Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Xi Ding, Wei-Jing Zhang, Rui You, Xiong Zou, Zhi-Qiang Wang, Yan-Feng Ouyang, Lan Peng, You-Ping Liu, Chong-Yang Duan, Qi Yang, Chao Lin, Yu-Long Xie, Si-Yuan Chen, Yong-Long Liu, Chen-Mei Gu, Ruo-Qi Xie, Pei-Yu Huang, Ming-Huang Hong, Yi-Jun Hua, Ming-Yuan Chen
Summary: This study investigated the activity and safety of combining immune checkpoint inhibitors and antiangiogenic therapy for recurrent/metastatic nasopharyngeal carcinoma. The results showed promising antitumor activity with camrelizumab plus apatinib in refractory patients, but there were also treatment-related adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yanshuo Cao, Ming Lu, Yu Sun, Jifang Gong, Jie Li, Zhihao Lu, Jian Li, Xiaotian Zhang, Yan Li, Zhi Peng, Jun Zhou, Xicheng Wang, Lin Shen
Summary: This study evaluated the safety and efficacy of the combination treatment of surufatinib and toripalimab in patients with advanced solid tumors, and determined the recommended dose. The results showed that this combination therapy was well tolerated and demonstrated preliminary anti-tumor activity.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Medicine, General & Internal
Jing-Jing Yuan, Jian-Wu Ding, Jin-Wei Li, Rong-Huan Hu, Dan Gong, Jia-Li Hu, Kai-Bin Zhu, Yan Liu, Yu-Hai Ding, Jia-Wang Wei, Jian-Lun Zeng, Zhi-Bing Lu, Wei-Hua Yin, Su-Fen Ai, Guo-Hua Zha, Zhi-Lin Zhang, Rui Zou, Lei Zeng
Summary: This study aims to explore individualized treatment strategies for patients with different ICT efficacy, in order to increase treatment intensity for patients with poor efficacy and reduce treatment toxicity for patients with favorable efficacy.
Review
Oncology
Wai Tong Ng, Yoke Lim Soong, Yong Chan Ahn, Hussain AlHussain, Horace C. W. Choi, June Corry, Vincent Gregoire, Kevin J. Harrington, Chao Su Hu, Kenneth Jensen, Dora L. Kwong, Johannes A. Langendijk, Quynh Thu Le, Nancy Y. Lee, Jin Ching Lin, Tai Xiang Lu, William M. Mendenhall, Brian O'Sullivan, Enis Ozyar, Jian Ji Pan, Lester J. Peters, Sharon S. Poh, David I. Rosenthal, Giuseppe Sanguineti, Yungan Tao, Joseph T. Wee, Sue S. Yom, Melvin L. K. Chua, Anne W. M. Lee
Summary: The reirradiation for locally recurrent nasopharyngeal carcinoma (NPC) is challenging due to the delicate balance needed between achieving local salvage and minimizing treatment toxicities. High-level evidence is lacking, but pragmatic consensus guidelines based on expert opinions provide useful references for decision-making. Through iterative revisions, recommendations with high-to-moderate agreement were formulated regarding general treatment strategies and details of reirradiation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Hai-Qiang Mai, Qiu-Yan Chen, Dongping Chen, Chaosu Hu, Kunyu Yang, Jiyu Wen, Jingao Li, Ying-Rui Shi, Feng Jin, Ruilian Xu, Jianji Pan, Shenhong Qu, Ping Li, Chunhong Hu, Yi-Chun Liu, Yi Jiang, Xia He, Hung-Ming Wang, Wan-Teck Lim, Wangjun Liao, Xiaohui He, Xiaozhong Chen, Zhigang Liu, Xianglin Yuan, Qi Li, Xiaoyan Lin, Shanghua Jing, Yanju Chen, Yin Lu, Ching-Yun Hsieh, Muh-Hwa Yang, Chia-Jui Yen, Jens Samol, Hui Feng, Sheng Yao, Patricia Keegan, Rui-Hua Xu
Summary: The study is a double-blind phase 3 trial that shows the combination of toripalimab with GP chemotherapy for RM-NPC patients provides a superior PFS compared to GP alone. Most adverse events were similar between the two arms, but immune-related AEs were more frequent in the toripalimab arm.
