Article
Neurosciences
Andrew J. Grottick, David L. MacQueen, Samuel A. Barnes, Chris Carroll, Erin K. Sanabria, Vishal Bobba, Jared W. Young
Summary: This study found consistent deficits in rats' performance in 5C-CPT across different laboratories when treated with MK-801, mirroring deficits seen in schizophrenia patients. Treatment with SKF38393, but not nicotine, was able to reverse these deficits. The 5C-CPT shows promise as a reliable method for detecting attention deficits induced by NMDA receptor disruption.
PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-Jeong Son, Min-Kyu Park, Hyeon-Jeong Park, Ha-Yeon Kim, Ye-Lim Jang, Young-Sim Choi, Jun-Gi Hwang, Ji-Hyung Seo, Yu-Kyong Kim
Summary: Compared to pelubiprofen, pelubiprofen tromethamine has improved solubility and absorption, combining the anti-inflammatory effect of pelubiprofen with the gastric protective function of tromethamine salt. The pharmacokinetic and pharmacodynamic characteristics of both substances were evaluated in healthy subjects, showing bioequivalence between 25 mg of pelubiprofen tromethamine and 30 mg of pelubiprofen. There was a trend of increased absorption and exposure for 30 mg of pelubiprofen tromethamine, but no significant pharmacodynamic variation compared to the reference.
Article
Anesthesiology
Hong Su, Douglas J. Eleveld, Michel M. R. F. Struys, Pieter J. Colin
Summary: We developed a mechanism-based pharmacodynamic model to quantitatively characterize the magnitude of propofol-induced hemodynamic effects during general anesthesia. This model has the potential to predict hemodynamic alterations and may have clinical implications.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Alfonsina D'Iorio, Gianpaolo Maggi, Chiara Baiano, Gabriella Santangelo
Summary: This study aimed to validate the Italian version of the alternative form (AF) of the PD-CRS (PD-CRS/AF) and collect normative values in a sample of Italian healthy adult and older population. The results showed significant associations between age and education level with total scores and sub-scores, while no significant effect of sex was revealed.
NEUROLOGICAL SCIENCES
(2022)
Article
Infectious Diseases
Yingying Hu, Qiong Wei, Xingchen Bian, Xinyi Yang, Jicheng Yu, Jingjing Wang, Haijing Yang, Guoying Cao, Xiaojie Wu, Jing Zhang
Summary: This study investigated the pharmacokinetics and safety of oral and intravenous lefamulin in healthy Chinese subjects, and evaluated the efficacy of the intravenous administration regimen. The results showed that lefamulin exhibited extensive distribution, and the PK parameters were consistent between oral and intravenous administration. The regimen was found to be microbiologically effective and well-tolerated.
Review
Pharmacology & Pharmacy
A. H. Alhowail
Summary: Prenatal nicotine exposure alters fetal brain development and impairs cognitive function in offspring, mainly through changes in nicotinic acetylcholine receptor subunits, reduction in neurogenesis, mitochondrial dysfunction, etc. These pathways may offer insights into potential molecular markers and therapeutic targets for cognitive dysfunction induced by prenatal nicotine exposure.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paola Piscopo, Valeria Manzini, Roberto Rivabene, Alessio Crestini, Loredana Le Pera, Elisabetta Pizzi, Caterina Veroni, Giuseppina Talarico, Martina Peconi, Anna Elisa Castellano, Carmelo D'Alessio, Giuseppe Bruno, Massimo Corbo, Nicola Vanacore, Eleonora Lacorte
Summary: Circulating non-coding RNAs, especially circular RNAs (circRNAs), show promise as biomarkers for Alzheimer's Disease (AD) diagnosis. Differential expression of circRNAs was observed in participants with AD compared to healthy controls, and these circRNAs are involved in processes related to the pathology of AD, such as nervous system development, protein phosphorylation, apoptosis, and inflammation pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Mohammed Sh Nadar, Abdullah M. Hasan, Mohammed Alsaleh
Summary: The study found that chronic tobacco smoking was associated with poorer performance across various neuropsychological domains, suggesting a negative impact on cognition. Smokers showed deficits in selective attention, alternating attention, memory functions, processing accuracy, and executive function compared to non-smokers. Smoking accumulation and an earlier onset of regular smoking were linked to lower neuropsychological function.
