Article
Immunology
Joseph A. Lewnard, Noga Givon-Lavi, Ron Dagan
Summary: The study analyzed the effectiveness of PCV in protecting children against pneumonia caused by different vaccine-targeted pneumococcal serotypes in southern Israel. The results showed that PCV could effectively reduce carriage of vaccine-serotype pneumococci and decrease the risk of disease progression.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Karin Hansen, Elisabeth Runow, Gustav Torisson, Christian Theilacker, Andreas Palmborg, Kaijie Pan, Qin Jiang, Jo Southern, Rohini Beavon, Bradford D. Gessner, Kristian Riesbeck, Jonas Ahl
Summary: The serotype distribution and potential coverage of pneumococcal conjugate vaccines (PCVs) in adults with community-acquired pneumonia (CAP) in Sweden were unknown. This study found that PCV20 expands the coverage of all-cause CAP compared to PCV13, indicating its potential effectiveness in preventing CAP caused by Streptococcus pneumoniae.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Kristina L. Bajema, Ryan Gierke, Monica M. Farley, William Schaffner, Ann Thomas, Arthur L. Reingold, Lee H. Harrison, Ruth Lynfield, Kari E. Burzlaff, Susan Petit, Meghan Barnes, Salina Torres, Paula M. Snippes Vagnone, Bernard Beall, Tamara Pilishvili
Summary: The incidence of antibiotic-nonsusceptible invasive pneumococcal disease (NS-IPD) has decreased in the United States after the introduction of 7- and 13-valent pneumococcal conjugate vaccines (PCVs). However, there has been an increase in nonvaccine type NS-IPD, particularly among older adults. The use of higher valency PCVs containing the common nonsusceptible serotypes could help further reduce NS-IPD.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Christopher C. Blyth, Kathryn J. Britton, Cattram D. Nguyen, Joycelyn Sapura, John Kave, Birunu Nivio, Jocelyn Chan, Catherine Satzke, Rebecca Ford, Wendy Kirarock, Deborah Lehmann, William Pomat, Fiona M. Russell
Summary: This study evaluates the effectiveness of the 13-valent pneumococcal conjugate vaccine (13vPCV) in reducing hypoxic pneumonia and hospitalization in children in Eastern Highlands Province, Papua New Guinea (PNG).
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Immunology
Carlos A. Sanchez, Michelle Lozada-Urbano, Pablo Best-Bandenay
Summary: This study analyzed the impact of conjugated pneumococcal vaccines (PCVs) on pneumonia mortality among young children in Peru. The results showed a decrease in pneumonia mortality rates for children between 1-4 years of age and infants after the introduction of PCVs. There was an inflection point in 2013 for infants, but not for toddlers/preschoolers, suggesting a difference in the impact of PCVs for each age group.
Article
Immunology
Brandon Essink, Charu Sabharwal, Kevin Cannon, Robert Frenck, Himal Lal, Xia Xu, Vani Sundaraiyer, Yahong Peng, Lisa Moyer, Michael W. Pride, Ingrid L. Scully, Kathrin U. Jansen, William C. Gruber, Daniel A. Scott, Wendy Watson
Summary: The 20-valent pneumococcal conjugate vaccine (PCV20) has shown to be safe and well tolerated, with immunogenicity comparable to that of the 13-valent pneumococcal conjugate vaccine or 23-valent polysaccharide vaccine. PCV20 is expected to provide expanded protection against pneumococcal disease in adults.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Kathryn J. Britton, Janessa L. Pickering, William S. Pomat, Camilla de Gier, Monica L. Nation, Casey L. Pell, Caitlyn M. Granland, Vela Solomon, Rebecca L. Ford, Andrew Greenhill, Jason Hinds, Hannah C. Moore, Peter C. Richmond, Christopher C. Blyth, Deborah Lehmann, Catherine Satzke, Lea-Ann S. Kirkham
Summary: The study found that in Papua New Guinea, PCV13 had no impact on pneumococcal carriage density, even for vaccine serotypes. The low prevalence of vaccine serotypes, high pneumococcal carriage density, and abundance of non-vaccine serotypes likely contribute to the lack of PCV13 impact on carriage in Papua New Guinean infants.
