Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
I. Daria Bogdan, D. L. Marinus Oterdoom, Teus van Laar, Rients B. Huitema, Vincent J. Odekerken, Judith A. Boel, Rob M. A. de Bie, J. Marc C. van Dijk
Summary: This study investigated the impact of unintentional high-frequency NBM-DBS on cognitive function in Parkinson's disease patients. The results showed that unintentional high-frequency NBM-DBS did not lead to significant cognitive decline. Further research is needed to determine the therapeutic role of NBM-DBS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Iago Garcia Diaz, Maria Cristina iniguez Alvarado, Jose Manuel Paz, Silvia Jesus, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernandez Vara, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Zebenzui Mendoza, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Seijo, Caridad Valero, Ruben Alonso Redondo, Maria Teresa Buongiorno, Carlos Ordas, Manuel Menendez-Gonzalez, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, A. D. Adarmes, A. D. Adarmes, M. Almeria, M. G. Alonso Losada, A. Alonso Canovas, F. Alonso Frech, R. Alonso Redondo, I. alvarez, M. alvarez Sauco, A. Aneiros Diaz, S. Arnaiz, S. Arribas, A. Ascunce Vidondo, M. Aguilar, M. A. avila, N. Nernardo Lambrich, H. Bejr-Kasem, M. Blazquez Estrada, M. Boti, C. Borrue, M. T. Buongiorno, C. Cabello Gonzalez, I. Cabo Lopez, N. Caballol, A. Camara Lorenzo, H. Canfield Medina, E. Carabajal Pendon, F. Carrillo, F. J. Carrillo Padilla, E. Casas, M. J. Catalan, P. Clavero, A. Cortina Fernandez, M. Cosgaya, A. Cots Foraster, A. Crespo Cuevas, E. Cubo, T. de Deus Fonticoba, O. de Fabregues-Boixar, M. Diez-Fairen, J. Dotor Garcia-Soto, E. Erro, S. Escalante, EEstelrich Peyret, N. Fernandez Guillan, P. Gamez, M. Gallego, J. Garcia Caldentey, C. Garcia Campos, C. Garcia Diez, J. M. Garcia Moreno, I. Gaston, M. P. Gomez Garre, V. Gomez Mayordomo, J. Gonzalez Aloy, I. Gonzalez-Aramburu, J. Gonzalez Ardura, B. Gonzalez Garcia, M. J. Gonzalez Palmas, G. R. Gonzalez Toledo, A. Golpe Diaz, M. Grau Sola, G. Guardia, J. Hernandez Vara, A. Horta-Barba, DIdoate Calderon, J. Infante, S. Jesus, J. Kulisevsky, M. Kurtis, C. Labandeira, M. A. Labrador, F. Lacruz, M. Lage Castro, S. Lastres Gomez, I. Legarda, NLopez Ariztegui, L. M. Lopez Diaz, D. Lopez Dominguez, L. Lopez Manzanares, B. Lopez Seoane, S. Lucas del Pozo, Y. Macias, M. Mata, G. Marti Andres, M. J. Marti, J. C. Martinez Castrillo, P. Martinez-Martin, D. McAfee, M. T. Meitin, Z. Mendoza Plasencia, M. Menendez Gonzalez, C. Mendez del Barrio, P. Mir, J. Miranda Santiago, M. I. Morales Casado, A. Moreno Dieguez, I. Muro Garcia, V. Nogueira, A. Novo Amado, S. Novo Ponte, C. Ordas, J. Pagonabarraga, I. Parees, B. Pascual-Sedano, P. Pastor, A. Perez Fuertes, R. Perez Noguera, A. Planas-Ballve, L. Planellas, M. A. Prats, C. Prieto Jurczynska, V. Puente, M. Pueyo Morlans, A. Puig Davi, N. Redondo Rafales, L. Rodriguez Mendez, ABRodriguez Perez, F. Roldan, M. Ruiz De Arcos, J. Ruiz Martinez, P. Sanchez Alonso, M. Sanchez-Carpintero, G. Sanchez Diez, A. Sanchez Rodriguez, P. Santacruz, D. Santos Garcia, J. C. Segundo Rodriguez, M. Seijo, M. Sierra Pena, B. Solano Vila, E. Suarez Castro, J. P. Tartari, C. Valero, L. Vargas, L. Vela, C. Villanueva
Summary: This study aimed to analyze the change in cognitive function in patients with young-onset Parkinson's disease (YOPD) compared to those with a later onset and controls. The results showed that YOPD patients had better cognitive function compared to non-YOPD patients and controls, while non-YOPD patients experienced a significant decline in cognitive function during the study. At the end of the study, the incidence of dementia and mild cognitive impairment was significantly higher in non-YOPD patients than in YOPD patients.
JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Miriam Goudsmit, Rocio Garcia-Ramos, Maria Jose Gil-Moreno, Maria Valles-Salgado, Maria Diez-Cirarda, Maria Dolores Zamarron-Cassinello, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: The Cross-Cultural Dementia (CCD) is a new screening tool that evaluates cognitive impairment from a cross-cultural perspective. It reduces the bias of education, language, and cultural differences. The CCD showed good discrimination properties and cut-off scores for dementia and extended its application to prodromal stages of Alzheimer's disease and Parkinson's disease.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Pengxu Wei
Summary: Alzheimer's pathology can be assessed using A beta and tau biomarkers. The preclinical period of the disease is long-lasting. While effective therapies for blocking the disease's pathological processes are lacking, developed countries have seen a decrease in the incidence and prevalence of dementia. Education, cognitive training, physical exercise, and a healthy lifestyle can protect cognitive function and promote healthy aging. Detection and intervention in the transitional cognitive decline stage may be more effective compared to the mild cognitive impairment (MCI) stage. New tools are needed for rapid screening of cognitive function.
Article
Psychology, Multidisciplinary
Hugo Juan Camilo Clavijo-Moran, Daniela Alvarez-Garcia, Gabriel D. Pinilla-Monsalve, Beatriz Munoz-Ospina, Jorge Orozco
Summary: This study investigated the cognitive assessment scale for patients with Parkinson's disease in the Colombian population and found that the Parkinson's Disease Cognitive Rating Scale (PD-CRS) has acceptable psychometric properties and significant correlation and agreement with another validated scale (MoCA).
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Michal Lubomski, Ryan L. Davis, Carolyn M. Sue
Summary: Cognitive impairment in Parkinson's disease patients is more common than in their caregivers. Caregivers with cognitive impairment have lower quality of life, which also affects the quality of life and mood of the respective PD patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Endocrinology & Metabolism
Sini Toppala, Laura L. Ekblad, Matti Viitanen, Juha O. Rinne, Antti Jula
Summary: The study found that higher 2-hour glucose values in the OGTT were associated with worse performance in the word-list delayed recall test after 10 years. This suggests that 2-hour glucose values may predict a decline in episodic memory 10 years later.
Article
Clinical Neurology
Aleksandra A. Szwedo, Ingvild Dalen, Kenn Freddy Pedersen, Marta Camacho, David Backstrom, Lars Forsgren, Charalampos Tzoulis, Sophie Winder-Rhodes, Gavin Hudson, Ganqiang Liu, Clemens R. Scherzer, Rachael A. Lawson, Alison J. Yarnall, Caroline H. Williams-Gray, Angus D. Macleod, Carl E. Counsell, Ole-Bjorn Tysnes, Guido Alves, Jodi Maple-Grodem
Summary: This study conducted a pooled analysis of six cohorts of newly diagnosed PD patients and found that APOE-ε4 and GBA mutations are closely associated with cognitive decline and risk of dementia in PD. The risk is even higher in patients carrying both genetic variants. However, no significant effects were observed for MAPT and SNCA rs356219 in PD cognitive decline.
MOVEMENT DISORDERS
(2022)
Review
Neurosciences
Laura Glass Umfleet, Robert M. Bilder, David W. Loring, April Thames, Benjamin M. Hampstead, Russell M. Bauer, Daniel L. Drane, Lucia Cavanagh
Summary: Cognitive screening instruments (CSI) have limited effectiveness for detecting dementia in older adults living in the community. This article proposes a framework for transitioning from traditional CSI to advanced dementia screening methods that incorporate psychometrics, neuroscience, and technology. A psychometrically advanced, automated selective assessment model utilizing item response theory is suggested for an assessment revolution. The article also discusses the modernization of CSIs, diversity and inclusion issues, challenges in differentiating normal from pathological aging, and ethical considerations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Sara Becker, Olga Boettinger, Patricia Sulzer, Markus A. Hobert, Kathrin Brockmann, Walter Maetzler, Daniela Berg, Inga Liepelt-Scarfone
Summary: Through FAQ assessment, it was found that PD-MCI patients had more difficulties with tax records and traveling, while AD-MCI patients were more impaired in managing finances and remembering appointments. The classification accuracy of the FAQ differed between MCI related to PD and AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Conor Owens-Walton, Chris Adamson, Mark Walterfang, Sara Hall, Danielle Westen, Oskar Hansson, Marnie Shaw, Jeffrey C. L. Looi
Summary: People diagnosed with Parkinson's disease can experience cognitive impairment and dementia, which may be related to structural changes in the corpus callosum. This study used magnetic resonance imaging to investigate the thickness of the corpus callosum and cortex in Parkinson's disease patients with varying levels of cognitive impairment. The results showed thinning of the callosum in patients with dementia, and a positive correlation between the thickness of the anterior callosum and the thickness of the cortex in patients with mild cognitive impairment.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Carel F. W. Peeters, Adriaan W. Hoogendoorn, Rob H. Hagen, Tanja Berk, Odile A. van den Heuvel, Chris Vriend
Summary: This study found no beneficial effect of eight-week computerized cognitive training on the primary outcome (planning accuracy) and only minor improvements on secondary outcomes (processing speed) with limited clinical impact.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Geriatrics & Gerontology
Michelle H. Zonneveld, Denise Abbel, Saskia le Cessie, J. Wouter Jukema, Raymond Noordam, Stella Trompet
Summary: This systematic review examined the association between cardiac troponin, cognitive function, and dementia. The findings suggest that elevated troponin is associated with cognitive impairment, increased risk of dementia, and higher prevalence of dementia hospitalization, specifically due to vascular dementia.
