Article
Biochemistry & Molecular Biology
Suresh Velnati, Sara Centonze, Federico Girivetto, Daniela Capello, Ricardo M. Biondi, Alessandra Bertoni, Roberto Cantello, Beatrice Ragnoli, Mario Malerba, Andrea Graziani, Gianluca Baldanzi
Summary: PKC zeta and PKC iota/lambda form the atypical protein kinase C subgroup, characterized by their regulation distinct from conventional PKCs. Both PKC zeta and PKC iota interact with phosphatidic acid and phosphatidylserine, while PKC iota uniquely binds to phosphatidylinositol-monophosphates. Additionally, phosphatidylinositol 4-phosphate specifically activates PKC iota, indicating a specific regulation of PKC iota by certain membrane lipids.
Article
Chemistry, Multidisciplinary
Vishal Maingi, Paul W. K. Rothemund
Summary: The study found that charge neutralization of DNA scaffolds was more important than the total hydrophobic content of their modifications in achieving bulk bilayer behavior. Additionally, complete charge neutralization of DNA scaffolds enabled better lipid binding and more stable bilayers. In conclusion, the simulations provide a guide for the design of DNA-scaffolded nanodiscs suitable for studying membrane proteins.
Article
Multidisciplinary Sciences
Shujun Cai, Yumei Wu, Andres Guillen-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli
Summary: Researchers have found in situ evidence for the bridge-like lipid transport mechanism of VPS13 at membrane contact sites using AlphaFold predictions and cryo-electron tomography.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Environmental
Jiajian Xing, Haiguang Zhang, Gaoliang Wei, Lei Du, Shuo Chen, Hongtao Yu, Xie Quan
Summary: By incorporating molybdenum sulfide (MoS2) nanosheets and applying external electrical assistance, both the 2D channel and charge density of reduced graphene oxide (rGO) membranes were regulated to enhance water flux and salt rejection. The resulting rGO/MoS2 membranes exhibited expanded nanochannels, resulting in significantly increased water permeance. In addition, the high capacitance and negative potential of the membranes contributed to improved rejection rates for NaCl and Na2SO4 ions. This study provides new insights for the design of membranes with high water flux and salt rejection efficiency.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Uxue Ballesteros, Asier Etxaniz, Marina N. Iriondo, Yaiza R. Varela, Melisa Lazaro, Ana R. Viguera, L. Ruth Montes, Mikel Valle, Felix M. Goni, Alicia Alonso
Summary: This study explores the binding of LC3C to lipid vesicles, bilayers, and monolayers, as well as the protein-dependent perturbing effects, in the absence of mitochondrial lipid cardiolipin. The results suggest that lipidated LC3C can induce vesicle aggregation, lipid mixing, and release of vesicular aqueous contents, supporting its role in autophagosome elongation and fusion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Chae Eun Lee, Sungjun Kim, Hee Won Park, Wonjeong Lee, Ashok Kumar Jangid, Yonghyun Choi, Woo-Jin Jeong, Kyobum Kim
Summary: In this study, a coating material was developed by conjugating hyaluronic acid with polyethylene glycol and lipid, which successfully improved the anticancer efficacy of NK cells. The coating enhanced the recognition of cancer cells by NK cells and prolonged the duration of hyaluronic acid on the NK cell surface, thereby improving the therapeutic effect.
Article
Biochemistry & Molecular Biology
Balint Csoboz, Imre Gombos, Zoltan Kota, Barbara Dukic, Eva Klement, Vanda Varga-Zsiros, Zoltan Lipinszki, Tibor Pali, Laszlo Vigh, Zsolt Torok
Summary: In this study, the interaction between HSPB1 and phospholipids was characterized, revealing that HSPB1 associates with membrane-forming lipids and has a strong affinity towards highly fluid membranes. HSPB1 modulates the physical properties of interacting membranes by altering lipid mobility and greatly affects the phase behavior of the plasma membrane under membrane fluidizing stress conditions. These findings suggest a new function for HSPB1 as a membrane chaperone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physics, Fluids & Plasmas
Bo Zhang, Yuhao Sun, Wenhu Han, Lei Fan, Wang Guo, Wendong Li, Haibao Mu, Guanjun Zhang
Summary: Plasma jet arrays, a flexible tool to generate large-scale non-thermal plasma, have attracted academic attention from multiple fields. This study focuses on the surface charge evolution in quartz dielectric deposited by plasma jet arrays. The results show that the fusion of surface charges is enhanced when more charges are transported onto targeted dielectrics, especially at smaller separations. In situ measurements of surface charges and corresponding simulations provide fresh insight into the electrical interaction in large-scale atmospheric-pressure plasma jets.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2023)
Review
Engineering, Environmental
Thuhin Kumar Dey, Jingwei Hou, Mika Sillanpaa, Biplob Kumar Pramanik
Summary: Micro/nanoplastics (MPs/NPs) are widespread and pose a significant threat to the environment. Metal-organic frameworks (MOFs)-based membranes have gained attention for their potential in removing MPs/NPs from water and wastewater. However, challenges such as re-aggregation, cross-contamination, and poor structural stability need to be addressed for the successful application of MOF membranes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Madhumalar Subramanian, Charlotte Kielar, Satoru Tsushima, Karim Fahmy, Jana Oertel
Summary: The use of engineered cysteines on membrane-scaffolding protein MSP1D1 allows the formation of multimers of nanodiscs, which is crucial for membrane protein research. Minimal interference with nanodisc formation and structure was demonstrated by various analytical techniques. Transmission electron microscopy showed the growth of submicron-sized tracts of stacked nanodiscs through oligonucleotide attachment to engineered cysteines.