Article
Medicine, General & Internal
Xinsheng Zhu, Liangdong Sun, Nan Song, Wenxin He, Boxiong Xie, Junjie Hu, Jing Zhang, Jie Yang, Jie Dai, Dongliang Bian, Haoran Xia, Fenghuan Sun, Anwen Xiong, Jie Luo, Lele Zhang, Huansha Yu, Ming Liu, Hongcheng Liu, Haifeng Wang, Haiping Zhang, Chang Chen, Chunyan Wu, Liang Duan, Yuming Zhu, Peng Zhang, Gening Jiang
Summary: This study aimed to analyze the safety, effectiveness, and transcriptomic characteristics of neoadjuvant toripalimab plus chemotherapy in patients with II-III non-small-cell lung cancer. The results showed that the treatment was safe and effective, with a high pathological response rate and manageable adverse events. Additionally, the expression of CHI3L1 was found to be predictive of treatment response and survival.
Article
Oncology
Yun Guan, Mingyuan Pan, Jun Yang, Qiuxia Lu, Liangfu Han, Ying Liu, Jing Li, Huaguang Zhu, Xiu Gong, Guanghai Mei, Xiaoxia Liu, Li Pan, Jiazhong Dai, Yang Wang, Enmin Wang, Xin Wang
Summary: This study aims to evaluate the efficacy and toxicity of the combination of hypofractionated stereotactic radiotherapy (HSRT) and intensity-modulated radiotherapy (IMRT) with temozolomide in GBM patients after surgery, and provide evidence for future randomized controlled trials. The study suggests that this treatment approach can improve the survival rate of patients after surgery, with acceptable toxicity and reduced treatment time.
Article
Oncology
Guanzhu Shen, Yinglin Peng, Jian Li, Haijun Wu, Guangshun Zhang, Chong Zhao, Xiaowu Deng
Summary: This study evaluated the incidence of hypothyroidism in patients with nasopharyngeal carcinoma after IMRT, finding that 34.8% of patients developed hypothyroidism 12 months after radiotherapy. The average thyroid dose and thyroid volume were identified as key factors affecting hypothyroidism, with an NTCP model constructed based on these factors showing good fit.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yi-Jun Hua, Yan-Feng Ou-Yang, Xiong Zou, Le Xia, Dong-Hua Luo, Ming-Yuan Chen
Summary: Radiotherapy is crucial for nasopharyngeal carcinoma patients, with a typical treatment duration of six to six and a half weeks. Prolonged radiotherapy duration is associated with higher risk of distant metastasis and death, highlighting the importance of avoiding prolonged treatment to improve outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing You, Shuchai Zhu, Jiancheng Li, Jie Li, Junyue Shen, Yidian Zhao, Xiaomin Li, Lin Jia, Qingshan Li, Jun Yang, Yiqun Wu, Wenbin Shen, Haishan Wu, Xueqin Wu, Xiaomin Wang, Yaqiong Ren, Jun He, Pingping Lin, Guangying Zhu, Anhui Shi
Summary: This study aimed to investigate whether a high dose of 59.4 Gy using intensity-modulated radiation therapy (IMRT) would improve survival without increasing toxicities in patients with esophageal cancer. The results showed that a high dose of radiation did not improve survival compared to the standard dose in patients with inoperable thoracic esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Oncology
Zhouying Peng, Yumin Wang, Yaxuan Wang, Ruohao Fan, Kelei Gao, Hua Zhang, Weihong Jiang
