Article
Cardiac & Cardiovascular Systems
Stephen J. Foulkes, Erin J. Howden, Hayley T. Dillon, Kristel Janssens, Rhys Beaudry, Amy M. Mitchell, Anniina Lindqvist, Imogen Wallace, Leah Wright, Benedict T. Costello, Guido Claessen, Mark J. Haykowsky, Andre La Gerche
Summary: This study evaluated the association between cardiorespiratory fitness (CRF) and ventricular size and function and examined the potential mechanism. The results showed that CRF was strongly associated with resting left ventricular end-diastolic volume and right ventricular end-diastolic volume, but weakly associated with resting left ventricular systolic and diastolic function. Additionally, a small ventricle was strongly associated with low CRF, which may lead to functional impairment and heart failure.
JACC-CARDIOVASCULAR IMAGING
(2023)
Editorial Material
Neurosciences
Richard S. Finkel, Kenneth H. Fischbeck
Summary: Gene replacement therapies have made significant progress in the treatment of spinal muscular atrophy, but there are concerns about the potential toxic overexpression of SMN protein in diseased mice.
NATURE NEUROSCIENCE
(2021)
Editorial Material
Cell Biology
Mark W. Pataky, K. Sreekumaran Nair
Summary: Moderate aerobic exercise is beneficial for health, but excessive and high-intensity aerobic exercise may have negative effects on mitochondrial function and glucose tolerance.
Review
Endocrinology & Metabolism
Frances M. Ashcroft, Matthew Lloyd, Elizabeth A. Haythorne
Summary: Type 2 diabetes is a global health problem characterized by inadequate insulin secretion and chronic high blood sugar. While it was initially believed that drugs stimulating glucokinase would enhance insulin secretion, recent studies have shown that it is the hyperactivation of glucose metabolism, not glucose itself, that leads to the progressive decline in beta-cell function. This perspective discusses the potential exacerbation of this decline by glucokinase activators and counterintuitively proposes that glucokinase inhibitors might be a better therapeutic strategy for preserving beta-cell function in Type 2 diabetes.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lea P. Wilhelm, Ian G. Ganley
Summary: Three new studies demonstrate that the disease-associated FBXL4 protein plays a crucial role in regulating constitutive mitophagy by controlling the stability of mitophagy receptors BNIP3 and NIX.
Article
Psychology, Multidisciplinary
Claudia Vogrincic-Haselbacher, Joachim I. Krueger, Brigitta Lurger, Isabelle Dinslaken, Julian Anslinger, Florian Caks, Arnd Florack, Hilmar Brohmer, Ursula Athenstaedt
Summary: When making online purchases, consumers are faced with a wealth of information, with varying degrees of willingness and ability to process it. Research shows that successful search strategies involve focused selection and processing of a moderate amount of information. Consumers can be categorized into three groups based on their information processing strategies, which also impact decision quality.
FRONTIERS IN PSYCHOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
John A. Hawley, David J. Bishop
Summary: Exercise training can have positive effects on mitochondrial function and metabolic health outcomes, but there may be a limit to the amount of high-intensity training that the body can tolerate before disruptions occur.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Anthony J. Michael
Summary: Researchers identified yeast high-affinity spermidine transporter, elucidated the translational mechanism driven by mRNA uORF/eIF5a for sensing spermidine levels, and demonstrated that excess spermidine competitively inhibits eIF5a function, leading to reduced spermidine uptake.
Review
Immunology
Christo Tsilifis, Mary A. Slatter, Andrew R. Gennery
Summary: Primary immune regulatory disorders (PIRDs) are a group of inborn errors of immunity caused by defects in the regulatory mechanism of the immune response. They can lead to various diseases such as infections, autoimmunity, autoinflammation, malignancy, and allergy. Recognition and treatment of PIRDs remain challenging due to their diverse phenotype and limited data on natural history and treatment. International collaboration is needed to better understand PIRDs and develop effective therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Article
Economics
JunJie Wu, Jialing Yu, Walid Oueslati
Summary: The significant variation in open space shares among US cities raises two questions: what determines the optimal amount of open space in urban areas, and is the current amount socially optimal? To address these questions, the study measures the natural, preserved, and developable open space in US metropolitan areas, and develops a framework to determine the optimal amount. The framework considers parameters such as land scarcity, price elasticities, economies of scale, and marginal benefits, and finds that most US metropolitan areas have insufficient open space in developed areas, indicating a need for additional conservation.