Article
Chemistry, Multidisciplinary
Huiyuan Wu, Shaoke Fu, Wencong He, Chuncai Shan, Jian Wang, Yan Du, Shihe Du, Bangxing Li, Chenguo Hu
Summary: This study reports a fast surface charge injection technique based on air breakdown effect, which allows for directional accumulation of charge and improves the output performance of triboelectric nanogenerator. A novel charge transfer mechanism is proposed, and a method for quantifying surface charge density is given.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Physical
Md Farhad Ismail, Muhammad Amirul Islam, Behnam Khorshidi, Ali Tehrani-Bagha, Mohtada Sadrzadeh
Summary: Thin-film composite membranes are widely used for low-cost and energy-efficient water desalination processes. This review discusses the importance of controlling surface parameters and evaluates the use of contact angle analysis for membrane surface characterization. Contact angle analysis provides useful information on surface properties that influence membrane permeation and fouling. Simplifying membrane evaluation through contact angle analysis can expedite the membrane development process.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Victor Vasquez-Montes, Vivek Tyagi, Eden Sikorski, Alexander Kyrychenko, J. Alfredo Freites, Damien Thevenin, Douglas J. Tobias, Alexey S. Ladokhin
Summary: The study investigates the effects of PS, Ca2+, and peptide protonation state on the interactions of pHLIP with lipid membranes. Cellular experiments demonstrate that exposed PS on the plasma membrane promotes pHLIP targeting and the magnitude of this effect depends on extracellular Ca2+ concentration. The mechanism of targeting is further explored through a combination of fluorescence and molecular dynamics simulations.
Review
Biochemistry & Molecular Biology
Johannes Thoma, Bjorn M. Burmann
Summary: Membrane proteins are evolved to reside in the hydrophobic lipid bilayers of cellular membranes, bridging different aqueous compartments separated by the membrane and dynamically interacting with their surrounding lipid environment. This interaction not only stabilizes membrane proteins, but also influences their folding, structure, and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Yilan Wu, Yan Li, Bin Li, Yangyang Zhang, Yuehan Wu, Shilin Liu
Summary: This study investigated the effect of bacterial cellulose nanofibrils (BCNF) surface charge density on the emulsification capacity of gelatin (GLT)/BCNF mixtures. The results showed that increasing BCNF surface charge density decreased the oil-water interfacial tension and reduced the emulsion droplet size. The addition of highly-charged BCNF also improved the emulsion stability by increasing the electrostatic repulsion between droplets.
FOOD HYDROCOLLOIDS
(2023)
Article
Biochemistry & Molecular Biology
Valerio Marino, Matteo Riva, Davide Zamboni, Karl-Wilhelm Koch, Daniele Dell'Orco
Summary: This study investigates the mechanism by which the calcium-sensor protein recoverin regulates the activity of rhodopsin kinase in photoreceptors. The presence of both GRK1 and membrane is crucial for the physiological response to changes in intracellular calcium levels, driving the structural transitions of recoverin via a conformational selection mechanism. These findings may have implications for other sensory transduction systems involving protein complexes and biological membranes.
