Article
Psychology, Developmental
Sarah Nazzari, Pasco Fearon, Frances Rice, Massimo Molteni, Alessandra Frigerio
Summary: This study investigated the role of maternal caregiving in the association between multiple markers of maternal antenatal stress and infant stress regulation. The results provide the first evidence that maternal sensitive caregiving may eliminate the association between antenatal maternal cortisol and infant cortisol regulation.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Stefanie Krick, E. Scott Helton, Molly Easter, Seth Bollenbecker, Rebecca Denson, Rennan Zaharias, Phillip Cochran, Shia Vang, Elex Harris, James M. Wells, Jarrod W. Barnes
Summary: This study suggests that the reduced expression of ST6GAL1 and alpha 2-6 sialylation could lead to increased IL-6 expression and secretion in human bronchial epithelial cells (HBECs), and could be associated with poor clinical outcomes in COPD. Exposures to cigarette smoke or BACE1 inhibition resulted in decreased ST6GAL1 secretion, reduced alpha 2-6 sialylation, and increased IL-6 production in HBECs. Plasma ST6GAL1 levels demonstrated an inverse association with prospective acute exacerbations of COPD, while IL-6 was positively associated.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Juan Chen, Yanghui Wei, Weiqin Yang, Qingnan Huang, Yong Chen, Kai Zeng, Jiawei Chen
Summary: Breast cancer is a leading cause of female mortality, and IL-6 plays a crucial role in its regulation. Recent studies have shown promising outcomes for breast cancer treatment through combination therapy of IL-6 inhibitory antibodies with other drugs.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Luana Heimfarth, Marilia Matos Rezende, Erik Willyame Menezes Pereira, Fabiolla Rocha Santos Passos, Brenda Souza Monteiro, Tiffany Karoline Barroso Santos, Natalia Teles Lima, Isana Carla Leal Souza, Ricardo Luiz Cavalcanti de Albuquerque Junior, Pollyana de Souza Siqueira Lima, Adriano Antunes de Souza Araujo, Lucindo Jose Quintans Junior, Bonglee Kim, Henrique D. M. Coutinho, Jullyana de Souza Siqueira Quintans
Summary: Inflammatory arthritis is a common chronic inflammatory disease, and oral administration of BIS and β CD/BIS can significantly alleviate its symptoms, with the cyclodextrin inclusion complex also improving the pharmacological profile of the drug.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Lihua Zhang, Zhongliang Li, Changcheng Xing, Ning Gao, Rui Xu
Summary: This study found that HHcy synergistically aggravated arterial damage in hypertensive rats through immune/inflammatory response, while folate demonstrated anti-inflammatory properties and reversed the NF-kappa B p65/Rela/IL-6 levels induced by HHcy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang
Summary: This study suggests that Saikosaponin C (SSc), a traditional Chinese medicine compound, has potential therapeutic effects on depressive symptoms by reducing inflammatory cytokines levels, enhancing synaptic plasticity, and alleviating chronic social defeat stress-induced depression-like behavior in mice. The mechanism of action may involve the inhibition of DNMT1 protein expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Lucia Fedullo, Antonio Schiattarella, Maddalena Morlando, Anna Raguzzini, Elisabetta Toti, Pasquale De Franciscis, Ilaria Peluso
Summary: This review emphasizes the impact of the Mediterranean Diet on GDM and GWG during the COVID-19 era, as well as the role of IL-6 in diabesity. The Mediterranean Diet, rich in beneficial nutrients, improves the immune system, lowers IL-6 levels, and helps prevent the development of diabesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Danny Luan, Benyamin Dadpey, Jessica Zaid, Pania E. Bridge-Comer, Julia H. DeLuca, Wenmin Xia, Joshua Castle, Shannon M. Reilly
Summary: The bidirectional interaction between adipocytes and adipose tissue immune cells is crucial for regulating adipose function, inflammation, and insulin responsiveness. Obesity reduces cAMP-driven IL-6 secretion from adipocytes, but restoring their catecholamine sensitivity can stimulate IL-6 secretion and activate macrophages to promote an anti-inflammatory gene expression pattern.
