Inhibition of miR-21-5p suppresses high glucose-induced proliferation and angiogenesis of human retinal microvascular endothelial cells by the regulation of AKT and ERK pathways via maspin

Renal Protection Mediated by Hypoxia Inducible Factor-1α Depends on Proangiogenesis Function of miR-21 by Targeting Thrombospondin 1

(2017) Xialian Xu et al.   TRANSPLANTATION

MiR-21-5p in urinary extracellular vesicles is a novel biomarker of urothelial carcinoma

(2017) Kyosuke Matsuzaki et al.   Oncotarget

Urine miR-21-5p as a potential non-invasive biomarker for gastric cancer

(2017) Hsiao-Wei Kao et al.   Oncotarget

Circulating miRNA-21-5p as a diagnostic biomarker for pancreatic cancer: evidence from comprehensive miRNA expression profiling analysis and clinical validation

(2017) Kai Qu et al.   Scientific Reports

Effect of microRNA-21 on the proliferation of human degenerated nucleus pulposus by targeting programmed cell death 4

(2016) B. Chen et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells

(2016) Yi Liu et al.   CANCER LETTERS

Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus

(2016) Felix Jansen et al.   Cardiovascular Diabetology

Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy

(2016) Jie Wei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Vegfa signals through ERK to promote angiogenesis, but not artery differentiation

(2016) Masahiro Shin et al.   DEVELOPMENT

MiR-18b suppresses high-glucose-induced proliferation in HRECs by targeting IGF-1/IGF1R signaling pathways

(2016) Jin-hui Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway

(2016) Jianming Wu et al.   MOLECULES

Upregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease

(2016) Ayumi Usui-Ouchi et al.   PLoS One

The progress in understanding and treatment of diabetic retinopathy

(2016) Alan W. Stitt et al.   PROGRESS IN RETINAL AND EYE RESEARCH

MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer

(2016) Yan-Ran Wu et al.   TUMOR BIOLOGY

Disruption of microRNA-21 by TALEN leads to diminished cell transformation and increased expression of cell–environment interaction genes

(2015) Buyuan Chen et al.   CANCER LETTERS

The Role of miR-21 in Cancer

(2015) Susan R. Pfeffer et al.   DRUG DEVELOPMENT RESEARCH

Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions

(2015) Irene Filippi et al.   Reproductive Sciences

Targeted Knock-Down of miR21 Primary Transcripts Using snoMEN Vectors Induces Apoptosis in Human Cancer Cell Lines

(2015) Motoharu Ono et al.   PLoS One

SOX11 promotes tumor angiogenesis through transcriptional regulation of PDGFA in mantle cell lymphoma

(2014) J. Palomero et al.   BLOOD

Altered Retinal MicroRNA Expression Profiles in Early Diabetic Retinopathy: AnIn SilicoAnalysis

(2014) Fen Xiong et al.   CURRENT EYE RESEARCH

Evaluation of proliferating cell abundance and phenotypes in proliferative diabetic retinopathy

(2014) Richard M. Feist et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Deciphering Combinations of PI3K/AKT/mTOR Pathway Drugs Augmenting Anti-Angiogenic Efficacy In Vivo

(2014) Temitope Sasore et al.   PLoS One

The Role of TLR2 and 4-Mediated Inflammatory Pathways in Endothelial Cells Exposed to High Glucose

(2014) Harshini Mudaliar et al.   PLoS One

miRNAs in Insulin Resistance and Diabetes-Associated Pancreatic Cancer: The ‘Minute and Miracle’ Molecule Moving as a Monitor in the ‘Genomic Galaxy’

(2013) Chiranjib Chakraborty et al.   CURRENT DRUG TARGETS

miR-21 is a key therapeutic target for renal injury in a mouse model of type 2 diabetes

(2013) X. Zhong et al.   DIABETOLOGIA

MiR-21 is Overexpressed in Response to High Glucose and Protects Endothelial Cells from Apoptosis

(2013) J. Zeng et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Knock-down of Pdcd4 stimulates angiogenesis via up-regulation of angiopoietin-2

(2012) Sebastian Krug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Enhanced PKCδ and ERK Signaling Mediate Cell Migration of Retinal Pigment Epithelial Cells Synergistically Induced by HGF and EGF

(2012) Yu Jung Chen et al.   PLoS One

MicroRNA-21 Orchestrates High Glucose-induced Signals to TOR Complex 1, Resulting in Renal Cell Pathology in Diabetes

(2011) Nirmalya Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin

(2011) Ping Dong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Altered MicroRNA Expression Profiles in Retinas with Diabetic Retinopathy

(2011) Jin-hui Wu et al.   OPHTHALMIC RESEARCH

MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells

(2011) Céline Sabatel et al.   PLoS One

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

Potential Therapeutic Roles for Inhibition of the PI3K/Akt/mTOR Pathway in the Pathophysiology of Diabetic Retinopathy

(2011) Jorge L. Jacot et al.   Journal of Ophthalmology

Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells

(2010) Mineko Terao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells

(2010) Rui Zhou et al.   NUCLEIC ACIDS RESEARCH

Maspin Suppresses Survival of Lung Cancer Cells through Modulation of Akt Pathway

(2010) Eunsook Nam et al.   Cancer Research and Treatment

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions

(2009) Elena I. Deryugina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma

(2009) Ramon Chua et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: The Twenty-five-Year Incidence of Macular Edema in Persons with Type 1 Diabetes

(2009) Ronald Klein et al.   OPHTHALMOLOGY

Projection of Diabetic Retinopathy and Other Major Eye Diseases Among People With Diabetes Mellitus

(2008) Jinan B. Saaddine   ARCHIVES OF OPHTHALMOLOGY

MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

(2008) Shuomin Zhu et al.   CELL RESEARCH

Maspin modulates prostate cancer cell apoptotic and angiogenic response to hypoxia via targeting AKT

(2008) S McKenzie et al.   ONCOGENE