Article
Mathematics, Interdisciplinary Applications
Najmeh Pakniyat, Balamurali Ramakrishnan, V. Pallavi, Ondrej Krejcar, Robert Frischer, Hamidreza Namazi
Summary: This study analyzed the complexity of EEG signals in patients with mild cognitive impairment (MCI) compared to healthy individuals and found that the EEG signals of MCI patients were more complex. This analysis method can be used to compare brain activity between healthy individuals and patients with other brain disorders.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Chloe G. McKee, Madison Hoffos, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: As individuals age, microglia, the resident immune cells of the central nervous system (CNS), become less effective at preserving brain circuits. Increases in microglial inflammatory activity are thought to contribute to age-related declines in cognitive functions and to transitions toward mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia are currently underway, but important questions about target selectivity and microglial heterogeneity remain unanswered.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Junnan Zhang, Nianmin Shi, Guohua Li, Li Li, Yunhua Bai, Liqing Yang, Weimin Zhao, Jian Gao, Jingshuang Wei, Wei Zhao, Lili Zhai, Peiyuan Huo, Lemin Ren, Lan Yu, Yufeng Li
Summary: In this study, a population pharmacodynamic model was established to compare the neutralizing antibody activities of Ormutivimab and HRIG, alone or combined with the vaccine. The results showed that Ormutivimab induced a higher and faster peak of neutralizing antibodies compared to HRIG, and a target dose of 20 IU.kg(-1) was recommended for further studies.
Article
Pharmacology & Pharmacy
Jacob T. Beckley, Teresa K. Aman, Michael A. Ackley, Tatiana M. Kazdoba, Michael C. Lewis, Anne C. Smith, Brandon J. Farley, Jing Dai, Wayne Deats, Ethan Hoffmann, Albert J. Robichaud, James J. Doherty, Michael C. Quirk
Summary: This study identified a neuroactive steroid NMDA receptor PAM called SAGE-718, which improves conditions associated with NMDA receptor hypofunction by increasing channel open probability.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Jorge Esteban Santos Toural, Arquimedes Montoya Pedron, Enrique Juan Maranon Reyes
Summary: By using wavelet decomposition and EEG signals, the study successfully achieved automatic classification of Alzheimer's disease, mild cognitive impairment, and healthy subjects with an accuracy of 92.6%. This method could be the basis for implementing a diagnosis-support tool.
PATTERN ANALYSIS AND APPLICATIONS
(2021)
Article
Chemistry, Medicinal
Sejung Hwang, Dae Young Lee, Joo-Youn Cho, Jae-Yong Chung, In-Jin Jang, Kyung-Sang Yu, SeungHwan Lee
Summary: The study found that after multiple oral doses of DA-8031 at 20, 30, and 40 mg, the systemic exposure of DA-8031 increased in a more than dose-proportional manner and was generally well tolerated. In addition, the genetic polymorphisms of CYP2D6 have an impact on the pharmacokinetics of DA-8031.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
JungJin Oh, Eunsol Yang, In-Jin Jang, Hyejung Lee, Hokyun Yoo, Jae-Yong Chung, SeungHwan Lee, Jaeseong Oh
Summary: This study aimed to evaluate the pharmacodynamic and pharmacokinetic interactions between aspirin and fexuprazan in healthy Koreans. The results showed that the combination of fexuprazan and aspirin had no significant effect on platelet aggregation inhibitory activity and systemic exposure to aspirin. This finding suggests the potential of fexuprazan for the prevention of aspirin-induced gastrointestinal complications.
Article
Genetics & Heredity
Ruben P. A. van Eijk, Marinus J. C. Eijkemans, Stavros Nikolakopoulos, Marc D. Jansen, Henk-Jan Westeneng, Kristel R. van Eijk, Rick A. A. van der Spek, Joke J. F. A. van Vugt, Sanne Piepers, Geert-Jan Groeneveld, Jan H. Veldink, Leonard H. van den Berg, Michael A. van Es
PHARMACOGENOMICS JOURNAL
(2020)
Article
Neurosciences
Malik Bechakra, Mariska D. Nieuwenhoff, Joost van Rosmalen, Geert Jan Groeneveld, Frank J. P. M. Huygen, Chris de Zeeuw, Pieter A. van Doorn, Joost L. M. Jongen
Article
Pharmacology & Pharmacy
Kirsten Riber Bergmann, Karen Broekhuizen, Geert Jan Groeneveld
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Clinical Neurology
Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier, Niels D. Prins
ALZHEIMERS RESEARCH & THERAPY
(2020)
Review
Pharmacology & Pharmacy
Maurits F. J. M. Vissers, Adam F. Cohen, Joop M. A. Van Gerven, Geert Jan Groeneveld
Summary: The decision to halt and restart clinical trials during the COVID-19 pandemic must consider ethical principles, balance between pandemic control and clinical trial development, and not overly cautious. It is equally important to protect the rights of research participants and promote the development of new drugs in the current situation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marijke Hyke Algera, Erik Olofsen, Laurence Moss, Robert L. Dobbins, Marieke Niesters, Monique van Velzen, Geert Jan Groeneveld, Jules Heuberger, Celine M. Laffont, Albert Dahan
