promising outcomes in terms of disease control.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shubing Jia, Jian Chen, Ningyi Ma, Jingfang Zhao, Jingfang Mao, Guoliang Jiang, Jiade Lu, Kailiang Wu
Summary: This study demonstrates the dosimetric benefits of adaptive carbon ion radiotherapy (CIRT) for locally advanced non-small cell lung cancer (LANSCLC) and compares the differences between patients with and without adaptive plans. The results show that adaptive plans can ensure target coverage and reduce spinal cord dose. Patients with adaptive plans have larger tumor volumes and greater volume changes. iGTV volume changes and iGTV center movements are the main factors influencing adaptive planning.
Article
Oncology
Fangzhu Wan, Haojiong Zhang, Jiyi Hu, Li Chen, Shikai Geng, Lin Kong, Jiade J. Lu
Summary: This study identified miR-125a as highly expressed in normal nasopharyngeal epithelial tissue compared to nasopharyngeal carcinoma. It demonstrated that miR-125a inhibits the migration and vasculogenic mimicry (VM) formation in nasopharyngeal carcinoma cells, targeting TAZ. Additionally, artificial engineering of mesenchymal stem cells (MSCs) allowed the generation of miR-125a-overexpressing exosomes which attenuated VM formation and migration in nasopharyngeal carcinoma, providing a potential therapeutic approach.
FRONTIERS IN ONCOLOGY
(2022)
Article
Ophthalmology
Jingli Guo, Xianxin Qiu, Wenyi Tang, Gezhi Xu, Michael F. Moyers, Wei Ren, Ying Xing, Jin Gao, Jiayao Sun, Jiade Lu, Lin Kong, Wei Liu
Summary: The study demonstrates that PBI combined with IVC may help promote regression and closure of polyps in PCV, reduce central macular thickness, and improve BCVA with good safety profile after 12 months. Hence, PBI may be a useful adjuvant therapy for patients with refractory or recurrent PCV.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Oncology
Dong Yang, Weiwei Wang, Jiyi Hu, Weixu Hu, Xiyu Zhang, Xiaodong Wu, Jiade J. Lu, Lin Kong
Summary: This study investigated the feasibility of lattice radiotherapy (LRT) using proton or carbon-ion beams in the treatment of sinonasal malignancies. The results showed that proton and carbon-ion LRT plans can better protect critical organs compared to photon LRT plans, despite minimal differences in PVDR.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Robert L. Foote, Hirohiko Tsujii, Reiko Imai, Hiroshi Tsuji, Eugen B. Hug, Tatsuaki Kanai, Jiade J. Lu, Juergen Debus, Rita Engenhart-Cabillic, Anita Mahajan
Summary: As of December 31, 2020, there were 12 facilities in Asia and Europe providing carbon ion radiotherapy (CIRT) for cancer patients, with a total of 37,548 patients treated worldwide. The absence of CIRT facilities in the U.S. limits access to this treatment for American cancer patients and prevents their inclusion in phase III clinical trials, which are essential for FDA approval and insurance coverage. Overcoming this barrier would require establishing a limited number of CIRT facilities in the U.S.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaofeng Xu, Peiru Zhang, Yangle Huang, Weizhong Shi, Jingfang Mao, Ningyi Ma, Lin Kong, Lin Guo, Jinlong Liu, Jian Chen, Renquan Lu
Summary: This study found that the levels of METTL3 and its mediated m6A modification were elevated in non-small-cell lung cancer (NSCLC) cells treated with carbon-ion radiotherapy. Knockdown of METTL3 impaired cell proliferation, migration, invasion, and enhanced DNA damage repair and cell survival.
Article
Cell Biology
Vivek Kumar, Mohit Vashishta, Lin Kong, Jiade J. Lu, Xiaodong Wu, Bilikere S. Dwarakanath, Chandan Guha
Summary: Photon-based radiotherapy and carbon ion radiotherapy have different effects on Notch signaling in glioma cells. Carbon ion radiotherapy regulates the expression of Notch signaling and reduces stemness and cell migration. These findings may contribute to reducing tumor regrowth and disease dissemination.
Article
Cell Biology
Qilin Zhang, Lijiang Fei, Rui Han, Ruofan Huang, Yongfei Wang, Hong Chen, Boyuan Yao, Nidan Qiao, Zhe Wang, Zengyi Ma, Zhao Ye, Yichao Zhang, Weiwei Wang, Ye Wang, Lin Kong, Xuefei Shou, Xiaoyun Cao, Xiang Zhou, Ming Shen, Haixia Cheng, Zhenwei Yao, Chao Zhang, Guoji Guo, Yao Zhao
Summary: By performing single-cell RNA sequencing, we revealed the cellular hierarchies of skull base chordoma (SBC) and identified potential targets and drugs for the treatment of SBC.
Article
Immunology
Wanzun Lin, Jing Gao, Haojiong Zhang, Li Chen, Xianxin Qiu, Qingting Huang, Jiyi Hu, Lin Kong, Jiade J. Lu
Summary: This study classified lower-grade glioma (LGG) into inflammation-, low, -mid, and -high subtypes based on the inflammatory response, which have distinct clinicopathologic features, prognosis, and tumor microenvironment. An inflammation-related prognostic model was also established with strong predictive power for prognosis assessment.
INFLAMMATION AND REGENERATION
(2022)