Article
Microbiology
Andrea Orsi, Alexander Domnich, Stefano Mosca, Matilde Ogliastro, Laura Sticchi, Rosa Prato, Francesca Fortunato, Domenico Martinelli, Fabio Tramuto, Claudio Costantino, Vincenzo Restivo, Vincenzo Baldo, Tatjana Baldovin, Elizabeth Begier, Christian Theilacker, Eva Agostina Montuori, Rohini Beavon, Bradford Gessner, Giancarlo Icardi
Summary: This study aimed to assess the serotype-specific epidemiology of pneumococci among hospitalized older adults in Italy. The prevalence of pneumococcal infection among hospitalized CAP cases was 13.1%, with serotypes 3, 8, 22F, and 11A being the most common. PCV20, which includes these serotypes, plays an important role in preventing pneumonia in older adults.
Review
Immunology
Kristin Andrejko, Buddhika Ratnasiri, Joseph A. Lewnard
Summary: This study reviewed the antimicrobial susceptibility of pneumococcal serotypes among children globally. The results showed geographical and temporal variation in nonsusceptibility, which was associated with biological characteristics of the serotypes. The implementation of PCVs led to an increase in nonsusceptibility among non-PCV serotypes.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Kevin Cannon, Charles Elder, Mariano Young, Daniel A. Scott, Ingrid L. Scully, Gary Baugher, Yahong Peng, Kathrin U. Jansen, William C. Gruber, Wendy Watson
Summary: The study demonstrated that PCV20 is well tolerated and immunogenic in adults over 65 years of age with a history of different pneumococcal vaccine regimens, showing robust immune responses to the 20 vaccine serotypes a month after vaccination.
Article
Immunology
Shahira Shahid, Amala Khan, Muhammad Imran Nisar, Farah Khalid, Muhammad Farrukh Qazi, Sheraz Ahmed, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Syed Asad Ali, Cynthia G. Whitney, Anita K. M. Zaidi, Fyezah Jehan
Summary: The 10-valent pneumococcal vaccine was introduced in Pakistan's Expanded Program on Immunization (EPI) in 2013. Three annual cross-sectional surveys were conducted from 2014-2016, showing a significant decrease in vaccine-type carriage in infants.
Article
Immunology
Haruka Maeda, Bhim Gopal Dhoubhadel, Eiichiro Sando, Motoi Suzuki, Akitsugu Furumoto, Norichika Asoh, Makito Yaegashi, Masahiro Aoshima, Masayuki Ishida, Sugihiro Hamaguchi, Yoshihito Otsuka, Konosuke Morimoto
Summary: The introduction of pediatric pneumococcal conjugate vaccines (PCVs) in Japan has reduced pneumococcal pneumonia and invasive disease caused by PCV-covered serotypes among children and adults. However, the long-term impact of PCV use in children on adult pneumococcal pneumonia in Japan remains unclear.
Article
Immunology
Ron Dagan, Qin Jiang, Christine Juergens, James Trammel, William C. Gruber, Daniel A. Scott
Summary: This study found that carrier-induced hyporesponsiveness to PCVs is common among infants, varies by serotype, and is influenced by the timing of carriage acquisition and the number of PCV doses administered. The immune response was consistently lower for certain serotypes carried before or at the time of vaccination, while other serotypes did not generally affect immune responses. Additionally, the study identified a complex interrelationship between carriage and immune response among cross-reacting serotypes.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Brandon Essink, James Peterson, Kari Yacisin, Himal Lal, Sarah Mirza, Xia Xu, Ingrid L. Scully, Daniel A. Scott, William C. Gruber, Kathrin U. Jansen, Wendy Watson
Summary: This study evaluated the safety and immunogenicity of the pneumococcal polysaccharide vaccine cPCV7 in healthy adults aged 50-85 years. The results showed that cPCV7 was safe, well tolerated, and elicited immune responses in adults in this age group.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Infectious Diseases
Jordi Camara, Inmaculada Grau, Aida Gonzalez-Diaz, Fe Tubau, Laura Calatayud, Meritxell Cubero, M. Angeles Dominguez, Josefina Linares, Jose Yuste, Roman Pallares, Carmen Ardanuy
Summary: The study revealed an overall reduction of MDR/PNS isolates in adults after the introduction of pneumococcal conjugate vaccines. However, a significant proportion of current resistant isolates are not covered by any of the upcoming PCV15/PCV20 vaccines. The burden of resistant disease is related to older patients with underlying conditions and caused by two major clones. Data show that MDR is not statistically significant in relation to increased mortality.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Parasitology
Adebiyi A. Adeniran, Luis M. Hernandez-Triana, Aldo I. Ortega-Morales, Javier A. Garza-Hernandez, Josue de la Cruz-Ramos, Rahuel J. Chan-Chable, Rafael Vazquez-Marroquin, Heron Huerta-Jimenez, Nadya I. Nikolova, Anthony R. Fooks, Mario A. Rodriguez-Perez
Summary: Mosquitoes in Mexico State were surveyed using DNA barcoding and morphology, resulting in a comprehensive species checklist with new records. The study highlights the utility of DNA barcoding as a complementary tool for accurate mosquito species identification.
Article
Infectious Diseases
Silvia Montolio Breva, Carmen Molina Clavero, Frederic Gomez Bertomeu, Ester Pico-Plana, Nuria Serrat Orus, Inmaculada Palau Sanchez, Maria Teresa Mestre-Prad, Maria Teresa Sans-Mateu
Summary: This study assessed the performance of five immunoassays and one rapid immunochromatographic test for the detection of anti-SARS-CoV-2 antibodies. The tests showed sensitivities around 70-90% and specificities greater than 95%.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2022)
Article
Medicine, General & Internal
Eva M. Satue-Gracia, Angel Vila-Corcoles, Cinte De Diego-Cabanes, Angel Vila-Rovira, Cristina Torrente-Fraga, Frederic Gomez-Bertomeu, Imma Hospital-Guardiola, Olga Ochoa-Gondar, Francisco Martin-Lujan
Summary: This study analyzed the susceptibility and risk factors for COVID-19 among middle-aged and older adults. The results showed that increasing age, nursing-home residence, and multiple comorbidities increased the risk of COVID-19, while the use of statins, angiotensin-receptor blockers/inhibitors, and influenza vaccination was associated with a reduced risk.
Article
Health Care Sciences & Services
Ross D. Williams, Aniek F. Markus, Cynthia Yang, Talita Duarte-Salles, Scott L. DuVall, Thomas Falconer, Jitendra Jonnagaddala, Chungsoo Kim, Yeunsook Rho, Andrew E. Williams, Amanda Alberga Machado, Min Ho An, Maria Aragon, Carlos Areia, Edward Burn, Young Hwa Choi, Iannis Drakos, Maria Tereza Fernandes Abrahao, Sergio Fernandez-Bertolin, George Hripcsak, Benjamin Skov Kaas-Hansen, Prasanna L. Kandukuri, Jan A. Kors, Kristin Kostka, Siaw-Teng Liaw, Kristine E. Lynch, Gerardo Machnicki, Michael E. Matheny, Daniel Morales, Fredrik Nyberg, Rae Woong Park, Albert Prats-Uribe, Nicole Pratt, Gowtham Rao, Christian G. Reich, Marcela Rivera, Tom Seinen, Azza Shoaibi, Matthew E. Spotnitz, Ewout W. Steyerberg, Marc A. Suchard, Seng Chan You, Lin Zhang, Lili Zhou, Patrick B. Ryan, Daniel Prieto-Alhambra, Jenna M. Reps, Peter R. Rijnbeek