Article
Immunology
Rita Haldar, Lee Shaashua Berger, Ella Rossenne, Arielle Radin, Anabel Eckerling, Elad Sandbank, Erica K. Sloan, Steve W. Cole, Shamgar Ben-Eliyahu
Summary: We demonstrated that minimally-invasive removal of primary tumors (PTs) and elimination of secreted factors can induce regression of micro-metastases in breast cancer. However, laparotomy during the procedure leads to an outbreak of micro-metastases. Administration of propranolol and etodolac can maintain metastatic dormancy following laparotomy.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Grzegorz Majka, Henryk Mazurek, Magdalena Strus, Marta Ciszek-Lenda, Rafal Szatanek, Agnieszka Pac, Edyta Golinska, Janusz Marcinkiewicz
Summary: The high concentration of sputum bacteria in cystic fibrosis patients with advanced lung disease is associated with increased levels of inflammatory markers and low levels of certain cytokines. Specific inflammatory biomarkers including blood CRP, NLR, and sputum elastase, IL-6, IL-8, and IL-10 are recommended for monitoring the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Yoo-Hun Noh, Junkee Hong, Ji-Won Lee, Sung-Su Kim, Il-Jun Kang, Wan Kyunn Whang, Soon-Chul Myung, Myung-Hee Chung, Moo-Ho Won
Summary: The mixture of Clematis mandshurica Rupr. and Erigeron annuus Pers., YES-10, has anti-inflammatory properties and can improve mental health by reducing depression and anxiety.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Pharmacology & Pharmacy
Liping Liao, Wenzhen Dang, Tingting Lin, Jinghua Yu, Tonghai Liu, Wen Li, Senhao Xiao, Lei Feng, Jing Huang, Rong Fu, Jiacheng Li, Liping Liu, Mingchen Wang, Hongru Tao, Hualiang Jiang, Kaixian Chen, Xingxing Diao, Bing Zhou, Xiaoyan Shen, Cheng Luo
Summary: PGK1 plays a role in immunometabolism by influencing metabolic status. The inhibitor DC-PGKI can suppress the activity of PGK1 and alleviate symptoms of inflammatory bowel disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang
Summary: Aberrant amino acid metabolism, particularly the excessive plasma kynurenine (Kyn), is common in obesity. This study demonstrates that overexpressed indoleamine 2,3-dioxygenase 1 (IDO1) in adipocytes is the primary source of excessive Kyn, highlighting the central role of adipocytes in Kyn metabolism. Depletion of Ido1 in adipocytes eliminates Kyn accumulation, protecting mice against obesity.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Erik L. Knight, Yanping Jiang, Jacqueline Rodriguez-Stanley, David M. Almeida, Christopher G. Engeland, Samuele Zilioli
Summary: Exposure to and perceptions of stress are associated with altered systemic inflammation, with diurnal cortisol slopes playing a role in linking self-reported psychological stress to inflammation. The results support an allostatic load model of psychosomatic health, highlighting the importance of cortisol in understanding the relationship between stress exposure, perceived stress, and immune functioning.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychology, Clinical
Whitney R. Ringwald, Miriam K. Forbes, Aidan G. C. Wright
Summary: This meta-analysis provides quantitative evidence supporting the validity of the HiTOP framework and confirms the placement of DSM diagnoses within transdiagnostic dimensions, highlighting its importance in conceptualizing and organizing psychopathology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Colin E. Vize, Whitney R. Ringwald, Elizabeth A. Edershile, Aidan G. C. Wright
Summary: This exploratory study examined the relationships between antagonism and its specific features with outcomes assessed using ecological momentary assessment (EMA) methods. The results showed consistent findings across different operationalizations of antagonism, along with more mixed results when it came to different measures of empathy. Future research directions for structural and functional accounts of antagonism were discussed.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Social
Aidan G. C. Wright, Christopher J. Hopwood
Summary: Authors in this Special Issue agreed that personality and psychopathology can be integrated within a common structure, which is important. However, distinguishing between the person and their mental health problems proved to be more challenging, as current methods are unable to adequately delineate these domains. Various directions for future research were recommended to develop more accurate measurement tools and tap different levels of behavior.
