Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes

(2017) Sebastiaan J. Trietsch et al.   Nature Communications

Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics

(2016) Dun-Xian Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pro-inflammatory signaling by 24,25-dihydroxyvitamin D3in HepG2 cells

(2016) Kent Wehmeier et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier

(2016) Maite R. Arana et al.   PHARMACOLOGICAL RESEARCH

Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

(2016) Marko Gröger et al.   Scientific Reports

Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

(2015) Hao-hao Zhang et al.   ACTA PHARMACOLOGICA SINICA

On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro

(2015) Mi Jang et al.   Biomicrofluidics

The Flaws and Human Harms of Animal Experimentation

(2015) AYSHA AKHTAR   CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS

MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression

(2015) Lin Dou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Melatonin or ramelteon therapy differentially affects hepatic gene expression profiles after haemorrhagic shock in rat — A microarray analysis

(2015) Astrid Kleber et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses

(2015) Yang Liu et al.   JOURNAL OF HEPATOLOGY

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

(2015) Edinson Lucumi Moreno et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Interleukin-6 and its receptors: A highly regulated and dynamic system

(2014) Janina Wolf et al.   CYTOKINE

Alterations of Canalicular ATP-Binding Cassette Transporter Expression in Drug-Induced Liver Injury

(2014) Gernot Zollner et al.   DIGESTION

Melatonin modifies cellular stress in the liver of septic mice by reducing reactive oxygen species and increasing the unfolded protein response

(2014) Astrid Kleber et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Proposing a Caco-2/HepG2 cell model for in vitro iron absorption studies

(2014) Nathalie M. Scheers et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

miR-200s Contribute to Interleukin-6 (IL-6)-induced Insulin Resistance in Hepatocytes

(2013) Lin Dou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion

(2012) Markus G. Donner et al.   BIOLOGICAL CHEMISTRY

Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways

(2012) D.-Y. Shin et al.   BLOOD

Effects of Culture Duration on Gene Expression of P450 Isoforms, Uptake and Efflux Transporters in Primary Hepatocytes Cultured in the Absence and Presence of Interleukin- 6: Implications for Experimental Design for the Evaluation of Downregulatory Effects of Biotherapeutics

(2012) Qian Yang et al.   CURRENT DRUG METABOLISM

Effect of Rifampin on Production of Inflammatory Mediators in HepG2 Liver Epithelial Cells

(2011) Yael Yuhas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cannabinoid Receptor Type 1 (CB1R) Signaling Regulates Hepatic Gluconeogenesis via Induction of Endoplasmic Reticulum-bound Transcription Factor cAMP-responsive Element-binding Protein H (CREBH) in Primary Hepatocytes

(2011) Dipanjan Chanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response

(2011) Jihwa Chung et al.   MOLECULAR IMMUNOLOGY

Regulation of MRP2/ABCC2 and BSEP/ABCB11 Expression in Sandwich Cultured Human and Rat Hepatocytes Exposed to Inflammatory Cytokines TNF-α, IL-6, and IL-1β

(2010) Lei Diao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

(2010) Jian Yang et al.   TOXICOLOGY LETTERS

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

(2010) Alexander M Mathes   WORLD JOURNAL OF GASTROENTEROLOGY

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Regulation of human hepatic drug transporter expression by pro-inflammatory cytokines

(2009) Olivier Fardel et al.   Expert Opinion on Drug Metabolism & Toxicology

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCζ-Akt-GSK3β pathway in hepatic cells

(2009) Jiunn-Min Shieh et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of procarcinogen-bioactivating human CYP1A1, CYP1A2 and CYP1B1 enzymes by melatonin

(2009) Thomas K. H. Chang et al.   JOURNAL OF PINEAL RESEARCH

Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-  or Interleukin-6

(2008) M. L. Vee et al.   DRUG METABOLISM AND DISPOSITION

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice

(2008) Kun L. Ma et al.   HEPATOLOGY

Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats

(2008) Jeng-Yuan Wu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH