The impact of aging on CD4+ T cell responses to influenza infection

Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus

(2018) Jae-Keun Park et al.   mBio

Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection

(2018) Susan L. Baldwin et al.   Frontiers in Immunology

Persistent Pathology in Influenza-Infected Mouse Lungs

(2016) Cindy M. Kanegai et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Vaccine efficacy and T helper cell differentiation change with aging

(2016) Julie S. Lefebvre et al.   Oncotarget

CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination

(2016) Zackery A. G. Knowlden et al.   Scientific Reports

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses

(2016) Julie S Lefebvre et al.   Scientific Reports

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Impact of ageing on the response and repertoire of influenza virus-specific CD4 T cells

(2014) Kathleen G Lanzer et al.   Immunity & Ageing

Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults

(2013) Janet E McElhaney et al.   Expert Review of Vaccines

Bacterial and viral infections associated with influenza

(2013) Carol Joseph et al.   Influenza and Other Respiratory Viruses

The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice

(2012) Julie S. Lefebvre et al.   AGING CELL

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Immunity to the Conserved Influenza Nucleoprotein Reduces Susceptibility to Secondary Bacterial Infections

(2012) L. Haynes et al.   JOURNAL OF IMMUNOLOGY

Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age

(2012) P. L. F. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

(2011) Heather D. Marshall et al.   IMMUNITY

ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6

(2011) Youn Soo Choi et al.   IMMUNITY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

(2011) Danelle Eto et al.   PLoS One

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Aging of the innate immune system

(2010) Albert C Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

Bim Dictates Naive CD4 T Cell Lifespan and the Development of Age-Associated Functional Defects

(2010) H. Tsukamoto et al.   JOURNAL OF IMMUNOLOGY

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

(2010) Shane Crotty et al.   NATURE IMMUNOLOGY

Follicular associated T cells and their B-cell helper qualities

(2010) Nicole M. Haynes   TISSUE ANTIGENS

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

T-cell immunosenescence: lessons learned from mouse models of aging

(2009) Alexander C. Maue et al.   TRENDS IN IMMUNOLOGY