Article
Oncology
Jiajia Gao, Lusong Tian, Yulin Sun, Wei Li, Lina Zhao, Yan Sun, Zongpan Jing, Lanping Zhou, Fang Liu, Xiaohang Zhao
Summary: PUR alpha promotes cell growth, migration, and invasion in ESCC, likely through inducing EMT to contribute to the progression of ESCC. High expression of PUR alpha is associated with lymph node metastasis, advanced AJCC stage, and worse survival outcomes in ESCC patients.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Cell Biology
Baoyu Chen, Wenhui Dong, Tinghui Shao, Xiulian Miao, Yan Guo, Xingyu Liu, Yifei Feng
Summary: The KDM4-DBC1-SIRT1 pathway was found to regulate EMT and contribute to the development of intestinal fibrosis. Depletion or inhibition of KDM4A attenuated TGF-beta induced EMT and normalized SIRT1 activity. Therefore, targeting this pathway may be a potential strategy for treating intestinal fibrosis in IBDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ali Dayoub, Artem I. Fokin, Maria E. Lomakina, John James, Marina Plays, Tom Jacquin, Nikita M. Novikov, Rostislav S. Vorobyov, Anastasia A. Schegoleva, Karina D. Rysenkova, Julia Gaboriaud, Sergey V. Leonov, Evgeny V. Denisov, Alexis M. Gautreau, Antonina Y. Alexandrova
Summary: Whole exome sequencing of invasive mammary carcinomas identified the association of PTEN and ZFHX3 mutations. In MCF10A cells, PTEN inactivation induced the formation of large colonies, while ZFHX3 inactivation in PTEN KO increased colony numbers and restored their size. PTEN KO enhanced coordinated cell motility and collective migration, while ZFHX3 KO resulted in uncoordinated cell movement and the expression of the mesenchymal marker vimentin. Double KO cells showed decreased coordination in collective migration, high vimentin levels, and restored linear adhesive junctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Haixiu Liao, Meng Ding, Nannan Zhou, Ying Yang, Liwen Chen
Summary: This study reveals that B7-H3 induces the upregulation of SIRT1 expression via the PI3K/AKT pathway, thereby promoting the metastasis of NSCLC. B7-H3 depletion and SIRT1 silencing inhibit the EMT process and reduce the migration and invasion abilities of NSCLC cells.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xiao Liu, Yu He, Yonghua Tong, Qiu Huang, Haojie Shang, Zhiqiang Chen, Kun Tang
Summary: PODNL1 has been identified as a potential therapeutic target and prognostic biomarker for bladder cancer (BLCA). Its high expression is associated with the clinical and pathological characteristics of BLCA, as well as poor prognosis. It plays a role in regulating the proliferation, migration, and epithelial mesenchymal transition (EMT) process of BLCA cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Nerea Palao, Celia Sequera, Angel M. Cuesta, Cristina Baquero, Paloma Bragado, Alvaro Gutierrez-Uzquiza, Aranzazu Sanchez, Carmen Guerrero, Almudena Porras
Summary: The knock-down of C3G enhances the migratory and invasive ability of oval cells and increases the expression of stemness markers. It also enhances the clonogenic capacity of oval cells. The knock-down of C3G impairs HGF/MET signaling and increases TGF-beta signaling in oval cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Lung cancer metastasis is a major cause of lung cancer-related deaths. This study investigated the potential of cycloartocarpin in inhibiting the metastasis of lung cancer cells. The results showed that non-toxic concentrations of cycloartocarpin effectively suppressed cell migration and attenuated anchorage-independent cell growth. This was accompanied by the inhibition of the EMT process through the suppression of the FAK/AKT signaling pathway.
Article
Food Science & Technology
Ji Feng, Yin Xu, Zhouling Wei, Yiju Xia, Haoxiang Zhang, Caifei Shen, Pu Wang, Wu Yan, Dianchun Fang, Yu Fang
Summary: This study aimed to investigate the effects of capsaicin on invasion and metastasis of esophageal squamous cell carcinoma (ESCC) and the underlying mechanisms. It was found that Cldn3 expression in ESCC was associated with better prognosis. Capsaicin inhibited migration, invasion, and metastasis of ESCC by overexpressing Cldn3 and inhibiting EMT.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biology
Qing Zhang, Feng Lin, Jianyong Huang, Chunyang Xiong
Summary: Cell phenotype heterogeneity within tumor tissue, especially due to epithelial-mesenchymal transition (EMT), plays a role in cancer invasion and metastasis. In this study, heterotypic tumor spheroids containing both epithelial and EMT cancer cells were generated and it was found that EMT cells dominated the periphery of the spheroid. Furthermore, EMT cells acted as leader cells to enhance the migration efficiency of epithelial cancer cells and promote dispersion and invasion of the spheroids through force transition and heterophilic N-cadherin/E-cadherin adhesion complexes. Impairment of this adhesion complex formation prevented EMT cells from guiding epithelial cancer cell migration and blocked the dispersion of tumor spheroids.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guanyue Su, Tang Feng, Tong Pei, Fan Yang, Denglian Sun, Hongchi Yu, Xiaoli Wang, Wenbo Gao, Jia He, Yang Shen, Xiaoheng Liu
Summary: Exposure to 1.4 dyne/cm(2) FSS was found to promote autophagosome formation and epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma cells, while inhibiting autophagy could impede FSS-induced cell migration. The study demonstrated that autophagy played a crucial role in FSS-induced EMT and cell migration in hepatocellular carcinoma.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Nguyen-Tuong Ho, Shu-Wei Lin, Yi-Rong Lee, Chii-Ruey Tzeng, Shu-Huei Kao
Summary: OPNb and OPNc are overexpressed in endometriosis and adenomyosis, and CD44v and the epithelial-mesenchymal transition (EMT) process are also upregulated. Overexpression of OPNb and OPNc splice variants leads to morphological changes, actin remodeling, cell proliferation, cell migration, and EMT through binding with CD44 and alpha v beta 3, subsequently activating the PI3K and NF-kappa B pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lei Du, Xuan Qian, Yuan Li, Xi-zhi Li, Lin-lin He, Liu Xu, Yi-qi Liu, Cheng-cheng Li, Pu Ma, Fang-lin Shu, Qian Lu, Xiao-xing Yin
Summary: This study demonstrates the important role of Sirt1 in renal tubular EMT of DN through mediating deacetylation of YY1, showing the potential for reversing the EMT process.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Medicine, Research & Experimental
Qin Zhang, Jia Liu, Ming-ming Deng, Run Tong, Gang Hou
Summary: This study found that plasma GHK levels were significantly lower in asthma patients compared to healthy controls, and GHK levels were moderately correlated with the severity of airflow limitation. Exogenous GHK-Cu administration could alleviate airway remodeling by increasing SIRT1 expression and activating SIRT1 deacetylation in airway epithelial cells, thus ameliorating asthma.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Rachel Vazana-Netzarim, Yishay Elmalem, Shachar Sofer, Hod Bruck, Naama Danino, Udi Sarig
Summary: By seeding hMSCs on pcECM, we observed a partial mesenchymal-to-epithelial transition (MET) and identified the crucial role of HAND2 gene in this process. HAND2 and its associated non-coding RNA are expressed at different levels in various tissues, and deviation from these basal levels is associated with various pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