Editorial Material
Genetics & Heredity
Emmanuelle Souzeau, Nicole Weisschuh, Jamie E. Craig, Francesca Pasutto, Karl-Wilhelm Koch
Article
Biochemistry & Molecular Biology
Nicole Ahrens, Enno Aeissen, Anka Lippe, Ulrike Janssen-Bienhold, Jens Christoffers, Karl-Wilhelm Koch
Summary: GRKs deactivate G-protein-coupled receptors through phosphorylation, with four orthologous GRKs participating in the deactivation of rod and cone opsins in photoreceptor cells. GRKs have consensus sites for lipid modification, allowing the attachment of isoprenoids. A semichemical approach was used to study the incorporation of a farnesyl moiety into a GRK and its cellular consequences.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Nicole Ahrens, Dana Elbers, Helena Greb, Ulrike Janssen-Bienhold, Karl-Wilhelm Koch
Summary: The study revealed diverse properties of recoverin and opsin kinase in zebrafish retina due to differential expression and interaction profiles, indicating distinct roles of different recoverin paralogs in rod and cone cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anne Rehkamp, Dirk Tanzler, Christian Tuting, Panagiotis L. Kastritis, Claudio Iacobucci, Christian H. Ihling, Marc Kipping, Karl-Wilhelm Koch, Andrea Sinz
Summary: The study conducted a 3D-structural analysis of ROS-GC1 from bovine retina using cross-linking/mass spectrometry and computational modeling, revealing its active full-length structure and proposing a novel intracellular domain organization. The data supports a dimeric architecture of native ROS-GC1 from bovine retina and the integrated approach serves as a blueprint for conducting 3D-structural studies of membrane proteins in their native environment.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Bishoy Khairalla, Izabella Brand
Summary: The study showed that techniques can be used to deposit lipid bilayers on a gold surface and control the stability and structure of the membrane electrochemically. The electrostatic interactions in the polar head group region of KLA were dependent on the direction of the electric field, influencing the orientation of KLA molecules.
Article
Biochemistry & Molecular Biology
Judith Rose, Izabella Brand, Merle Bilstein-Schloemer, Barbara Jachimska, Richard M. Twyman, Dirk Prufer, Gundula A. Noll
Summary: Forisomes are giant self-assembling mechanoproteins that undergo reversible structural changes by binding to Ca2+, with aggregation being essential for enabling the Ca2+ response in forisome polymers.
Article
Biochemistry & Molecular Biology
Anna Avesani, Laura Bielefeld, Nicole Weisschuh, Valerio Marino, Pascale Mazzola, Katarina Stingl, Tobias B. Haack, Karl-Wilhelm Koch, Daniele Dell'Orco
Summary: This study characterizes the biochemical and biophysical properties of human GCAP3 and identifies a mutation in GUCA1C that may contribute to retinitis pigmentosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Manisha Kumari Shahu, Fabian Schuhmann, Alexander Scholten, Ilia A. Solov'yov, Karl-Wilhelm Koch
Summary: Membrane-bound guanylate cyclases (GCs) have different activation modes. Hormone peptides bind to the extracellular domain of hormone-receptor-type GCs, triggering a conformational change in the enzyme's intracellular domain. Sensory GCs in rod and cone cells have binding sites for regulatory Ca2+-sensor proteins. Our study showed that there is no alpha-helix rotation involved in the activation of guanylate cyclases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Katharina Goertemaker, Chad Yee, Rabea Bartoelke, Heide Behrmann, Jan-Oliver Voss, Jessica Schmidt, Jingjing Xu, Vita Solovyeva, Bo Leberecht, Elmar Behrmann, Henrik Mouritsen, Karl-Wilhelm Koch
Summary: This study reveals the interaction between the alpha-subunit of the cone-specific heterotrimeric G protein and the photolyase homolog in European robin, and confirms its existence in living cells. These findings support the important role of light-induced radical-pair formation in the bird's retina, which may be the first biochemical signaling step in magnetoreception.