Summary: This meta-analysis compared the efficacy of IMRT and ES for high T-stage recurrent NPC. Results suggest that ES may improve survival in recurrent NPC with rT3-4, with potentially fewer complications. More studies are needed to confirm these findings.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Fen Xue, Xiaoshuang Niu, Chaosu Hu, Xiayun He
Summary: This study aimed to determine the long-term risk of second primary lung adenocarcinoma (SPLAC) in nasopharyngeal cancer (NPC) patients after intensity-modulated radiotherapy (IMRT). The results showed that the incidence of SPLAC in NPC patients after IMRT was similar to that of the normal population, and most cases were detected in early stages during follow-up, with good surgical efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Xingzhe Li, Sarin Kitpanit, Anna Lee, Dennis Mah, Kevin Sine, Eric J. Sherman, Lara A. Dunn, Loren S. Michel, James Fetten, Kaveh Zakeri, Yao Yu, Linda Chen, Jung Julie Kang, Daphna Y. Gelblum, Sean M. McBride, Chiaojung J. Tsai, Nadeem Riaz, Nancy Y. Lee
Summary: This study compared the toxic effects and oncologic outcomes of patients with nonmetastatic NPC treated with IMPT vs IMRT with or without chemotherapy. The results showed that IMPT was associated with lower acute toxicity burden compared with IMRT, rare late complications, and excellent oncologic outcomes, including 100% locoregional control at 2 years.
Article
Oncology
You-Ping Liu, Yi-Hui Wen, Jun Tang, Yi Wei, Rui You, Xiao-Lin Zhu, Jian Li, Lin Chen, Li Ling, Ning Zhang, Xiong Zou, Yi-Jun Hua, You-Mou Chen, Lei Chen, Li-Xia Lu, Ming-Yuan Chen, Wei-Ping Wen
Summary: Surgery significantly improved overall survival compared with IMRT in patients with resectable locally recurrent NPC. ENPG could be considered as the standard treatment option for this patient population, although long-term follow-up is needed to further determine the efficacy and toxicity of this strategy.
Article
Oncology
Mei Lin, Qi Yang, Rui You, Xiong Zou, Chong-yang Duan, You-ping Liu, Pei-yu Huang, Yu-long Xie, Zhi-qiang Wang, Ting Liu, Si-Yuan Chen, Yi-jun Hua, Ming-yuan Chen
Summary: This study analyzed the survival outcomes of nasopharyngeal carcinoma patients with metastasis and found that patients with bone and/or liver involvement tended to have lower survival rates, emphasizing the need for careful treatment selection.
Article
Oncology
Wei-Xiong Xia, Xing Lv, Hu Liang, Guo-Ying Liu, Rui Sun, Qi Zeng, Si-Wei Li, Hao-Yuan Mo, Fei Han, Dong-Hua Luo, Qing Liu, Meng-Yun Shi, Yan-Fang Ye, Jing Yang, Liang-Ru Ke, Meng-Yun Qiang, Wen-Ze Qiu, Ya-Hui Yu, Kui-Yuan Liu, Xin-Jun Huang, Wang-Zhong Li, Shu-Hui Lv, Zhuo-Chen Cai, Jing-Jing Miao, Ling Guo, Ming-Yuan Chen, Ka-Jia Cao, Lin Wang, Chong Zhao, Pei-Yu Huang, Qiu-Yan Chen, Yi-Jun Hua, Lin-Quan Tang, Chao-Nan Qian, Hai-Qiang Mai, Xiang Guo, Yan-Qun Xiang
Summary: The study found that once-every-3-weeks cisplatin is noninferior to once-a-week cisplatin for locoregionally advanced nasopharyngeal carcinoma treatment. However, the former has lower acute toxicities and late-onset auditory loss compared to the latter.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Jiang-Ping Li, Chang-You Wu, Ming-Yuan Chen, Shang-Xin Liu, Shu-Mei Yan, Yin-Feng Kang, Cong Sun, Jennifer R. Grandis, Mu-Sheng Zeng, Qian Zhong
