4-Hydroxynonenal-induced GPR109A (HCA2 receptor) activation elicits bipolar responses, Gαi -mediated anti-inflammatory effects and Gβγ -mediated cell death

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

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(2017) Ying Shi et al.   Scientific Reports

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(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7

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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

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Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells

(2012) Mary A. Zimmerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent Mechanisms

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Docosahexaenoic acid-induced unfolded protein response, cell cycle arrest, and apoptosis in vascular smooth muscle cells are triggered by Ca2+-dependent induction of oxidative stress

(2012) Slaven Crnkovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Short-term exposure of 4-hydroxynonenal induces mitochondria-mediated apoptosis in PC12 cells

(2012) MA Siddiqui et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

4-Hydroxynonenal Induces Mitochondrial-Mediated Apoptosis and Oxidative Stress in SH-SY5Y Human Neuronal Cells

(2011) Sunny O. Abarikwu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

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(2011) Sarah Gerlo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Calcium Signaling Is Involved in Cadmium-Induced Neuronal Apoptosis via Induction of Reactive Oxygen Species and Activation of MAPK/mTOR Network

(2011) Baoshan Xu et al.   PLoS One

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

(2010) Jens-Uwe Peters et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

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Protective Effects of Red Wine Flavonols on 4-Hydroxynonenal-Induced Apoptosis in PC12 Cells

(2009) Young Jin Jang et al.   Annals of the New York Academy of Sciences

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

Downregulation of p22phox in Retinal Pigment Epithelial Cells Inhibits Choroidal Neovascularization in Mice

(2008) Qiuhong Li et al.   MOLECULAR THERAPY

4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas†

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4-Hydroxynonenal–protein adducts: A reliable biomarker of lipid oxidation in liver diseases

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