The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats

Chemogenetic enhancement of functional recovery after a sciatic nerve injury

(2017) Poonam B. Jaiswal et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment

(2017) Anthony Burgos-Robles et al.   NATURE NEUROSCIENCE

The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management

(2017) Marco Venniro et al.   NEURON

Glutamatergic Projections from the Entorhinal Cortex to Dorsal Dentate Gyrus Mediate Context-Induced Reinstatement of Heroin Seeking

(2017) Feifei Ge et al.   NEUROPSYCHOPHARMACOLOGY

The Role of Mesolimbic Reward Neurocircuitry in Prevention and Rescue of the Activity-Based Anorexia (ABA) Phenotype in Rats

(2017) Claire J Foldi et al.   NEUROPSYCHOPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

(2017) Juan L. Gomez et al.   SCIENCE

Chemogenetic Inhibition of Pain Neurons in a Mouse Model of Osteoarthritis

(2017) Rachel E. Miller et al.   Arthritis & Rheumatology

A Chemogenetic Receptor That Enhances the Magnitude and Frequency of Glycinergic Inhibitory Postsynaptic Currents without Inducing a Tonic Chloride Flux

(2016) Robiul Islam et al.   ACS Chemical Neuroscience

Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors

(2016) Bin Ji et al.   JOURNAL OF NEUROSCIENCE

Role of Ventral Subiculum in Context-Induced Relapse to Alcohol Seeking after Punishment-Imposed Abstinence

(2016) N. J. Marchant et al.   JOURNAL OF NEUROSCIENCE

Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action

(2016) Fernanda Carvalho Poyraz et al.   JOURNAL OF NEUROSCIENCE

Divergent Routing of Positive and Negative Information from the Amygdala during Memory Retrieval

(2016) Anna Beyeler et al.   NEURON

The Rhesus Monkey Connectome Predicts Disrupted Functional Networks Resulting from Pharmacogenetic Inactivation of the Amygdala

(2016) David S. Grayson et al.   NEURON

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

179 Chemogenetic Stimulation of the Lumbar Locomotor Network Enhances Motor Function Following Experimental Cervical Spinal Cord Injury

(2016) Spyridon K. Karadimas et al.   NEUROSURGERY

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

(2016) Yuji Nagai et al.   Nature Communications

Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake

(2016) Ken-ichiro Nakajima et al.   Nature Communications

The First Structure–Activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs

(2015) Xin Chen et al.   ACS Chemical Neuroscience

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

(2015) Daniel J. Urban et al.   Annual Review of Pharmacology and Toxicology

Pharmacogenetic Excitation of Dorsomedial Prefrontal Cortex Restores Fear Prediction Error

(2015) J. O.-Y. Yau et al.   JOURNAL OF NEUROSCIENCE

Chemogenetic disconnection of monkey orbitofrontal and rhinal cortex reversibly disrupts reward value

(2015) Mark A G Eldridge et al.   NATURE NEUROSCIENCE

A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior

(2015) Eyal Vardy et al.   NEURON

Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats

(2015) Nathan J Marchant et al.   NEUROPSYCHOPHARMACOLOGY

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons

(2015) Daniel J Urban et al.   NEUROPSYCHOPHARMACOLOGY

Double Virus Vector Infection to the Prefrontal Network of the Macaque Brain

(2015) Mineki Oguchi et al.   PLoS One

Leptin Mediates the Increase in Blood Pressure Associated with Obesity

(2014) Stephanie E. Simonds et al.   CELL

Cre recombinase induces DNA damage and tetraploidy in the absence ofLoxPsites

(2014) Vaibhao Janbandhu et al.   CELL CYCLE

Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

(2014) Stephen V Mahler et al.   NATURE NEUROSCIENCE

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

(2014) Tevye J. Stachniak et al.   NEURON

Combined Use of the Canine Adenovirus-2 and DREADD-Technology to Activate Specific Neural Pathways In Vivo

(2014) Arjen J. Boender et al.   PLoS One

Chronic activation of a designer Gq-coupled receptor improves β cell function

(2013) Shalini Jain et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell-type specific inactivation of hippocampal CA1 disrupts location-dependent object recognition in the mouse

(2013) J. Haettig et al.   LEARNING & MEMORY

Distinct extended amygdala circuits for divergent motivational states

(2013) Joshua H. Jennings et al.   NATURE

A Gαs DREADD Mouse for Selective Modulation of cAMP Production in Striatopallidal Neurons

(2013) Martilias S Farrell et al.   NEUROPSYCHOPHARMACOLOGY

Reverse Pharmacogenetic Modulation of the Nucleus Accumbens Reduces Ethanol Consumption in a Limited Access Paradigm

(2013) Daniela Cassataro et al.   NEUROPSYCHOPHARMACOLOGY

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain

(2013) Dominik F. Aschauer et al.   PLoS One

Pharmacosynthetics: Reimagining the pharmacogenetic approach

(2012) Martilias S. Farrell et al.   BRAIN RESEARCH

RECENT ADVANCES IN RATIONAL APPROACHES FOR ENZYME ENGINEERING

(2012) Kerstin Steiner et al.   Computational and Structural Biotechnology Journal

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Chemical and Genetic Engineering of Selective Ion Channel-Ligand Interactions

(2011) C. J. Magnus et al.   SCIENCE

An Improved Ivermectin-activated Chloride Channel Receptor for Inhibiting Electrical Activity in Defined Neuronal Populations

(2010) Timothy Lynagh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

(2010) Susan M Ferguson et al.   NATURE NEUROSCIENCE

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

(2010) Shuyun Dong et al.   Nature Protocols

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

A chemical-genetic approach to study G protein regulation of β cell function in vivo

(2009) Jean-Marc Guettier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS