Article
Psychiatry
Matthieu Hein, Anais Mungo, Gwenole Loas
Summary: This study aimed to investigate the risk of relapse within 6 months in major depressed individuals with borderline personality disorder (BPD) treated with electroconvulsive therapy. The findings showed that there was a high risk of relapse within 6 months in major depressed individuals treated with electroconvulsive therapy, and BPD was identified as a risk factor for relapse.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Abigail Powers, Jessica M. Petri, Chelsea Sleep, Yara Mekawi, Emma C. Lathan, Karen Shebuski, Bekh Bradley, Negar Fani
Summary: There is debate about the validity of the complex posttraumatic stress disorder (CPTSD) diagnosis and whether disturbances in self-organization (DSO) in CPTSD can be differentiated from borderline personality disorder (BPD). Using exploratory structural equation modeling (ESEM), this study found distinguishing and overlapping features of ICD-11 PTSD, CPTSD, and BPD, emphasizing the importance of considering the diagnostic structure of PTSD in determining the distinctiveness of CPTSD as a construct.
JOURNAL OF ANXIETY DISORDERS
(2022)
Article
Psychiatry
Alvaro Cabral Araujo, Nickolas Carui, Alia Garrudo Guirado, Daniela Schiller, Francisco Lotufo Neto, Felipe Corchs
Summary: Delivering ECT after retrieving traumatic memories can enhance the treatment efficacy in PTSD by reducing symptoms and reactivity. Regardless of memory retrieval, the sample as a whole experienced reduction in anxiety, mood symptoms, and physiological reactivity to traumatic memories.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Luc Morin, Laurent Savale, Tai Pham, Romain Colle, Samy Figueiredo, Anatole Harrois, Matthieu Gasnier, Anne-Lise Lecoq, Olivier Meyrignac, Nicolas Noel, Elodie Baudry, Marie-France Bellin, Antoine Beurnier, Walid Choucha, Emmanuelle Corruble, Laurent Dortet, Isabelle Hardy-Leger, Francois Radiguer, Sabine Sportouch, Christiane Verny, Benjamin Wyplosz, Mohamad Zaidan, Laurent Becquemont, David Montani, Xavier Monnet
Summary: After 4 months of hospitalization for COVID-19, a significant proportion of patients reported new symptoms and abnormalities in lung scans were common. Further research is needed to understand the long-term consequences of COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Heather Burrell Ward, Agustin Yip, Rameez Siddiqui, Oscar G. Morales, Stephen J. Seiner, Shan H. Siddiqi
Summary: The study found that borderline personality traits did not significantly affect treatment response to transcranial magnetic stimulation for major depressive disorder, but had an impact on the response to electroconvulsive therapy.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Nikolaus Kleindienst, Regina Steil, Kathlen Priebe, Meike Mueller-Engelmann, Miriam Biermann, Thomas Fydrich, Christian Schmahl, Martin Bohus
Summary: This study demonstrates that psychotherapeutic treatment can effectively improve the full symptomatic spectrum of both BPD and PTSD for adults with a dual diagnosis. DBT-PTSD showed significant advantages in improving symptoms of PTSD, BPD, and dissociation.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2021)
Article
Clinical Neurology
Linda Steinholtz, Johan Reutfors, Lena Brandt, Pia Nordanskog, Elin Thornblom, Jonas Persson, Robert Boden
Summary: Response rates to electroconvulsive therapy in depression may be lower in patients with concurrent personality or anxiety disorders, but the majority of patients still respond positively. The impact of comorbidity decreases with higher age and severity of depressive episode; subjective ratings of memory impairment do not differ between patients with and without comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Nina Oginska-Bulik, Paulina Michalska
Summary: The study found that dimensions of type-D personality, including negative affectivity and social inhibition, were positively associated with depression and PTSD symptoms in adolescents exposed to trauma. Depression played a mediating role between type-D personality and PTSD, and PTSD also mediated the relationship between type-D personality and depression. Decreasing negative emotions and social inhibition tendencies may help reduce symptoms of depression and PTSD after trauma exposure.
