Article
Biotechnology & Applied Microbiology
Andrew George, Ilyas Sahin, Benedito A. Carneiro, Don S. Dizon, Howard P. Safran, Wafik S. El-Deiry
Summary: Immunotherapy has shown promise in treating various cancers, but does not work effectively in all cases. Strategies to sensitize tumors are being explored to overcome resistance to immunotherapy and prevent hyperprogression, ultimately aiming to improve treatment effectiveness.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Engineering, Biomedical
Pei-Wei Shueng, Lu-Yi Yu, Hsin-Cheng Chiu, Hui-Ching Chang, Yen-Ling Chiu, Tzu-Yu Kuo, Yu-Wei Yen, Chun-Liang Lo
Summary: Recent studies suggest that immunotherapy alone for cancer treatment is not viable, and combination with other strategies is necessary. A newly designed micelle can enhance ROS levels in the entire tumor tissue, inhibiting cancer cell growth and boosting immune response through various mechanisms.
Review
Oncology
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Summary: Macrophages play a crucial role in the tumor microenvironment, where they can be polarized into tumor-associated macrophages (TAMs). The abundance of TAMs in tumors is closely linked with poor prognosis, leading to investigations into therapeutic strategies targeting TAMs. These strategies include inhibiting macrophage recruitment to tumors, repolarizing TAMs towards an anti-tumor phenotype, and inducing macrophage-mediated destruction of cancer cells. As tumor immunotherapy gains more importance, new anti-tumor strategies focusing on TAMs are being discussed.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Cong Zhang, Sisi Wei, Suli Dai, Xiaoya Li, Huixia Wang, Hongtao Zhang, Guogui Sun, Baoen Shan, Lianmei Zhao
Summary: The lncRNA NR_109 plays a crucial role in regulating the polarization of M2-like macrophages through the NR_109/FUBP1/c-Myc positive feedback loop. High expression of NR_109 is associated with poor clinical stages in gastric cancer and breast cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Jia-Xin An, Zi-Yi Han, You-Teng Qin, Chu-Xin Li, Jin-Lian He, Xian-Zheng Zhang
Summary: This study reports a strategy of attaching bacteria to macrophages, which sustainably stimulates the polarization of macrophages and reduces tumor progression in an immunosuppressive tumor microenvironment without any side effects. This research opens a new avenue for the development of cell therapies.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Xiaonan Xiang, Jianguo Wang, Di Lu, Xiao Xu
Summary: Tumor-associated macrophages (TAMs) play a significant role in tumor immunotherapies, with potential therapeutic value in enhancing treatment outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Immunology
Mengyuan Li, Ping Jiang, Shuhua Wei, Junjie Wang, Chunxiao Li
Summary: Recent studies have shown that tumor-associated macrophages play a crucial role in tumor initiation and progression as the most abundant stromal cells in the tumor microenvironment. The proportion of macrophages in the tumor microenvironment is associated with cancer prognosis. These macrophages can polarize into anti-tumorigenic and pro-tumorigenic phenotypes, exerting opposing effects on tumor progression. Additionally, there is extensive communication between tumor-associated macrophages and other immune cells, impacting tumor development and treatment outcomes. Targeting the molecules and signaling pathways involved in these interactions can be a potential immunotherapeutic strategy for malignant tumors.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Marit J. van Elsas, Camilla Labrie, Anders Etzerodt, Pornpimol Charoentong, Jordi J. C. van Stigt Thans, Thorbald Van Hall, Sjoerd H. van der Burg
Summary: A small population of CD163(hi) tissue-resident macrophages is identified to be responsible for primary and secondary resistance against T-cell-based immunotherapies. While these CD163(hi) M2 macrophages are resistant to Csf1r-targeted therapies, in-depth characterization and identification of the underlying mechanisms driving immunotherapy resistance allows the specific targeting of this subset of macrophages, thereby creating new opportunities for therapeutic intervention with the aim to overcome immunotherapy resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Wenhui Shen, Peishang Shi, Qingyu Dong, Xiuman Zhou, Chunxia Chen, Xinghua Sui, Wentong Tian, Xueqin Zhu, Xiaoxi Wang, Shengzhe Jin, Yahong Wu, Guanyu Chen, Lu Qiu, Wenjie Zhai, Yanfeng Gao
Summary: A CD24/Siglec-10 blocking peptide (CSBP) was identified, which not only blocked the interaction of CD24/Siglec-10, but also PD-1/PD-L1. CSBP promoted the phagocytosis of tumor cells by macrophages and M-MDSCs, and elevated the activity of CD8(+) T cells. Furthermore, combination of CSBP and radiotherapy synergistically reduced tumor growth and altered the tumor microenvironment in both anti-PD-1-responsive MC38 and anti-PD-1-resistant 4T1 tumor models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Yukiko Yamaguchi, Jackson Gibson, Kevin Ou, Lupita S. Lopez, Rachel H. Ng, Neena Leggett, Vanessa D. Jonsson, Jelani C. Zarif, Peter P. Lee, Xiuli Wang, Catalina Martinez, Tanya B. Dorff, Stephen J. Forman, Saul J. Priceman
Summary: This study reveals an alternative mechanism by which the combination of CAR T cells and immune checkpoint blockade modulates the immune landscape of solid tumors to enhance therapeutic efficacy of CAR T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Mengshi Jiang, Xiang Li, Junlei Zhang, Yichao Lu, Yingying Shi, Chunqi Zhu, Yu Liu, Bing Qin, Zhenyu Luo, Yongzhong Du, Lihua Luo, Ling Peng, Jian You
Summary: By inhibiting both ER stress and oxidative stress, M2-tumor associated macrophages (TAMs) can be effectively repolarized, providing significant implications for anti-tumor therapy.
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Kunpeng Lv, Mengyao Sun, Hanji Fang, Jieti Wang, Chao Lin, Hao Liu, Heng Zhang, He Li, Hongyong He, Yun Gu, Ruochen Li, Fei Shao, Jiejie Xu
Summary: In gastric cancer, Siglec-10 positive tumor-associated macrophages (TAMs) contribute to immune evasion by exhibiting an immunosuppressive phenotype and hindering CD8+ T cell-mediated antitumor immune response. Blocking Siglec-10 can reinvigorate the antitumor immune response and synergistically enhance the efficacy of anti-PD-1 immunotherapy in an ex vivo gastric cancer tumor fragment platform.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Shi-Qiang Wang, Shaza Darwish, Xiao-Qing Meng, Ze Chang, Xian-He Bu, Michael J. Zaworotko
Summary: The study demonstrates that a previously reported square lattice coordination network can undergo acetylene-induced switching between closed and open phases. The resulting stepped sorption isotherms exhibit consistent high uptake and benchmark working capacity for acetylene storage under temperature control.
CHEMICAL COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Yi Lu, Xiaoqing Meng, Jiajun Wang, Mahlatsi Yorgan Dieketseng, Yifan Xiao, Su Yan, Yu Chen, Lixiang Zhou, Guanyu Zheng
Summary: Conditioning can significantly improve the dewaterability of sewage sludge, with bioleaching conditioning showing superior results in reducing the abundance of ARGs in compost products compared to chemical conditioning using Fe[III]/CaO or PAM. Additionally, bioleaching conditioning resulted in the lowest abundances of ARG subtypes and ARG-associated bacteria in the sludge compost product.
Article
Chemistry, Analytical
Jingjing Xiang, Chunbai Xiang, Lihua Zhou, Mengsi Sun, Lixiong Feng, Chuangjun Liu, Lintao Cai, Ping Gong
Summary: In this study, a rational design strategy for A beta 42 fluorescence probes based on rhodamine-copper complexes was reported. The results showed that the Rho4-Cu probe exhibited high sensitivity, high affinity, and high selectivity, and was able to effectively differentiate normal mice and AD mice.
ANALYTICAL CHEMISTRY
(2022)
Correction
Plant Sciences
Siyuan Liu, Chengbin Zhang, Fen Guo, Qing Sun, Jing Yu, Tingting Dong, Xin Wang, Weihan Song, Zongyun Li, Xiaoqing Meng, Mingku Zhu
Article
Engineering, Environmental
Xiaoqing Meng, Hua Li, Su Yan, Zengping Ning, Quan Yuan, Chengshuai Liu, Lixiang Zhou, Guanyu Zheng
Summary: The present study found that pre-acidification greatly promoted the inactivation of a multi-drug resistant bacterium and the degradation of carried antibiotic resistance genes (ARGs) in wastewater. Pre-acidification led to cell lysis and the release of ARGs, which were then degraded by the generated radicals. This study highlights the importance of efficiently lysing ARB cells to promote the degradation of carried ARGs and reduce antibiotic resistance in wastewater.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Plant Sciences
Xiaoqing Meng, Siyuan Liu, Chengbin Zhang, Junna He, Daifu Ma, Xin Wang, Tingting Dong, Fen Guo, Jing Cai, Tiandan Long, Zongyun Li, Mingku Zhu
Summary: In this study, a stress-induced transcription factor named IbNAC3 from sweet potato was identified. IbNAC3 was found to enhance the tolerance of Arabidopsis to single and combined salt and drought stresses. It interacts with a group of NAC transcription factors and regulates the expression of downstream target genes, thus affecting stress tolerance. Additionally, IbNAC3 regulates the ubiquitin pathway and abscisic acid signaling to modulate the combined stress tolerance.