Summary: The study analyzed tolerance to the respiratory effects of fentanyl in chronic opioid users and opioid-naive individuals. Despite higher tolerance to fentanyl-induced respiratory depression in chronic users, apnea still occurred, indicating potential danger even in opioid-tolerant individuals.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pharmacology & Pharmacy
Marcus P. J. van Diemen, Ellen P. Hart, Anthony Abbruscato, Liz Mead, Ilse van Beelen, Sandrin C. Bergheanu, Pieter W. Hameeteman, Emma Coppen, Jessica Y. Winder, Matthijs Moerland, Hermien Kan, Jeroen van der Grond, Andrew Webb, Raymund A. C. Roos, Geert Jan Groeneveld
Summary: Huntington's disease is a neurodegenerative disease characterized by cognitive, motor and psychiatric symptoms. A study was conducted to evaluate the safety, pharmacokinetics and pharmacodynamics of a novel compound, SBT-020, in early stage HD patients. Although no significant improvement in mitochondrial function was observed overall with SBT-020 treatment, patients with higher level of mitochondrial dysfunction showed more improvement in a posthoc analysis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Samantha Prins, Thalia F. Doef, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Summary: HTL0018318 is a promising selective M-1 receptor partial agonist for the symptomatic treatment of cognitive and behavioural symptoms in Alzheimer's disease and other dementias, showing well-characterized pharmacokinetics and generally good tolerability in the studied dose range. However, there were no statistically significant effects on cognitive function detected in this study.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Jonas M. den Heijer, Arnoud Schmitz, Peter Lansbury, Valerie C. Cullen, Dana C. Hilt, Vincenzo Bonifati, Geert Jan Groeneveld
Summary: A study discovered a polymerase specific allelic imbalance phenomenon during GBA1 gene sequencing using next generation sequencing, which may lead to false-negative results. This issue was resolved by changing the specific polymerase, while variations in primer, annealing temperature, or DNA input did not affect allele frequency. Regions with low variant calling frequencies in GBA1 sequencing output may require additional attention in previous and future studies.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Jonas M. den Heijer, Annelieke C. Kruithof, Guido van Amerongen, Marieke L. de Kam, Eva Thijssen, Hendrika W. Grievink, Matthijs Moerland, Mike Walker, Kees Been, Renato Skerlj, Craig Justman, Lindsay Dudgeon, Peter Lansbury, Valerie C. Cullen, Dana C. Hilt, Geert Jan Groeneveld
Summary: The study demonstrated that LTI-291 was well tolerated in healthy volunteers when given orally once daily for 14 consecutive days. Pharmacokinetic results showed dose-proportional increases in C-max, AUC(0-24) and AUC(0-inf), with a median half-life of 28.0 hours after multiple dosing. No neurocognitive adverse effects were detected.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld
Summary: The failure rate for disease-modifying treatments in major neurodegenerative disorders has been nearly 100%, with many compounds failing in clinical trials due to lack of efficacy. This review proposes a roadmap for incorporating early biomarkers in DMT clinical trials to increase research and development productivity in an area with high unmet medical need.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Anesthesiology
Hemme J. Hijma, Pieter S. Siebenga, Marieke L. de Kam, Geert Jan Groeneveld
Summary: The study evaluated the analgesic potential, safety, tolerability, and pharmacokinetics of VX-150, a pro-drug of a highly selective Na(v)1.8 inhibitor, in healthy subjects. Results showed that VX-150 induced analgesia in various evoked pain tests without impacting subject safety, supporting its potential as a treatment for various pain indications.
Article
Anesthesiology
Ricardo Alvarez-Jimenez, Maud A. S. Weerink, Laura N. Hannivoort, Hong Su, Michel M. R. F. Struys, Stephan A. Loer, Pieter J. Colin
Summary: This study developed a nonlinear three-compartment pharmacokinetic model that accurately described dexmedetomidine plasma concentrations. Simulations showed that currently approved dosing regimens in the intensive care unit may potentially lead to higher-than-expected dexmedetomidine plasma concentrations.
Review
Chemistry, Analytical
Ahnjili ZhuParris, Annika A. de Goede, Iris E. Yocarini, Wessel Kraaij, Geert Jan Groeneveld, Robert Jan Doll
Summary: This narrative literature review provides an overview of the current development of biomarkers using mHealth technologies and machine learning. The reviewed publications offer recommendations for creating accurate, reliable, and interpretable biomarkers for the remote monitoring of CNS disorders. Further research and standardization of study designs are needed to advance this field.
Article
Clinical Neurology
Jonas M. den Heijer, Jacobus J. van Hilten, Anneke J. A. Kievit, Vincenzo Bonifati, Geert Jan Groeneveld
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)