Summary: This study investigated the possibility of using influenza data to develop prediction models for COVID-19 in order to speed up the development and validation of reliable prediction models in the early stages of a pandemic. The researchers developed COVID-19 Estimated Risk (COVER) scores based on historical data from patients with influenza or flu-like symptoms, and tested them on COVID-19 patients. The results showed that the COVER scores performed well in predicting the risk of hospital admission, intensive services, and fatality in COVID-19 patients. However, there were some calibration issues in the COVID-19 validations, possibly due to differences in symptom severity between the two diseases. Recalibrating the models in each location before use could be a possible solution.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Pharmacology & Pharmacy
Nicolas H. Thurin, Romin Pajouheshnia, Giuseppe Roberto, Caitlin Dodd, Giulia Hyeraci, Claudia Bartolini, Olga Paoletti, Hedvig Nordeng, Helle Wallach-Kildemoes, Vera Ehrenstein, Elena Dudukina, Thomas MacDonald, Giorgia De Paoli, Maria Loane, Christine Damase-Michel, Anna-Belle Beau, Cecile Droz-Perroteau, Regis Lassalle, Jorieke Bergman, Karin Swart, Tania Schink, Clara Cavero-Carbonell, Laia Barrachina-Bonet, Ainhoa Gomez-Lumbreras, Maria Giner-Soriano, Maria Aragon, Amanda J. Neville, Aurora Puccini, Anna Pierini, Valentina Ientile, Gianluca Trifiro, Anke Rissmann, Maarit K. Leinonen, Visa Martikainen, Sue Jordan, Daniel Thayer, Ieuan Scanlon, Mary E. Georgiou, Marianne Cunnington, Morris Swertz, Miriam Sturkenboom, Rosa Gini
Summary: The ConcePTION project aims to reduce uncertainty about the safety of medication use in pregnancy and breastfeeding by building an ecosystem and leveraging a common data model. The model enables European data sources to contribute to major projects and facilitate effective deployment of distributed analytics.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Elena Roel, Andrea Pistillo, Martina Recalde, Sergio Fernandez-Bertolin, Maria Aragon, Isabelle Soerjomataram, Mazda Jenab, Diana Puente, Daniel Prieto-Alhambra, Edward Burn, Talita Duarte-Salles
Summary: This study showed that cancer patients have a higher risk of COVID-19 diagnosis, hospitalization, and death compared to non-cancer patients. These associations were stronger for patients recently diagnosed with cancer, under 70 years old, and those with hematological cancers. Therefore, these patients should be prioritized in COVID-19 vaccination campaigns and ongoing non-pharmaceutical interventions.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Elena Yeregui, Jenifer Masip, Consuelo Vilades, Pere Domingo, Yolanda M. Pacheco, Julia Blanco, Josep Mallolas, Veronica Alba, Montserrat Vargas, Graciano Garcia-Pardo, Eugenia Negredo, Montserrat Olona, Judit Vidal-Gonzalez, Maria Peraire, Anna Marti, Laia Reverte, Frederic Gomez-Bertomeu, Manuel Leal, Francesc Vidal, Joaquim Peraire, Anna Rull
Summary: Low concentrations of adiponectin receptor (APLNR) and zinc-alpha-2-glycoprotein (ZAG) were associated with poor immune recovery in treated PLHIV, indicating potential predictive biomarkers of a discordant immunological response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Edward Burn, Xintong Li, Kristin Kostka, Henry Morgan Stewart, Christian Reich, Sarah Seager, Talita Duarte-Salles, Sergio Fernandez-Bertolin, Maria Aragon, Carlen Reyes, Eugenia Martinez-Hernandez, Edelmira Marti, Antonella Delmestri, Katia Verhamme, Peter Rijnbeek, Scott Horban, Daniel R. Morales, Daniel Prieto-Alhambra
Summary: The study found that non-vaccine induced TTS is a very rare event among the general population, with higher rates typically seen in older individuals, males, as well as those with more comorbidities and greater medication use.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Oncology
Laia Reverte, Elena Yeregui, Montserrat Olona, Alicia Gutierrez-Valencia, Maria Jose Buzon, Anna Marti, Frederic Gomez-Bertomeu, Teresa Auguet, Luis F. Lopez-Cortes, Joaquin Burgos, Clara Benavent-Bofill, Carme Boque, Graciano Garcia-Pardo, Ezequiel Ruiz-Mateos, Maria Teresa Mestre, Francesc Vidal, Consuelo Vilades, Joaquim Peraire, Anna Rull
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Berta Raventos, Andrea Pistillo, Carlen Reyes, Sergio Fernandez-Bertolin, Maria Aragon, Anna Berenguera, Constanza Jacques-Avino, Laura Medina-Perucha, Edward Burn, Talita Duarte-Salles
Summary: The COVID-19 pandemic initially led to an increase in anxiety diagnoses, but the number of cases decreased as the pandemic continued. Diagnoses of depressive disorders were lower than expected throughout the pandemic.