CURRENT PSYCHOLOGY
(2021)
Article
Psychiatry
Serena Borroni, Elisabetta Masci, Chiara Franzoni, Antonella Somma, Andrea Fossati
Summary: The study found that the presence of adverse events does not necessarily lead to borderline personality disorder, and there may not be a co-occurrence of borderline personality disorder, complex PTSD, and PTSD. A significant association was only observed between complex PTSD and schizoid personality disorder.
PSYCHIATRY RESEARCH
(2021)
Review
Medicine, General & Internal
Martin Bohus, Jutta Stoffers-Winterling, Carla Sharp, Annegret Krause-Utz, Christian Schmahl, Klaus Lieb
Summary: Borderline personality disorder (BPD) is a complex mental disorder that often develops during adolescence and is associated with various negative outcomes. Early diagnosis and appropriate intervention, including psychotherapy, are crucial for improving treatment outcomes. Awareness of BPD among both specialists and non-specialists is important for providing effective care.
Article
Psychiatry
Thanos Karatzias, Martin Bohus, Mark Shevlin, Philip Hyland, Jonathan I. I. Bisson, Neil Roberts, Marylene Cloitre
Summary: Although complex post-traumatic stress disorder and borderline personality disorder are distinct disorders, there is confusion in clinical practice regarding their diagnostic profiles. We provide a summary of clinically informative differences in diagnostic criteria and use case studies to illustrate these differences, aiming to improve diagnostic accuracy in clinical practice.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Marco Cavicchioli, Lavinia Barone, Donatella Fiore, Monica Marchini, Paola Pazzano, Pietro Ramella, Ilaria Riccardi, Michele Sanza, Cesare Maffei
Summary: Maladaptive emotion regulation strategies may directly increase the risk of developing physical diseases, while certain metabolic and chronic conditions can impact emotional functioning through biological alterations. There is a high co-occurrence rate between borderline personality disorder and several chronic diseases, with dialectical behavior therapy playing a role in addressing problematic behaviors associated with emotion dysregulation and promoting physical health as a goal for a meaningful life.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Carolin Steuwe, Michaela Berg, Thomas Beblo, Martin Driessen
Summary: The study found that both NET and DBT-bt significantly improved symptoms in patients with comorbid BPD and PTSD, with no significant difference in improvement between the two treatments. However, NET had a higher remission rate than DBT-bt, and remission of PTSD was associated with remission of BPD in all cases.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Multidisciplinary
Gabriel Martin-Gagnon, Lina Normandin, Peter Fonagy, Karin Ensink
Summary: This study found that childhood emotional abuse is associated with adolescent borderline personality features, depression, and anxiety symptoms. Uncertainty/confusion about mental states mediates the relationships between childhood emotional abuse and these outcomes.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Marion A. Stopyra, Joe J. Simon, Christiane Rheude, Christoph Nikendei
Summary: Despite diagnostic overlap, complex posttraumatic stress disorder (CPTSD) is recognized as a distinct entity from simple posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). Neuroimaging studies may help differentiate these disorders, but direct comparisons are lacking. This review summarizes diagnostic differences and similarities and provides a qualitative comparison of neuroimaging findings.