Article
Biochemistry & Molecular Biology
Justyna Bozek, Joanna Tomala, Sylwia Wojcik, Beata Kaminska, Izabella Brand, Ewa Pochec, Elzbieta Szostak
Summary: This study evaluated the cytotoxic effects of Piptoporus betulinus extract on melanoma cells and found that it affects cancer cells in a dose-dependent manner without significant toxicity to normal cells. The active compound betulin was identified in the extract. Additionally, tests on model cell membranes confirmed the impact of the extract on melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yaoyu Chen, Anja U. Braeuer, Karl-Wilhelm Koch
Summary: The protein RD3 plays a regulatory role in photoreceptor cells, inhibiting specific membrane guanylate cyclases. Its physiological role in non-retinal tissue and protein targets outside the retina have not been identified. This study shows that RD3 can inhibit hormone-stimulated GC-A and GC-B, indicating a new regulatory feature of these hormone receptors.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Chad Yee, Katharina Goertemaker, Rieke Wellpott, Karl-Wilhelm Koch
Summary: The cone photoreceptor cells of night-migratory songbirds have the ability to process both vision and magnetoreception. Recent studies have shown a link between a putative magnetoreceptor and a cone specific G-protein in European robins. This research investigates the interaction between the G protein and the cytoplasmic regions of long wavelength opsin in European robins and identifies a critical binding interface. The results suggest that the G protein binding to the magnetoreceptor can compete with the interaction with non-photoexcited long wavelength opsin.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Chemistry, Physical
Izabella Brand
Summary: Proteins in the cytoplasm bind selectively and sensitively to DNA, leading to structural changes in both biomolecules. Detection of these changes requires sophisticated analytical methods, with electrochemical detection being particularly suitable. This has laid the foundations for the development of biosensors.
CURRENT OPINION IN ELECTROCHEMISTRY
(2023)
Article
Chemistry, Physical
Maja Hanic, Lewis M. Antill, Angela S. Gehrckens, Jessica Schmidt, Katharina Gortemaker, Rabea Bartolke, Tarick J. El-Baba, Jingjing Xu, Karl-Wilhelm Koch, Henrik Mouritsen, Justin L. P. Benesch, P. J. Hore, Ilia A. Solov'yov
Summary: Experimental and computational investigations were conducted to explore the dimerization of robin Cry4a protein. It was found that disulfide-linked dimers are routinely formed, especially under blue light exposure. Computational modeling and molecular dynamics simulations were used to assess possible dimer structures. The relevance of these findings to avian magnetoreception was discussed.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Biochemistry & Molecular Biology
Priyanga Kumar, Noel Nesakumar, Jayashree Gopal, Sakthivel Sivasubramanian, Srinivasan Vedantham, John Bosco Balaguru Rayappan
Summary: This study developed an electrochemical biosensor for measuring MG levels in the plasma of type-2 diabetes mellitus patients. The biosensor showed a wide linear concentration range, high sensitivity, and a 90% correlation with ELISA data. It also exhibited a significant correlation with HbA1c and fasting plasma glucose levels.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Cristina Tortolini, Valeria Gigli, Antonio Angeloni, Federico Tasca, Nguyen T. K. Thanh, Riccarda Antiochia
Summary: The development of a novel voltammetric immunosensor for the detection of salivary MMP-8 at the point-of-care is described. The sensor showed good performance and comparable results to the conventional ELISA method when tested in real saliva samples. This biosensor is single-use, cost-effective, and requires a small quantity of test medium and a short preparation time.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Rimsha B. Jamal, Ulrich Bay Gosewinkel, Elena E. Ferapontova
Summary: Pathogen-triggered infections are a severe global threat to human health. Researchers have developed a fast and inexpensive electrocatalytic aptamer assay for the specific and ultrasensitive detection of E. coli, allowing for timely treatment and prevention. The method is fast, sensitive, and can be used in field and point-of-care applications for analysis of bacteria in the human environment.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Miao Liu, Yuwei Wang, Shanshan Tang, Wei Wang, Axin Liang, Aiqin Luo
Summary: An unlabeled ratiometric molecular imprinted electrochemiluminescence sensor was developed for the determination of trace uric acid using MXene@NaAsc, CdSe@ZnS quantum dots, and molecularly imprinted polymer composites modified glass carbon electrode. This sensor, with easy preparation, great selectivity, and excellent sensitivity, successfully detected uric acid in human serum.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Charlotte Da Silva, Camille Lamarche, Carole Pichereaux, Emmanuelle Mouton-Barbosa, Gauthier Demol, Sebastien Boisne, Etienne Dague, Odile Burlet-Schiltz, Flavien Pillet, Marie-Pierre Rols
Summary: Low-energy electron beams (LEEB) are a safe and practical sterilization solution for industrial applications. To address the limitations of LEEB, we developed a low-energy pulsed electron beam generator (LEPEB) that can effectively and efficiently eradicate bacteria in a wide range of industrial applications.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Daniel Dobrovodsky, Ales Danhel, Daniel Renciuk, Jean-Louis Mergny, Miroslav Fojta