Review
Geriatrics & Gerontology
Juan Huang, Xingxing Yuan, Lin Chen, Binbin Hu, Lijuan Jiang, Ting Shi, Hui Wang, Wei Huang
Summary: Cognitive impairment in Parkinson's disease worsens prognosis and causes burdens for caregivers and economic consequences. Subjective cognitive decline (SCD) has been regarded as an at-risk state for mild cognitive impairment (MCI) and a prodromal stage for dementia in Alzheimer's disease (AD). However, there is a lack of consensus on the definition and evaluation of SCD in Parkinson's disease (PD). This review found an association between PD-SCD and objective cognitive function, suggesting the importance of establishing a guideline for defining and evaluating SCD in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Statistics & Probability
Ryuji Uozumi, Shinjo Yada, Kazushi Maruo, Atsushi Kawaguchi
Summary: This paper proposes a simple method to construct confidence intervals for the difference between binomial proportions based on parameter estimates of logistic regression, and suggests that the score-based confidence interval is a recommended method for sensitivity analysis in randomized clinical trials.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2022)
Article
Geriatrics & Gerontology
Yosuke Osuka, Yoshiro Okubo, Yu Nofuji, Hiroyuki Sasai, Satoshi Seino, Kazushi Maruo, Yoshinori Fujiwara, Hiroyuki Oka, Shoji Shinkai, Stephen R. Lord, Hunkyung Kim
Summary: This study identified modifiable intrinsic factors related to falls during occupational activities among older workers. The use of fall-risk-increasing medications, reduced functional strength, poor standing balance, and poor visuospatial ability were independently associated with occupational falls.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Takashi Kawahara, Koji Kawai, Takahiro Kojima, Yoshiyuki Nagumo, Shotarou Sakka, Shuya Kandori, Hiromitsu Negoro, Bryan J. Mathis, Kazushi Maruo, Koji Miura, Noriaki Sakamoto, Nobuo Shinohara, Shinichi Yamashita, Kan Yonemori, Takeshi Kishida, Osamu Ukimura, Kazuo Nishimura, Yasuyuki Kobayashi, Hiroyuki Nishiyama
Summary: This phase II study evaluated the efficacy and safety of nivolumab for relapsed germ cell tumor. The results showed that tumor mutation burden may be a potential biomarker for assessing the response of germ cell tumors.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Clinical Neurology
Terunori Sano, Tomoya Kawazoe, Ayako Shioya, Madoka Mori-Yoshimura, Yasushi Oya, Kazushi Maruo, Ichizo Nishino, Mikio Hoshino, Shigeo Murayama, Yuko Saito
Summary: This study is the first to report unique Lewy pathology in patients with myotonic dystrophy type 1 (DM1), which differs from the typical form of Lewy pathology. The distribution of Lewy pathology in the brain of DM1 patients is distinct and does not follow the traditional pattern of Lewy pathology progression.