Article
Immunology
Jenifer Masip, Norma Rallon, Elena Yeregui, Montserrat Olona, Salvador Resino, Jose M. Benito, Consuelo Vilades, Graciano Garcia-Pardo, Jose Alcami, Ezequiel Ruiz-Mateos, Frederic Gomez-Bertomeu, Montserrat Vargas, Marta Navarro, Jose A. Oteo, Juan A. Pineda, Anna Marti, Veronica Alba, Francesc Vidal, Joaquin Peraire, Anna Rull
Summary: Long-term elite controllers exhibit elevated tricarboxylic acid (TCA) cycle function and alpha-ketoglutaric acid is identified as a key metabolite in persistent control. Conversely, lipidomics analysis suggests that an elevated lipidomics plasma profile could predict the reignition of viral replication in LTEC individuals.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Carles Perpinan, Laia Bertran, Ximena Terra, Carmen Aguilar, Jessica Binetti, Miguel Lopez-Dupla, Anna Rull, Laia Reverte, Elena Yeregui, Frederic Gomez-Bertomeu, Joaquim Peraire, Teresa Auguet
Summary: This study investigates the feasibility of using baseline cytokines as early prognostic biomarkers for COVID-19, and analyzes the impact of comorbidities such as obesity or metabolic syndrome on the cytokine profile. The results reveal that resistin and IL-15 are associated with worse prognosis of COVID-19 and serve as the best early predictors for requiring invasive ventilation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Raquel Cuadros, Mar Perez, Daniel Ruiz-Gabarre, Felix Hernandez, Vega Garcia-Escudero, Jesus Avila
Summary: W-Tau, a new human-specific splicing isoform, can inhibit the aggregation of tau and β-amyloid peptides through its unique 18-amino-acid sequence.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jenifer Masip, Rosa Jorba, Miguel Lopez-Dupla, Pere Domingo, Yolanda Maria Pacheco, Graciano Garcia-Pardo, Esteban Martinez, Consuelo Vilades, Sergi Veloso, Veronica Alba, Montserrat Olona, Francesc Vidal, Frederic Gomez-Bertomeu, Joaquim Peraire, Anna Rull
Summary: Nuclear magnetic resonance (NMR)-based lipoprotein tests have shown that LDL-P and HDL-P are better predictors of cardiovascular risk than traditional cholesterol markers. In people with HIV, impaired immune function may be associated with preclinical atherosclerosis and vascular dysfunction. Starting antiretroviral therapy (ART) can equalize the lipoprotein-based cardiovascular risk markers between individuals with poor immunological response (INR) and good immunological response (IR).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Edward Burn, Elena Roel, Andrea Pistillo, Sergio Fernandez-Bertolin, Maria Aragon, Berta Raventos, Carlen Reyes, Katia Verhamme, Peter Rijnbeek, Xintong Li, Victoria Y. Strauss, Daniel Prieto-Alhambra, Talita Duarte-Salles
Summary: This study compares the rates of thrombosis and thrombocytopenia following vaccination against and infection with SARS-CoV-2 in Catalonia, Spain with the expected rates in the general population. The results show that adverse events after vaccination are generally similar to background rates, while the rates are significantly increased for COVID-19 cases, highlighting the importance of vaccination.
NATURE COMMUNICATIONS
(2022)