Summary: The study revealed the presence of a PD-1(+)CXCR5(-)CD4(+) Th-CXCL13 cell subset in NPC, which serves as a major source of CXCL13 and is comparable in numbers to Th1 and Tfh cells in the TLSs. Monocytes activated by toll-like receptor 4 agonists efficiently trigger the expansion of Th-CXCL13 cells, with TGF-beta 1 stimulation and activation of Sox4 being crucial for their induction and polarization. Additionally, the recruitment of TABs by Th-CXCL13 cells in TLSs induces plasma cell differentiation and immunoglobulin production, potentially leading to improved survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Qi Yang, Le Xia, Mei Lin, Meng-Xia Zhang, Chong-Yang Duan, You-Ping Liu, Yu-Long Xie, Zhi-Qiang Wang, Rui You, Xiong Zou, Yi-Jun Hua, Pei-Yu Huang, Rui Sun, Ming-Huang Hong, Ming-Yuan Chen
Summary: This study confirmed that induction chemotherapy (IC) followed by concurrent chemo-radiotherapy (CCRT) had better long-term quality of life outcomes compared with CCRT alone in patients with locoregionally advanced nasopharyngeal carcinoma. The IC followed by CCRT group showed significantly improved results in role functioning, cognitive functioning, social functioning, fatigue, pain, and constipation, while showing poorer results in senses problems.
Article
Oncology
Xian-Wen Wang, Tian-Liang Xia, Hao-Cheng Tang, Xiong Liu, Ri Han, Xiong Zou, Yun-Teng Zhao, Ming-Yuan Chen, Gang Li
Summary: In this study, a living biobank using the NPCO model was successfully established, which has enormous potential in basic and clinical research on NPC.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xi Ding, Wei-Jing Zhang, Rui You, Xiong Zou, Zhi-Qiang Wang, Yan-Feng Ouyang, Lan Peng, You-Ping Liu, Chong-Yang Duan, Qi Yang, Chao Lin, Yu-Long Xie, Si-Yuan Chen, Yong-Long Liu, Chen-Mei Gu, Ruo-Qi Xie, Pei-Yu Huang, Ming-Huang Hong, Yi-Jun Hua, Ming-Yuan Chen
Summary: This study investigated the activity and safety of combining immune checkpoint inhibitors and antiangiogenic therapy for recurrent/metastatic nasopharyngeal carcinoma. The results showed promising antitumor activity with camrelizumab plus apatinib in refractory patients, but there were also treatment-related adverse events.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Rui You, You -Ping Liu, Yu -Long Xie, Chao Lin, Chong -Yang Duan, Dong-Ping Chen, Yi Pan, Bin Qi, Xiong Zou, Ling Guo, Jing-Yu Cao, Yi-Nuan Zhang, Zhi-Qiang Wang, Yong -Long Liu, Yan-Feng Ouyang, Kai Wen, Qi Yang, Ruo-Qi Xie, Hui-Feng Li, Xiao-Tong Duan, Xi Ding, Lan Peng, Si -Yuan Chen, Jiong-Lin Liang, Zheng-Kai Feng, Tian-Liang Xia, Rui-Ling Xie, Rou Jiang, Chen-Mei Gu, Rong-Zeng Liu, Rui Sun, Xin Yang, Li-Zhi Liu, Li Ling, Qing Liu, Wai Tong Ng, Yi-Jun Hua, Pei-Yu Huang, Ming-Yuan Chen
Summary: This study compared the efficacy and safety of hyperfractionation with standard fractionation in intensity-modulated radiotherapy. The results showed that hyperfractionation significantly reduced the incidence of severe late complications and improved overall survival, suggesting that it could be used as the standard of care for patients with locally advanced recurrent nasopharyngeal carcinoma.