Summary: In this study, N-methyl mesoporphyrin IX (NMM) was utilized as a voltammetric probe for the electrochemical detection of G4s. The detection of NMM was achieved by cyclic voltammetry on a hanging mercury drop electrode (HMDE) with a limit of detection (LOD) of 40 nM. The reduction signal of NMM was found to be significantly higher when G4 oligodeoxynucleotides (G4 ODNs) were present compared to single- or double-stranded ODNs or unfolded ODNs capable of forming G4s. Gradual transition from unstructured single strand to G4, induced by increasing concentrations of the G4 stabilizing K+ ions, was detected for the first time using electrochemical methods. Circular dichroism spectroscopy provided support for the obtained results. This work expands on the utilization of electrochemical probes for DNA secondary structure recognition and offers a proof of principle for the development of novel electroanalytical methods for nucleic acid structure studies.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Mengjiao Zhu, Yu Liu, Meiyue Wang, Tao Liu, Zhenyu Chu, Wanqin Jin
Summary: Early rapid diagnosis of COVID-19 is crucial for reducing the risk of severe symptoms and loss of lung function. Researchers have proposed an ultrafast and ultrasensitive DNA sensor that can accurately detect the virus in a short period of time, with outstanding selectivity.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Fatima-Zahra Ait-Itto, James A. Behan, Mathieu Martinez, Frederic Barriere
Summary: This study investigated the feasibility of using ancient marine sediments as inoculum for bioanode development in microbial fuel cells (MFC). The results showed the presence of two exoelectrogenic bacterial genera in these iron-rich sediments and confirmed that the development of the bioanode derived from the native microbiota. This study has important implications for understanding the role of these bacteria in broader paleoenvironmental phenomena.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Issa Fall, Bastien Doumeche, Sofiene Abdellaoui, Caroline Remond, Harivony Rakotoarivonina, Marjorie Ochs
Summary: This article presents a novel electrochemical tool based on lignin-coated paper electrodes for the detection and characterization of ligninolytic activity. The suitability of this method has been demonstrated using a catalaseperoxidase isolated from Thermobacillus xylanilyticus.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Chenyi Zhuo, Dehong Yu, Jiuying Cui, Zichun Song, Qianli Tang, Xianjiu Liao, Zhao Liu, Ning Xin, Lu Lou, Fenglei Gao
Summary: A label-free detection strategy for quantification of Apolipoprotein A4 (Apo-A4) has been developed based on rolling circle amplification (RCA) and proximity hybridization-induced DNAzyme-driven bipedal DNA walker. This method shows high sensitivity and selectivity for a wide range of protein targets.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Niloufar Fattahi, Jeffrey Reed, Evan Heronemus, Priyasha Fernando, Ryan Hansen, Prathap Parameswaran
Summary: In this study, polyethylene glycol hydrogels were developed as protective coatings for electroactive biofilms, improving their viability under low resource conditions and ammonia-N shocks.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xiaopeng Hou, Qiongyi Cheng, Hui Wang
Summary: A self-cleaning paper-based microfluidic biosensor was developed using hydrophobic paper decorated with polymeric octadecyl trichlorosilane. The biosensor showed improved performance and could effectively measure the concentration of copper ions in livestock feed and manure.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Yanling Zhang, Jie Wang, Min Liu, Yun Ni, Yao Yue, Dawei He, Ruijiang Liu
Summary: An innovative electrochemical biosensor has been developed for sensitive detection of HER2 protein, an important tumor marker for breast cancer diagnosis and treatment evaluation. The biosensor utilizes specific recognition probes and nanomaterials, along with a unique sensing strategy, to achieve ultra-low detection limit and demonstrate excellent selectivity, reproducibility, and stability.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Humayun Amir, Vasanth Subramanian, Sundaram Sornambikai, Nagamony Ponpandian, Chinnusamy Viswanathan
Summary: In this study, the electrochemical detection of breast cancer biomarker HER2 was successfully achieved using the N-CQDs/GS as the detector. The BSA-modified HER2 Antibody/N-CQDs/GS immunoelectrode preserved excellent activity for the biosensor, while the GS electrode provided high stability and conductivity. The method exhibited a low detection limit and optimal specificity, stability, and reproducibility for detecting HER-2 protein in untreated blood samples from breast cancer patients.
BIOELECTROCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ilona Uzieliene, Anton Popov, Raminta Vaiciuleviciute, Gailute Kirdaite, Eiva Bernotiene, Almira Ramanaviciene
Summary: This review discusses the application of polypyrrole (Ppy), an electroconductive polymer, in cell culture experiments with electrical stimulation (ES) and its potential for tissue regeneration. Ppy can direct ES to cells and stimulate differentiation towards different cell lineages. Different types of Ppy materials and their combination with active molecules are explored.
BIOELECTROCHEMISTRY
(2024)