The role of Pdcd4 in tumour suppression and protein translation

Tumor suppressor Pdcd4 attenuates Sin1 translation to inhibit invasion in colon carcinoma

(2017) Q Wang et al.   ONCOGENE

miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis and sensitizes nasopharyngeal carcinoma to cisplatin

(2016) Y Zhen et al.   ONCOGENE

Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells

(2016) Yong'An Chen et al.   Oncology Letters

RSK-mediated down-regulation of PDCD4 is required for proliferation, survival, and migration in a model of triple-negative breast cancer

(2016) Rafael Cuesta et al.   Oncotarget

Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4

(2014) Y Yang et al.   CANCER GENE THERAPY

Enhanced Arginine Methylation of Programmed Cell Death 4 Protein during Nutrient Deprivation Promotes Tumor Cell Viability

(2014) Marta M. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4

(2014) Olesja Fehler et al.   NUCLEIC ACIDS RESEARCH

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation

(2014) A Biyanee et al.   ONCOGENE

Helicobacter pylori Promotes Epithelial–Mesenchymal Transition in Gastric Cancer by Downregulating Programmed Cell Death Protein 4 (PDCD4)

(2014) Han Yu et al.   PLoS One

Down-regulation of programmed cell death 4 leads to epithelial to mesenchymal transition and promotes metastasis in mice

(2013) Qing Wang et al.   EUROPEAN JOURNAL OF CANCER

Tumor suppressor PDCD4 modulates miR-184-mediated direct suppression of C-MYC and BCL2 blocking cell growth and survival in nasopharyngeal carcinoma

(2013) Yan Zhen et al.   Cell Death & Disease

Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc

(2012) Qing Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

(2012) Shile Huang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Tumor Suppressor PDCD4 Represses Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Proteins and Is Regulated by S6 Kinase 2

(2012) U. Liwak et al.   MOLECULAR AND CELLULAR BIOLOGY

Tumour Suppressive Function and Modulation of Programmed Cell Death 4 (PDCD4) in Ovarian Cancer

(2012) Na Wei et al.   PLoS One

Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4

(2011) M. A. Powers et al.   CANCER RESEARCH

Tumor Suppressor Protein Pdcd4 Inhibits Translation of p53 mRNA

(2011) Lena Wedeken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Tandem MA-3 Region of Pdcd4 Protein and Characterization of Its Interactions with eIF4A and eIF4G

(2011) Lorna C. Waters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation

(2011) P Singh et al.   ONCOGENE

Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation

(2010) Akifumi Hayashi et al.   HUMAN PATHOLOGY

Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse

(2010) Soon-Kyung Hwang et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion

(2010) A N Santhanam et al.   ONCOGENE

Structural basis for translational inhibition by the tumour suppressor Pdcd4

(2009) Portia G Loh et al.   EMBO JOURNAL

Programmed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells

(2009) Shuhong Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Downregulation of E-cadherin is an essential event in activating β-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells

(2009) Q Wang et al.   ONCOGENE

Crystal structure of the eIF4A-PDCD4 complex

(2009) J. H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line

(2008) Brigitte Lankat-Buttgereit et al.   BIOLOGY OF THE CELL

Programmed Cell Death 4 inhibits breast cancer cell invasion by increasing Tissue Inhibitor of Metalloproteinases-2 expression

(2008) René Nieves-Alicea et al.   BREAST CANCER RESEARCH AND TREATMENT

Translation Inhibitor Pdcd4 Is Targeted for Degradation during Tumor Promotion

(2008) T. Schmid et al.   CANCER RESEARCH

MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

(2008) Z Lu et al.   ONCOGENE