Article
Integrative & Complementary Medicine
Han-Wen Chuang, Tse-Yen Wang, Chih-Chia Huang, I-Hua Wei
Summary: This study reveals that Echinacoside has antidepressant-like effects in mice through the activation of the AMPAR-Akt/ERK-mTOR pathway in the hippocampus, and provides insights into the neuroprotective effect of Echinacoside.
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Editorial Material
Oncology
Jiong Lin
Summary: The paper focused on the anti-tumor activity of echinacoside in liver cancer through the miR-503-3p/TGF-beta 1/Smad axis, suggesting it as a safe and effective treatment. However, the presence of some confusing issues in the paper raised concerns.
CANCER CELL INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Nisha Wang, Jipeng Ma, Yan Ma, Linhe Lu, Chao Ma, Pei Qin, Erhe Gao, Mingzhang Zuo, Jian Yang, Lifang Yang
Summary: Electroacupuncture has a protective effect against myocardial ischemia/reperfusion injury, improving cardiac function and reducing infarct size. The treatment activates the XBP1/GRP78/Akt signaling pathway to protect the heart from injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
A. Funes, I Alvarez-Manzaneda, A. del Arco, J. de Vicente, I de Vicente
Summary: The study demonstrated that adding phosphorus adsorbents can effectively reduce phosphorus release in sediment cores from a shallow eutrophic lake exposed to anoxic and sediment resuspension conditions. Both CFH-12 (R) and Phoslock (R) showed high efficiency in phosphorus removal, making them promising agents for lake restoration under such circumstances. Further research on the performance of CFH-12 (R) under different factors is needed.
ENVIRONMENTAL POLLUTION
(2021)
Article
Pharmacology & Pharmacy
Tao Jiang, Hanwen Gu, Jian Wei
Summary: This study found that ECH can inhibit bone resorption and osteoclast differentiation, and alleviate bone loss in an in vivo model. These findings suggest that ECH may be a potentially effective therapeutic agent for osteoclast-related bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zheyi Yan, Yuanlin Zhang, Chunfang Wang, Yanjie Li, Qiang Su, Jimin Cao, Xiaoming Cao
Summary: This study found that Withaferin A protects human retinal microvascular endothelial cells from ischemia-reperfusion-induced apoptosis by increasing the production of antioxidants Prdx-1 and HO-1. These results suggest that Withaferin A is a promising drug candidate for the treatment of retinal ischemia-reperfusion injury.
Article
Medicine, Research & Experimental
Shanshan Qiao, Dexin Yang, Xiaofeng Li, Weiping Li, Yuan Zhang, Wenlan Liu
Summary: The study reveals the crucial role of PAQR3 in ischemia/reperfusion injury, showing that silencing PAQR3 protects neuronal cells and improves cell survival by inhibiting the apoptosis pathway. Knockdown of PAQR3 significantly attenuates apoptosis and increases cell viability, offering a novel therapeutic target for preventing cerebral ischemia/reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Liang Wang, Xuebai Lv, Jue Tian, Xiaoliang Wang, Ye Wu, Hui Rong Liu
Summary: The study found that Nec-1 may reduce myocardial cell death and maintain myocardial architectural integrity, thus inhibiting the reactive fibrosis process in rats during myocardial ischemia/late reperfusion. Administration of Nec-1 at the onset of reperfusion significantly reduced the release of creatine kinase and downregulated autophagy within 24 hours after reperfusion, with a significantly positive correlation between them.
CARDIOVASCULAR THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott, Timothy R. Billiar
Summary: The study demonstrated that MaR1 can protect the liver against hepatic ischemia/reperfusion injury through the ALXR/Akt signaling pathway. MaR1 treatment significantly reduces liver injury, suppresses inflammatory responses, oxidative stress, and decreases hepatocyte apoptosis.
MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Bokang Zhang, Wan Yang, Lanren Chen
Summary: This study found that Secreted phosphoprotein 1 (SPP1) expression is upregulated in renal ischemia-reperfusion injury (IRI) and can promote cell apoptosis, exacerbating kidney damage. Further experiments revealed that downregulation of SPP1 activates the PI3K/AKT signaling pathway, inhibiting cell apoptosis.
Article
Cardiac & Cardiovascular Systems
Antje Schauer, Peggy Barthel, Volker Adams, Axel Linke, David M. Poitz, Christof Weinbrenner
Summary: Both pharmacological preconditioning and postconditioning with levosimendan protect anoxia/reoxygenation-stressed cells by reducing apoptosis and necrosis, with preconditioning showing a stronger impact. Preconditioning also increases autophagy, while postconditioning depends on mK(ATP) activation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Enhui Yao, Lili Luo, Chenxi Lin, Jing Wen, Yanglongfei Li, Tong Ren, Yujie Chen, Jinhua Huang, Xin Jin
Summary: This study found that oleoylethanolamide (OEA) can alleviate myocardial cell apoptosis in diabetic rats with myocardial ischemia-reperfusion injury (MIRI) by activating the PI3K/Akt signaling pathway. These findings provide a theoretical basis for the use of OEA as a potential therapeutic agent for MIRI in diabetic patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Tuo Ji, Meng Chen, Yinyin Liu, Haixing Jiang, Na Li, Xianghu He
Summary: This study aimed to investigate the effect of Artesunate on intestinal ischemia/reperfusion (II/R) injury and the mechanism of how Artesunate works in mice. The results showed that Artesunate pretreatment can alleviate lung injury, regulate oxidative stress, inflammatory response, and apoptosis, and activate AKT and HO-1, providing a novel therapeutic candidate for the treatment of II/R-induced acute lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)