Article
Medicine, Research & Experimental
Rui You, Xiong Zou, Xi Ding, Wei-Jing Zhang, Meng-Xia Zhang, Xiao Wang, Han-Shi Xu, Yong-Long Liu, Yan-Feng Ouyang, Chong-Yang Duan, Chen-Mei Gu, Zhi-Qiang Wang, You-Ping Liu, Yi-Jun Hua, Pei Yu Huang, Ming-Yuan Chen
Summary: This study investigated the efficacy and safety of gemcitabine plus apatinib and toripalimab in RM-NPC, and found that this triple combination therapy exhibited promising antitumor activity and manageable toxicities. Patients with repeated radiotherapy and an interval of less than 12 months from the last radiotherapy should be carefully selected for antiangiogenic therapies.
Article
Oncology
Meng-Xia Zhang, Ting Liu, Rui You, Xiong Zou, Yong-Long Liu, Xi Ding, Chong-Yang Duan, Han-Shi Xu, You-Ping Liu, Rou Jiang, Zhi-Qiang Wang, Chao Lin, Yu-Long Xie, Si-Yuan Chen, Yan-Feng Ouyang, Ruo-Qi Xie, Yi-Jun Hua, Rui Sun, Pei-Yu Huang, Shun-Lan Wang, Ming-Yuan Chen
Summary: The study found that local therapy directed at liver and lung metastases from nasopharyngeal carcinoma can improve overall survival rates for patients, with a more significant benefit seen in liver and lung metastases. However, the survival benefits of local therapy for bone metastases were not as prominent, and a biological effective dose greater than 60 Gy was found to yield more survival benefit in these cases.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiajun Xie, Zifeng Wang, Wenjun Fan, Youping Liu, Fang Liu, Xiangbo Wan, Meiling Liu, Xuan Wang, Deshun Zeng, Yan Wang, Bin He, Min Yan, Zijian Zhang, Mengjuan Zhang, Zhijie Hou, Chunli Wang, Zhijie Kang, Wenfeng Fang, Li Zhang, Eric W-F Lam, Xiang Guo, Jinsong Yan, Yixin Zeng, Mingyuan Chen, Quentin Liu
Summary: The study reveals that EBV latent protein LMP1 induces cellular dedifferentiation and stem-like status by inhibiting histone acetylation of the CEBPA gene. HDAC inhibition can restore CEBPA expression and reverse this cellular status. This suggests a promising concept of differentiation therapy in solid tumors using HDAC inhibitors to target cellular plasticity.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Letter
Oncology
You-Ping Liu, Yi-Hui Wen, Ming-Yuan Chen, Wei-Ping Wen
Article
Oncology
Mei Lin, Qi Yang, Xiong Zou, Rui You, Chong-Yang Duan, You-Ping Liu, Pei-Yu Huang, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Yi-Jun Hua, Ming-Yuan Chen
Summary: The study found that biopsy of distant metastasis was not associated with impaired survival outcomes for nasopharyngeal carcinoma patients. Patients who underwent biopsy showed comparable survival rates to those who did not undergo biopsy. Therefore, biopsy of distant metastasis could be considered as another diagnostic option for patients with suspected distant metastasis.
Article
Medicine, Research & Experimental
Mei Lin, Xiao-Long Zhang, Xiong Zou, Rui You, Qi Yang, Xiong Zou, Kai Yu, You-Ping Liu, Ru-Hai Zou, Yi-Jun Hua, Pei-Yu Huang, Jin Wang, Qi Zhao, Xiao-Bing Jiang, Jun Tang, Yang-Kui Gu, Tao Yu, Gui-Ping He, Yu-Long Xie, Zhi-Qiang Wang, Ting Liu, Si-Yuan Chen, Zhi-Xiang Zuo, Ming-Yuan Chen
Summary: By sequencing samples from 26 nasopharyngeal carcinoma patients, it was found that NPC has a higher neoantigen load compared to other cancers. Neoantigen depletion was more severe in metastatic sites, with the reduction occurring during metastasis.