JOURNAL OF PERSONALITY
(2022)
Article
Psychology, Experimental
Nicholas C. Jacobson, Kelsey J. Evey, Aidan G. C. Wright, Michelle G. Newman
Summary: Researchers have debated the validity of discrete emotions versus global affect for a long time. This study integrates these perspectives by examining the structures of state emotions and trait affect across time. The results suggest that positive affect and negative affect can differentiate individuals, but at least seven differentiated emotions are experienced within individuals across time.
Review
Psychology, Clinical
Roman Kotov, David C. Cicero, Christopher C. Conway, Colin G. DeYoung, Alexandre Dombrovski, Nicholas R. Eaton, Michael B. First, Miriam K. Forbes, Steven E. Hyman, Katherine G. Jonas, Robert F. Krueger, Robert D. Latzman, James J. Li, Brady D. Nelson, Darrel A. Regier, Craig Rodriguez-Seijas, Camilo J. Ruggero, Leonard J. Simms, Andrew E. Skodol, Irwin D. Waldman, Monika A. Waszczuk, David Watson, Thomas A. Widiger, Sylia Wilson, Aidan G. C. Wright
Summary: The Hierarchical Taxonomy of Psychopathology (HiTOP) is a quantitative approach to psychiatric nosology that identifies psychopathology constructs based on patterns of co-variation among signs and symptoms. HiTOP is a living model that undergoes revision as new data become available. It has advantages in psychiatric practice and research and can contribute to progress in psychiatry and complement traditional nosologies. It also facilitates research on genetic and environmental causes of psychopathology, as well as the search for neurobiologic mechanisms and novel treatments. It has implications for public health programs and prevention of mental disorders.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Craig J. R. Sewall, Tina R. Goldstein, Aidan G. C. Wright, Daniel Rosen
Summary: Despite many studies, the link between digital-technology use and psychological distress among young adults remains uncertain. This study examined the long-term effects of digital-technology use on psychological distress among 384 young adults and found that most effects were not significant and very small, with no evidence to support the claim that digital-technology use is more harmful for women and/or younger people.
CLINICAL PSYCHOLOGICAL SCIENCE
(2022)
Article
Psychology, Social
Whitney R. Ringwald, Aleksandra Kaurin, Caitlin M. DuPont, Peter J. Gianaros, Anna L. Marsland, Matthew F. Muldoon, Aidan G. C. Wright, Stephen B. Manuck
Summary: The higher-order personality trait of Stability is associated with preclinical atherosclerosis and this association may be explained by correlated variations in cardiometabolic risk factors.
JOURNAL OF PERSONALITY
(2023)
Article
Psychology, Multidisciplinary
Brianna N. Natale, Stephen B. Manuck, Daniel S. Shaw, Karen A. Matthews, Matthew F. Muldoon, Aidan G. C. Wright, Anna L. Marsland
Summary: This study found an association between childhood socioeconomic disadvantage and increased risk for cardiometabolic disease in midlife. The relationship between childhood socioeconomic status and adult cardiometabolic risk was partially explained by higher levels of C-reactive protein, suggesting that systemic inflammation may contribute to socioeconomic disparities in cardiometabolic risk.
ANNALS OF BEHAVIORAL MEDICINE
(2023)
Article
Psychiatry
Whitney R. Ringwald, Michael N. Hallquist, Alexandre Y. Dombrovski, Aidan G. C. Wright
Summary: Emotional and behavioral variability are common characteristics of borderline personality disorder, which should be understood as a general personality pathology. This study clarified the conceptualization of BPD by examining variability in affect, interpersonal behavior, and perceptions of others.
