Echinacoside exhibits antidepressant-like effects through AMPAR–Akt/ERK–mTOR pathway stimulation and BDNF expression in mice

BDNF signaling in depression and antidepressant action

(2021) Eero Castrén et al.   BIOLOGICAL PSYCHIATRY

Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic

(2021) Damian F Santomauro et al.   LANCET

Systemic Administration of the AMPA Receptor Antagonist, NBQX, Reduces Alcohol Drinking in Male C57BL/6J, But Not Female C57BL/6J or High‐Alcohol‐Preferring, Mice

(2020) Meredith R. Bauer et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function

(2019) Ronald S. Duman et al.   MOLECULAR PSYCHIATRY

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

(2019) Ciaran P.C. Galts et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Rehmannia glutinosa Libosch Extracts Prevent Bone Loss and Architectural Deterioration and Enhance Osteoblastic Bone Formation by Regulating the IGF-1/PI3K/mTOR Pathway in Streptozotocin-Induced Diabetic Rats

(2019) Wan Gong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of PI3K/Akt and MEK/ERK Signalling in cAMP/Epac-Mediated Endothelial Barrier Stabilisation

(2019) Dursun Gündüz et al.   Frontiers in Physiology

Echinacoside alleviated LPS-induced cell apoptosis and inflammation in rat intestine epithelial cells by inhibiting the mTOR/STAT3 pathway

(2018) Lei Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Echinacoside, an Inestimable Natural Product in Treatment of Neurological and other Disorders

(2018) Jingjing Liu et al.   MOLECULES

The AMPA Receptor Code of Synaptic Plasticity

(2018) Graham H. Diering et al.   NEURON

Acute Amino Acid d-Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms

(2017) I-Hua Wei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fast-acting antidepressants rapidly stimulate ERK signaling and BDNF release in primary neuronal cultures

(2016) Ashley E. Lepack et al.   NEUROPHARMACOLOGY

Immune mechanisms linked to depression via oxidative stress and neuroprogression

(2015) Nataliia Bakunina et al.   IMMUNOLOGY

Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT

(2015) Katarzyna B. Leszczynska et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer’s disease-like rat model: relevance for amyloid deposition and central neurotransmitter function

(2014) Chi-Rei Wu et al.   BMC Complementary and Alternative Medicine

Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons

(2014) Sung Woo Park et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

(2014) Yong-Seok Lee et al.   NATURE NEUROSCIENCE

Scopolamine Rapidly Increases Mammalian Target of Rapamycin Complex 1 Signaling, Synaptogenesis, and Antidepressant Behavioral Responses

(2013) Bhavya Voleti et al.   BIOLOGICAL PSYCHIATRY

Transient exposure to echinacoside is sufficient to activate Trk signaling and protect neuronal cells from rotenone

(2012) Min Zhu et al.   JOURNAL OF NEUROCHEMISTRY

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

(2011) Gislaine Z. Réus et al.   BEHAVIOURAL BRAIN RESEARCH

Estrogen-induced signaling attenuates soluble Aβ peptide-mediated dysfunction of pathways in synaptic plasticity

(2011) Shaun M. Logan et al.   BRAIN RESEARCH

The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

(2011) Courtney S. Jernigan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neurotrophic and neurorescue effects of Echinacoside in the subacute MPTP mouse model of Parkinson's disease

(2010) Qing Zhao et al.   BRAIN RESEARCH

AMPA-receptor trafficking and injury-induced cell death

(2010) Michael S. Beattie et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach

(2009) Wei Lu et al.   NEURON

AKAP79 Selectively Enhances Protein Kinase C Regulation of GluR1 at a Ca2+-Calmodulin-dependent Protein Kinase II/Protein Kinase C Site

(2008) Steven J. Tavalin   JOURNAL OF BIOLOGICAL CHEMISTRY

Postsynaptic α-2 Adrenergic Receptors are Critical for the Antidepressant-Like Effects of Desipramine on Behavior

(2008) Han-Ting Zhang et al.   NEUROPSYCHOPHARMACOLOGY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY