Article
Dermatology
Piergiorgio Malagoli, Paolo Dapavo, Giulia Pavia, Fabrizio Amoruso, Giuseppe Argenziano, Federico Bardazzi, Martina Burlando, Carlo G. Carrera, Giovanni Damiani, Valentina Dini, Giampiero Girolomoni, Claudio Guarneri, Francesco Loconsole, Alessandra Narcisi, Francesca Sampogna, Massimo Travaglini, Antonio Costanzo
Summary: Psoriasis is a common inflammatory skin disease that significantly impacts patients' quality of life. Ixekizumab, an effective and safe treatment, has been proven in clinical trials. By inhibiting inflammation, Ixekizumab can improve the clinical condition of psoriasis.
DERMATOLOGIC THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Yuan Wei, Xiao Xiao, Xiang-Ming Lao, Limin Zheng, Dong-Ming Kuang
Summary: The PD-1/PD-L1 axis is a crucial target for anti-tumor immunity in cancer patients, with potential for durable remission. However, challenges remain in broadening application, guiding personalized therapeutic strategies, and improving clinical responses. PD-L1 expression is regulated by multiple factors, with the host immune microenvironment playing a key role in determining clinical efficacy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Saiyang Xie, Si-Chi Xu, Wei Deng, Qizhu Tang
Summary: Cardiac aging is characterized by reduced function and is associated with heart failure. Recent studies have revealed the role of metabolic microenvironment in cardiovascular diseases. Metabolic pathways in cardiomyocytes and noncardiomyocytes contribute to cellular senescence in the aging heart. Cellular senescence has been implicated in cardiac injuries such as heart failure and myocardial ischemia and infarction. However, the complex metabolic status in aging hearts hinders the development of targeted strategies.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Review
Pharmacology & Pharmacy
Christopher R. Neil, Michael W. Seiler, Dominic J. Reynolds, Jesse J. Smith, Frederic H. Vaillancourt, Peter G. Smith, Anant A. Agrawal
Summary: The production of mature mRNA requires coordination of multiple processing steps, which control its content, localization, and stability. Recent advances in understanding the underlying mechanisms have led to a new wave of therapeutics seeking to target RNA processing, offering the potential for sequence-specific resolution in drug design.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Cell Biology
Mostafa Vaghari-Tabari, Gordon A. Ferns, Durdi Qujeq, Ali Nosrati Andevari, Zahra Sabahi, Soheila Moein
Summary: In cancerous cells, there are significant changes in signaling pathways and metabolism, which play a crucial role in promoting uncontrolled proliferation, resistance to apoptosis, and metastasis. Therapeutic approaches targeting cancer cell metabolism have become a focus in cancer treatment research.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Inna S. Afonina, Elien Van Nuffel, Rudi Beyaert
Summary: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation and aberrant differentiation of keratinocytes, leading to skin redness. The pathogenesis of psoriasis is still not completely understood, but genetic predisposition plays a significant role in its development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Yashika Tomar, Srividya Gorantla, Gautam Singhvi
Summary: Psoriasis is a chronic autoimmune skin disorder with complex etiology. Significant progress has been made in understanding the pathogenesis and treatment of psoriasis, including the role of different signaling pathways and the development of new molecules. This review also highlights the potential of nanotherapeutics in improving the efficacy of psoriasis treatment.
DRUG DISCOVERY TODAY
(2023)
Review
Immunology
Xu-Yue Zhou, Kun Chen, Jia-An Zhang
Summary: This article reviews the interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis, highlighting the important role of mast cell-centered cell networks in the development of psoriasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Benjamin Lockshin, Angel Cronin, Ryan W. Harrison, Robert R. McLean, Laura Anatale-Tardiff, Russel Burge, Baojin Zhu, William N. Malatestinic, Bilal Atiya, Mwangi J. Murage, Gaia Gallo, Bruce Strober, Abby Van Voorhees
Summary: In a study of real-world patients with psoriasis, initiators of ixekizumab had longer drug survival compared to initiators of TNF inhibitors and other IL-17 inhibitors, with persistence up to 2 years of follow-up.
DERMATOLOGIC THERAPY
(2021)
Review
Dermatology
Aaminah Azhar, Marcus Zaayman, Annika Silfvast-Kaiser, Dario Kivelevitch, Alan Menter, So Yeon Paek
Summary: Ixekizumab is a humanized monoclonal antibody approved for plaque psoriasis treatment, demonstrating superiority in clinical trials with no significant difference in side effects. Chronicity of psoriasis requires continual treatment for disease clearance.
DERMATOLOGIC THERAPY
(2021)
Review
Oncology
Elisha Hayden, Holly Holliday, Rebecca Lehmann, Aaminah Khan, Maria Tsoli, Benjamin S. Rayner, David S. Ziegler
Summary: DMGs are fatal pediatric brain tumors with inherent resistance to conventional therapy. Recent advances in understanding the molecular mechanisms have led to the identification of novel targets and the development of potential therapies, with several agents now in clinical translation to test their efficacy. This overview discusses current therapies targeting epigenetic and mutational drivers, cellular pathway aberrations, and tumor microenvironment mechanisms in DMGs, aiming to facilitate therapy development and a holistic approach to patient treatment.
Article
Dermatology
April Armstrong, David Amato, William Huster, Clement Ojeh, Abby S. Van Voorhees
Summary: The study found that ixekizumab, an interleukin 17 inhibitor, demonstrated high efficacy in treating patients with plaque psoriasis, achieving the treatment targets defined by NPF.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Immunology
Haoyu Liu, Zhicheng Wang, Yuntao Zhou, Yanming Yang
Summary: Women have a higher likelihood of developing breast cancer compared to other types of cancer. Various treatments including surgery, radiotherapy, chemotherapy, and immunotherapy are available based on the subtype and stage of breast cancer. Myeloid-derived suppressor cells (MDSCs) play a crucial role in promoting tumor growth and metastasis by suppressing the immune system and promoting non-immune mechanisms. MDSCs are strongly associated with poor prognosis and clinical progression in breast cancer, making them a potential target for therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rita Ribeiro, Maria Joao Carvalho, Joao Goncalves, Joao Nuno Moreira
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is more common in young pre-menopausal women. This review discusses the implications of TNBC's characteristics, such as its lack of hormone receptors and high tumor mutational burden, for diagnosis, treatment, and prognosis. It highlights the potential of immunotherapy as an alternative treatment for TNBC, including the use of immune gene signatures and tumor-infiltrating lymphocytes as biomarkers. The review also explores different formats of immunotherapy currently under clinical research, such as immune checkpoint inhibitors and antibody-drug conjugates.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Genetics & Heredity
Yunqing Zeng, Huimin Rong, Jianwei Xu, Ruyue Cao, Shuhua Li, Yanjing Gao, Baoquan Cheng, Tao Zhou
Summary: DNA methylation plays a significant role in the occurrence and development of gastric cancer, and research in this area is crucial for finding cancer biomarkers.
FRONTIERS IN GENETICS
(2022)
Review
Dermatology
Arvin Ighani, Arun C. R. Partridge, Neil H. Shear, Charles Lynde, Wayne P. Gulliver, Cathryn Sibbald, Patrick Fleming
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2019)
Article
Dermatology
Brittany A. M. Waller, Annie Liu, Patrick Fleming, Perla Lansang
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2019)
Review
Dermatology
Arunima Sivanand, Wayne P. Gulliver, Chitmandeep K. Josan, Raed Alhusayen, Patrick J. Fleming
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Avee Naidoo, Cathryn Sibbald, Patrick J. Fleming, Vincent Piguet
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Khalad Maliyar, Patrick Fleming, Boluwaji Ogunyemi, Charles Lynde
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Vijay Kumari Sandhu, Arvin Ighani, Patrick Fleming, Charles W. Lynde
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Article
Dermatology
Airiss R. Chan, Vijay K. Sandhu, Aaron M. Drucker, Patrick Fleming, Charles W. Lynde
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Yue Bo Yang, Charles W. Lynde, Patrick Fleming
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Matthew Ladda, Charles Lynde, Patrick Fleming
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Letter
Dermatology
Maria Leis, Patrick Fleming, Charles W. Lynde
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2021)
Letter
Dermatology
Anthony Zara, Patrick Fleming, Charles Lynde
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2020)
Review
Dermatology
Megan Lam, Angie Hu, Patrick Fleming, Charles W. Lynde
Summary: The study shows that acne treatment significantly affects the diversity of the skin microbiota, with different treatments leading to inconsistent changes in diversity. Variability in individual microbiome composition and heterogeneity in study sampling techniques may limit quantitative synthesis of results.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2022)
Editorial Material
Dermatology
P. Fleming
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Dermatology
Dong Goo Lee, Xi Yao Gui, Ilya Mukovozov, Patrick Fleming, Charles Lynde
Summary: Atopic dermatitis is linked to poor sleep and various health risks in children. A literature review identified two prevalent types of sleep disturbances in pediatric AD patients: loss of sleep and unusual behaviors during sleep. Pruritus, induced scratching, and increased proinflammatory markers were identified as potential mechanisms behind these sleep disturbances.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Meeting Abstract
Dermatology
Arunima Sivanand, Wayne P. Gulliver, Chitmandeep Josan, Raed Alhusayen, Patrick Fleming
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2019)
