Clinical trial simulations of the interaction between cannabidiol and clobazam and effect on drop‐seizure frequency

Drug–drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program

(2019) Tyler E. Gaston et al.   EPILEPSY & BEHAVIOR

Gaps in predicting clinical doses for cannabinoids therapy: Overview of issues for pharmacokinetics and pharmacodynamics modelling

(2018) Zheng Liu et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabis Contaminants - sources, distribution, human toxicity and pharmacologic effects

(2018) Laura M. Dryburgh et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Pharmacokinetics and the Pharmacodynamics of Cannabinoids

(2018) C.J. Lucas et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Clinical issues in cannabis use

(2018) Yvonne Bonomo et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The challenges of ‘medical cannabis’ and mental health: a clinical perspective

(2018) Giles Newton-Howes   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial

(2018) Elizabeth A Thiele et al.   LANCET

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome

(2018) Orrin Devinsky et al.   NEUROLOGY

Effect of Cannabidiol on Drop Seizures in the Lennox–Gastaut Syndrome

(2018) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Care and concern with cannabinoids used therapeutically

(2018) Jennifer H. Martin et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Interactions between cannabidiol and commonly used antiepileptic drugs

(2017) Tyler E. Gaston et al.   EPILEPSIA

Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome

(2017) Orrin Devinsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plant-Derived and Endogenous Cannabinoids in Epilepsy

(2016) Alberto Verrotti et al.   CLINICAL DRUG INVESTIGATION

Drug-drug interaction between clobazam and cannabidiol in children with refractory epilepsy

(2015) Alexandra L. Geffrey et al.   EPILEPSIA

Drug-metabolism mechanism: Knowledge-based population pharmacokinetic approach for characterizing clobazam drug-drug interactions

(2015) Dwain Tolbert et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Molecular Targets of Cannabidiol in Neurological Disorders

(2015) Clementino Ibeas Bih et al.   Neurotherapeutics

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability

(2014) Fabio Arturo Iannotti et al.   ACS Chemical Neuroscience

Clinical Trial Simulation: A Review

(2010) N Holford et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS