A live cell assay of GPCR coupling allows identification of optogenetic tools for controlling Go and Gi signaling

β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway

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GPCRdb: the G protein-coupled receptor database - an introduction

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Comprehensive analysis of chemokine-induced cAMP-inhibitory responses using a real-time luminescent biosensor

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Whole-Genome Comparative Analysis of Two Carbapenem-Resistant ST-258Klebsiella pneumoniaeStrains Isolated during a North-Eastern Ohio Outbreak: Differences within the High Heterogeneity Zones

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Emerging therapies for inherited retinal degeneration

(2016) H. P. N. Scholl et al.   Science Translational Medicine

The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go

(2016) Ying Xu et al.   Scientific Reports

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist

(2015) L. Laprell et al.   ACS Chemical Neuroscience

Forskolin-free cAMP assay for Gi-coupled receptors

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Restoration of Vision with Ectopic Expression of Human Rod Opsin

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Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential

(2015) Andreas Reiner et al.   CURRENT OPINION IN PHARMACOLOGY

Dynamics of G protein effector interactions and their impact on timing and sensitivity of G protein-mediated signal transduction

(2015) Eva-Lisa Bodmann et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Differential function of Gγ13 in rod bipolar and ON cone bipolar cells

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Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity

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Targeting Channelrhodopsin-2 to ON-bipolar Cells With Vitreally Administered AAV Restores ON and OFF Visual Responses in Blind Mice

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Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

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Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

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Restoring the ON Switch in Blind Retinas: Opto-mGluR6, a Next-Generation, Cell-Tailored Optogenetic Tool

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Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

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Crosstalk between beta-2-adrenoceptor and muscarinic acetylcholine receptors in the airway

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Vertebrate Cone Opsins Enable Sustained and Highly Sensitive Rapid Control of G i/o Signaling in Anxiety Circuitry

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Optogenetic control of chemokine receptor signal and T-cell migration

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Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice

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Diversity of animal opsin-based pigments and their optogenetic potential

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Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes

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Human melanopsin forms a pigment maximally sensitive to blue light ( max   479 nm) supporting activation of Gq/11 and Gi/o signalling cascades

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TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

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Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

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The manipulation of neural and cellular activities by ectopic expression of melanopsin

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Reproducible and Sustained Regulation of Gαs Signalling Using a Metazoan Opsin as an Optogenetic Tool

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G-protein-mediated inhibition of the Trp channel TRPM1 requires the G   dimer

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Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

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Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Enzymatic assembly of DNA molecules up to several hundred kilobases

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Molecular Mechanisms of Go Signaling

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Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration

(2008) Pamela S Lagali et al.   NATURE NEUROSCIENCE

Restoration of visual function in retinal degeneration mice by ectopic expression of melanopsin

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