JOURNAL OF THE ASSOCIATION OF ENVIRONMENTAL AND RESOURCE ECONOMISTS
(2023)
Article
Economics
JunJie Wu, Jialing Yu, Walid Oueslati
Summary: The variations in open space share in US cities prompt two questions: what determines the optimal amount of open space in an urban area and is the current amount socially optimal? To answer these questions, the study measures the natural, preserved, and developable open space in US metropolitan areas and develops a framework to identify the optimal amount. Findings indicate that the scarcity of land, price elasticity of housing demand and supply, economies of scale in municipal services provision, and marginal benefits from open-space conservation are the key factors. Empirical evidence reveals that the majority of US metropolitan areas (97.39%) have insufficient open space in their developed areas and increasing open-space conservation would improve social welfare.
JOURNAL OF THE ASSOCIATION OF ENVIRONMENTAL AND RESOURCE ECONOMISTS
(2023)
Article
Management
Woon Leong Lin
Summary: The purpose of this study is to contribute to existing research on the impact of CSR on FP. Using a sample of 132 automotive companies, the study finds a non-linear relationship between CSR and FP, with the direction depending on the level of CSR engagement. The study also shows that the impact of CSR on FP is positively moderated by technological innovation.
REVIEW OF MANAGERIAL SCIENCE
(2023)
Article
Cell Biology
Chen Han, May Barakat, Luisa A. DiPietro
Summary: Angiogenesis, the growth of new blood vessels, is crucial for wound repair. The restoration of normal oxygen levels is essential for proper tissue healing. However, excessive angiogenesis can lead to abnormal blood vessels. Fine-tuning capillary regrowth in wounds has significant therapeutic potential in treating poorly healing wounds.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Kevin J. Downes, Jennifer L. Goldman
Summary: Antimicrobials are a common cause of drug toxicity, and understanding the relationship between systemic antimicrobial exposure and toxicity is necessary for healthcare providers to prevent undesired drug effects. Different categories are used to classify the relationship between exposure and toxicity of antimicrobial agents, which can help minimize observed toxicities and integrate effective therapeutic drug monitoring strategies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Editorial Material
Neurosciences
Safwan K. Elkhatib, David A. Ross, Adam J. Case
BIOLOGICAL PSYCHIATRY
(2021)
Editorial Material
Neurosciences
Lauren A. M. Lebois, David A. Ross, Milissa L. Kaufman
BIOLOGICAL PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Bernice N. Yau, David A. Ross
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Nicole Leistikow, Erica B. Baller, Phillip J. Bradshaw, Julia Nardi Riddle, David A. Ross, Lauren M. Osborne
BIOLOGICAL PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Austin W. Blum, David A. Ross
BIOLOGICAL PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Stephen Allsop Aza, Hassan W. Chaudhry, Andrew M. Novick, David A. Ross
BIOLOGICAL PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Phillip J. Bradshaw, Erica B. Baller, Julia N. Riddle, Nicole Leistikow, David A. Ross, Lauren M. Osborne
BIOLOGICAL PSYCHIATRY
(2022)
Meeting Abstract
Psychology, Developmental
David Ross, Hanna Stevens, Tara Thompson-Felix
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Editorial Material
Neurosciences
Sean L. Wilkes, David A. Ross
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Evan J. Kyzar, Andrew M. Novick, David A. Ross
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Mohamed W. ElSayed, Andrew M. Novick, Joseph J. Cooper, David A. Ross
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Julia N. Riddle, Bernice Yau, Erica Baller, Phillip Bradshaw, Nicole Leistikow, David A. Ross, Lauren M. Osborne
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Yoel D. Green, Yaakov S. Green, Bernice N. Yau, David A. Ross
BIOLOGICAL PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Jennifer Hsu, Joseph J. Cooper, David A. Ross
BIOLOGICAL PSYCHIATRY
(2023)
Article
Education, Scientific Disciplines
Johsias A. Maru, Jiangxia Wang, O'Rese J. Knight, Brittany C. Tsou, Julius T. Oatts, David A. Ross, Edward Z. Moore, Alice Yang Zhang, Saras Ramanathan, Fasika A. Woreta
Summary: This study aimed to elucidate race-based differences in word usage within ophthalmology residency letters of recommendation that may disproportionately affect underrepresented in medicine (URiM) applicants. The results showed that URiM applicants had lower USMLE Step 1 scores compared to non-URiM applicants. Non-URiM letters of recommendation were more likely to describe applicants as dependable and highlight research, while URiM letters were more likely to describe applicants as warm and caring.
JOURNAL OF SURGICAL EDUCATION
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