REVIEWS IN THE NEUROSCIENCES
(2023)
Article
Neurosciences
Neda Rashidi-Ranjbar, Tarek K. Rajji, Colin Hawco, Sanjeev Kumar, Nathan Herrmann, Linda Mah, Alastair J. Flint, Corinne E. Fischer, Meryl A. Butters, Bruce G. Pollock, Erin W. Dickie, Christopher R. Bowie, Matan Soffer, Benoit H. Mulsant, Aristotle N. Voineskos
Summary: This study compared resting state functional connectivity in older adults with major depressive disorder (MDD) or mild cognitive impairment (MCI), and found that the alterations in functional connectivity in certain brain networks were associated with an increased risk of cognitive impairment.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Osnat C. Melamed, Sumeet Kalia, Rahim Moineddin, Michelle Greiver, Stefan Kloiber, Benoit H. Mulsant, Peter Selby, Braden G. O'Neill
Summary: This study aims to identify demographic, socioeconomic and medical factors associated with the initiation of antidepressant medication in adult patients with diabetes. The study found that younger age, female gender, insulin treatment, and polypharmacy were associated with higher odds of antidepressant initiation. Patients also had increased visits to primary care after antidepressant initiation.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Psychology, Clinical
Melissa Milanovic, Chelsea Wood-Ross, Meryl A. Butters, Corinne E. Fischer, Alastair J. Flint, Philip Gerretsen, Nathan Herrmann, Krista L. Lanctot, Linda Mah, Benoit H. Mulsant, Bruce G. Pollock, Tarek K. Rajji, Christopher R. Bowie
Summary: This study assessed the concordance between self-report and informant-report of cognitive decline, and compared them with objective cognitive and functional performance. The results showed a poor concordance between self-report and informant-report of cognitive decline in patients with mild cognitive impairment. Underestimators of cognitive decline had lower objective cognitive and functional performance. Cognitive performance significantly predicted functional performance in all groups, and this relationship was influenced by the discrepancy between self-report and informant-report.
Correction
Psychiatry
Tarek K. Rajji, David C. Mamo, Jason Holden, Eric Granholm, Benoit H. Mulsant
SCHIZOPHRENIA RESEARCH
(2023)
Article
Geriatrics & Gerontology
Emma Mastrobattista, Eric J. Lenze, Charles F. Reynolds, Benoit H. Mulsant, Julie Wetherell, Gregory F. Wu, Daniel M. Blumberger, Jordan F. Karp, Meryl A. Butters, Ana Paula Mendes-Silva, Erica L. Vieira, George Tseng, Breno S. Diniz
Summary: This study assessed the levels of GDF-15 in 393 older adults, including 308 with major depressive disorder (MDD) and 85 non-depressed individuals. The results showed that older adults with MDD had significantly higher levels of GDF-15, which were associated with physical comorbidity burden, cognitive decline, and late-onset depression.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Nicholas J. Ainsworth, Hailey Wright, Ksenya Tereshchenko, Daniel M. Blumberger, Alastair J. Flint, Eric J. Lenze, Athina Perivolaris, Benoit H. Mulsant
Summary: This study evaluated the effectiveness of online recruitment for a clinical trial of pharmacotherapy for late-life depression during COVID-19. The study found that provider referrals had a higher yield compared to Facebook self-referrals. Participants who self-referred from Facebook had higher education levels. Future research should assess the cost-effectiveness and potential barriers of online recruitment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Hanadi Ajam Oughli, Marie Anne Gebara, Adam Ciarleglio, Helen Lavretsky, Patrick J. Brown, Alastair J. Flint, Nuri B. Farber, Jordan F. Karp, Benoit H. Mulsant, Charles F. Reynolds, Steven P. Roose, Lei Yang, Meryl A. Butters, Eric J. Lenze
Summary: This pilot study suggests that repeated IV ketamine infusions are well-tolerated and associated with improvement in depression and executive function in older adults with TRD. These promising findings need to be confirmed and extended in a larger randomized controlled trial.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Article
Psychiatry
Alastair J. Flint, Kathleen S. Bingham, George S. Alexopoulos, Patricia Marino, Benoit H. Mulsant, Nicholas H. Neufeld, Anthony J. Rothschild, Aristotle N. Voineskos, Ellen M. Whyte, Barnett S. Meyers