Article
Surgery
Yoshiro Ito, Eiichi Ishikawa, Masayuki Sato, Aiki Marushima, Mikito Hayakawa, Kazushi Maruo, Tomoji Takigawa, Noriyuki Kato, Wataro Tsuruta, Kazuya Uemura, Yuji Matsumaru
Summary: This study investigated the clinical outcomes of carotid artery stenting (CAS) performed at institutions that selected the treatment strategy based on risk factors and those that performed CAS as the first-line treatment. The results showed that the CAS-specific treatment strategies can achieve the same level of outcomes as the treatment strategy based on risk factors.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Article
Clinical Neurology
Noriko Nishikawa, Miho Murata, Taku Hatano, Yohei Mukai, Yuji Saitoh, Takashi Sakamoto, Takashi Hanakawa, Yuichi Kamei, Hisateru Tachimori, Kenji Hatano, Hiroshi Matsuda, Yosuke Taruno, Nobukatsu Sawamoto, Yuta Kajiyama, Kensuke Ikenaka, Kazuya Kawabata, Tomohiko Nakamura, Hirotaka Iwaki, Hiroshi Kadotani, Yukiyoshi Sumi, Yuichi Inoue, Toshihiro Hayashi, Takeshi Ikeuchi, Yasushi Shimo, Hideki Mochizuki, Hirohisa Watanabe, Nobutaka Hattori, Yuji Takahashi, Ryosuke Takahashi
Summary: iRBD is a specific prodromal symptom of synucleinopathies, including PD. The J-PPMI study aimed to investigate biomarkers in Japanese iRBD patients. DaT and MIBG were found to be important biomarkers for confirming synucleinopathies, with a majority of patients meeting PD diagnostic criteria.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Risa Yamada, Ayumu Wada, Andrew Stickley, Yuma Yokoi, Tomiki Sumiyoshi
Summary: A systematic review and meta-analysis found that add-on therapy with 5-HT1A receptor partial agonists improved overall psychotic symptoms and positive symptoms in patients with schizophrenia. The therapy also had a positive effect on attention/processing speed. Further clinical trials are needed to determine its benefits.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yusuke Yamaguchi, Kentaro Takeda, Satoshi Yoshida, Kazushi Maruo
Summary: With the development of molecular targeted agents and immunotherapies in cancer treatment, the concept of optimal biological dose (OBD) has been introduced to phase I oncology clinical trials. Dose-escalation rules based on both toxicity and efficacy are used to establish the OBD, but the best approach for selecting the OBD is still uncertain. In this study, a simulation was conducted to evaluate different OBD selection approaches and their operating characteristics.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS
(2023)
Review
Public, Environmental & Occupational Health
Masahiko Gosho, Tomohiro Ohigashi, Kengo Nagashima, Yuri Ito, Kazushi Maruo
Summary: Logistic regression models can lead to bias in sparse data, but Bayesian methods can reduce the bias and are suitable for sparse data analysis. Simulation and real data analysis show that the hyper-g prior modeling and log F-type priors can reduce the bias, but the choice of method depends on the null and alternative hypotheses.
JOURNAL OF EPIDEMIOLOGY
(2023)
Correction
Public, Environmental & Occupational Health
Masahiko Gosho, Tomohiro Ohigashi, Kengo Nagashima, Yuri Ito, Kazushi Maruo
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Y. Osuka, Y. Okubo, Y. Nofuji, K. Maruo, Y. Fujiwara, H. Oka, S. Shinkai, S. R. Lord, H. Sasai
Summary: A valid and reliable Occupational Fall Risk Assessment Tool (OFRAT) was developed to assess the risk of occupational falls in older workers.
OCCUPATIONAL MEDICINE-OXFORD
(2023)
Article
Mathematical & Computational Biology
Masahiko Gosho, Ryota Ishii, Hisashi Noma, Kazushi Maruo
Summary: Using GEE can lead to biased regression coefficients for small samples or sparse data. BCGEE and PGEE were proposed as solutions to correct the bias in small samples. Modified covariance estimators have also been proposed to address the bias in standard error. This study reviewed the performance of modified GEEs and covariance estimators in sparse binary data from small-sample longitudinal studies.
STATISTICS IN MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Yuta Nemoto, Shinichiro Sato, Yoshinori Kitabatake, Noriko Takeda, Kazushi Maruo, Takashi Arao
Summary: It is unclear whether mentally active sedentary behavior (MASB) and passive sedentary behavior (PSB) have differential effects on cognitive function and whether these associations differ according to physical activity level.
JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Neurosciences
Miho Ota, Noriko Sato, Moto Nakaya, Yoko Shigemoto, Yukio Kimura, Emiko Chiba, Yuma Yokoi, Tadashi Tsukamoto, Hiroshi Matsuda
Summary: Tau protein accumulation in the brain is believed to be a contributing factor to Alzheimer's disease (AD). Recent research has found that the choroid plexus (CP) plays a role in clearing β-amyloid and tau proteins in the brain. In this study, the relationships between CP volume and the deposition of β-amyloid and tau proteins were evaluated. The results showed a positive correlation between CP volume and the uptake of β-amyloid and tau proteins/inflammatory markers, suggesting that CP volume could serve as a biomarker for assessing tau deposition and neuroinflammation.
Article
Orthopedics
Taeko Fukuda, Shinobu Imai, Kazushi Maruo, Hiromasa Horiguchi
Summary: A prediction model for low functional status following colorectal cancer surgery was developed, and the relationship between low functional status and outcomes was investigated. The study found that low-ADL patients had lower rates of discharge to homes, longer hospital stays, and higher medical costs. Therefore, pre-operative prediction of low ADL status is important for taking efficient preventive measures.
INTERNATIONAL JOURNAL OF SURGERY OPEN
(2023)
