Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases

Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems

(2017) Eric M. Feeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane alterations induced by nonstructural proteins of human norovirus

(2017) Sylvie Y. Doerflinger et al.   PLoS Pathogens

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

Targeting by AutophaGy proteins (TAG): Targeting of IFNG-inducible GTPases to membranes by the LC3 conjugation system of autophagy

(2016) Sungwoo Park et al.   Autophagy

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

(2016) Jelena Maric-Biresev et al.   BMC BIOLOGY

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

(+) RNA virus replication compartments: a safe home for (most) viral replication

(2016) Ana Shulla et al.   CURRENT OPINION IN MICROBIOLOGY

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

Interferon-induced guanylate-binding proteins in inflammasome activation and host defense

(2016) Bae-Hoon Kim et al.   NATURE IMMUNOLOGY

Mouse Norovirus infection promotes autophagy induction to facilitate replication but prevents final autophagosome maturation

(2016) Tanya B. O’Donnell et al.   VIROLOGY

Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells

(2016) Arun K. Haldar et al.   mBio

Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus

(2016) Diede Oudshoorn et al.   mBio

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

(2016) Christopher J. Neufeldt et al.   PLoS Pathogens

Guanylate binding proteins directly attack Toxoplasma gondii via supramolecular complexes

(2016) Elisabeth Kravets et al.   eLife

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Viral Sensing of the Subcellular Environment Regulates the Assembly of New Viral Replicase Complexes during the Course of Infection

(2015) Peter D. Nagy   JOURNAL OF VIROLOGY

Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins

(2015) Arun K. Haldar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrastructure of the replication sites of positive-strand RNA viruses

(2015) Christian Harak et al.   VIROLOGY

Japanese encephalitis virus replication is negatively regulated by autophagy and occurs on LC3-I- and EDEM1-containing membranes

(2014) Manish Sharma et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Triphosphate Induced Dimerization of Human Guanylate Binding Protein 1 Involves Association of the C-Terminal Helices: A Joint Double Electron–Electron Resonance and FRET Study

(2014) Tobias Vöpel et al.   BIOCHEMISTRY

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes

(2014) Meng-meng Fu et al.   DEVELOPMENTAL CELL

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

New Function of Type I IFN: Induction of Autophagy

(2014) Hana Schmeisser et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases

(2014) Etienne Meunier et al.   NATURE

The E2-Like Conjugation Enzyme Atg3 Promotes Binding of IRG and Gbp Proteins to Chlamydia- and Toxoplasma-Containing Vacuoles and Host Resistance

(2014) Arun K. Haldar et al.   PLoS One

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS

(2014) D. M. Pilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

(2014) Inés Romero-Brey et al.   Viruses-Basel

The dengue virus conceals double-stranded RNA in the intracellular membrane to escape from an interferon response

(2014) Leo Uchida et al.   Scientific Reports

Identification of the Microsporidian Encephalitozoon cuniculi as a New Target of the IFNγ-Inducible IRG Resistance System

(2014) Marialice da Fonseca Ferreira-da-Silva et al.   PLoS Pathogens

Autophagy and Viruses: Adversaries or Allies?

(2013) Xiaonan Dong et al.   Journal of Innate Immunity

Cellular Self-Defense: How Cell-Autonomous Immunity Protects Against Pathogens

(2013) F. Randow et al.   SCIENCE

Hepatitis C Virus-Induced Cytoplasmic Organelles Use the Nuclear Transport Machinery to Establish an Environment Conducive to Virus Replication

(2013) Christopher J. Neufeldt et al.   PLoS Pathogens

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

Self and Non-self Discrimination of Intracellular Membranes by the Innate Immune System

(2013) Jörn Coers   PLoS Pathogens

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

(2013) Elizabeth M. Selleck et al.   PLoS Pathogens

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

IFN-Inducible GTPases in Host Cell Defense

(2012) Bae-Hoon Kim et al.   Cell Host & Microbe

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

(2012) Seungmin Hwang et al.   Cell Host & Microbe

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

(2012) Julia Romanov et al.   EMBO JOURNAL

A Cluster of Interferon-γ-Inducible p65 GTPases Plays a Critical Role in Host Defense against Toxoplasma gondii

(2012) Masahiro Yamamoto et al.   IMMUNITY

Replication of Hepatitis C Virus RNA on Autophagosomal Membranes

(2012) Donna Sir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Cell-Autonomous Role for Interferon (IFN) Regulatory Factor 1 in IFN- -Mediated Inhibition of Norovirus Replication in Macrophages

(2012) N. S. Maloney et al.   JOURNAL OF VIROLOGY

Guanylate-binding protein 1 participates in cellular antiviral response to dengue virus

(2012) Wen Pan et al.   Virology Journal

Autophagy promotes the replication of encephalomyocarditis virus in host cells

(2011) Yongning Zhang et al.   Autophagy

Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate

(2011) Eleanor M. Cottam et al.   Autophagy

The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

(2011) Jonathan C Howard et al.   CURRENT OPINION IN MICROBIOLOGY

A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication

(2011) Alexandra Nordmann et al.   FASEB JOURNAL

Manipulation or capitulation: virus interactions with autophagy

(2011) Tristan X. Jordan et al.   MICROBES AND INFECTION

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

The dependence of viral RNA replication on co-opted host factors

(2011) Peter D. Nagy et al.   NATURE REVIEWS MICROBIOLOGY

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

(2011) Patrice Codogno et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Family of IFN- -Inducible 65-kD GTPases Protects Against Bacterial Infection

(2011) B.-H. Kim et al.   SCIENCE

Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories

(2010) Johan A. den Boon et al.   Annual Review of Microbiology

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

(2010) Fulvio Reggiori et al.   Cell Host & Microbe

Cytoplasmic Viral Replication Complexes

(2010) Johan A. den Boon et al.   Cell Host & Microbe

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Tick-Borne Encephalitis Virus Delays Interferon Induction and Hides Its Double-Stranded RNA in Intracellular Membrane Vesicles

(2010) A. K. Overby et al.   JOURNAL OF VIROLOGY

Endocytosis of Murine Norovirus 1 into Murine Macrophages Is Dependent on Dynamin II and Cholesterol

(2010) J. W. Perry et al.   JOURNAL OF VIROLOGY

The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens

(2010) Julia P. Hunn et al.   MAMMALIAN GENOME

Structural basis of oligomerization in the stalk region of dynamin-like MxA

(2010) Song Gao et al.   NATURE

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function

(2010) A. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-localization of constituents of the dengue virus translation and replication machinery with amphisomes

(2009) M. Panyasrivanit et al.   JOURNAL OF GENERAL VIROLOGY

Balance of Irgm protein activities determines IFN-γ-induced host defense

(2009) Stanley C. Henry et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mouse Norovirus Replication Is Associated with Virus-Induced Vesicle Clusters Originating from Membranes Derived from the Secretory Pathway

(2009) J. L. Hyde et al.   JOURNAL OF VIROLOGY

A Helical Membrane-Binding Domain Targets theToxoplasmaROP2 Family to the Parasitophorous Vacuole

(2009) Michael L. Reese et al.   TRAFFIC

Death and Resurrection of the Human IRGM Gene

(2009) Cemalettin Bekpen et al.   PLoS Genetics

Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

(2009) Yang O. Zhao et al.   PLoS Pathogens

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

(2008) Zijiang Zhao et al.   Cell Host & Microbe

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii

(2008) Julia P Hunn et al.   EMBO JOURNAL