Opioid-induced inhibition of the human 5-HT and noradrenaline transporters in vitro : link to clinical reports of serotonin syndrome

Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)

(2018) Dino Luethi et al.   NEUROPHARMACOLOGY

Pharmacological profile of mephedrone analogs and related new psychoactive substances

(2018) Dino Luethi et al.   NEUROPHARMACOLOGY

Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats

(2017) Vijay Benade et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic Pain: How Challenging Are DDIs in the Analgesic Treatment of Inpatients with Multiple Chronic Conditions?

(2017) Klarissa Siebenhuener et al.   PLoS One

Evaluation of the route dependency of the pharmacokinetics and neuro-pharmacokinetics of tramadol and its main metabolites in rats

(2016) Behjat Sheikholeslami et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

(2015) Tuukka Saarikoski et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Relationship between plasma concentrations of the l-enantiomer of methadone and response to methadone maintenance treatment

(2015) Milo Meini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impact of fraction unbound, CYP3A, and CYP2D6 in vivo activities, and other potential covariates to the clearance of tramadol enantiomers in patients with neuropathic pain

(2015) Natália V. de Moraes et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates

(2015) Magnus Schou et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Opioid Concentrations in Oral Fluid and Plasma in Cancer Patients With Pain

(2015) Tarja Heiskanen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)

(2015) Anna Rickli et al.   NEUROPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

Transport Characteristics of Tramadol in the Blood–Brain Barrier

(2014) Atsushi Kitamura et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Effects of opioids on human serotonin transporters

(2014) M. Barann et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Clinical Pharmacokinetics of Morphine and Its Metabolites During Morphine Dose Titration for Chronic Cancer Pain

(2014) Simona De Gregori et al.   THERAPEUTIC DRUG MONITORING

Monoamine transporter and receptor interaction profiles of a new series of designer cathinones

(2013) L.D. Simmler et al.   NEUROPHARMACOLOGY

Pharmacological characterization of designer cathinonesin vitro

(2012) LD Simmler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

(2012) Tuukka Saarikoski et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Duloxetine Inhibits Effects of MDMA (“Ecstasy") In Vitro and in Humans in a Randomized Placebo-Controlled Laboratory Study

(2012) Cédric M. Hysek et al.   PLoS One

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

(2011) W. Schroder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats

(2011) P. Bloms-Funke et al.   NEUROSCIENCE LETTERS

Dextromethorphan, chlorphenamine and serotonin toxicity: case report and systematic literature review

(2010) Andrew A. Monte et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Population Pharmacokinetics of Tapentadol Immediate Release (IR) in Healthy Subjects and Patients with Moderate or Severe Pain

(2010) Xu Steven Xu et al.   CLINICAL PHARMACOKINETICS

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

Serotonin syndrome induced by dextromethorphan (Medicon) administrated at the conventional dose

(2010) Hiroyuki Kinoshita et al.   Geriatrics & Gerontology International

A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception

(2010) F.S. Hall et al.   NEUROSCIENCE

Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

(2010) Lucy A. Bee et al.   PAIN

Serotonin Syndrome Induced by Tramadol Intoxication in an 8-Month-Old Infant

(2010) Céline Maréchal et al.   PEDIATRIC NEUROLOGY

Meperidine-induced serotonin syndrome in a susceptible patient

(2009) S.-L. Guo et al.   BRITISH JOURNAL OF ANAESTHESIA

Dextromethorphan-induced serotonin syndrome

(2009) Anna R. Schwartz et al.   CLINICAL TOXICOLOGY

Effect of metabolic blockade on the psychoactive effects of dextromethorphan

(2009) Laurie A. Zawertailo et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice

(2009) Meredith A. Fox et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

(2009) Markus Fridén et al.   JOURNAL OF MEDICINAL CHEMISTRY