Review
Nanoscience & Nanotechnology
Yuhan Wang, Guojun Huang, Qi Hou, Hong Pan, Lintao Cai
Summary: Cell nanomodification is a reliable and efficient strategy that combines cell activity with nanomaterials to achieve remarkable treatment results.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Physical
Guojun Huang, Lanlan Liu, Hong Pan, Lintao Cai
Summary: This review summarizes the recent advances in using biomimetic active materials to guide immunogenic cell death (ICD) for cancer immunotherapy. It introduces two main strategies, including naive organism-derived nanoagents and engineered bioactive platforms. The challenges and future developments of using biomimetic active materials guided ICD in cancer immunotherapy applications are also discussed.
Article
Chemistry, Multidisciplinary
Lishan Zhang, Baozhen Zhang, Ruijing Liang, Hui Ran, Denghui Zhu, Jian Ren, Lanlan Liu, Aiqing Ma, Lintao Cai
Summary: A self-driving yeast micro/nanorobot (Cur@ CaY-robot) is designed via dual biomineralization and acid catalysis, which demonstrates efficient motion in gastric acid and can penetrate the thick gastric mucus for improved drug accumulation in the stomach wall tissue. Additionally, the released Ca2+ cations from the robot synergistically repair the gastric motility of gastritis mice. The biocompatible and biodegradable nature of these yeast micro/nanorobots, along with their good drug loading capacity, make them promising for active drug delivery and precise therapy.
Article
Biotechnology & Applied Microbiology
Wenwen Ma, Liujin Zhang, Deyu Ren, Xiaoqing Meng, Jia Yin, Qiang Sun
Summary: This study aimed to explore parental preferences for rotavirus vaccination for children under 5 years old in China. A Discrete Choice Experiment was conducted on 415 parents, identifying five attributes and measuring their relative importance. The study found that the risk of mild side-effects was the most important factor influencing vaccination, while the time required for vaccination was the least important attribute.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Plant Sciences
Chengbin Zhang, Tingting Dong, Jing Yu, Haiting Hong, Siyuan Liu, Fen Guo, Hongting Ma, Jianling Zhang, Mingku Zhu, Xiaoqing Meng
Summary: In this study, 43 IbDof genes were identified in sweetpotato, and they were found to be disproportionately dispersed across the 15 chromosomes of the crop. These genes were mainly derived from segmental duplications. Comparative analysis with orthologs from eight other plants revealed the potential evolutionary history of the Dof gene family. Furthermore, five selected IbDof genes were shown to be induced under various abiotic stress conditions and hormone treatments, and their promoter regions contained cis-acting elements associated with stress and hormone responses.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Baozhen Zhang, Hong Pan, Ze Chen, Ting Yin, Mingbin Zheng, Lintao Cai
Summary: A twin-bioengine yeast micro/nanorobot (TBY-robot) with self-propelling and self-adaptive capabilities has been developed for targeted gastrointestinal inflammation therapy. The TBY-robot uses an enzyme-macrophage switching mechanism to autonomously navigate to inflamed sites. It successfully overcomes barriers in the gastrointestinal tract and enhances drug accumulation at the diseased site, demonstrating its potential for precision treatment of inflammatory diseases.
Article
Chemistry, Multidisciplinary
Zhiwei Zhang, Jingjing Xiang, Lijiao Guan, Pu Chen, Changzhong Li, Chunlei Guo, Yan Hu, Saipeng Huang, Lintao Cai, Ping Gong
Summary: By designing and synthesizing a pH-activated photothermal sensitizer IR-PE, it is possible to trigger the lysosomal dysfunction-mediated Fenton pathway under near-infrared light irradiation, thereby inducing ferroptosis and improving antitumor efficacy while mitigating systemic side effects.
Article
Chemistry, Multidisciplinary
Zhihong Sun, Zhuokai Sun, Jie Liu, Xiaohan Gao, Liping Jiao, Qi Zhao, Yongli Chu, Xiaozhong Wang, Guanjun Deng, Lintao Cai
Summary: This study presents a strategy that combines photodynamic therapy (PDT), immune checkpoints, and EV antigens to greatly improve the efficiency of tumor immunotherapy and overcome immune escape by improving the tumor immunosuppressive microenvironment.