JOURNAL OF PERSONALITY DISORDERS
(2022)
Article
Psychology, Clinical
Whitney R. Ringwald, Michael N. Hallquist, Alexandre Y. Dombrovski, Aidan G. C. Wright
Summary: Research shows that humans adapt to a dynamic environment while maintaining psychological equilibrium, and systems theories of personality suggest that generalized processes regulate stability by controlling a person's reactivity to different situations. Our study tested this hypothesis using ambulatory assessment and found that reactivity is strongly associated with stability and general personality pathology. These findings provide insight into how individuals fundamentally adapt to their environments and lay the groundwork for more practical models of human functioning.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Review
Immunology
Catherine P. Walsh, Emily K. Lindsay, Philip Grosse, Brianna N. Natale, Samantha Fairlie, Amanda Bwint, Luke Schaffer, Katie McMahon, Colin Del Duke, Jenny Forse, Noemi Lamonja-Vicente, Anna L. Marsland
Summary: Single assessments of inflammatory biomarkers may be sufficient for evaluating stable individual differences in the short term, while repeated measurements are recommended over intervals of 6 months to 3 years and absolutely necessary over intervals exceeding 3 years to reliably identify stable individual differences in health risk. These findings align with stability estimates and clinical recommendations for other cardiovascular risk measures.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Gertraud Maskarinec, Sayaka M. Brown, Jordyn Lee, David Bogumil, Catherine Walsh, Christopher A. Haiman, Veronica Wendy Setiawan, Yurii B. Shvetsov, Loic Le Marchand
Summary: This study found an association between T2D and NHL incidence in several subgroups but not in the total population, and identified excess body weight in early life as a predictor of NHL incidence.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Editorial Material
Psychology, Multidisciplinary
Aidan G. C. Wright, Whitney R. Ringwald, Christopher J. Hopwood, Aaron L. Pincus
Summary: The reply argues against the use of personality trait models as the preferred way to redefine personality disorders. While personality trait models are descriptive tools, they lack the ability to define and explain, making them unable to accurately define and differentiate personality disorders. In contrast, a specific interpersonal model is proposed and adopted in psychiatric classification.
AMERICAN PSYCHOLOGIST
(2023)
Article
Psychology, Clinical
Aleksandra Kaurin, Kevin M. King, Aidan G. C. Wright
Summary: Ecological momentary assessment (EMA) has become an important method in studying personality pathology, but there is little systematic work on its conceptual adequacy and cross-study consistency in personality disorder research. Researchers face core decisions in designing an EMA study, including density, depth, and duration. A review of relevant studies from 2000 to 2021 found that studies typically had around 6.5 assessments per day, with an average of 21 items, lasting for about 13 days. Generally, denser studies had less depth and shorter duration, while longer duration protocols tended to be deeper.
PERSONALITY DISORDERS-THEORY RESEARCH AND TREATMENT
(2023)
Article
Psychology, Social
Colin G. DeYoung, Michael Chmielewski, Lee Anna Clark, David M. Condon, Roman Kotov, Robert F. Krueger, Donald R. Lynam, Kristian E. Markon, Joshua D. Miller, Stephanie N. Mullins-Sweatt, Douglas B. Samuel, Martin Sellbom, Susan C. South, Katherine M. Thomas, David Watson, Ashley L. Watts, Thomas A. Widiger, Aidan G. C. Wright
Summary: The study introduces the Hierarchical Taxonomy of Psychopathology (HiTOP) as a dimensional classification system for describing psychopathology. It provides working definitions of symptoms and traits, highlighting the difference in time frame. The study discusses the implications of these definitions for understanding the relations between symptoms and traits, as well as the distinctions between psychopathology, normal personality variation, and dysfunction.
JOURNAL OF PERSONALITY
(2022)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)