Summary: This study aimed to identify a prediction model for the risk of relapse in psychotic depression and examine if predictors moderated the effect of treatment on relapse. The number of depressive episodes, severity of residual depressive symptoms, and psychomotor disturbance predicted the risk of relapse. Multivariable models had an accuracy of 69-70% in predicting relapse. Future research is needed to determine if a combination of clinical and biological variables can improve the accuracy of predicting relapse in psychotic depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Psychiatry
Brett D. M. Jones, Madeha Umer, Mary E. Kittur, Ofer Finkelstein, Siqi Xue, Mikaela K. Dimick, Abigail Ortiz, Benjamin I. Goldstein, Benoit H. Mulsant, Muhammad I. Husain
Summary: This systematic review examined the efficacy of dialectical behavior therapy (DBT) for mood symptoms in patients with bipolar disorder (BD), finding that DBT may be effective in improving core symptoms of BD. However, limited sample sizes, heterogeneity, and high risk of bias in the included trials limit the confidence in this conclusion. Larger, well-designed randomized controlled trials are needed to establish the effectiveness of DBT in BD.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Health Care Sciences & Services
Lenka Vojtila, Diana Sherifali, Rosa Dragonetti, Iqra Ashfaq, Scott Veldhuizen, Farooq Naeem, Sri Mahavir Agarwal, Osnat C. Melamed, Allison Crawford, Philip Gerretsen, Margaret Hahn, Sean Hill, Sean Kidd, Benoit Mulsant, Eva Serhal, Leah Tackaberry-Giddens, Carly Whitmore, Jennifer Marttila, Frank Tang, Seeta Ramdass, Gloria Lourido, Sanjeev Sockalingam, Peter Selby
Summary: This study aims to test the feasibility of a technology-enabled collaborative care (TECC) model for diabetes management and mental health support among adults with T2D. Thirty adults with T2D in Ontario, Canada will participate in an 8-week web-based health coaching program supported by a digital care team. The study results, expected to be available by the end of 2023, will provide valuable insights for supporting individuals with T2D and mental health challenges.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Jianmeng Song, Benoit H. Mulsant, Marcos Sanches, George S. Alexopoulos, Patricia Marino, Barnett S. Meyers, Anthony J. Rothschild, Aristotle N. Voineskos, Ellen M. Whyte, Alastair J. Flint, Philip Gerretsen, STOP-PD I. I. Study Group Behalf STOP PD II Study Grp
Summary: This study examined the relationship between participant characteristics and impaired insight into delusions in remitted psychotic depression, as well as whether impaired insight is associated with risk of relapse during continuation pharmacotherapy. The results showed that the severity of psychosis before treatment initiation was the only participant characteristic associated with the change in insight. Neither change in insight nor insight at the end of stabilization treatment predicted risk of relapse.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
Muhammad Ishrat Husain, Nicole Ledwos, Elise Fellows, Jenna Baer, Joshua D. Rosenblat, Daniel M. Blumberger, Benoit H. Mulsant, David J. Castle
Summary: This article reviews the mechanisms underlying the antidepressant effect of serotonergic psychedelics, including their serotonin 2A agonist effects, impact on brain derived neurotrophic factor and immunomodulatory responses, and disruption of the default mode network. However, further research is needed to validate these mechanisms and determine which theories are supported by robust evidence.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
M. Ishrat Husain, Imran B. Chaudhry, Ameer B. Khoso, Tayyeba Kiran, Nawaz Khan, Farooq Ahmad, John Hodsoll, M. Omair Husain, Haider A. Naqvi, Asad T. Nizami, Nasim Chaudhry, Hazrat A. Khan, Fareed Minhas, Jeffrey H. Meyer, Moin A. Ansari, Benoit H. Mulsant, Nusrat Husain, Allan H. Young
Summary: This study aimed to assess the efficacy and tolerability of adjunctive simvastatin in reducing depressive symptoms in treatment-resistant depression (TRD). The results showed no significant differences between the simvastatin group and the placebo group in primary and secondary outcomes, and there were also no significant differences in adverse effects between the two groups. Therefore, simvastatin did not provide additional therapeutic benefit for depressive symptoms in TRD.
Correction
Psychiatry
M. Ishrat Husain, Madeha Umer, Muqaddas Asif, Ameer B. Khoso, Tayyeba Kiran, Moin Ansari, Huma Aslam, Moti Ram Bhatia, Farasat A. Dogar, M. Omair Husain, Hazrat A. Khan, Ali A. Mufti, Benoit H. Mulsant, Farooq Naeem, Haider A. Naqvi, Claire de Oliveira, M. Sajjad Siddiqui, Asad Tamizuddin, Wei Wang, Juveria Zaheer, Nusrat Husain, Nasim Chaudhry, Imran B. Chaudhry
